PT673937E - Derivados biciclicos heterociclicos de sulfonamida e de ester sulfonico - Google Patents
Derivados biciclicos heterociclicos de sulfonamida e de ester sulfonicoInfo
- Publication number
- PT673937E PT673937E PT94926372T PT94926372T PT673937E PT 673937 E PT673937 E PT 673937E PT 94926372 T PT94926372 T PT 94926372T PT 94926372 T PT94926372 T PT 94926372T PT 673937 E PT673937 E PT 673937E
- Authority
- PT
- Portugal
- Prior art keywords
- ring
- nitrogen
- optionally substituted
- sulfonamide
- sulfononic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24861493 | 1993-09-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT673937E true PT673937E (pt) | 2004-04-30 |
Family
ID=17180741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT94926372T PT673937E (pt) | 1993-09-10 | 1994-09-08 | Derivados biciclicos heterociclicos de sulfonamida e de ester sulfonico |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5767283A (pt) |
| EP (1) | EP0673937B1 (pt) |
| KR (2) | KR0174752B1 (pt) |
| CN (2) | CN1221533C (pt) |
| AT (1) | ATE255106T1 (pt) |
| AU (2) | AU683492B2 (pt) |
| CA (1) | CA2146961C (pt) |
| DE (1) | DE69433353T2 (pt) |
| DK (1) | DK0673937T3 (pt) |
| ES (1) | ES2206469T3 (pt) |
| HU (1) | HU224069B1 (pt) |
| NO (1) | NO303778B1 (pt) |
| NZ (1) | NZ273073A (pt) |
| PT (1) | PT673937E (pt) |
| RU (2) | RU2121997C1 (pt) |
| WO (1) | WO1995007276A1 (pt) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1048246C (zh) * | 1993-06-25 | 2000-01-12 | 组合化学工业株式会社 | 吲唑磺酰脲类衍生物、用途及其制造中的中间体 |
| WO1996034866A1 (en) * | 1995-05-01 | 1996-11-07 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivatives and their use as bone resorption inhibitors |
| JP4130700B2 (ja) * | 1996-02-26 | 2008-08-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗腫瘍剤含有組成物 |
| JP2000247949A (ja) | 1999-02-26 | 2000-09-12 | Eisai Co Ltd | スルホンアミド含有インドール化合物 |
| JP4516942B2 (ja) * | 1999-02-26 | 2010-08-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有インドール化合物 |
| US6653309B1 (en) | 1999-04-26 | 2003-11-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme technical field of the invention |
| US6521658B1 (en) | 1999-05-28 | 2003-02-18 | Abbott Laboratories | Cell proliferation inhibitors |
| KR100767002B1 (ko) * | 2000-02-03 | 2007-10-15 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 인테그린 발현 저해제 |
| DE60141889D1 (de) * | 2000-02-03 | 2010-06-02 | Eisai R&D Man Co Ltd | Inhibitoren der integrinexpression |
| TWI283575B (en) * | 2000-10-31 | 2007-07-11 | Eisai Co Ltd | Medicinal compositions for concomitant use as anticancer agent |
| WO2002042493A1 (fr) * | 2000-11-24 | 2002-05-30 | Eisai C0. Ltd. | Procede d'essai de la sensibilite aux agents anticancereux de cellules tumorales |
| CA2438427C (en) * | 2001-02-21 | 2011-04-12 | Eisai Co., Ltd. | Method for testing effect of angiogenesis inhibitor via integrin expression inhibition |
| JP2004529110A (ja) | 2001-03-06 | 2004-09-24 | アストラゼネカ アクチボラグ | 脈管損傷活性を有するインドール誘導体 |
| JPWO2003022271A1 (ja) * | 2001-09-05 | 2004-12-24 | エーザイ株式会社 | リンパ球活性化抑制剤および自己免疫疾患治療剤 |
| JP4845379B2 (ja) * | 2002-09-19 | 2011-12-28 | シェーリング コーポレイション | サイクリン依存性キナーゼインヒビターとしてのイミダゾピリジン |
| US8772269B2 (en) | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| EP2364699A1 (en) | 2004-09-13 | 2011-09-14 | Eisai R&D Management Co., Ltd. | Joint use of sulfonamide based compound with angiogenesis inhibitor |
| JPWO2006054456A1 (ja) | 2004-11-17 | 2008-05-29 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 二環式へテロ環含有スルホンアミド化合物の結晶 |
| PL1859793T3 (pl) * | 2005-02-28 | 2011-09-30 | Eisai R&D Man Co Ltd | Nowe połączone zastosowanie związku sulfonamidowego w leczeniu choroby nowotworowej |
| EP2308839B1 (en) | 2005-04-20 | 2017-03-01 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| ES2493466T3 (es) * | 2005-05-12 | 2014-09-11 | Abbvie Bahamas Ltd. | Promotores de la apoptosis |
| US20100291592A1 (en) | 2006-04-20 | 2010-11-18 | Taro Semba | Novel marker for sensitivity against sulfonamide compound |
| US8410087B2 (en) | 2006-10-19 | 2013-04-02 | Takeda Pharmaceutical Company Limited | Indole compound |
| EP3243814B1 (en) | 2007-04-16 | 2018-10-17 | AbbVie Inc. | 7-substituted indole as mcl-1 inhibitors |
| BRPI0815154B1 (pt) * | 2007-08-17 | 2024-01-30 | Lg Chem, Ltd | Compostos de indol, composição, e, método de preparação da mesma |
| CN101952281B (zh) | 2008-01-04 | 2014-04-02 | 株式会社Lg生命科学 | 具有细胞、组织及器官保存效果的吲哚及吲唑衍生物 |
| EP2229929B1 (en) | 2009-03-18 | 2017-06-14 | DENTSPLY DETREY GmbH | Temporary root canal sealer dispersion |
| TWI410408B (zh) * | 2010-03-16 | 2013-10-01 | Purzer Pharmaceutical Co Ltd | 苯磺醯胺衍生物及其醫藥組合物 |
| CN102199148A (zh) * | 2010-03-25 | 2011-09-28 | 瑞安大药厂股份有限公司 | 苯磺酰胺衍生物及其医药组合物 |
| EP2632920A1 (en) | 2010-10-27 | 2013-09-04 | Dynamix Pharmaceuticals Ltd. | Sulfonamides for the modulation of pkm2 |
| CN102875549B (zh) * | 2012-09-14 | 2015-11-04 | 浙江大学 | 7-芳（甲）胺基-5-胺基-6-氮杂吲哚衍生物及制备与用途 |
| CN105636956B (zh) | 2013-08-22 | 2019-07-09 | 株式会社Lg化学 | 作为细胞坏死阻碍剂的吲哚化合物 |
| CN105658625B (zh) | 2013-08-22 | 2019-05-03 | 株式会社Lg化学 | 作为细胞坏死阻碍剂的吲哚酰胺化合物 |
| WO2020256432A1 (ko) | 2019-06-19 | 2020-12-24 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
| EP3971183A4 (en) | 2019-06-19 | 2022-08-10 | LG Chem, Ltd. | PROCESS FOR THE PREPARATION OF INDOLE OR INDAZOLE COMPOUNDS |
| CN114080386A (zh) | 2019-06-19 | 2022-02-22 | 株式会社Lg化学 | 制备吲哚或吲唑化合物的方法 |
| WO2020256429A1 (ko) | 2019-06-19 | 2020-12-24 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
| WO2023064669A2 (en) * | 2021-09-21 | 2023-04-20 | The Trustees Of Princeton University | Inhibitors of the mtdh-snd1 protein complex for cancer therapy |
| MA54773B1 (fr) * | 2021-10-29 | 2023-10-31 | Univ Euro Mediterraneenne De Fes Uemf | Nouvelles familles de composés à base de sulfonamides pour le traitement du cancer du sein triple négatif |
| WO2024039689A1 (en) * | 2022-08-15 | 2024-02-22 | Recursion Pharmaceuticals, Inc. | Heterocycle rbm39 modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS539256A (en) * | 1976-07-14 | 1978-01-27 | Hitachi Kiden Kogyo Kk | Two hook type club |
| DE3686688T2 (de) * | 1985-06-24 | 1993-03-18 | Merck & Co Inc | Verwendung von sulfanilamido quinoxalinen zur behandlung von neoplastischen krankheiten. |
| JP2790926B2 (ja) * | 1990-08-20 | 1998-08-27 | エーザイ株式会社 | スルホンアミド誘導体 |
| LU87814A1 (fr) * | 1990-09-27 | 1992-05-25 | Oreal | Composition cosmetique comportant une dispersion de vesicules lipidiques ainsi que des pigments melaniques,et son utilisation |
-
1994
- 1994-09-08 AU AU76237/94A patent/AU683492B2/en not_active Ceased
- 1994-09-08 RU RU96119782A patent/RU2121997C1/ru not_active IP Right Cessation
- 1994-09-08 DE DE69433353T patent/DE69433353T2/de not_active Expired - Lifetime
- 1994-09-08 CN CNB011194561A patent/CN1221533C/zh not_active Expired - Fee Related
- 1994-09-08 EP EP94926372A patent/EP0673937B1/en not_active Expired - Lifetime
- 1994-09-08 KR KR1019950701862A patent/KR0174752B1/ko not_active IP Right Cessation
- 1994-09-08 ES ES94926372T patent/ES2206469T3/es not_active Expired - Lifetime
- 1994-09-08 WO PCT/JP1994/001487 patent/WO1995007276A1/ja active IP Right Grant
- 1994-09-08 CN CN94190672A patent/CN1079097C/zh not_active Expired - Fee Related
- 1994-09-08 NZ NZ273073A patent/NZ273073A/en not_active IP Right Cessation
- 1994-09-08 AT AT94926372T patent/ATE255106T1/de active
- 1994-09-08 CA CA002146961A patent/CA2146961C/en not_active Expired - Fee Related
- 1994-09-08 HU HU9501363A patent/HU224069B1/hu not_active IP Right Cessation
- 1994-09-08 PT PT94926372T patent/PT673937E/pt unknown
- 1994-09-08 RU RU95112848A patent/RU2128648C1/ru not_active IP Right Cessation
- 1994-09-08 DK DK94926372T patent/DK0673937T3/da active
-
1995
- 1995-05-09 NO NO19951813A patent/NO303778B1/no not_active IP Right Cessation
-
1997
- 1997-01-17 US US08/785,610 patent/US5767283A/en not_active Expired - Lifetime
- 1997-04-09 AU AU17785/97A patent/AU711438B2/en not_active Ceased
-
1998
- 1998-09-07 KR KR1019980707044A patent/KR100188846B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69433353T2 (de) | 2004-09-09 |
| CN1491941A (zh) | 2004-04-28 |
| CA2146961C (en) | 2006-11-07 |
| EP0673937A1 (en) | 1995-09-27 |
| EP0673937B1 (en) | 2003-11-26 |
| AU7623794A (en) | 1995-03-27 |
| WO1995007276A1 (fr) | 1995-03-16 |
| KR0174752B1 (ko) | 1999-02-01 |
| AU683492B2 (en) | 1997-11-13 |
| AU1778597A (en) | 1997-08-14 |
| DE69433353D1 (de) | 2004-01-08 |
| CN1114506A (zh) | 1996-01-03 |
| RU2121997C1 (ru) | 1998-11-20 |
| CN1221533C (zh) | 2005-10-05 |
| ES2206469T3 (es) | 2004-05-16 |
| KR100188846B1 (en) | 1999-06-01 |
| HU224069B1 (hu) | 2005-05-30 |
| US5767283A (en) | 1998-06-16 |
| NO951813D0 (no) | 1995-05-09 |
| NO303778B1 (no) | 1998-08-31 |
| CA2146961A1 (en) | 1995-03-16 |
| KR950704304A (ko) | 1995-11-17 |
| AU711438B2 (en) | 1999-10-14 |
| HU9501363D0 (en) | 1995-06-28 |
| CN1079097C (zh) | 2002-02-13 |
| HUT71551A (en) | 1995-12-28 |
| RU95112848A (ru) | 1997-03-20 |
| ATE255106T1 (de) | 2003-12-15 |
| RU2128648C1 (ru) | 1999-04-10 |
| NO951813L (no) | 1995-05-09 |
| NZ273073A (en) | 1996-09-25 |
| EP0673937A4 (en) | 1996-01-17 |
| DK0673937T3 (da) | 2004-03-22 |
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