RU2007125381A - Варианты il-7 со сниженной иммуногенностью - Google Patents
Варианты il-7 со сниженной иммуногенностью Download PDFInfo
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- RU2007125381A RU2007125381A RU2007125381/13A RU2007125381A RU2007125381A RU 2007125381 A RU2007125381 A RU 2007125381A RU 2007125381/13 A RU2007125381/13 A RU 2007125381/13A RU 2007125381 A RU2007125381 A RU 2007125381A RU 2007125381 A RU2007125381 A RU 2007125381A
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- polypeptide
- polypeptide according
- molecule
- modified
- leu108val
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5418—IL-7
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Microbiology (AREA)
- AIDS & HIV (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (19)
1. Полипептид, содержащий модифицированную молекулу человеческого IL-7 или ее активный участок, в которой Т-клеточный эпитоп модифицирован для снижения Т-клеточного ответа против IL-7, где указанный модифицированный IL-7 содержит аминокислотную замену в одном или более чем одном остатке IL-7 дикого типа, соответствующем Gln22, Leu24, Ile30, Phe39, Met54, Phe57, Arg58, Ala60, Arg61, Leu63, Lys68, Met69, Leu77, Ile88, Val96, Leu104, Leu128, Met147, Thr149 или Lys150.
2. Полипептид по п.1, содержащий по меньшей мере две из указанных аминокислотных замен.
3. Полипептид по п.1, содержащий по меньшей мере четыре из указанных аминокислотных замен.
4. Полипептид по п.1, где замена представляет собой замену в одном или более чем одном из остатков Phe39, Phe57, Leu77 и Leu128.
5. Полипептид по п.1, содержащий одну или более чем одну из приведенных ниже замен: Gln22Asp, Leu24Asp, Ile30Thr, Phe39Pro, Met54Ala, Phe57Lys, Phe57Asn, Arg58Asp, Ala60Ser, Arg61Glu, Leu77Asp, Leu104Ser, Leu104Val, Leu128Ala, Leu128Val, Leu128Pro, Leu128Ser, Met147Lys, Thr149Ser или Lys150Stop.
6. Полипептид по п.5, где этот полипептид содержит одну или более чем одну из замен Phe39Pro, Phe57Asn, Leu77Asp и Leu128Ser.
7. Полипептид по п.6, где этот полипептид содержит замены Phe39Pro, Phe57Asn, Leu77Asp и Leu128Ser.
8. Полипептид по п.1, где указанный полипептид является по меньшей мере на 80% идентичным человеческому IL-7 дикого типа.
9. Полипептид по любому из пп.1-8, где указанный полипептид дополнительно содержит молекулу иммуноглобулина или ее участок, слитый с указанной модифицированной молекулой IL-7 или ее активным фрагментом.
10. Полипептид по п.9, где указанная молекула иммуноглобулина или ее участок слиты через свой С-конец с N-концом указанной модифицированной молекулы IL-7 или ее активного фрагмента.
11. Полипептид по п.9, где указанная молекула иммуноглобулина представляет собой человеческий иммуноглобулин.
12. Полипептид по п.9, где указанная молекула иммуноглобулина представляет собой IgG2.
13. Полипептид по п.9, где указанный иммуноглобулин представляет собой участок Fc.
14. Молекула нуклеиновой кислоты, кодирующая полипептид по любому из пп.1-13.
15. Экспрессионный вектор, содержащий молекулу нуклеиновой кислоты по п.14.
16. Прокариотическая клетка, содержащая экспрессионный вектор по п.15.
17. Применение полипептида по любому из пп.1-13 для изготовления лекарства для лечения раковых заболеваний или ВИЧ.
18. Применение по п.17, где эффективное количество полипептида, вводимое пациенту, составляет между 0,01 и 10 мг/кг/сут.
19. Способ лечения пациента, страдающего раковыми заболеваниями или ВИЧ, путем введения указанному пациенту терапевтически эффективного количества полипептида по любому из пп.1-13.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63447004P | 2004-12-09 | 2004-12-09 | |
US60/634,470 | 2004-12-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2007125381A true RU2007125381A (ru) | 2009-01-20 |
RU2437893C2 RU2437893C2 (ru) | 2011-12-27 |
Family
ID=36578271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2007125381/10A RU2437893C2 (ru) | 2004-12-09 | 2005-12-08 | Варианты il-7 со сниженной иммуногенностью |
Country Status (14)
Country | Link |
---|---|
US (1) | US7589179B2 (ru) |
EP (1) | EP1819728B1 (ru) |
JP (1) | JP4937132B2 (ru) |
KR (1) | KR20070085886A (ru) |
CN (1) | CN101072793B (ru) |
AT (1) | ATE465176T1 (ru) |
AU (1) | AU2005313492B2 (ru) |
BR (1) | BRPI0519000A2 (ru) |
CA (1) | CA2591297C (ru) |
DE (1) | DE602005020837D1 (ru) |
ES (1) | ES2342964T3 (ru) |
RU (1) | RU2437893C2 (ru) |
WO (1) | WO2006061219A2 (ru) |
ZA (1) | ZA200705559B (ru) |
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- 2005-12-08 EP EP05850240A patent/EP1819728B1/en not_active Not-in-force
- 2005-12-08 JP JP2007544816A patent/JP4937132B2/ja not_active Expired - Fee Related
- 2005-12-08 DE DE602005020837T patent/DE602005020837D1/de active Active
- 2005-12-08 AU AU2005313492A patent/AU2005313492B2/en not_active Ceased
- 2005-12-08 BR BRPI0519000-2A patent/BRPI0519000A2/pt not_active IP Right Cessation
- 2005-12-08 US US11/297,166 patent/US7589179B2/en not_active Expired - Fee Related
- 2005-12-08 ES ES05850240T patent/ES2342964T3/es active Active
- 2005-12-08 CA CA2591297A patent/CA2591297C/en not_active Expired - Fee Related
- 2005-12-08 RU RU2007125381/10A patent/RU2437893C2/ru not_active IP Right Cessation
- 2005-12-08 KR KR1020077012885A patent/KR20070085886A/ko not_active Application Discontinuation
- 2005-12-08 AT AT05850240T patent/ATE465176T1/de not_active IP Right Cessation
- 2005-12-08 CN CN2005800422055A patent/CN101072793B/zh not_active Expired - Fee Related
- 2005-12-08 WO PCT/EP2005/013145 patent/WO2006061219A2/en active Application Filing
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AU2005313492B2 (en) | 2011-12-15 |
CA2591297A1 (en) | 2006-06-15 |
EP1819728A2 (en) | 2007-08-22 |
JP4937132B2 (ja) | 2012-05-23 |
ES2342964T3 (es) | 2010-07-20 |
WO2006061219A3 (en) | 2007-01-11 |
ATE465176T1 (de) | 2010-05-15 |
WO2006061219A2 (en) | 2006-06-15 |
CN101072793B (zh) | 2012-06-20 |
CN101072793A (zh) | 2007-11-14 |
US7589179B2 (en) | 2009-09-15 |
US20060141581A1 (en) | 2006-06-29 |
KR20070085886A (ko) | 2007-08-27 |
RU2437893C2 (ru) | 2011-12-27 |
DE602005020837D1 (de) | 2010-06-02 |
AU2005313492A1 (en) | 2006-06-15 |
ZA200705559B (en) | 2008-10-29 |
EP1819728B1 (en) | 2010-04-21 |
JP2008522600A (ja) | 2008-07-03 |
CA2591297C (en) | 2015-01-13 |
BRPI0519000A2 (pt) | 2008-12-23 |
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