CA2720368C - Anticorps specifiques de her2/neu et procedes d'utilisation de ceux-ci - Google Patents
Anticorps specifiques de her2/neu et procedes d'utilisation de ceux-ci Download PDFInfo
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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Abstract
La présente invention concerne des anticorps qui se lient spécifiquement à HER2/neu, et particulièrement des anticorps 4D5 chimères contre HER2/neu, qui ont une glycosylation réduite par rapport à des anticorps 4D5 connus. Linvention concerne en outre des procédés dutilisation des anticorps 4D5 et des compositions comprenant ceux-ci dans le diagnostic, le pronostic et la thérapie de maladies telles que le cancer, des maladies auto-immunes, des troubles inflammatoires, et des maladies infectieuses.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4164908P | 2008-04-02 | 2008-04-02 | |
US61/041,649 | 2008-04-02 | ||
PCT/US2009/038201 WO2009123894A2 (fr) | 2008-04-02 | 2009-03-25 | Anticorps spécifiques de her2/neu et procédés d’utilisation de ceux-ci |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2720368A1 CA2720368A1 (fr) | 2009-10-08 |
CA2720368C true CA2720368C (fr) | 2017-08-22 |
Family
ID=41136073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2720368A Active CA2720368C (fr) | 2008-04-02 | 2009-03-25 | Anticorps specifiques de her2/neu et procedes d'utilisation de ceux-ci |
Country Status (22)
Country | Link |
---|---|
US (6) | US8802093B2 (fr) |
EP (2) | EP3067063A1 (fr) |
JP (1) | JP5555223B2 (fr) |
KR (1) | KR101606386B1 (fr) |
CN (3) | CN107236044B (fr) |
AU (1) | AU2009231991B2 (fr) |
BR (1) | BRPI0906309A2 (fr) |
CA (1) | CA2720368C (fr) |
CY (1) | CY1117922T1 (fr) |
DK (1) | DK2247304T3 (fr) |
ES (1) | ES2587937T3 (fr) |
HK (1) | HK1144248A1 (fr) |
HR (1) | HRP20161050T1 (fr) |
HU (1) | HUE029925T2 (fr) |
IL (1) | IL208204A (fr) |
LT (1) | LT2247304T (fr) |
MX (1) | MX2010010737A (fr) |
PL (1) | PL2247304T3 (fr) |
PT (1) | PT2247304T (fr) |
SG (1) | SG189730A1 (fr) |
SI (1) | SI2247304T1 (fr) |
WO (1) | WO2009123894A2 (fr) |
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- 2009-03-25 EP EP16164701.1A patent/EP3067063A1/fr not_active Withdrawn
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- 2009-03-25 JP JP2011503039A patent/JP5555223B2/ja not_active Expired - Fee Related
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- 2009-03-25 US US12/933,885 patent/US8802093B2/en active Active
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