MX2019008803A - Anticuerpos contra el inhibidor del activador de plasminogeno tipo 1 (pai-1) y usos de los mismos. - Google Patents
Anticuerpos contra el inhibidor del activador de plasminogeno tipo 1 (pai-1) y usos de los mismos.Info
- Publication number
- MX2019008803A MX2019008803A MX2019008803A MX2019008803A MX2019008803A MX 2019008803 A MX2019008803 A MX 2019008803A MX 2019008803 A MX2019008803 A MX 2019008803A MX 2019008803 A MX2019008803 A MX 2019008803A MX 2019008803 A MX2019008803 A MX 2019008803A
- Authority
- MX
- Mexico
- Prior art keywords
- pai
- antibodies
- plasminogen activator
- activator inhibitor
- specifically bind
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
La invención proporciona anticuerpos que se unen específicamente al Inhibidor del Activador de Plasminógeno de tipo 1 (PAI-1). La invención también proporciona composiciones farmacéuticas, así como ácidos nucleicos que codifican anticuerpos anti-PAI-1, vectores de expresión recombinantes y células hospedantes para preparar tales anticuerpos, o fragmentos de los mismos. También se proporcionan métodos de uso de anticuerpos para modular la actividad de PAI-1 o detectar PAI-1, ya sea in vitro o in vivo. Además la descripción proporciona métodos de producción de anticuerpos que se unen específicamente a PAI-1 en el estado conformacional activo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361865451P | 2013-08-13 | 2013-08-13 | |
EP14305757 | 2014-05-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019008803A true MX2019008803A (es) | 2019-09-16 |
Family
ID=56194112
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016001851A MX2016001851A (es) | 2013-08-13 | 2014-08-13 | Anticuerpos contra el inhibidor del activador de plasminogeno tipo 1 (pai-1) y usos de los mismos. |
MX2019008803A MX2019008803A (es) | 2013-08-13 | 2016-02-10 | Anticuerpos contra el inhibidor del activador de plasminogeno tipo 1 (pai-1) y usos de los mismos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016001851A MX2016001851A (es) | 2013-08-13 | 2014-08-13 | Anticuerpos contra el inhibidor del activador de plasminogeno tipo 1 (pai-1) y usos de los mismos. |
Country Status (17)
Country | Link |
---|---|
US (4) | US9845363B2 (es) |
JP (4) | JP6696899B2 (es) |
KR (1) | KR20160035077A (es) |
CN (2) | CN112142845A (es) |
BR (1) | BR112016002753A2 (es) |
CL (1) | CL2016000324A1 (es) |
CR (2) | CR20190319A (es) |
DO (1) | DOP2016000042A (es) |
EA (1) | EA033403B1 (es) |
ES (1) | ES2770507T3 (es) |
HK (1) | HK1221725A1 (es) |
MX (2) | MX2016001851A (es) |
PE (1) | PE20160244A1 (es) |
PH (1) | PH12016500239A1 (es) |
SG (1) | SG10201710013RA (es) |
TN (1) | TN2016000048A1 (es) |
UA (1) | UA118267C2 (es) |
Families Citing this family (21)
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JP6682008B2 (ja) | 2015-12-18 | 2020-04-15 | タレンゲン インターナショナル リミテッドTalengen International Limited | 糖尿病性腎症を予防及び治療するための方法 |
JP6783870B2 (ja) | 2015-12-18 | 2020-11-11 | タレンゲン インターナショナル リミテッドTalengen International Limited | 心血管病を予防及び治療するための新しい方法 |
JP2019500426A (ja) | 2015-12-18 | 2019-01-10 | タレンゲン インターナショナル リミティッドTalengen International Limited | 糖尿病網膜症を予防または治療するための方法 |
WO2017101867A1 (zh) | 2015-12-18 | 2017-06-22 | 深圳瑞健生命科学研究院有限公司 | 一种预防或治疗糖尿病性神经损伤及其相关病症的方法 |
EP3556379A4 (en) | 2016-12-15 | 2020-08-19 | Talengen International Limited | METHOD AND DRUG FOR THE PREVENTION AND TREATMENT OF OBESITY |
TW202123962A (zh) * | 2016-12-15 | 2021-07-01 | 大陸商深圳瑞健生命科學研究院有限公司 | 一種預防和治療腎纖維化的方法 |
CN108210910A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 预防和治疗***性硬化症的药物及其用途 |
WO2018107708A1 (zh) | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种促进胰岛素受体底物-2表达的方法 |
TW202123963A (zh) | 2016-12-15 | 2021-07-01 | 大陸商深圳瑞健生命科學研究院有限公司 | 一種治療冠狀動脈粥樣硬化及其併發症的方法 |
TWI657823B (zh) * | 2016-12-15 | 2019-05-01 | 大陸商深圳瑞健生命科學研究院有限公司 | 一種預防和治療系統性硬化症的方法 |
CN108210895A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 预防动脉粥样硬化及其并发症的药物及其用途 |
CA3067890A1 (en) | 2017-06-19 | 2018-12-27 | Talengen International Limited | Method for regulating and controling glp-1/glp-1r and drug |
TW201904990A (zh) * | 2017-06-23 | 2019-02-01 | 美商波麥堤克生物治療股份有限公司 | 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療 |
CN117700548A (zh) | 2017-08-03 | 2024-03-15 | 艾利妥 | 抗cd33抗体及其使用方法 |
EP4039276A4 (en) | 2019-09-30 | 2023-11-15 | Renascience Inc. | INHIBITOR AGAINST THE EXPRESSION OF AN IMMUNE CHECKPOINT MOLECULE |
AU2020397070A1 (en) * | 2019-12-05 | 2022-07-14 | Seagen Inc. | Anti-avb6 antibodies and antibody-drug conjugates |
CN115605219A (zh) * | 2020-02-11 | 2023-01-13 | 泰伦基国际有限公司(Hk) | 一种治疗病毒性肺炎的方法和药物 |
CN111072780B (zh) * | 2020-03-24 | 2020-06-23 | 深圳汉盛汇融再生医学科技有限公司 | 白血病干细胞抑制剂及其在治疗慢性粒细胞白血病中的应用 |
CN114605550B (zh) * | 2020-12-08 | 2023-09-22 | 东莞市朋志生物科技有限公司 | 抗ca19-9的抗体、其应用和检测ca19-9的试剂盒 |
CN114686442B (zh) * | 2020-12-31 | 2023-11-07 | 广州万孚生物技术股份有限公司 | 一种杂交瘤细胞株及其应用 |
CN114686441B (zh) * | 2020-12-31 | 2023-11-03 | 广州万孚生物技术股份有限公司 | 一种能分泌tPAI-C单克隆抗体的杂交瘤细胞株及其应用 |
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2014
- 2014-08-13 SG SG10201710013RA patent/SG10201710013RA/en unknown
- 2014-08-13 CN CN202010898460.6A patent/CN112142845A/zh active Pending
- 2014-08-13 EA EA201690377A patent/EA033403B1/ru not_active IP Right Cessation
- 2014-08-13 UA UAA201602278A patent/UA118267C2/uk unknown
- 2014-08-13 MX MX2016001851A patent/MX2016001851A/es unknown
- 2014-08-13 BR BR112016002753A patent/BR112016002753A2/pt not_active Application Discontinuation
- 2014-08-13 CN CN201480055157.2A patent/CN105705520B/zh active Active
- 2014-08-13 CR CR20190319A patent/CR20190319A/es unknown
- 2014-08-13 KR KR1020167005652A patent/KR20160035077A/ko not_active Application Discontinuation
- 2014-08-13 US US14/911,429 patent/US9845363B2/en active Active
- 2014-08-13 ES ES14761451T patent/ES2770507T3/es active Active
- 2014-08-13 PE PE2016000243A patent/PE20160244A1/es unknown
- 2014-08-13 TN TN2016000048A patent/TN2016000048A1/en unknown
- 2014-08-13 JP JP2016534815A patent/JP6696899B2/ja active Active
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2016
- 2016-02-03 DO DO2016000042A patent/DOP2016000042A/es unknown
- 2016-02-03 PH PH12016500239A patent/PH12016500239A1/en unknown
- 2016-02-10 MX MX2019008803A patent/MX2019008803A/es unknown
- 2016-02-10 CL CL2016000324A patent/CL2016000324A1/es unknown
- 2016-03-07 CR CR20160117A patent/CR20160117A/es unknown
- 2016-08-17 HK HK16109838.9A patent/HK1221725A1/zh unknown
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2017
- 2017-11-10 US US15/809,935 patent/US20180155444A1/en not_active Abandoned
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2019
- 2019-08-06 US US16/533,048 patent/US20190359729A1/en not_active Abandoned
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2020
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2021
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2022
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2023
- 2023-02-02 JP JP2023014335A patent/JP2023055852A/ja active Pending
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Publication number | Publication date |
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CR20190319A (es) | 2019-08-29 |
US20180155444A1 (en) | 2018-06-07 |
JP2023055852A (ja) | 2023-04-18 |
EA033403B1 (ru) | 2019-10-31 |
CN105705520B (zh) | 2020-09-25 |
SG10201710013RA (en) | 2018-01-30 |
ES2770507T3 (es) | 2020-07-01 |
TN2016000048A1 (en) | 2017-07-05 |
JP2021155440A (ja) | 2021-10-07 |
JP6696899B2 (ja) | 2020-05-20 |
US9845363B2 (en) | 2017-12-19 |
KR20160035077A (ko) | 2016-03-30 |
CN105705520A (zh) | 2016-06-22 |
EA201690377A1 (ru) | 2016-06-30 |
US20190359729A1 (en) | 2019-11-28 |
MX2016001851A (es) | 2016-05-16 |
HK1221725A1 (zh) | 2017-06-09 |
JP2020125333A (ja) | 2020-08-20 |
JP2016529255A (ja) | 2016-09-23 |
BR112016002753A2 (pt) | 2017-11-21 |
CN112142845A (zh) | 2020-12-29 |
US20230015181A1 (en) | 2023-01-19 |
JP7223069B2 (ja) | 2023-02-15 |
US20160200831A1 (en) | 2016-07-14 |
UA118267C2 (uk) | 2018-12-26 |
JP6907380B2 (ja) | 2021-07-21 |
CR20160117A (es) | 2016-05-20 |
DOP2016000042A (es) | 2016-04-04 |
CL2016000324A1 (es) | 2016-10-21 |
PH12016500239A1 (en) | 2016-05-16 |
PE20160244A1 (es) | 2016-05-10 |
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