CO2021006474A2 - Proteínas heterodiméricas fusionadas con fc - Google Patents

Proteínas heterodiméricas fusionadas con fc

Info

Publication number
CO2021006474A2
CO2021006474A2 CONC2021/0006474A CO2021006474A CO2021006474A2 CO 2021006474 A2 CO2021006474 A2 CO 2021006474A2 CO 2021006474 A CO2021006474 A CO 2021006474A CO 2021006474 A2 CO2021006474 A2 CO 2021006474A2
Authority
CO
Colombia
Prior art keywords
advantageous
fused protein
proteins fused
heterodimeric proteins
protein constructs
Prior art date
Application number
CONC2021/0006474A
Other languages
English (en)
Inventor
William Haney
Asya Grinberg
Nicolai Wagtmann
Ann F Cheung
Jean-Marie Cuillerot
Eva Gutierrez
Original Assignee
Dragonfly Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dragonfly Therapeutics Inc filed Critical Dragonfly Therapeutics Inc
Publication of CO2021006474A2 publication Critical patent/CO2021006474A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

Abstract

La presente invención proporciona constructos de proteínas fusionadas con Fc, que como dímeros monovalentes tienen una semivida en suero más alta en comparación con una molécula nativa/natural, y, por lo tanto, son ventajosos para lograr títulos más altos de las proteínas durante la producción, mayor estabilidad durante el almacenamiento, y eficacia mejorada cuando se usan como un agente terapéutico. También se proporcionan constructos de proteínas fusionadas con Fc que tienen mutaciones en la región Fc que reducen las funciones efectoras, que tienen una actividad incrementada para inhibir el crecimiento tumoral y, por lo tanto, son ventajosos cuando se usan como un tratamiento contra el cáncer.
CONC2021/0006474A 2018-10-23 2021-05-19 Proteínas heterodiméricas fusionadas con fc CO2021006474A2 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862749489P 2018-10-23 2018-10-23
US201862781898P 2018-12-19 2018-12-19
US201962788499P 2019-01-04 2019-01-04
US201962827347P 2019-04-01 2019-04-01
US201962895889P 2019-09-04 2019-09-04
PCT/US2019/057721 WO2020086758A1 (en) 2018-10-23 2019-10-23 Heterodimeric fc-fused proteins

Publications (1)

Publication Number Publication Date
CO2021006474A2 true CO2021006474A2 (es) 2021-06-10

Family

ID=68583501

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2021/0006474A CO2021006474A2 (es) 2018-10-23 2021-05-19 Proteínas heterodiméricas fusionadas con fc

Country Status (17)

Country Link
US (2) US20220119533A1 (es)
EP (1) EP3870598A1 (es)
JP (1) JP2022505871A (es)
KR (1) KR20210080460A (es)
CN (1) CN113286808A (es)
AU (1) AU2019366956A1 (es)
BR (1) BR112021007175A2 (es)
CA (1) CA3117212A1 (es)
CL (2) CL2021001058A1 (es)
CO (1) CO2021006474A2 (es)
IL (1) IL281954A (es)
MA (1) MA53982A (es)
MX (1) MX2021004711A (es)
PE (1) PE20211279A1 (es)
SG (1) SG11202104136YA (es)
TW (1) TW202033547A (es)
WO (1) WO2020086758A1 (es)

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