AR033444A1 - Forma solida de dosificacion util para la administracion oral de un compuesto activo de nicotina, a traves de la mucosa y uso de un compuesto activo de nicotina para prepararla - Google Patents
Forma solida de dosificacion util para la administracion oral de un compuesto activo de nicotina, a traves de la mucosa y uso de un compuesto activo de nicotina para prepararlaInfo
- Publication number
- AR033444A1 AR033444A1 ARP020101068A ARP020101068A AR033444A1 AR 033444 A1 AR033444 A1 AR 033444A1 AR P020101068 A ARP020101068 A AR P020101068A AR P020101068 A ARP020101068 A AR P020101068A AR 033444 A1 AR033444 A1 AR 033444A1
- Authority
- AR
- Argentina
- Prior art keywords
- dosage form
- nicotine
- nicotine compound
- active
- active nicotine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Addiction (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Psychiatry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Una forma solida de dosificacion oral, util para la administracion oral de un compuesto activo de nicotina a través de la mucosa que comprende: a) una matriz vítrea que comprende por lo menos un azucar - alcohol sustancialmente no higroscopico capaz de formar una estructura vítrea,y b) un compuesto activo de nicotina, en una cantidad eficaz para reducir el ansia de nicotina. El azucar - alcohol puede comprender una mezcla de 1,6-GPS(6-O-alfa-D-glucopiranosil-D-sorbitol) y 1,1-GMP(1-O-alfa-D-glucopiranosil-D-manitol) en una relacion ponderal de aproximadamente 99:1 a aproximadamente 1:99. El compuesto activo de nicotina se puede seleccionar de nicotina, derivados de nicotina, y combinaciones de los mismos. Uso de un compuesto activo de nicotina para preparar la forma solida de dosificacion oral descripta en un método de aplicacion para reducir el ansia de nicotina y/o el uso del tabaco que comprende administrar oralmente la forma de dosificacion a una persona que necesite reduccion del ansia de nicotina o el uso de tabaco. Dicha forma de dosificacion puede proporcionar una concentracion de compuesto activo de nicotina en el plasma sanguíneo de por lo menos aproximadamente 6 ng/ml después de iniciar la administracion oral de la forma de dosificacion
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27860601P | 2001-03-26 | 2001-03-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR033444A1 true AR033444A1 (es) | 2003-12-17 |
Family
ID=23065632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020101068A AR033444A1 (es) | 2001-03-26 | 2002-03-22 | Forma solida de dosificacion util para la administracion oral de un compuesto activo de nicotina, a traves de la mucosa y uso de un compuesto activo de nicotina para prepararla |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1372392A4 (es) |
| JP (1) | JP2004525928A (es) |
| CN (2) | CN101301275A (es) |
| AR (1) | AR033444A1 (es) |
| AU (1) | AU2002252470B2 (es) |
| BR (1) | BR0208382A (es) |
| CA (1) | CA2440713A1 (es) |
| MX (1) | MXPA03008762A (es) |
| NZ (1) | NZ528167A (es) |
| PL (1) | PL364621A1 (es) |
| WO (1) | WO2002076211A1 (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040253307A1 (en) * | 2003-02-04 | 2004-12-16 | Brian Hague | Sugar-free oral transmucosal solid dosage forms and uses thereof |
| US9119846B2 (en) | 2003-04-29 | 2015-09-01 | Neurim Pharmaceuticals (1991) Ltd. | Method and composition for enhancing cognition in alzheimer's patients |
| IL155666A (en) | 2003-04-29 | 2013-12-31 | Neurim Pharma 1991 | Insomnia treatment |
| DK2446881T3 (da) * | 2003-07-24 | 2014-06-02 | Glaxosmithkline Llc | Oral opløselige film |
| GB0320854D0 (en) | 2003-09-05 | 2003-10-08 | Arrow No 7 Ltd | Buccal drug delivery |
| US20070191815A1 (en) | 2004-09-13 | 2007-08-16 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery |
| US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| BRPI0415741B1 (pt) | 2003-11-07 | 2013-07-23 | composições de tabaco e métodos de fabricação de uma composição de tabaco | |
| US8097271B2 (en) * | 2004-08-11 | 2012-01-17 | Kraft Foods Global Brands Llc | Warming compositions and delivery systems therefor |
| US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
| BRPI0719428A2 (pt) * | 2006-12-01 | 2014-02-25 | Cima Labs Inc | Forma de dosagem transmucosal oral sólida, método para tratar dependência de nicotina em um receptor que deseja tal tratamento, sistema de distribuição de nicotina transmucosal oral, e, método de substituíção de nicotina. |
| GB2468424B (en) * | 2007-04-02 | 2011-11-09 | Parkinson S Inst | Methods and compositions for reduction of side effects of therapeutic treatments |
| CN103977003A (zh) * | 2007-04-02 | 2014-08-13 | 帕金森氏病研究院 | 用于降低治疗的副作用的方法和组合物 |
| DE102008012015A1 (de) * | 2008-03-01 | 2009-09-10 | Südzucker AG Mannheim/Ochsenfurt | Verbesserte Isomalt-haltige Komprimate und Verfahren zu ihrer Herstellung |
| KR20130008535A (ko) * | 2010-02-18 | 2013-01-22 | 자틴 바산트 타카르 | 니코틴을 함유하는 소프트 젤라틴 알약 |
| US20110274628A1 (en) | 2010-05-07 | 2011-11-10 | Borschke August J | Nicotine-containing pharmaceutical compositions |
| UA112974C2 (uk) | 2010-09-16 | 2016-11-25 | Джеі. Бі. Кемікалс Енд Фармасьютікалс Лімітид | Нікотиновмісна композиція (варіанти) |
| WO2013006643A1 (en) | 2011-07-06 | 2013-01-10 | The Parkinson's Institute | Compositions and methods for treatment of symptoms in parkinson's disease patients |
| US9474303B2 (en) * | 2011-09-22 | 2016-10-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9629392B2 (en) | 2011-09-22 | 2017-04-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US20130078307A1 (en) | 2011-09-22 | 2013-03-28 | Niconovum Usa, Inc. | Nicotine-containing pharmaceutical composition |
| US9084439B2 (en) | 2011-09-22 | 2015-07-21 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9907748B2 (en) | 2011-10-21 | 2018-03-06 | Niconovum Usa, Inc. | Excipients for nicotine-containing therapeutic compositions |
| US9044035B2 (en) | 2012-04-17 | 2015-06-02 | R.J. Reynolds Tobacco Company | Remelted ingestible products |
| AR096223A1 (es) * | 2013-05-10 | 2015-12-16 | Glaxosmithkline Llc | Pastilla de nicotina para administración oral |
| CN104132895B (zh) * | 2014-07-08 | 2017-08-25 | 国家烟草质量监督检验中心 | 适用于连续流动法测定烟草及烟草制品中总植物碱的缓冲体系 |
| AU2016211330A1 (en) | 2015-01-28 | 2017-08-03 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
| AU2016228779A1 (en) | 2015-03-12 | 2017-09-07 | Chrono Therapeutics Inc. | Craving input and support system |
| JP2020503950A (ja) | 2017-01-06 | 2020-02-06 | クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 経皮薬剤送達の装置及び方法 |
| SE541358C2 (en) * | 2017-05-30 | 2019-08-13 | Enorama Pharma Ab | Nicotine-containing chewing gum compositions |
| JP7420797B2 (ja) | 2018-05-29 | 2024-01-23 | モーニングサイド ベンチャー インベストメンツ リミテッド | 薬剤送達の方法及びシステム |
| MX2022008739A (es) * | 2020-01-15 | 2022-10-07 | Mcneil Ab | Pastilla. |
| US20220313678A1 (en) * | 2021-04-06 | 2022-10-06 | Altria Client Services Llc | Spray dried nicotine for inclusion in oral products |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9310412D0 (en) * | 1993-05-20 | 1993-07-07 | Danbiosyst Uk | Nasal nicotine system |
| US5549906A (en) * | 1993-07-26 | 1996-08-27 | Pharmacia Ab | Nicotine lozenge and therapeutic method for smoking cessation |
| US5362496A (en) * | 1993-08-04 | 1994-11-08 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
| DE19536394A1 (de) * | 1995-09-29 | 1997-04-03 | Basf Ag | Feste Arzneiformen, erhältlich durch Extrusion einer Isomalt enthaltenden Polymer-Wirkstoff-Schmelze |
| DE19639342C2 (de) * | 1996-09-25 | 1998-07-16 | Suedzucker Ag | Kaugummi, enthaltend ein Süßungsmittel |
| US6322806B1 (en) * | 1999-04-06 | 2001-11-27 | Wm. Wrigley Jr. Company | Over-coated chewing gum formulations including tableted center |
-
2002
- 2002-03-22 CN CNA2008101253651A patent/CN101301275A/zh active Pending
- 2002-03-22 EP EP02721544A patent/EP1372392A4/en not_active Withdrawn
- 2002-03-22 AU AU2002252470A patent/AU2002252470B2/en not_active Ceased
- 2002-03-22 NZ NZ528167A patent/NZ528167A/en not_active IP Right Cessation
- 2002-03-22 PL PL02364621A patent/PL364621A1/xx not_active Application Discontinuation
- 2002-03-22 CN CNA028073339A patent/CN1553771A/zh active Pending
- 2002-03-22 JP JP2002574739A patent/JP2004525928A/ja active Pending
- 2002-03-22 WO PCT/US2002/008914 patent/WO2002076211A1/en active IP Right Grant
- 2002-03-22 AR ARP020101068A patent/AR033444A1/es unknown
- 2002-03-22 CA CA002440713A patent/CA2440713A1/en not_active Abandoned
- 2002-03-22 MX MXPA03008762A patent/MXPA03008762A/es active IP Right Grant
- 2002-03-22 BR BR0208382-5A patent/BR0208382A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2440713A1 (en) | 2002-10-03 |
| NZ528167A (en) | 2005-04-29 |
| EP1372392A1 (en) | 2004-01-02 |
| EP1372392A4 (en) | 2004-06-23 |
| CN101301275A (zh) | 2008-11-12 |
| WO2002076211A1 (en) | 2002-10-03 |
| PL364621A1 (en) | 2004-12-13 |
| JP2004525928A (ja) | 2004-08-26 |
| AU2002252470B2 (en) | 2008-05-22 |
| MXPA03008762A (es) | 2004-02-18 |
| BR0208382A (pt) | 2004-06-15 |
| CN1553771A (zh) | 2004-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |