RU2008101513A - Пленки, растворяющиеся в полости рта - Google Patents
Пленки, растворяющиеся в полости рта Download PDFInfo
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- RU2008101513A RU2008101513A RU2008101513/15A RU2008101513A RU2008101513A RU 2008101513 A RU2008101513 A RU 2008101513A RU 2008101513/15 A RU2008101513/15 A RU 2008101513/15A RU 2008101513 A RU2008101513 A RU 2008101513A RU 2008101513 A RU2008101513 A RU 2008101513A
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- agent
- dosage form
- nicotine
- active agent
- sensory impulse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
1. Пероральная дозированная форма, содержащая ! a) по меньшей мере, один никотиновый активный агент; ! b) по меньшей мере, один биоадгезивный материал, способный образовывать водородную связь с никотиновым активным агентом, и ! c) по меньшей мере, один быстро высвобождающийся сенсорный импульсный агент; ! в которой быстро высвобождающийся сенсорный импульсный агент присутствует в количестве, эффективном для быстрого ослабления тяги к никотину, при этом дозированная форма обеспечивает быстрое и продолжительное ослабление тяги к никотину у нуждающегося в этом человека. ! 2. Дозированная форма по п.1, в которой сенсорный импульсный агент выбран из группы, включающей капсиацин, горчицу, хрен, имбирь, васаби, дым и черный перец; мягкие раздражители, например освобожденный от никотина дым, лимонную кислоту, аскорбиновую кислоту и их смеси. ! 3. Дозированная форма по п.1, дополнительно содержащая щелочной буферный агент. ! 4. Дозированная форма по п.1, дополнительно содержащая пластификатор. ! 5. Способ обеспечения быстрого и продолжительного облегчения тяги к никотину посредством введения нуждающемуся в этом человеку перорально дозированной формы, содержащей, по меньшей мере, один никотиновый активный агент, по меньшей мере, один биоадгезивный компонент и, по меньшей мере, один быстро высвобождающийся сенсорный импульсный агент, где сенсорный импульсный агент присутствует в количестве, эффективном для быстрого облегчения тяги у указанного человека. ! 6. Способ по п.5, в котором сенсорный импульсный агент выбран из группы, состоящей из капсиацина, горчицы, хрена, имбиря, васаби, дыма и черного перца; мягких раздражителей, наприме�
Claims (8)
1. Пероральная дозированная форма, содержащая
a) по меньшей мере, один никотиновый активный агент;
b) по меньшей мере, один биоадгезивный материал, способный образовывать водородную связь с никотиновым активным агентом, и
c) по меньшей мере, один быстро высвобождающийся сенсорный импульсный агент;
в которой быстро высвобождающийся сенсорный импульсный агент присутствует в количестве, эффективном для быстрого ослабления тяги к никотину, при этом дозированная форма обеспечивает быстрое и продолжительное ослабление тяги к никотину у нуждающегося в этом человека.
2. Дозированная форма по п.1, в которой сенсорный импульсный агент выбран из группы, включающей капсиацин, горчицу, хрен, имбирь, васаби, дым и черный перец; мягкие раздражители, например освобожденный от никотина дым, лимонную кислоту, аскорбиновую кислоту и их смеси.
3. Дозированная форма по п.1, дополнительно содержащая щелочной буферный агент.
4. Дозированная форма по п.1, дополнительно содержащая пластификатор.
5. Способ обеспечения быстрого и продолжительного облегчения тяги к никотину посредством введения нуждающемуся в этом человеку перорально дозированной формы, содержащей, по меньшей мере, один никотиновый активный агент, по меньшей мере, один биоадгезивный компонент и, по меньшей мере, один быстро высвобождающийся сенсорный импульсный агент, где сенсорный импульсный агент присутствует в количестве, эффективном для быстрого облегчения тяги у указанного человека.
6. Способ по п.5, в котором сенсорный импульсный агент выбран из группы, состоящей из капсиацина, горчицы, хрена, имбиря, васаби, дыма и черного перца; мягких раздражителей, например освобожденного от никотина дыма, лимонной кислоты, аскорбиновой кислоты и их смесей.
8. Растворяющаяся в полости рта композиция пленки по п.7, в которой косметический или терапевтический активный агент представляет собой никотиновый активный агент.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48985503P | 2003-07-24 | 2003-07-24 | |
US60/489,855 | 2003-07-24 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2006105630/15A Division RU2351315C2 (ru) | 2003-07-24 | 2004-07-22 | Пленки, растворяющиеся в полости рта |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2008101513A true RU2008101513A (ru) | 2009-07-20 |
Family
ID=34102944
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2006105630/15A RU2351315C2 (ru) | 2003-07-24 | 2004-07-22 | Пленки, растворяющиеся в полости рта |
RU2008101513/15A RU2008101513A (ru) | 2003-07-24 | 2008-01-14 | Пленки, растворяющиеся в полости рта |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2006105630/15A RU2351315C2 (ru) | 2003-07-24 | 2004-07-22 | Пленки, растворяющиеся в полости рта |
Country Status (24)
Country | Link |
---|---|
US (1) | US9675548B2 (ru) |
EP (2) | EP1648421B1 (ru) |
JP (4) | JP2006528636A (ru) |
CN (1) | CN100508976C (ru) |
AR (1) | AR045076A1 (ru) |
AU (2) | AU2004259006B2 (ru) |
BR (1) | BRPI0412752B8 (ru) |
CA (1) | CA2533577C (ru) |
CL (2) | CL2008002406A1 (ru) |
DK (2) | DK2446881T3 (ru) |
ES (2) | ES2654062T3 (ru) |
HK (1) | HK1169802A1 (ru) |
HR (1) | HRP20171944T1 (ru) |
HU (1) | HUE037508T2 (ru) |
LT (1) | LT1648421T (ru) |
MX (1) | MXPA06000852A (ru) |
PE (1) | PE20050496A1 (ru) |
PL (2) | PL1648421T3 (ru) |
PT (2) | PT1648421T (ru) |
RU (2) | RU2351315C2 (ru) |
SI (1) | SI1648421T1 (ru) |
TW (1) | TW200514579A (ru) |
UY (1) | UY28431A1 (ru) |
WO (1) | WO2005009386A2 (ru) |
Families Citing this family (107)
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BRPI0415741B1 (pt) | 2003-11-07 | 2013-07-23 | composições de tabaco e métodos de fabricação de uma composição de tabaco | |
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DE102005058569B4 (de) * | 2005-12-08 | 2010-07-15 | Lts Lohmann Therapie-Systeme Ag | Schaumwafer mit Polyvinylalkohol-Polyethylenglycol-Pfropfcopolymer |
US7810507B2 (en) | 2006-02-10 | 2010-10-12 | R. J. Reynolds Tobacco Company | Smokeless tobacco composition |
WO2007095600A2 (en) * | 2006-02-17 | 2007-08-23 | Novartis Ag | Disintegrable oral films |
US20100015068A1 (en) * | 2006-07-06 | 2010-01-21 | Massachusetts Institute Of Technology | Methods and Compositions For Altering Biological Surfaces |
WO2008080773A1 (de) * | 2006-12-29 | 2008-07-10 | Basf Se | Verfahren zur herstellung von festen dosierungsformen enthaltend pfropfcopolymere |
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WO2009043588A2 (en) * | 2007-10-02 | 2009-04-09 | LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH | Ph regulating antibacterial films for the oral or vaginal cavity |
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