SG11201607364RA - Composition and method for stabilizing nucleic acids in biological samples - Google Patents

Composition and method for stabilizing nucleic acids in biological samples

Info

Publication number
SG11201607364RA
SG11201607364RA SG11201607364RA SG11201607364RA SG11201607364RA SG 11201607364R A SG11201607364R A SG 11201607364RA SG 11201607364R A SG11201607364R A SG 11201607364RA SG 11201607364R A SG11201607364R A SG 11201607364RA SG 11201607364R A SG11201607364R A SG 11201607364RA
Authority
SG
Singapore
Prior art keywords
composition
nucleic acids
biological samples
stabilizing nucleic
stabilizing
Prior art date
Application number
SG11201607364RA
Other languages
English (en)
Inventor
Hyman Chaim Birnboim
Lindsay Pozza
Hernandez Carlos Alberto Merino
Evgueni Vladimirovitch Doukhanine
Original Assignee
Dna Genotek Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dna Genotek Inc filed Critical Dna Genotek Inc
Publication of SG11201607364RA publication Critical patent/SG11201607364RA/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SG11201607364RA 2014-03-07 2015-03-06 Composition and method for stabilizing nucleic acids in biological samples SG11201607364RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461949692P 2014-03-07 2014-03-07
US201462057769P 2014-09-30 2014-09-30
PCT/CA2015/050173 WO2015131291A1 (en) 2014-03-07 2015-03-06 Composition and method for stabilizing nucleic acids in biological samples

Publications (1)

Publication Number Publication Date
SG11201607364RA true SG11201607364RA (en) 2016-10-28

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201807736SA SG10201807736SA (en) 2014-03-07 2015-03-06 Composition and method for stabilizing nucleic acids in biological samples
SG11201607364RA SG11201607364RA (en) 2014-03-07 2015-03-06 Composition and method for stabilizing nucleic acids in biological samples

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201807736SA SG10201807736SA (en) 2014-03-07 2015-03-06 Composition and method for stabilizing nucleic acids in biological samples

Country Status (18)

Country Link
US (2) US10435735B2 (es)
EP (1) EP3114225B1 (es)
JP (1) JP6670765B2 (es)
KR (1) KR102392407B1 (es)
CN (1) CN106255753B (es)
AU (1) AU2015226811B2 (es)
CA (1) CA2941764C (es)
DK (1) DK3114225T3 (es)
ES (1) ES2880310T3 (es)
IL (1) IL247662A0 (es)
MX (1) MX2016011495A (es)
PL (1) PL3114225T3 (es)
PT (1) PT3114225T (es)
RU (1) RU2717644C2 (es)
SA (2) SA516371797B1 (es)
SG (2) SG10201807736SA (es)
WO (1) WO2015131291A1 (es)
ZA (1) ZA201906139B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7482116B2 (en) 2002-06-07 2009-01-27 Dna Genotek Inc. Compositions and methods for obtaining nucleic acids from sputum
EP3150702B1 (en) 2011-06-19 2021-05-19 DNA Genotek, Inc. Devices, solutions and methods for sample collection
SG10201807736SA (en) * 2014-03-07 2018-10-30 Dna Genotek Inc Composition and method for stabilizing nucleic acids in biological samples
MX2019010800A (es) 2017-03-15 2020-07-28 Ancestry Com Dna Llc Dispositivo y metodo de recoleccion de muestras.
NZ764035A (en) 2017-10-06 2020-05-29 Ancestry Com Dna Llc Systems, devices, and methods for sample collection
US11426734B2 (en) 2017-11-22 2022-08-30 Ancestry.Com Dna, Llc Sample collection kit including cap having selectively movable sleeve
EP3713498A4 (en) 2017-11-22 2021-08-04 Ancestry.com DNA, LLC SAMPLE COLLECTION KIT INCLUDING A CAP WITH A SELECTIVELY MOBILE SLEEVE
CN107955810A (zh) * 2017-12-25 2018-04-24 宁波卡尔新材料科技有限公司 一种新型动物肝脏核酸提取试剂盒及提取方法
AU2019221318A1 (en) 2018-02-14 2020-09-24 Salignostics Ltd. Methods and apparatus for detecting analytes
CN108893523A (zh) * 2018-05-31 2018-11-27 厦门安捷致善医学数据科技有限公司 一种粪便样品常温保存液
MX2021005762A (es) * 2018-11-14 2021-08-11 Spectrum Solutions L L C Solución de preservación de rna y métodos de fabricación y uso.
AU2020227306A1 (en) 2019-02-27 2021-10-07 Ancestry.Com Dna, Llc Graphical user interface displaying relatedness based on shared DNA
CN109810974B (zh) * 2019-04-08 2020-11-24 珠海丽珠试剂股份有限公司 提取人类免疫缺陷病毒hiv-1核酸的试剂组合产品及其方法
CA3152793A1 (en) 2019-09-05 2021-03-11 The Regents Of The University Of California Noninvasive method to quantify kidney function and functional decline
CN113186185B (zh) * 2020-01-14 2023-05-26 东北林业大学 一种从哺乳动物粪便中高效富集宿主dna的方法
WO2021150775A1 (en) * 2020-01-21 2021-07-29 Board Of Regents Of The University Of Texas System Discriminating parkinson's disease from multiple system atrophy using alpha-synuclein pmca
US20230242898A1 (en) * 2020-03-11 2023-08-03 Kao Corporation Method for preparing rna derived from skin surface lipids
US20220064709A1 (en) * 2020-09-01 2022-03-03 Longhorn Vaccines And Diagnostics, Llc Compositions and Methods for Screening Biological Samples
WO2022103978A1 (en) * 2020-11-11 2022-05-19 Biocept, Inc. Pathogen inactivating and nucleic acid stabilization media for microorganism collection and transport
WO2022219514A1 (en) * 2021-04-16 2022-10-20 Grifols Diagnostic Solutions Inc. Compositions and methods for storing a biological sample
WO2023019124A1 (en) * 2021-08-09 2023-02-16 University Of Central Florida Research Foundation, Inc. Method to preserve nucleic acids in water samples
WO2023150879A1 (en) * 2022-02-10 2023-08-17 Dna Genotek Inc. Methods and systems for defining test sample read count limits for a range of microbial sequence reads

Family Cites Families (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663161A (en) * 1985-04-22 1987-05-05 Mannino Raphael J Liposome methods and compositions
GB8614084D0 (en) * 1986-06-10 1986-07-16 Serono Diagnostics Ltd Immunoassay
US4918178A (en) 1987-10-22 1990-04-17 Wisconsin Alumni Research Foundation Test for Johne's disease
JP2791367B2 (ja) 1988-04-21 1998-08-27 マイクロプローブ・コーポレーション 核酸抽出方法
JPH04187077A (ja) 1990-11-22 1992-07-03 Shimadzu Corp 核酸の抽出精製装置
JPH0599923A (ja) 1991-10-11 1993-04-23 Nitto Denko Corp ヒトヘモグロビンの検出方法及びそれに用いる便溶解用緩衝液
DE4204012A1 (de) * 1992-02-12 1993-08-19 Ulrich Prof Dr Zimmermann Mitogenfreie substanz, deren herstellung und verwendung
ES2210239T3 (es) 1992-04-01 2004-07-01 The Johns Hopkins University School Of Medicine Metodo para detectar acidos nucleicos de mamiferos aislados en heces y reactivos para el mismo.
DE4321904B4 (de) 1993-07-01 2013-05-16 Qiagen Gmbh Verfahren zur chromatographischen Reinigung und Trennung von Nucleinsäuregemischen
JP3866762B2 (ja) 1993-11-29 2007-01-10 ジェン−プローブ・インコーポレイテッド 広範な生物からの核酸抽出法
GB9506843D0 (en) 1995-04-03 1995-05-24 Chiroscience Ltd Oxidative process and products thereof
DE19530132C2 (de) 1995-08-16 1998-07-16 Max Planck Gesellschaft Verfahren zur Reinigung, Stabilisierung oder Isolierung von Nukleinsäuren aus biologischen Materialien
GB9518156D0 (en) 1995-09-06 1995-11-08 Medical Res Council Method of isolating cells
NO954667D0 (no) 1995-11-17 1995-11-17 Dagfinn Oegreid Fremgangsmåte til deteksjon av Ki-ras mutasjoner
EP0920535B1 (de) 1996-08-26 2007-11-14 Invitek Gesellschaft für Biotechnik & Biodesign mbH. Verfahren zum nachweis klinisch relevanter veränderungen der dns-sequenz des ki-ras-onkogens, seine verwendung und testkit zur früherkennung von tumoren
AU4775497A (en) 1996-09-19 1998-04-14 W. Kurt Roth Method for purifying and eventually analyzing nucleic acids from biological test samples
US6268136B1 (en) 1997-06-16 2001-07-31 Exact Science Corporation Methods for stool sample preparation
WO1998058081A1 (en) 1997-06-16 1998-12-23 Exact Laboratories, Inc. Methods for stool sample preparation
WO1999032616A2 (de) 1997-12-18 1999-07-01 Invitek Gmbh Verfahren zur isolierung von kurz- und langkettigen nukleinsäuren
WO1999038962A2 (en) 1998-02-02 1999-08-05 Gentra Systems, Inc. Compositions and methods for using a lysing matrix for isolating dna
EP0939118A1 (en) 1998-02-20 1999-09-01 Universiteit Maastricht Method for isolating DNA and RNA from faeces
WO2000008136A1 (fr) 1998-08-04 2000-02-17 Center For Advanced Science And Technology Incubation, Ltd. Amplification enzymatique d'acide nucleique
AU1716500A (en) 1998-11-12 2000-06-05 University Of Virginia Patent Foundation Non-invasive detection of helicobacter pylori infection
DE19856064C2 (de) * 1998-12-04 2000-11-30 Invitek Gmbh Universelles Verfahren zur Isolierung von DNA aus beliebigen Ausgangsmaterialien
DE19900638C2 (de) 1999-01-11 2002-12-19 Max Planck Gesellschaft Methode zur Isolierung von DNA aus biologischen Materialien
US6551777B1 (en) 1999-02-25 2003-04-22 Exact Sciences Corporation Methods for preserving DNA integrity
US20020004206A1 (en) 1999-04-09 2002-01-10 Berger Barry M. Methods of screening for disease
WO2000066606A1 (en) 1999-04-30 2000-11-09 Whatman, Inc. Substrate including anionic detergent for purifying nucleic acid
US6270970B1 (en) * 1999-05-14 2001-08-07 Promega Corporation Mixed-bed solid phase and its use in the isolation of nucleic acids
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
EP1238106A2 (en) 1999-12-07 2002-09-11 Exact Sciences Corporation Apparatus and methods for drug screening based 0on nucleic acid analysis
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
DE50113146D1 (de) 2000-02-04 2007-11-29 Qiagen Gmbh Nukleinsäure-isolierung aus stuhlproben und anderen biologischen materialien, die reich an inhibitoren sind
BR0108198A (pt) * 2000-02-09 2003-03-25 Basf Ag ácido nucleico isolado, construção de gene, sequência de aminoácidos, vetor, organismo, anticorpo, molécula de ácido nucleico anti-sentido, processo para a preparação de pufas, óleo, lipìdeo ou ácido graxo ou uma fração destes, composição, uso da composição oleaginosa, lipìdica ou de ácido graxo, kit, e, processo para identificar um antagonista de elongases
FR2808276B1 (fr) 2000-04-26 2004-04-02 Renaud Nalin Procede d'extraction indirecte de l'adn d'organismes non cultivables et adn susceptible d'etre obtenu par ledit procede
DE10031236A1 (de) 2000-06-27 2002-01-10 Qiagen Gmbh Verwendung von Carbonsäuren und anderen Additiven in Kombination mit kationischen Verbindungen zur Stabilisierung von Nukleinsäuren in biologischen Materialien
JP4599684B2 (ja) 2000-07-26 2010-12-15 株式会社島津製作所 糞便からの核酸精製法
CU23095A1 (es) * 2000-11-07 2005-11-18 Cnic Ct Nac Investigaciones Proceso para la tipificación rápida de microorganismos y juego de reactivos empleado
US7029840B2 (en) 2000-11-15 2006-04-18 Becton, Dickinson And Company Method for preservation of cells and nucleic acid targets
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
DE10102338A1 (de) * 2001-01-19 2002-07-25 Basf Plant Science Gmbh Verfahren zur Expression von Biosynthesegenen in pflanzlichen Samen unter Verwendung von neuen multiplen Expressionskonstrukten
CA2484062A1 (en) 2001-08-20 2003-02-27 James C. Davis Dna purification and recovery from high particulate and solids samples
EP1438426A1 (en) 2001-10-12 2004-07-21 Gentra Systems Inc. Compositions and methods for using a solid support to purify rna
US7148343B2 (en) 2001-10-12 2006-12-12 Gentra Systems, Inc. Compositions and methods for using a solid support to purify RNA
US7893228B2 (en) 2001-10-12 2011-02-22 Qiagen North American Holdings, Inc. Compositions and methods for using a solid support to purify RNA
US20030109548A1 (en) * 2001-11-09 2003-06-12 Royt Paulette W. Compositions and methods of treating iron excess
DE10222133A1 (de) 2002-05-17 2003-12-04 Gl Biotech Gmbh Verfahren zur Nukleinsäure-Extraktion und Nukleinsäure-Reinigung
US20030215954A1 (en) 2002-05-17 2003-11-20 Cockerill Franklin R. Nucleic acid recovery reagents and methods
EP1527172B1 (en) 2002-05-17 2008-11-26 Molzym GmbH & Co. KG Method for nucleic acid extraction and nucleic acid purification
WO2003097816A1 (fr) 2002-05-21 2003-11-27 Arkray, Inc. Procede permettant d'effectuer la lyse d'une bacterie resistante aux acides et procede permettant de realiser une amplification ou une detection de gene
JP4092141B2 (ja) 2002-06-07 2008-05-28 株式会社島津製作所 核酸抽出同時精製法
JP4092139B2 (ja) 2002-06-06 2008-05-28 株式会社島津製作所 核酸抽出法
US6852495B2 (en) 2002-06-06 2005-02-08 Shimadzu Corporation Process of extracting nucleic acid and process of simultaneously carrying out extraction and purification of nucleic acid
US7482116B2 (en) * 2002-06-07 2009-01-27 Dna Genotek Inc. Compositions and methods for obtaining nucleic acids from sputum
EP1391520A1 (en) 2002-08-20 2004-02-25 Becton Dickinson and Company Method for preservation of cells and nucleic acid targets
US20040157219A1 (en) 2003-02-06 2004-08-12 Jianrong Lou Chemical treatment of biological samples for nucleic acid extraction and kits therefor
FR2861085B1 (fr) 2003-10-15 2006-01-27 Bertin Technologies Sa Methode d'extraction d'acides nucleiques et son application dans l'analyse de la population microbienne de l'air
US20050239045A1 (en) 2003-12-08 2005-10-27 Arkray Inc. Microorganism or cell collecting method, and microorganism or cell collecting implement used for the method
DE102004004901B4 (de) * 2004-01-30 2006-01-05 Johannes-Gutenberg-Universität Mainz Verfahren zur Herstellung von Sorbicillacton A
WO2005113769A1 (en) 2004-05-14 2005-12-01 Exact Sciences Corporation Method for stabilizing biological samples for nucleic acid analysis
EP1756136B1 (en) 2004-05-21 2014-10-29 Mo Bio Laboratories, Inc. Kits and processes for removing contaminants from nucleic acids in environmental and biological samples
ATE441669T1 (de) 2004-05-24 2009-09-15 Genvault Corp Stabile lagerung von protein und stabile lagerung von nukleinsäure in wiedergewinnbarer form
US20050277121A1 (en) 2004-06-11 2005-12-15 Ambion, Inc. Crude biological derivatives competent for nucleic acid detection
CN101124321B (zh) * 2004-11-05 2012-02-29 恰根北美控股有限公司 用于从稳定剂中纯化核酸的组合物和方法
WO2006053435A1 (en) * 2004-11-17 2006-05-26 Forensink Corporation Inc. Compositions for marking objects with dna and methods for marking and linking an object to its owner
EP1859039A4 (en) 2005-03-16 2009-06-03 Dna Genotek Inc COMPOSITIONS AND METHOD FOR STORING NUCLEIC ACID FROM BODY FLUIDS
US20070141582A1 (en) 2005-12-15 2007-06-21 Weiwei Li Method and kit for detection of early cancer or pre-cancer using blood and body fluids
JP2007248170A (ja) * 2006-03-15 2007-09-27 Hitachi Ltd 糞便懸濁液作製用容器
WO2008021995A1 (en) 2006-08-10 2008-02-21 Cohen Ariel B Methods and compositions for detecting an analyte in a biological sample
US8080645B2 (en) * 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
US20100099149A1 (en) 2006-10-06 2010-04-22 Dna Genotek Inc. Stabilizing compositions and methods for extraction of ribonucleic acid
US20080286831A1 (en) 2007-01-15 2008-11-20 Greg Liang Sample collector and tester
WO2008152980A1 (ja) 2007-06-12 2008-12-18 Olympus Corporation 生物学的試料と試薬との混合用容器及び生物学的試料と試薬との混合方法
WO2009085355A2 (en) * 2007-10-01 2009-07-09 Longhorn Vaccines & Diagnostics Llc Biological specimen collection and transport system and methods of use
JPWO2009057695A1 (ja) 2007-10-30 2011-03-10 オリンパス株式会社 遺伝子解析による腺腫又はがんの検出方法
EP2218791B1 (en) 2007-11-05 2015-01-07 Eiken Kagaku Kabushiki Kaisha Method and kit for preparation of sample for use in nucleic acid amplification
WO2009066695A1 (ja) 2007-11-20 2009-05-28 Olympus Corporation 糞便試料の調製方法、糞便試料調製用溶液、及び採便用キット
WO2009102788A2 (en) 2008-02-15 2009-08-20 Mayo Foundation For Medical Education And Research Detecting neoplasm
JPWO2009133928A1 (ja) 2008-05-02 2011-09-01 アークレイ株式会社 白血球の分析方法およびそれに使用する分析試薬
EP2287331A4 (en) 2008-05-12 2012-01-25 Olympus Corp PROCESS FOR PROCESSING EXCREMENTS AND CONTAINERS FOR PROCESSING EXCREMENTS
WO2010010914A1 (ja) 2008-07-23 2010-01-28 オリンパス株式会社 糞便試料からの核酸回収方法、核酸解析方法及び糞便試料処理装置
JPWO2010024251A1 (ja) 2008-08-26 2012-01-26 オリンパス株式会社 糞便試料の調製方法、糞便試料調製用溶液、及び採便用キット
US20100121046A1 (en) 2008-09-05 2010-05-13 Mayo Foundation For Medical Education And Research Collecting and processing complex macromolecular mixtures
US8405379B1 (en) 2008-09-18 2013-03-26 Luc Montagnier System and method for the analysis of DNA sequences in biological fluids
JPWO2010064628A1 (ja) 2008-12-05 2012-05-10 オリンパス株式会社 核酸含有試料の調製方法、試料調製用溶液、及び核酸の解析方法
WO2010064634A1 (ja) 2008-12-05 2010-06-10 オリンパス株式会社 糞便試料の調製方法、糞便試料調製用溶液、及び採便用キット
US8427428B2 (en) 2009-03-31 2013-04-23 Key Ovation Llc Adjustable ergonomic keyboard
JPWO2010134245A1 (ja) 2009-05-20 2012-11-08 オリンパス株式会社 哺乳細胞由来核酸の回収方法、核酸解析方法、及び採便用キット
WO2010134246A1 (ja) 2009-05-20 2010-11-25 オリンパス株式会社 核酸含有試料の調製方法
JP2011250757A (ja) 2010-06-03 2011-12-15 Olympus Corp 生体試料中の核酸検出方法
US9845489B2 (en) * 2010-07-26 2017-12-19 Biomatrica, Inc. Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
WO2012018638A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
AU2011286165B2 (en) 2010-08-04 2016-10-20 Thomas Julius Borody Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them
US20120083597A1 (en) 2010-10-01 2012-04-05 Patricia Okamoto Enrichment of Low Molecular Weight DNA
US8530228B2 (en) 2010-12-28 2013-09-10 Bexmart Integrated versatile and systems preparation of specimens
JP6030633B2 (ja) 2011-04-19 2016-11-24 ポーレックス コーポレイション 焼結多孔性プラスチックを含む試料貯蔵および送達のためのカード
US20130071847A1 (en) 2011-09-19 2013-03-21 BioPet Vet Lab Methods and materials for determining the source of waste
SG10201807736SA (en) * 2014-03-07 2018-10-30 Dna Genotek Inc Composition and method for stabilizing nucleic acids in biological samples

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