MX2021003543A - Polipeptidos de citocinas enmascaradas. - Google Patents

Polipeptidos de citocinas enmascaradas.

Info

Publication number
MX2021003543A
MX2021003543A MX2021003543A MX2021003543A MX2021003543A MX 2021003543 A MX2021003543 A MX 2021003543A MX 2021003543 A MX2021003543 A MX 2021003543A MX 2021003543 A MX2021003543 A MX 2021003543A MX 2021003543 A MX2021003543 A MX 2021003543A
Authority
MX
Mexico
Prior art keywords
cytokine
masking moiety
links
cleavable linker
binding
Prior art date
Application number
MX2021003543A
Other languages
English (en)
Inventor
Huawei Qiu
Margaret Karow
Deborah Moore Lai
Dheeraj Tomar
Parker Johnson
Raphael Rozenfeld
Ronan O''HAGAN
Original Assignee
Xilio Dev Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xilio Dev Inc filed Critical Xilio Dev Inc
Publication of MX2021003543A publication Critical patent/MX2021003543A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2086—IL-13 to IL-16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Abstract

En el presente documento se proporcionan citocinas o fragmentos funcionales de las mismas que, en algunas modalidades, se modifican para enmascararse mediante un resto de enmascaramiento en uno o más sitios de unión al receptor de la citocina o fragmento funcional de la misma. En algunas modalidades, las citocinas se modifican para que sean activables por una proteasa en un sitio diana, tal como en un microambiente tumoral, al incluir un enlazador escindible proteolíticamente. En algunas modalidades, el enlazador escindible proteolíticamente une la citocina al resto de enmascaramiento, une la citocina a un dominio de extensión de la vida media y/o une el resto de enmascaramiento a un dominio de extensión de la vida media. El resto de enmascaramiento bloquea, ocluye, inhibe (p. ej., disminuye) o de otro modo previene (p. ej., enmascara) la actividad o unión de la citocina a su receptor o proteína análogos. Tras la escisión proteolítica del enlazador escindible en el sitio diana, la citocina se activa, lo que la hace capaz de unirse a su receptor o proteína análogos con mayor afinidad.
MX2021003543A 2018-09-27 2019-09-27 Polipeptidos de citocinas enmascaradas. MX2021003543A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862737803P 2018-09-27 2018-09-27
US201962888276P 2019-08-16 2019-08-16
US201962891199P 2019-08-23 2019-08-23
PCT/US2019/053588 WO2020069398A1 (en) 2018-09-27 2019-09-27 Masked cytokine polypeptides

Publications (1)

Publication Number Publication Date
MX2021003543A true MX2021003543A (es) 2021-06-23

Family

ID=69949916

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021003543A MX2021003543A (es) 2018-09-27 2019-09-27 Polipeptidos de citocinas enmascaradas.

Country Status (13)

Country Link
US (6) US20220002370A1 (es)
EP (2) EP3856764A4 (es)
JP (1) JP2022502088A (es)
KR (1) KR20210087027A (es)
CN (1) CN113286812A (es)
AU (1) AU2019347751A1 (es)
BR (1) BR112021005907A2 (es)
CA (1) CA3112989A1 (es)
IL (1) IL281776A (es)
MX (1) MX2021003543A (es)
PH (1) PH12021550648A1 (es)
SG (1) SG11202102777PA (es)
WO (1) WO2020069398A1 (es)

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