OA12916A - Novel benzoimidazole derivatives useful as antiproliferative agents. - Google Patents

Novel benzoimidazole derivatives useful as antiproliferative agents. Download PDF

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Publication number
OA12916A
OA12916A OA1200500059A OA1200500059A OA12916A OA 12916 A OA12916 A OA 12916A OA 1200500059 A OA1200500059 A OA 1200500059A OA 1200500059 A OA1200500059 A OA 1200500059A OA 12916 A OA12916 A OA 12916A
Authority
OA
OAPI
Prior art keywords
compound
group
formula
benzoimidazol
optionally substituted
Prior art date
Application number
OA1200500059A
Other languages
English (en)
Inventor
John Charles Kath
Huifen Faye Wang
Joseph Peter Lyssikatos
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of OA12916A publication Critical patent/OA12916A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
OA1200500059A 2002-08-28 2003-08-14 Novel benzoimidazole derivatives useful as antiproliferative agents. OA12916A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40652402P 2002-08-28 2002-08-28
US41704702P 2002-10-08 2002-10-08

Publications (1)

Publication Number Publication Date
OA12916A true OA12916A (en) 2006-10-13

Family

ID=31981411

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200500059A OA12916A (en) 2002-08-28 2003-08-14 Novel benzoimidazole derivatives useful as antiproliferative agents.

Country Status (41)

Country Link
US (1) US7071337B2 (sr)
EP (1) EP1594858B1 (sr)
JP (1) JP4551771B2 (sr)
KR (2) KR100816166B1 (sr)
CN (1) CN1319966C (sr)
AP (1) AP2005003237A0 (sr)
AR (1) AR041055A1 (sr)
AT (1) ATE445610T1 (sr)
AU (1) AU2003250499B2 (sr)
BR (1) BRPI0313942C1 (sr)
CA (1) CA2495577C (sr)
CR (1) CR7698A (sr)
CU (1) CU23413B7 (sr)
CY (1) CY1110580T1 (sr)
DE (1) DE60329715D1 (sr)
DK (1) DK1594858T3 (sr)
DO (1) DOP2003000694A (sr)
EA (1) EA008448B1 (sr)
EC (1) ECSP055633A (sr)
ES (1) ES2333219T3 (sr)
GE (1) GEP20064005B (sr)
HK (1) HK1078571A1 (sr)
HN (1) HN2003000257A (sr)
HR (1) HRP20050191B1 (sr)
IL (1) IL166832A (sr)
IS (1) IS2738B (sr)
MA (1) MA27389A1 (sr)
MX (1) MXPA05001256A (sr)
MY (1) MY139357A (sr)
NO (1) NO20051303L (sr)
NZ (1) NZ538427A (sr)
OA (1) OA12916A (sr)
PA (1) PA8580301A1 (sr)
PE (1) PE20050131A1 (sr)
PL (1) PL377678A1 (sr)
PT (1) PT1594858E (sr)
RS (1) RS20050180A (sr)
SI (1) SI1594858T1 (sr)
TW (1) TW200407131A (sr)
UY (1) UY27952A1 (sr)
WO (1) WO2004020431A2 (sr)

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JP2007530654A (ja) * 2004-03-30 2007-11-01 ファイザー・プロダクツ・インク シグナル伝達阻害剤の組合せ
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WO2006038111A1 (en) * 2004-10-07 2006-04-13 Pfizer Products Inc. Benzoimidazole derivatives useful as antiproliferative agents
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MY164457A (en) 2005-09-07 2017-12-15 Amgen Fremont Inc Human monoclonal antibodies to activin receptor-like kinase-1
RS20080525A (en) 2006-05-09 2009-09-08 Pfizer Products Inc., Cycloalkylamino acid derivatives and pharmaceutical compositions thereof
UA101611C2 (ru) 2007-04-03 2013-04-25 Аррей Байофарма Инк. СОЕДИНЕНИЯ ИМИДАЗО[1,2-а]ПИРИДИНА КАК ИНГИБИТОРЫ ТИРОЗИНКИНАЗЫ РЕЦЕПТОРОВ
SI2300455T1 (sl) * 2008-05-21 2017-12-29 Incyte Holdings Corporation Soli 2-fluoro-n-metil-4-(7-(kinolin-6-il-metil)-imidazo(1,2-b)1,2,4) triazin-2-il)benzamid in postopki v zvezi z njihovo pripravo
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US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
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GB201103578D0 (en) 2011-03-02 2011-04-13 Sabrepharm Ltd Dipyridinium derivatives
KR101738063B1 (ko) 2012-09-21 2017-05-19 아로그 파마슈티칼스, 인코퍼레이티드 구조적으로 활성인 인산화된 ｆｌｔ３ 키나제의 억제 방법
US11642340B2 (en) 2012-09-26 2023-05-09 Arog Pharmaceuticals, Inc. Method of inhibiting mutant C-KIT
US10835525B2 (en) 2012-09-26 2020-11-17 Arog Pharmaceuticals, Inc. Method of inhibiting mutant C-KIT
KR20140040594A (ko) 2012-09-26 2014-04-03 아로그 파마슈티칼스, 엘엘씨 돌연변이체 c-kit의 억제 방법
BR112015016282A2 (pt) 2013-01-07 2017-07-11 Arog Pharmaceuticals Inc crenolanibe para tratamento de distúrbios proliferativos de flt3 mutado
US10463658B2 (en) 2013-10-25 2019-11-05 Videra Pharmaceuticals, Llc Method of inhibiting FLT3 kinase
KR102548547B1 (ko) * 2014-10-31 2023-06-27 제노사이언스 파마 신규한 항암제로서의 치환 ２,４ 디아미노-퀴놀린
GB2543550A (en) 2015-10-21 2017-04-26 Hox Therapeutics Ltd Peptides
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
WO2017191599A1 (en) * 2016-05-04 2017-11-09 Genoscience Pharma Substituted 2, 4-diamino-quinoline derivatives for use in the treatment of proliferative diseases
JP2019532011A (ja) 2016-11-02 2019-11-07 アログ・ファーマシューティカルズ・インコーポレイテッドＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Ｆｌｔ３突然変異増殖性疾患および関連する突然変異を治療するためのクレノラニブ
CN107382984B (zh) * 2017-08-24 2020-07-10 扬州市三药制药有限公司 一种治疗白血病药物的制备方法
CN107382983B (zh) * 2017-08-24 2020-08-07 扬州市三药制药有限公司 一种治疗白血病药物的合成方法
CN110840893A (zh) 2018-12-13 2020-02-28 安罗格制药有限责任公司 含克莱拉尼的药物组合物及其用途
US11471451B2 (en) 2019-08-19 2022-10-18 Arog Pharmaceuticals, Inc. Uses of crenolanib
CN114702428B (zh) * 2019-12-09 2023-11-28 苏州恩华生物医药科技有限公司 连双环结构sigma-1受体抑制剂
US11713310B2 (en) 2020-07-20 2023-08-01 Arog Pharmaceuticals, Inc. Crystal forms of crenolanib and methods of use thereof
WO2022031928A1 (en) * 2020-08-05 2022-02-10 The General Hospital Corporation Salt inducible kinase inhibitors
US11524006B2 (en) 2020-09-17 2022-12-13 Arog Pharmaceuticals, Inc. Crenolanib for treating TRK kinase associated proliferative disorders
US11969420B2 (en) 2020-10-30 2024-04-30 Arog Pharmaceuticals, Inc. Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders
CN113683594B (zh) * 2021-09-07 2022-12-27 曲靖师范学院 一种喹啉-苯并咪唑盐类化合物及其合成方法和应用
JP2023063189A (ja) 2021-10-22 2023-05-09 アログ・ファーマシューティカルズ・インコーポレイテッド 以前の治療に対して再発性／不応性のｆｌｔ３突然変異増殖性障害を治療するためのクレノラニブ
CA3237696A1 (en) 2021-11-08 2023-05-11 Progentos Therapeutics, Inc. Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof
CN114409632B (zh) * 2022-02-22 2024-04-30 北京鲲达宇科技有限公司 2-取代氨基-3-苯并咪唑取代的喹啉衍生物及其制备方法与应用

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Also Published As

Publication number Publication date
ECSP055633A (es) 2005-04-18
KR20070086768A (ko) 2007-08-27
SI1594858T1 (sl) 2010-01-29
AU2003250499A1 (en) 2004-03-19
PA8580301A1 (es) 2005-05-24
NO20051303L (no) 2005-05-18
JP2006501309A (ja) 2006-01-12
HN2003000257A (es) 2004-12-01
DE60329715D1 (de) 2009-11-26
CU23413B7 (es) 2009-09-08
IL166832A (en) 2011-03-31
AU2003250499B2 (en) 2009-04-23
HRP20050191A9 (hr) 2013-11-22
CY1110580T1 (el) 2015-04-29
DOP2003000694A (es) 2004-02-29
PE20050131A1 (es) 2005-03-21
CA2495577A1 (en) 2004-03-11
DK1594858T3 (da) 2009-12-14
WO2004020431A2 (en) 2004-03-11
HRP20050191A2 (en) 2005-10-31
ES2333219T3 (es) 2010-02-18
CR7698A (es) 2007-11-23
EP1594858B1 (en) 2009-10-14
BRPI0313942B8 (pt) 2020-08-04
NZ538427A (en) 2007-04-27
IS2738B (is) 2011-06-15
EP1594858A2 (en) 2005-11-16
CN1319966C (zh) 2007-06-06
KR20050036984A (ko) 2005-04-20
UY27952A1 (es) 2004-03-31
PL377678A1 (pl) 2006-02-06
EA200500174A1 (ru) 2005-08-25
TW200407131A (en) 2004-05-16
AP2005003237A0 (en) 2005-03-31
MA27389A1 (fr) 2005-06-01
IS7660A (is) 2005-01-20
HRP20050191B1 (hr) 2013-12-20
MXPA05001256A (es) 2005-06-08
ATE445610T1 (de) 2009-10-15
HK1078571A1 (en) 2006-03-17
MY139357A (en) 2009-09-30
BR0313942A (pt) 2005-07-12
CA2495577C (en) 2010-06-15
WO2004020431A3 (en) 2004-05-13
US20050124599A1 (en) 2005-06-09
AR041055A1 (es) 2005-04-27
JP4551771B2 (ja) 2010-09-29
GEP20064005B (en) 2006-12-25
BRPI0313942C1 (pt) 2021-05-25
PT1594858E (pt) 2009-12-14
BRPI0313942B1 (pt) 2019-06-04
EA008448B1 (ru) 2007-06-29
KR100816166B1 (ko) 2008-03-21
CN1678604A (zh) 2005-10-05
US7071337B2 (en) 2006-07-04
RS20050180A (en) 2007-08-03

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