RU2006120458A - Способ регенерации ткани - Google Patents
Способ регенерации ткани Download PDFInfo
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- RU2006120458A RU2006120458A RU2006120458/13A RU2006120458A RU2006120458A RU 2006120458 A RU2006120458 A RU 2006120458A RU 2006120458/13 A RU2006120458/13 A RU 2006120458/13A RU 2006120458 A RU2006120458 A RU 2006120458A RU 2006120458 A RU2006120458 A RU 2006120458A
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- use according
- epo
- cells
- tissue
- regeneration
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Physiology (AREA)
- Developmental Biology & Embryology (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
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Claims (17)
1. Применение нативного или рекомбинантного эритропоэтина (ЭПО) или его сходных по действию производных для регенерации паренхиматозных тканей и образования структур стенок в координированной и трехмерной форме в травматически поврежденных клетках и органах.
2. Применение согласно п.1, отличающееся тем, что применяют рецепторсвязывающий домен ЭПО.
3. Применение согласно п.1 для синтеза тканевых структур и образованных из них функциональных органов.
4. Применение согласно п.3 для регенерации печени.
5. Применение согласно п.3 для заживления ран при структурообразовательном процессе в отношении воспроизведения прежней ткани.
6. Применение согласно п.3 для лечения воспалений и репаративных процессов в области зубов.
7. Применение согласно п.1 или 3, отличающееся тем, что регенерация проходит in vivo.
8. Применение согласно п.1 или 3, отличающееся тем, что регенерация ткани регулируется локально.
9. Применение согласно п.1 или 3, отличающееся тем, что дополнительно используют эндотелиальные клетки.
10. Применение согласно п.1 или 3, отличающееся тем, что дополнительно используют один или несколько факторов роста, выбранных из группы: трансформирующий фактор роста бета (TGF beta), гранулоцитарно-макрофагальный колониестимулирующий фактор (GM-CSF), гранулоцитарный колониестимулирующий фактор (G-CSF), фактор роста нервов (NGF), фактор роста сосудистого эндотелия (VEGF) и тромбоцитарный фактор роста (PDGF).
11. Применение согласно п.1 или 3, отличающееся тем, что используют ЭПО человека.
12. Применение согласно п.1 или 3, отличающееся тем, что ЭПО или один из его производных используются местно.
13. Применение согласно п.1 или 3, отличающееся тем, что ЭПО или один из его производных используется системно.
14. Применение согласно п.1, отличающееся тем, что процесс регенерации поддерживается опорной матрицей, которую обрабатывают ЭПО или одним из его производных.
15. Применение согласно п.14, отличающееся тем, что опорная матрица представляет собой имплантат, трансплантат или опорный материал для размножения клеток.
16. Применение согласно п.14 или 15, отличающееся тем, что опорную матрицу предварительно заселяют тканеспецифичными клетками или клетками-предшественниками взрослых людей, или подготавливают для заселения клетками in vivo или для индуктивной коррекции in vitro.
17. Применение согласно п.16, отличающееся тем, что в качестве клеток используют остеобласты, фибробласты, гепатоциты или гладкомышечные клетки.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03029961A EP1550715A1 (de) | 2003-12-30 | 2003-12-30 | Verfahren zur Regenation von Gewebe |
DE10361813A DE10361813A1 (de) | 2003-12-30 | 2003-12-30 | Verfahren zur Regeneration von Gewebe |
EP03029961.4 | 2003-12-30 | ||
DE10361813.9 | 2003-12-30 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2010105646/10A Division RU2542391C2 (ru) | 2003-12-30 | 2004-12-30 | Способ регенерации ткани |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2006120458A true RU2006120458A (ru) | 2008-02-10 |
RU2392314C2 RU2392314C2 (ru) | 2010-06-20 |
Family
ID=34740522
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2006120458/13A RU2392314C2 (ru) | 2003-12-30 | 2004-12-30 | Способ регенерации ткани |
RU2010105646/10A RU2542391C2 (ru) | 2003-12-30 | 2004-12-30 | Способ регенерации ткани |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2010105646/10A RU2542391C2 (ru) | 2003-12-30 | 2004-12-30 | Способ регенерации ткани |
Country Status (14)
Country | Link |
---|---|
US (2) | US7910547B2 (ru) |
EP (2) | EP1699915B1 (ru) |
JP (2) | JP4903580B2 (ru) |
AT (1) | ATE469654T1 (ru) |
AU (2) | AU2004309083B2 (ru) |
BR (1) | BRPI0418326A (ru) |
CA (1) | CA2550301A1 (ru) |
DE (1) | DE502004011252D1 (ru) |
DK (2) | DK2233150T3 (ru) |
ES (2) | ES2346226T3 (ru) |
PL (2) | PL2233150T3 (ru) |
PT (1) | PT1699915E (ru) |
RU (2) | RU2392314C2 (ru) |
WO (1) | WO2005063965A1 (ru) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10026480A1 (de) * | 2000-05-29 | 2001-12-13 | Augustinus Bader | Verfahren zur Herstellung eines empfängerspezifischen Gewebe-Transplantats oder -Implantats |
PT1699915E (pt) * | 2003-12-30 | 2010-08-31 | Augustinus Bader | Utilização de eritropoietina para a regeneração de tecido hepático |
JP4982841B2 (ja) * | 2005-10-12 | 2012-07-25 | 国立大学法人名古屋大学 | 再生医療骨組成物 |
US20080107632A1 (en) * | 2006-09-06 | 2008-05-08 | Henrich Cheng | Fibrin glue composition for repairing nerve damage and methods thereof |
JP4696247B2 (ja) * | 2006-12-11 | 2011-06-08 | 国立大学法人 筑波大学 | 肝線維化抑制剤 |
JP5098018B2 (ja) * | 2007-03-06 | 2012-12-12 | 国立大学法人 筑波大学 | 肝炎治療剤 |
AR065613A1 (es) * | 2007-03-09 | 2009-06-17 | Chugai Pharmaceutical Co Ltd | Agentes de proteccion para organos transplantados |
EP2018835B1 (de) | 2007-07-09 | 2014-03-05 | Augustinus Bader | Wirkstoff abgebendes Pflaster |
WO2009022338A2 (en) | 2007-08-16 | 2009-02-19 | Saher Hamed | Erythropoietin and fibronectin compositions for therapeutic and cosmetic applications |
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US20110172150A1 (en) | 2011-07-14 |
EP2233150A2 (de) | 2010-09-29 |
JP2012067117A (ja) | 2012-04-05 |
RU2542391C2 (ru) | 2015-02-20 |
EP1699915B1 (de) | 2010-06-02 |
EP1699915A1 (de) | 2006-09-13 |
PL1699915T3 (pl) | 2010-11-30 |
JP2007517001A (ja) | 2007-06-28 |
AU2004309083A1 (en) | 2005-07-14 |
DK2233150T3 (en) | 2016-12-12 |
JP4903580B2 (ja) | 2012-03-28 |
PT1699915E (pt) | 2010-08-31 |
DK1699915T3 (da) | 2010-09-13 |
ES2606068T3 (es) | 2017-03-17 |
DE502004011252D1 (de) | 2010-07-15 |
US7910547B2 (en) | 2011-03-22 |
AU2011200538A1 (en) | 2011-03-03 |
EP2233150A3 (de) | 2013-01-09 |
RU2010105646A (ru) | 2011-08-27 |
AU2011200538B2 (en) | 2012-02-23 |
ATE469654T1 (de) | 2010-06-15 |
BRPI0418326A (pt) | 2007-05-02 |
PL2233150T3 (pl) | 2017-06-30 |
ES2346226T3 (es) | 2010-10-13 |
AU2004309083B2 (en) | 2010-11-11 |
WO2005063965A1 (de) | 2005-07-14 |
RU2392314C2 (ru) | 2010-06-20 |
CA2550301A1 (en) | 2005-07-14 |
EP2233150B1 (de) | 2016-09-07 |
US20080031850A1 (en) | 2008-02-07 |
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