CY1250A - N-heterocyclyl-4-piperdinamines,methods for their preparation and pharmaceutical compositions comprising them - Google Patents

N-heterocyclyl-4-piperdinamines,methods for their preparation and pharmaceutical compositions comprising them

Info

Publication number: CY1250A
Authority: CY; Cyprus
Prior art keywords: piperdinamines; heterocyclyl; preparation; methods; pharmaceutical compositions
Prior art date: 1978-04-03

Application number

CY1250A

Other languages

English (en)

Inventor

Frans Janssen

Raymond Stokbroekx

Joseph Torremans

Marcel Luyckx

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-03

Filing date

1979-03-30

Publication date

1984-08-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26670178&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1250(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1979-01-10 Priority claimed from US06/002,276 external-priority patent/US4219559A/en

1979-03-30 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1984-08-31 Publication of CY1250A publication Critical patent/CY1250A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)

CY1250A 1978-04-03 1979-03-30 N-heterocyclyl-4-piperdinamines,methods for their preparation and pharmaceutical compositions comprising them CY1250A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US89253478A	1978-04-03	1978-04-03
US06/002,276 US4219559A (en)	1979-01-10	1979-01-10	N-Heterocyclyl-4-piperidinamines

Publications (1)

Publication Number	Publication Date
CY1250A true CY1250A (en)	1984-08-31

Family

ID=26670178

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY1250A CY1250A (en)	1978-04-03	1979-03-30	N-heterocyclyl-4-piperdinamines,methods for their preparation and pharmaceutical compositions comprising them

Country Status (29)

Country	Link
EP (1)	EP0005318B1 (xx)
JP (2)	JPS54151982A (xx)
AT (1)	AT373887B (xx)
AU (1)	AU523352B2 (xx)
BG (1)	BG38164A3 (xx)
CA (1)	CA1140119A (xx)
CS (1)	CS256358B2 (xx)
CY (1)	CY1250A (xx)
DE (1)	DE2961740D1 (xx)
DK (1)	DK169325B1 (xx)
EG (1)	EG13913A (xx)
ES (1)	ES479206A1 (xx)
FI (1)	FI64801C (xx)
GR (1)	GR64907B (xx)
HK (1)	HK3184A (xx)
HU (1)	HU182965B (xx)
IE (1)	IE47818B1 (xx)
IL (1)	IL56992A (xx)
MY (1)	MY8500046A (xx)
NO (2)	NO154058C (xx)
NZ (1)	NZ189978A (xx)
PH (1)	PH15877A (xx)
PL (1)	PL123380B1 (xx)
PT (1)	PT69429A (xx)
RO (1)	RO79320A (xx)
SG (1)	SG29883G (xx)
SU (1)	SU1056902A3 (xx)
YU (2)	YU42484B (xx)
ZA (1)	ZA791557B (xx)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MA19091A1 (fr) *	1980-03-10	1981-10-01	Janssen Pharmaceutica Nv	Nouveaux derives de i-(4-aryl-cyclohexyl)piperidine .
IN156065B (xx) *	1982-07-12	1985-05-04	Janssen Pharmaceutica Nv
US4556660A (en) *	1982-07-12	1985-12-03	Janssen Pharmaceutica N.V.	N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) *	1983-10-06	1987-01-06	Janssen Pharmaceutica, N.V.	Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
EP0144101B1 (en) *	1983-11-30	1991-02-06	Janssen Pharmaceutica N.V.	Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
JPS60174778A (ja) *	1984-01-09	1985-09-09	ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ	Ｎ−ヘテロシクリル−４−ピペリジンアミン
KR930005004B1 (ko) *	1985-04-15	1993-06-11	쟈안센 파아마슈우티카 엔. 부이.	치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8515934D0 (en) *	1985-06-24	1985-07-24	Janssen Pharmaceutica Nv	(4-piperidinomethyl and-hetero)purines
DE3781173T2 (de) *	1986-02-03	1992-12-17	Janssen Pharmaceutica Nv	N-heterozyklische-4-piperidinamine enthaltende anti-histaminische zusammensetzungen.
NZ223654A (en) *	1987-03-09	1990-03-27	Janssen Pharmaceutica Nv	1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
FR2618435B1 (fr) *	1987-07-23	1989-10-27	Synthelabo	Derives de benzimidazole, leur preparation et leur application en therapeutique
US5210091A (en) *	1991-06-24	1993-05-11	Neurosearch A/S	Imidazole compounds and their use
KR960702445A (ko) *	1993-05-20	1996-04-27	간자와 무츠오	1-(2-벤조이미다졸일)-1, 5- 디아자시클로옥탄 유도체(1-(2-benzimidazo-lyl)-1,5-diazacyclooctane compounds)
US5547966A (en) *	1993-10-07	1996-08-20	Bristol-Myers Squibb Company	Aryl urea and related compounds
BR9907951A (pt) *	1998-03-06	2001-01-30	Janssen Pharmaceutica Nv	Inibidores de transporte de glicina
CA2376785A1 (en) *	1999-06-28	2001-01-04	Janssen Pharmaceutica N.V.	Benzimidazoles and imidazopyridines as respiratory syncytial virus replication inhibitors
SK18942001A3 (sk)	1999-06-28	2002-10-08	Janssen Pharmaceutica N. V.	Inhibítory replikácie respiračného syncytiálneho vírusu
UA74787C2 (en)	1999-06-28	2006-02-15	Janssen Pharmaceutica Nv	Respiratory syncytial virus replication inhibitors
IL151164A0 (en)	2000-03-06	2003-04-10	Acadia Pharm Inc	Azacyclic compounds for use in the treatment of serotonin related diseases
US7129358B2 (en)	2001-02-02	2006-10-31	Teva Pharmaceutical Industries Ltd.	Processes for the production of substituted 2-(2-pyridylmethyl) sulfinyl-1H-benzimidazoles
KR20100008799A (ko)	2001-12-28	2010-01-26	아카디아 파마슈티칼스 인코포레이티드	모노아민 수용체 조정자로서의 스피로아자사이클릭 화합물
EP2266590A3 (en)	2002-02-22	2011-04-20	Shire LLC	Active agent delivery sytems and methods for protecting and administering active agents
US7253186B2 (en)	2002-06-24	2007-08-07	Carl-Magnus Andersson	N-substituted piperidine derivatives as serotonin receptor agents
AU2003247615B2 (en)	2002-06-24	2007-08-09	Acadia Pharmaceuticals Inc.	N-substituted piperidine derivatives as serotonin receptor agents
US7538222B2 (en)	2002-06-24	2009-05-26	Acadia Pharmaceuticals, Inc.	N-substituted piperidine derivatives as serotonin receptor agents
CA2512639C (en)	2003-01-16	2012-10-30	Acadia Pharmaceuticals Inc.	Selective serotonin 2a/2c receptor inverse agonists as therapeutics for neurodegenerative diseases
DK1723136T3 (da)	2003-12-18	2011-06-27	Tibotec Pharm Ltd	Piperidinamino-benzimidazol-derivat som inhibitorer af replikation af respiratorisk syncytial virus
RU2369606C2 (ru)	2003-12-18	2009-10-10	Тиботек Фармасьютикалз Лтд.	Производные 5- или 6-замещенных бензимидазолов в качестве ингибиторов репликации респираторного синцитиального вируса
BRPI0417811A (pt)	2003-12-18	2007-03-27	Tibotec Pharm Ltd	aminobenzimidazóis e benzimidazóis como inibidores da replicação do vìrus sincicial respiratório
US7820695B2 (en)	2004-05-21	2010-10-26	Acadia Pharmaceuticals, Inc.	Selective serotonin receptor inverse agonists as therapeutics for disease
US20050261278A1 (en)	2004-05-21	2005-11-24	Weiner David M	Selective serotonin receptor inverse agonists as therapeutics for disease
EP2289879B1 (en)	2004-09-27	2014-11-12	Acadia Pharmaceuticals Inc.	Synthesis of a crystalline form of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide tartrate salt
US7790899B2 (en)	2004-09-27	2010-09-07	Acadia Pharmaceuticals, Inc.	Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
WO2008116024A2 (en)	2007-03-19	2008-09-25	Acadia Pharmaceuticals Inc.	Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics
PL3325444T3 (pl)	2015-07-20	2021-12-06	Acadia Pharmaceuticals Inc.	Sposoby wytwarzania N-(4-fluorobenzylo)-N-(1-metylopiperydyn-4-ylo)-N'-(4-(2-metylopropyloksy)fenylometylo)karbamidu oraz jego soli winianowej i postaci polimorficznej C
US10953000B2 (en)	2016-03-25	2021-03-23	Acadia Pharmaceuticals Inc.	Combination of pimavanserin and cytochrome P450 modulators
WO2017165635A1 (en)	2016-03-25	2017-09-28	Acadia Pharmaceuticals Inc.	Combination of pimavanserin and cytochrome p450 modulators
EP3558311A1 (en)	2016-12-20	2019-10-30	Acadia Pharmaceuticals Inc.	Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis
US11135211B2 (en)	2017-04-28	2021-10-05	Acadia Pharmaceuticals Inc.	Pimavanserin for treating impulse control disorder
US20210077479A1 (en)	2017-08-30	2021-03-18	Acadia Pharmaceuticals Inc.	Formulations of pimavanserin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2857391A (en) *	1955-04-15	1958-10-21	Merck & Co Inc	Aminomethylbenzimidazoles
US2971005A (en) *	1958-10-17	1961-02-07	Merck & Co Inc	Nu-substituted derivatives of 2-benzylaminobenzimidazoles
BE788065A (fr) *	1971-08-26	1973-02-26	Degussa	Nouvelles aza-benzimidazoles et procede pour leur preparation

1979
- 1979-03-19 CA CA000323763A patent/CA1140119A/en not_active Expired
- 1979-03-21 AU AU45296/79A patent/AU523352B2/en not_active Expired
- 1979-03-23 NZ NZ189978A patent/NZ189978A/en unknown
- 1979-03-29 DK DK129879A patent/DK169325B1/da not_active IP Right Cessation
- 1979-03-29 GR GR58721A patent/GR64907B/el unknown
- 1979-03-30 CY CY1250A patent/CY1250A/xx unknown
- 1979-03-30 RO RO7997082A patent/RO79320A/ro unknown
- 1979-03-30 EP EP79300525A patent/EP0005318B1/en not_active Expired
- 1979-03-30 DE DE7979300525T patent/DE2961740D1/de not_active Expired
- 1979-04-01 EG EG200/79A patent/EG13913A/xx active
- 1979-04-02 ZA ZA791557A patent/ZA791557B/xx unknown
- 1979-04-02 ES ES479206A patent/ES479206A1/es not_active Expired
- 1979-04-02 IL IL56992A patent/IL56992A/xx unknown
- 1979-04-02 AT AT0242579A patent/AT373887B/de not_active IP Right Cessation
- 1979-04-02 NO NO791097A patent/NO154058C/no unknown
- 1979-04-02 JP JP3844779A patent/JPS54151982A/ja active Granted
- 1979-04-02 FI FI791084A patent/FI64801C/fi not_active IP Right Cessation
- 1979-04-02 CS CS792227A patent/CS256358B2/cs unknown
- 1979-04-03 SU SU792747000A patent/SU1056902A3/ru active
- 1979-04-03 YU YU784/79A patent/YU42484B/xx unknown
- 1979-04-03 PL PL1979214648A patent/PL123380B1/pl unknown
- 1979-04-03 PH PH22344A patent/PH15877A/en unknown
- 1979-04-03 PT PT69429A patent/PT69429A/pt unknown
- 1979-04-03 BG BG7943114A patent/BG38164A3/xx unknown
- 1979-04-03 HU HU79JA841A patent/HU182965B/hu unknown
- 1979-08-08 IE IE676/79A patent/IE47818B1/en not_active IP Right Cessation
1983
- 1983-03-02 YU YU502/83A patent/YU43158B/xx unknown
- 1983-05-26 SG SG298/83A patent/SG29883G/en unknown
1984
- 1984-01-12 HK HK31/84A patent/HK3184A/xx not_active IP Right Cessation
- 1984-06-25 NO NO842563A patent/NO154090C/no unknown
1985
- 1985-12-30 MY MY46/85A patent/MY8500046A/xx unknown
1988
- 1988-06-14 JP JP63144898A patent/JPH01117880A/ja active Granted

Also Published As

Publication number	Publication date
YU42484B (en)	1988-10-31
PH15877A (en)	1983-04-13
ES479206A1 (es)	1979-12-16
DE2961740D1 (en)	1982-02-25
EP0005318A1 (en)	1979-11-14
ZA791557B (en)	1980-11-26
BG38164A3 (en)	1985-10-15
YU50283A (en)	1983-12-31
NO842563L (no)	1979-10-04
NO154058B (no)	1986-04-01
IE47818B1 (en)	1984-06-27
GR64907B (en)	1980-06-07
CS222779A2 (en)	1987-03-12
YU78479A (en)	1983-10-31
PL214648A1 (xx)	1980-03-24
NO154090B (no)	1986-04-07
AT373887B (de)	1984-02-27
JPS54151982A (en)	1979-11-29
PT69429A (pt)	1979-05-01
NZ189978A (en)	1984-05-31
SU1056902A3 (ru)	1983-11-23
AU523352B2 (en)	1982-07-22
SG29883G (en)	1984-04-19
RO79320A (ro)	1982-08-17
EP0005318B1 (en)	1982-01-06
NO154090C (no)	1986-07-16
CA1140119A (en)	1983-01-25
JPS641477B2 (xx)	1989-01-11
JPH0240666B2 (xx)	1990-09-12
AU4529679A (en)	1979-10-18
FI791084A (fi)	1979-10-04
CS256358B2 (en)	1988-04-15
NO154058C (no)	1986-07-09
JPH01117880A (ja)	1989-05-10
IL56992A (en)	1983-03-31
FI64801B (fi)	1983-09-30
HU182965B (en)	1984-03-28
PL123380B1 (en)	1982-10-30
HK3184A (en)	1984-01-20
MY8500046A (en)	1985-12-31
IE790676L (en)	1979-10-03
FI64801C (fi)	1984-01-10
ATA242579A (de)	1983-07-15
DK169325B1 (da)	1994-10-10
EG13913A (en)	1982-09-30
NO791097L (no)	1979-10-04
IL56992A0 (en)	1979-07-25
YU43158B (en)	1989-04-30
DK129879A (da)	1979-10-04

Publication	Publication Date	Title
CY1250A (en)	1984-08-31	N-heterocyclyl-4-piperdinamines,methods for their preparation and pharmaceutical compositions comprising them
DE2962051D1 (en)	1982-03-11	Benzimidazoles, their preparation and pharmaceutical compositions containing them
IL57708A0 (en)	1979-11-30	Aminopropoxyindole derivatives,their preparation and pharmaceutical compositions containing them
DE2960954D1 (en)	1981-12-24	1-aryloxy-3-nitratoalkylamino-2-propanols, process for their preparation and pharmaceutical compositions
IL56724A0 (en)	1979-05-31	Antigen derivatives,their preparation and pharmaceutical compositions containing them
IL60918A0 (en)	1980-10-26	6-pyridayinones,their preparation and pharmaceutical compositions cosntaining them
IL59558A (en)	1984-05-31	9-aminoalkylfluorenes,their preparation and pharmaceutical compositions comprising them
DE2965287D1 (en)	1983-06-01	Bis-imidazoles, their preparation and pharmaceutical compositions containing them
IL57297A0 (en)	1979-09-30	4-amino-2-piperidinoquinazoline derivatives,their preparation and pharmaceutical compositions containing them
IL57891A0 (en)	1979-11-30	Alkylthiophenoxyalkylamines,their preparation and pharmaceutical compositions containing them
IL56686A0 (en)	1979-05-31	Acylaminoalkyl-syanoguanidines,their preparation and pharmaceutical compositions containing them
IL56816A0 (en)	1979-05-31	N-phenylaniline derivatives,their preparation and pharmaceutical compositions containing them
IL58620A (en)	1982-12-31	Aryltrifluoroethanol derivatives,their preparation and pharmaceutical compositions containing them
IL57754A0 (en)	1979-11-30	Benzopyranotriazoles,their preparation and pharmaceutical compositions containing them
IL57219A (en)	1982-12-31	10-methoxy-daunorubicin,10-methoxy-doxorubicin,their derivatives,preparation thereof,and pharmaceutical compositions comprising them
DE3060079D1 (en)	1982-01-21	Spiro-quinolylhydantoins, process for their preparation and pharmaceutical compositions thereof
IL56890A0 (en)	1979-05-31	2-amino-carbazole derivatives,their preparation and pharmaceutical compositions containing them
IL56913A (en)	1982-08-31	Sprio-steroid-oxazolidinone derivatives,their preparation and pharmaceutical compositions containing them
DE2963868D1 (en)	1982-11-25	Carbostyrile derivatives, their preparation and pharmaceutical compositions containing them
IL56728A (en)	1981-11-30	Androstadienes,their preparation and pharmaceutical compositions containing them
IL56075A0 (en)	1979-01-31	Novel arylaminoimidazoline derivatives,their preparation and pharmaceutical compositions containing them
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