RU95112848A - Гетеробициклические производные сульфонамида и сульфонового эфира, способы получения, антиопухолевое средство, фармакологическая композиция, способ лечения - Google Patents

Гетеробициклические производные сульфонамида и сульфонового эфира, способы получения, антиопухолевое средство, фармакологическая композиция, способ лечения

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RU95112848A
RU95112848A RU95112848/04A RU95112848A RU95112848A RU 95112848 A RU95112848 A RU 95112848A RU 95112848/04 A RU95112848/04 A RU 95112848/04A RU 95112848 A RU95112848 A RU 95112848A RU 95112848 A RU95112848 A RU 95112848A
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formula
substituents
sulfonic ester
sulfonoamide
nitrogen atom
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RU95112848/04A
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RU2128648C1 (ru
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Йосино Хироси
Jp]
Ова Такаси
Окаути Татсуо
Йосимацу Кентаро
Суги Наоко
Нагасу Такеси
Озава Йоити
Койанаги Нозому
Кито Косуке
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Эйсай Ко.
Эйсай Ко., Лтд.
Лтд. (Jp)
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Предложены новые гетеробициклические производные сульфанамида или сульфонового эфира следующей общей формулы I, которые проявляют антиопухолевую активность и обладают низкой токсичностью, и способ их получения. Производное сульфонамида или производное сульфонового эфира представлено общей формулой I, или его фармакологически приемлемая сольгде A - моноциклическое или бициклическое ароматическое кольцо, которое может иметь заместители; B - шестичленное ненасыщенное углеводородное кольцо или шестичленный ненасыщенный гетероцикл, содержащий в качестве гетероатома один атом азота, при этом каждое из этих колец может иметь заместители; C - пятичленный гетероцикл, содержащий один или два атома азота, который может иметь заместители; W - простая связь или группа, представленная формулой -CH= CH-; X - группа, представленная формулой -N(R)-, или атом кислорода; Y - углерод или азот; Z - группа, представленная формулой -N(R)-, или атом азота; Rи Rмогут совпадать или отличаться друг от друга и каждый обозначает атом водорода или низший алкил.

Claims (1)

  1. Предложены новые гетеробициклические производные сульфанамида или сульфонового эфира следующей общей формулы I, которые проявляют антиопухолевую активность и обладают низкой токсичностью, и способ их получения. Производное сульфонамида или производное сульфонового эфира представлено общей формулой I, или его фармакологически приемлемая соль
    Figure 00000001

    где A - моноциклическое или бициклическое ароматическое кольцо, которое может иметь заместители; B - шестичленное ненасыщенное углеводородное кольцо или шестичленный ненасыщенный гетероцикл, содержащий в качестве гетероатома один атом азота, при этом каждое из этих колец может иметь заместители; C - пятичленный гетероцикл, содержащий один или два атома азота, который может иметь заместители; W - простая связь или группа, представленная формулой -CH= CH-; X - группа, представленная формулой -N(R1)-, или атом кислорода; Y - углерод или азот; Z - группа, представленная формулой -N(R2)-, или атом азота; R1 и R2 могут совпадать или отличаться друг от друга и каждый обозначает атом водорода или низший алкил.
RU95112848A 1993-09-10 1994-09-08 Производные сульфонамида, способы их получения, фармацевтическая композиция и способ лечения RU2128648C1 (ru)

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JP5/248614 1993-09-10
JP24861493 1993-09-10
JP5/248.614 1993-09-10
PCT/JP1994/001487 WO1995007276A1 (fr) 1993-09-10 1994-09-08 Derives bicycliques heterocycliques d'ester sulfonique et de sulfonamide

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DE69433353T2 (de) 2004-09-09
CN1491941A (zh) 2004-04-28
CA2146961C (en) 2006-11-07
EP0673937A1 (en) 1995-09-27
EP0673937B1 (en) 2003-11-26
AU7623794A (en) 1995-03-27
WO1995007276A1 (fr) 1995-03-16
KR0174752B1 (ko) 1999-02-01
AU683492B2 (en) 1997-11-13
AU1778597A (en) 1997-08-14
PT673937E (pt) 2004-04-30
DE69433353D1 (de) 2004-01-08
CN1114506A (zh) 1996-01-03
RU2121997C1 (ru) 1998-11-20
CN1221533C (zh) 2005-10-05
ES2206469T3 (es) 2004-05-16
KR100188846B1 (en) 1999-06-01
HU224069B1 (hu) 2005-05-30
US5767283A (en) 1998-06-16
NO951813D0 (no) 1995-05-09
NO303778B1 (no) 1998-08-31
CA2146961A1 (en) 1995-03-16
KR950704304A (ko) 1995-11-17
AU711438B2 (en) 1999-10-14
HU9501363D0 (en) 1995-06-28
CN1079097C (zh) 2002-02-13
HUT71551A (en) 1995-12-28
ATE255106T1 (de) 2003-12-15
RU2128648C1 (ru) 1999-04-10
NO951813L (no) 1995-05-09
NZ273073A (en) 1996-09-25
EP0673937A4 (en) 1996-01-17
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