DK169325B1 - Analogifremgangsmåde til fremstilling af N-heterocyclyl-4-piperidinaminer - Google Patents
Analogifremgangsmåde til fremstilling af N-heterocyclyl-4-piperidinaminer Download PDFInfo
- Publication number
- DK169325B1 DK169325B1 DK129879A DK129879A DK169325B1 DK 169325 B1 DK169325 B1 DK 169325B1 DK 129879 A DK129879 A DK 129879A DK 129879 A DK129879 A DK 129879A DK 169325 B1 DK169325 B1 DK 169325B1
- Authority
- DK
- Denmark
- Prior art keywords
- parts
- group
- methyl
- piperidinyl
- benzimidazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK083183A DK171841B1 (da) | 1978-04-03 | 1983-02-24 | N-hetero-cyclyl-4-piperidinaminer |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89253478A | 1978-04-03 | 1978-04-03 | |
US89253478 | 1978-04-03 | ||
US06/002,276 US4219559A (en) | 1979-01-10 | 1979-01-10 | N-Heterocyclyl-4-piperidinamines |
US227679 | 1979-01-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
DK129879A DK129879A (da) | 1979-10-04 |
DK169325B1 true DK169325B1 (da) | 1994-10-10 |
Family
ID=26670178
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK129879A DK169325B1 (da) | 1978-04-03 | 1979-03-29 | Analogifremgangsmåde til fremstilling af N-heterocyclyl-4-piperidinaminer |
Country Status (29)
Country | Link |
---|---|
EP (1) | EP0005318B1 (ro) |
JP (2) | JPS54151982A (ro) |
AT (1) | AT373887B (ro) |
AU (1) | AU523352B2 (ro) |
BG (1) | BG38164A3 (ro) |
CA (1) | CA1140119A (ro) |
CS (1) | CS256358B2 (ro) |
CY (1) | CY1250A (ro) |
DE (1) | DE2961740D1 (ro) |
DK (1) | DK169325B1 (ro) |
EG (1) | EG13913A (ro) |
ES (1) | ES479206A1 (ro) |
FI (1) | FI64801C (ro) |
GR (1) | GR64907B (ro) |
HK (1) | HK3184A (ro) |
HU (1) | HU182965B (ro) |
IE (1) | IE47818B1 (ro) |
IL (1) | IL56992A (ro) |
MY (1) | MY8500046A (ro) |
NO (2) | NO154058C (ro) |
NZ (1) | NZ189978A (ro) |
PH (1) | PH15877A (ro) |
PL (1) | PL123380B1 (ro) |
PT (1) | PT69429A (ro) |
RO (1) | RO79320A (ro) |
SG (1) | SG29883G (ro) |
SU (1) | SU1056902A3 (ro) |
YU (2) | YU42484B (ro) |
ZA (1) | ZA791557B (ro) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA19091A1 (fr) * | 1980-03-10 | 1981-10-01 | Janssen Pharmaceutica Nv | Nouveaux derives de i-(4-aryl-cyclohexyl)piperidine . |
US4556660A (en) * | 1982-07-12 | 1985-12-03 | Janssen Pharmaceutica N.V. | N-(Bicyclic heterocyclyl)-4-piperidinamines |
IN156065B (ro) * | 1982-07-12 | 1985-05-04 | Janssen Pharmaceutica Nv | |
US4634704A (en) * | 1983-10-06 | 1987-01-06 | Janssen Pharmaceutica, N.V. | Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines |
DE3484096D1 (de) * | 1983-11-30 | 1991-03-14 | Janssen Pharmaceutica Nv | Bizyklisches heterozyklyl aufveisende n-(bizyklisches heterozyklyl-4-piperidinamine. |
PL144514B1 (en) * | 1984-01-09 | 1988-06-30 | Janssen Pharmaceutica Nv | Method of obtaining novel derivatives of n-/4-piperidinolo/-2-imidazoloamine |
KR930005004B1 (ko) * | 1985-04-15 | 1993-06-11 | 쟈안센 파아마슈우티카 엔. 부이. | 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법 |
GB8515934D0 (en) * | 1985-06-24 | 1985-07-24 | Janssen Pharmaceutica Nv | (4-piperidinomethyl and-hetero)purines |
DE3781173T2 (de) * | 1986-02-03 | 1992-12-17 | Janssen Pharmaceutica Nv | N-heterozyklische-4-piperidinamine enthaltende anti-histaminische zusammensetzungen. |
NZ223654A (en) * | 1987-03-09 | 1990-03-27 | Janssen Pharmaceutica Nv | 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions |
FR2618435B1 (fr) * | 1987-07-23 | 1989-10-27 | Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique |
US5210091A (en) * | 1991-06-24 | 1993-05-11 | Neurosearch A/S | Imidazole compounds and their use |
WO1994027973A1 (fr) * | 1993-05-20 | 1994-12-08 | Kissei Pharmaceutical Co., Ltd. | Derive 1-(2-benzimidazolyl)-1,5-diazacyclooctane |
US5547966A (en) * | 1993-10-07 | 1996-08-20 | Bristol-Myers Squibb Company | Aryl urea and related compounds |
PL343435A1 (en) * | 1998-03-06 | 2001-08-13 | Janssen Pharmaceutica Nv | Glycine transport inhibitors |
EP1196409B1 (en) * | 1999-06-28 | 2004-02-04 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
AU779516B2 (en) * | 1999-06-28 | 2005-01-27 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
IL147328A0 (en) * | 1999-06-28 | 2002-08-14 | Janssen Pharmaceutica Nv | Respiratory syncytial virus replication inhibitors |
ES2278729T3 (es) | 2000-03-06 | 2007-08-16 | Acadia Pharmaceuticals Inc. | Compuestos azaciclicos para usar en el tratamiento de enfermedades relacionadas con la serotonina. |
CN100347167C (zh) | 2001-02-02 | 2007-11-07 | 特瓦制药工业有限公司 | 取代的2-(2-吡啶基甲基)亚磺酰基-1h-苯并咪唑化合物的生产方法 |
WO2003057698A2 (en) | 2001-12-28 | 2003-07-17 | Acadia Pharmaceuticals, Inc. | Spiroazacyclic compounds as monoamine receptor modulators |
EP2266590A3 (en) | 2002-02-22 | 2011-04-20 | Shire LLC | Active agent delivery sytems and methods for protecting and administering active agents |
US7253186B2 (en) | 2002-06-24 | 2007-08-07 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
RU2320646C2 (ru) | 2002-06-24 | 2008-03-27 | Акадиа Фармасьютикалз Инк. | N-замещенные производные пиперидина в качестве агентов серотонинового рецептора |
US7538222B2 (en) | 2002-06-24 | 2009-05-26 | Acadia Pharmaceuticals, Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
CN101780080B (zh) | 2003-01-16 | 2014-06-04 | 阿卡蒂亚药品公司 | 用于神经退行性疾病的治疗的选择性五羟色胺2a/2c受体反向激动剂 |
DE602004031555D1 (de) | 2003-12-18 | 2011-04-07 | Little Island Co Cork | 5- oder 6-substituierte benzimidazolderivate als inhibitoren der replikation des respiratory syncytial virus |
CN1894239A (zh) | 2003-12-18 | 2007-01-10 | 泰博特克药品有限公司 | 作为呼吸道合胞病毒复制的抑制剂的哌啶-氨基-苯并咪唑类衍生物 |
RU2379302C2 (ru) | 2003-12-18 | 2010-01-20 | Тиботек Фармасьютикалз Лтд. | Аминобензимидазолы и бензимидазолы в качестве ингибиторов репликации респираторно-синцитиального вируса |
US20050261278A1 (en) | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
US7820695B2 (en) | 2004-05-21 | 2010-10-26 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
US7790899B2 (en) | 2004-09-27 | 2010-09-07 | Acadia Pharmaceuticals, Inc. | Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms |
NZ553702A (en) | 2004-09-27 | 2010-10-29 | Acadia Pharm Inc | Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms |
CN101677971A (zh) | 2007-03-19 | 2010-03-24 | 阿卡蒂亚药品公司 | 5-ht2a反向激动剂和拮抗剂与抗精神病药物的组合 |
CA2992728A1 (en) | 2015-07-20 | 2017-01-26 | Acadia Pharmaceuticals Inc. | Methods for preparing n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c |
US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
WO2017165635A1 (en) | 2016-03-25 | 2017-09-28 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome p450 modulators |
WO2018118626A1 (en) | 2016-12-20 | 2018-06-28 | Acadia Pharmaceuticals Inc. | Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis |
US11135211B2 (en) | 2017-04-28 | 2021-10-05 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
WO2019046167A1 (en) | 2017-08-30 | 2019-03-07 | Acadia Pharmaceuticals Inc. | PIMAVANSERIN FORMULATIONS |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2857391A (en) * | 1955-04-15 | 1958-10-21 | Merck & Co Inc | Aminomethylbenzimidazoles |
US2971005A (en) * | 1958-10-17 | 1961-02-07 | Merck & Co Inc | Nu-substituted derivatives of 2-benzylaminobenzimidazoles |
BE788065A (fr) * | 1971-08-26 | 1973-02-26 | Degussa | Nouvelles aza-benzimidazoles et procede pour leur preparation |
-
1979
- 1979-03-19 CA CA000323763A patent/CA1140119A/en not_active Expired
- 1979-03-21 AU AU45296/79A patent/AU523352B2/en not_active Expired
- 1979-03-23 NZ NZ189978A patent/NZ189978A/en unknown
- 1979-03-29 DK DK129879A patent/DK169325B1/da not_active IP Right Cessation
- 1979-03-29 GR GR58721A patent/GR64907B/el unknown
- 1979-03-30 CY CY1250A patent/CY1250A/xx unknown
- 1979-03-30 RO RO7997082A patent/RO79320A/ro unknown
- 1979-03-30 DE DE7979300525T patent/DE2961740D1/de not_active Expired
- 1979-03-30 EP EP79300525A patent/EP0005318B1/en not_active Expired
- 1979-04-01 EG EG200/79A patent/EG13913A/xx active
- 1979-04-02 ES ES479206A patent/ES479206A1/es not_active Expired
- 1979-04-02 NO NO791097A patent/NO154058C/no unknown
- 1979-04-02 CS CS792227A patent/CS256358B2/cs unknown
- 1979-04-02 FI FI791084A patent/FI64801C/fi not_active IP Right Cessation
- 1979-04-02 AT AT0242579A patent/AT373887B/de not_active IP Right Cessation
- 1979-04-02 ZA ZA791557A patent/ZA791557B/xx unknown
- 1979-04-02 JP JP3844779A patent/JPS54151982A/ja active Granted
- 1979-04-02 IL IL56992A patent/IL56992A/xx unknown
- 1979-04-03 PH PH22344A patent/PH15877A/en unknown
- 1979-04-03 HU HU79JA841A patent/HU182965B/hu unknown
- 1979-04-03 BG BG7943114A patent/BG38164A3/xx unknown
- 1979-04-03 SU SU792747000A patent/SU1056902A3/ru active
- 1979-04-03 PT PT69429A patent/PT69429A/pt unknown
- 1979-04-03 PL PL1979214648A patent/PL123380B1/pl unknown
- 1979-04-03 YU YU784/79A patent/YU42484B/xx unknown
- 1979-08-08 IE IE676/79A patent/IE47818B1/en not_active IP Right Cessation
-
1983
- 1983-03-02 YU YU502/83A patent/YU43158B/xx unknown
- 1983-05-26 SG SG298/83A patent/SG29883G/en unknown
-
1984
- 1984-01-12 HK HK31/84A patent/HK3184A/xx not_active IP Right Cessation
- 1984-06-25 NO NO842563A patent/NO154090C/no unknown
-
1985
- 1985-12-30 MY MY46/85A patent/MY8500046A/xx unknown
-
1988
- 1988-06-14 JP JP63144898A patent/JPH01117880A/ja active Granted
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PUP | Patent expired |