RU2014119426A - Способы применения антагонистов scd1 - Google Patents

Способы применения антагонистов scd1 Download PDF

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RU2014119426A
RU2014119426A RU2014119426/15A RU2014119426A RU2014119426A RU 2014119426 A RU2014119426 A RU 2014119426A RU 2014119426/15 A RU2014119426/15 A RU 2014119426/15A RU 2014119426 A RU2014119426 A RU 2014119426A RU 2014119426 A RU2014119426 A RU 2014119426A
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genes
cancer
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fgfr3
malignant tumor
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Ави АШКЕНАЗИ
Сяннань ДУ
Цзин ЦИН
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Дженентек, Инк.
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Abstract

1. Применение антагониста SCD1 для получения лекарственного средства для лечения злокачественной опухоли, где злокачественная опухоль экспрессирует повышенные уровни одного или нескольких биомаркеров, при котором одним или несколькими биомаркерами является FGFR3, зрелые SREBP1, Δ9-мононенасыщенные жирные кислоты, отношение Δ9-мононенасыщенных жирных кислот к насыщенным жирным кислотам, или один или несколько генов FGFR3-регулированной липогенной сигнатуры.2. Применение по п. 1, при котором злокачественной опухолью является клетка эндометриальной злокачественной опухоли, злокачественная опухоль головы и шеи, злокачественная опухоль почки, злокачественная опухоль яичника, злокачественная опухоль толстой кишки, злокачественная опухоль поджелудочной железы, злокачественная опухоль мочевыводящих путей или злокачественная опухоль мочевого пузыря.3. Применение по п. 2, при котором злокачественной опухолью является злокачественная опухоль почки, злокачественная опухоль поджелудочной железы или злокачественная опухоль мочевого пузыря.4. Применение по п. 3, при котором злокачественной опухолью является злокачественная опухоль мочевого пузыря.5. Применение по любому из пп. 1-4, при котором одним или несколькими биомаркерами является FGFR3.6. Применение по п. 5, при котором одним или несколькими биомаркерами является фосфорилированный FGFR3.7. Применение по любому из пп. 1-4, при котором одним или несколькими биомаркерами является один или несколько генов FGFR3-регулированной липогенной сигнатуры.8. Применение по п. 7, при котором один или несколько генов FGFR3-регулированной липогенной сигнатуры содержат, состоят или состоят главным

Claims (16)

1. Применение антагониста SCD1 для получения лекарственного средства для лечения злокачественной опухоли, где злокачественная опухоль экспрессирует повышенные уровни одного или нескольких биомаркеров, при котором одним или несколькими биомаркерами является FGFR3, зрелые SREBP1, Δ9-мононенасыщенные жирные кислоты, отношение Δ9-мононенасыщенных жирных кислот к насыщенным жирным кислотам, или один или несколько генов FGFR3-регулированной липогенной сигнатуры.
2. Применение по п. 1, при котором злокачественной опухолью является клетка эндометриальной злокачественной опухоли, злокачественная опухоль головы и шеи, злокачественная опухоль почки, злокачественная опухоль яичника, злокачественная опухоль толстой кишки, злокачественная опухоль поджелудочной железы, злокачественная опухоль мочевыводящих путей или злокачественная опухоль мочевого пузыря.
3. Применение по п. 2, при котором злокачественной опухолью является злокачественная опухоль почки, злокачественная опухоль поджелудочной железы или злокачественная опухоль мочевого пузыря.
4. Применение по п. 3, при котором злокачественной опухолью является злокачественная опухоль мочевого пузыря.
5. Применение по любому из пп. 1-4, при котором одним или несколькими биомаркерами является FGFR3.
6. Применение по п. 5, при котором одним или несколькими биомаркерами является фосфорилированный FGFR3.
7. Применение по любому из пп. 1-4, при котором одним или несколькими биомаркерами является один или несколько генов FGFR3-регулированной липогенной сигнатуры.
8. Применение по п. 7, при котором один или несколько генов FGFR3-регулированной липогенной сигнатуры содержат, состоят или состоят главным образом из одного или нескольких генов из группы, состоящей из SREBF1, G6PD, ACOT7, PTPLA, PCCB, FADS1, RDH11, ACER3, PDSS1, MVD, AGPAT5, HSD17B2, ACSL4, EBP, PIGW, LBR, ACLY, ADORA2B, GPCPD1, CYP24A1, ACSL3, MVK, ACSS2, FDPS, ELOVL5, HMGCR, LIPG, ME1, DHCR7, LSS, ACAT2, FASN, CYP51A1, IDI1, FDFT1, FAR2, HMGCS1, SDR16C5, LDLR, MSMO1, INSIG1, DHRS9, LRP8, SQLE, PCSK9, SCD1, FABP4 и их комбинаций.
9. Применение по п. 8, при котором один или несколько генов FGFR3-регулированной липогенной сигнатуры содержат, состоят или состоят главным образом из одного или нескольких генов из группы, состоящей из ELOVL5, HMGCR, LIPG, ME1, DHCR7, LSS, ACAT2, FASN, CYP51A1, IDI1, FDFT1, FAR2, HMGCS1, SDR16C5, LDLR, MSMO1, INSIG1, DHRS9, LRP8, SQLE, PCSK9, SCD1, FABP4 и их комбинаций.
10. Применение по п. 9, при котором один или несколько генов FGFR3-регулированной липогенной сигнатуры содержат, состоят или состоят главным образом из одного или нескольких генов из группы, состоящей из CYP51A1, IDI1, FDFT1, FAR2, HMGCS1, SDR16C5, LDLR, MSMO1, INSIG1, DHRS9, LRP8, SQLE, PCSK9, SCD1, FABP4 и их комбинаций.
11. Применение по п. 10, при котором один или несколько генов FGFR3-регулированной липогенной сигнатуры содержат, состоят или состоят главным образом из одного или нескольких генов из группы, состоящей из LDLR, MSMO1, INSIG1, DHRS9, LRP8, SQLE, PCSK9, SCD1, FABP4 и их комбинаций.
12. Применение по п. 11, при котором один или несколько генов FGFR3-регулированной липогенной сигнатуры содержат, состоят или состоят главным образом из одного или нескольких генов из группы, состоящей из SQLE, PCSK9, SCD1, FABP4 и их комбинаций.
13. Применение по любому из пп. 1-4, при котором одним или несколькими биомаркерами являются зрелые SREBP1.
14. Применение по любому из пп. 1-4, при котором одним или несколькими биомаркерами являются Δ9-мононенасыщенные жирные кислоты.
15. Применение по любому из пп. 1-4, при котором одним или несколькими биомаркерами является отношение Δ9-мононенасыщенных жирных кислот к насыщенным жирным кислотам.
16. Применение по любому из пп. 1-4, при котором антагонистом SCD1 является антитело, связывающий полипептид, связывающая малая молекула или полинуклеотид.
RU2014119426/15A 2011-10-15 2012-10-12 Способы применения антагонистов scd1 RU2014119426A (ru)

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US201161547706P 2011-10-15 2011-10-15
US61/547,706 2011-10-15
US201261704397P 2012-09-21 2012-09-21
US61/704,397 2012-09-21
PCT/US2012/060094 WO2013056148A2 (en) 2011-10-15 2012-10-12 Methods of using scd1 antagonists

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JP2015501301A (ja) 2015-01-15
JP6254087B2 (ja) 2017-12-27
CN103998027A (zh) 2014-08-20
EP2766000A2 (en) 2014-08-20
WO2013056148A2 (en) 2013-04-18
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US20130096181A1 (en) 2013-04-18
MX2014004426A (es) 2014-07-09

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