RS20050180A - Novel benzoimidazole derivatives useful as antiproliferative agensts - Google Patents

Novel benzoimidazole derivatives useful as antiproliferative agensts

Info

Publication number
RS20050180A
RS20050180A YUP-2005/0180A YUP18005A RS20050180A RS 20050180 A RS20050180 A RS 20050180A YU P18005 A YUP18005 A YU P18005A RS 20050180 A RS20050180 A RS 20050180A
Authority
RS
Serbia
Prior art keywords
agensts
antiproliferative
derivatives useful
compounds
formula
Prior art date
Application number
YUP-2005/0180A
Other languages
English (en)
Inventor
John Charles Kath
Joseph Peter Lyssikatos
Huifen Faye Wang
Original Assignee
Pfizer Products Inc.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc., filed Critical Pfizer Products Inc.,
Publication of RS20050180A publication Critical patent/RS20050180A/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

Pronalazak se odnosi na jedinejnja formule 1 i njihove farmaceutski prihvatljive soli, prolekove i solvate, gde su R1, R2, R3 i R4 kao što je ovde definisano. Pronalazak se takođe odnosi na postupke lečenja rasta abnormalnih ćelija, kao što je rak, kod sisara, administracijom jedinjenja formule 1 i na farmaceutske preparate za lečenje ovih oboljenja koji sadrže jedinjenja formule 1. Pronalazak se takođe odnosi na postupke za dobijanje jedinjenja formule 1.
YUP-2005/0180A 2002-08-28 2005-08-14 Novel benzoimidazole derivatives useful as antiproliferative agensts RS20050180A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40652402P 2002-08-28 2002-08-28
US41704702P 2002-10-08 2002-10-08
PCT/IB2003/003634 WO2004020431A2 (en) 2002-08-28 2003-08-14 Novel benzoimidazole derivatives useful as antiproliferative agents

Publications (1)

Publication Number Publication Date
RS20050180A true RS20050180A (en) 2007-08-03

Family

ID=31981411

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-2005/0180A RS20050180A (en) 2002-08-28 2005-08-14 Novel benzoimidazole derivatives useful as antiproliferative agensts

Country Status (41)

Country Link
US (1) US7071337B2 (sr)
EP (1) EP1594858B1 (sr)
JP (1) JP4551771B2 (sr)
KR (2) KR20070086768A (sr)
CN (1) CN1319966C (sr)
AP (1) AP2005003237A0 (sr)
AR (1) AR041055A1 (sr)
AT (1) ATE445610T1 (sr)
AU (1) AU2003250499B2 (sr)
BR (1) BRPI0313942C1 (sr)
CA (1) CA2495577C (sr)
CR (1) CR7698A (sr)
CU (1) CU23413B7 (sr)
CY (1) CY1110580T1 (sr)
DE (1) DE60329715D1 (sr)
DK (1) DK1594858T3 (sr)
DO (1) DOP2003000694A (sr)
EA (1) EA008448B1 (sr)
EC (1) ECSP055633A (sr)
ES (1) ES2333219T3 (sr)
GE (1) GEP20064005B (sr)
HK (1) HK1078571A1 (sr)
HN (1) HN2003000257A (sr)
HR (1) HRP20050191B1 (sr)
IL (1) IL166832A (sr)
IS (1) IS2738B (sr)
MA (1) MA27389A1 (sr)
MX (1) MXPA05001256A (sr)
MY (1) MY139357A (sr)
NO (1) NO20051303L (sr)
NZ (1) NZ538427A (sr)
OA (1) OA12916A (sr)
PA (1) PA8580301A1 (sr)
PE (1) PE20050131A1 (sr)
PL (1) PL377678A1 (sr)
PT (1) PT1594858E (sr)
RS (1) RS20050180A (sr)
SI (1) SI1594858T1 (sr)
TW (1) TW200407131A (sr)
UY (1) UY27952A1 (sr)
WO (1) WO2004020431A2 (sr)

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BRPI0608096A2 (pt) 2005-04-26 2009-11-10 Pfizer anticorpos p-caderina
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BRPI0809998B8 (pt) 2007-04-03 2021-05-25 Array Biopharma Inc composto de imidazo[1,2-a] piridina como inibidores do receptor tirosina quinase, seus usos, seus processos de preparação e composições farmacêuticas
MX2010012718A (es) * 2008-05-21 2011-04-04 Incyte Corp Sales de 2-fluoro-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b ][1,2,4] triazin-2-il]benzamida y procesos relacionados con la preparacion de las mismas.
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GB201103578D0 (en) 2011-03-02 2011-04-13 Sabrepharm Ltd Dipyridinium derivatives
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US10835525B2 (en) 2012-09-26 2020-11-17 Arog Pharmaceuticals, Inc. Method of inhibiting mutant C-KIT
TWI599356B (zh) 2012-09-26 2017-09-21 安羅格製藥有限責任公司 抑制突變型ｃ－ｋｉｔ的方法
US11642340B2 (en) 2012-09-26 2023-05-09 Arog Pharmaceuticals, Inc. Method of inhibiting mutant C-KIT
BR112015016282A2 (pt) 2013-01-07 2017-07-11 Arog Pharmaceuticals Inc crenolanibe para tratamento de distúrbios proliferativos de flt3 mutado
US10463658B2 (en) 2013-10-25 2019-11-05 Videra Pharmaceuticals, Llc Method of inhibiting FLT3 kinase
RS58328B1 (sr) * 2014-10-31 2019-03-29 Genoscience Pharma Sas Supstituisani 2,4 diamino-hinolini kao novi antitumorski agensi
GB2543550A (en) 2015-10-21 2017-04-26 Hox Therapeutics Ltd Peptides
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
DK3452465T3 (da) 2016-05-04 2021-02-08 Genoscience Pharma Substituerede 2,4-diaminoquinolinderivater til anvendelse til behandling af proliferative sygdomme
WO2018085292A1 (en) 2016-11-02 2018-05-11 Arog Pharmaceuticals, Inc. Crenolanib for treating flt3 mutated proliferative disorders associated mutations
CN107382984B (zh) * 2017-08-24 2020-07-10 扬州市三药制药有限公司 一种治疗白血病药物的制备方法
CN107382983B (zh) * 2017-08-24 2020-08-07 扬州市三药制药有限公司 一种治疗白血病药物的合成方法
CN110840893A (zh) 2018-12-13 2020-02-28 安罗格制药有限责任公司 含克莱拉尼的药物组合物及其用途
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CN117447376A (zh) * 2019-12-09 2024-01-26 苏州恩华生物医药科技有限公司 连双环结构sigma-1受体抑制剂
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JP2023063189A (ja) 2021-10-22 2023-05-09 アログ・ファーマシューティカルズ・インコーポレイテッド 以前の治療に対して再発性／不応性のｆｌｔ３突然変異増殖性障害を治療するためのクレノラニブ
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UA75055C2 (uk) * 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
CA2393026A1 (en) * 1999-11-30 2001-06-07 Paul A. Wender Bryostatin analogues, synthetic methods and uses
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Also Published As

Publication number Publication date
UY27952A1 (es) 2004-03-31
CA2495577A1 (en) 2004-03-11
HK1078571A1 (en) 2006-03-17
EA008448B1 (ru) 2007-06-29
MA27389A1 (fr) 2005-06-01
MXPA05001256A (es) 2005-06-08
PE20050131A1 (es) 2005-03-21
CN1678604A (zh) 2005-10-05
WO2004020431A3 (en) 2004-05-13
EP1594858A2 (en) 2005-11-16
BRPI0313942B8 (pt) 2020-08-04
US7071337B2 (en) 2006-07-04
PA8580301A1 (es) 2005-05-24
BR0313942A (pt) 2005-07-12
CA2495577C (en) 2010-06-15
NZ538427A (en) 2007-04-27
TW200407131A (en) 2004-05-16
EP1594858B1 (en) 2009-10-14
NO20051303L (no) 2005-05-18
IL166832A (en) 2011-03-31
AU2003250499A1 (en) 2004-03-19
AP2005003237A0 (en) 2005-03-31
ECSP055633A (es) 2005-04-18
SI1594858T1 (sl) 2010-01-29
BRPI0313942B1 (pt) 2019-06-04
IS2738B (is) 2011-06-15
DE60329715D1 (de) 2009-11-26
AR041055A1 (es) 2005-04-27
JP4551771B2 (ja) 2010-09-29
KR100816166B1 (ko) 2008-03-21
CR7698A (es) 2007-11-23
DOP2003000694A (es) 2004-02-29
KR20050036984A (ko) 2005-04-20
PL377678A1 (pl) 2006-02-06
KR20070086768A (ko) 2007-08-27
AU2003250499B2 (en) 2009-04-23
ES2333219T3 (es) 2010-02-18
CY1110580T1 (el) 2015-04-29
JP2006501309A (ja) 2006-01-12
HN2003000257A (es) 2004-12-01
MY139357A (en) 2009-09-30
CU23413B7 (es) 2009-09-08
OA12916A (en) 2006-10-13
DK1594858T3 (da) 2009-12-14
IS7660A (is) 2005-01-20
HRP20050191A2 (en) 2005-10-31
ATE445610T1 (de) 2009-10-15
BRPI0313942C1 (pt) 2021-05-25
US20050124599A1 (en) 2005-06-09
WO2004020431A2 (en) 2004-03-11
EA200500174A1 (ru) 2005-08-25
CN1319966C (zh) 2007-06-06
GEP20064005B (en) 2006-12-25
HRP20050191A9 (hr) 2013-11-22
HRP20050191B1 (hr) 2013-12-20
PT1594858E (pt) 2009-12-14

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