PT84571B - Processo para a preparacao de derivados de quinazolina com efeito anti-tumoral - Google Patents

Processo para a preparacao de derivados de quinazolina com efeito anti-tumoral

Info

Publication number
PT84571B
PT84571B PT84571A PT8457187A PT84571B PT 84571 B PT84571 B PT 84571B PT 84571 A PT84571 A PT 84571A PT 8457187 A PT8457187 A PT 8457187A PT 84571 B PT84571 B PT 84571B
Authority
PT
Portugal
Prior art keywords
preparation
tumor effect
quinazoline derivatives
quinazoline
derivatives
Prior art date
Application number
PT84571A
Other languages
English (en)
Other versions
PT84571A (en
Inventor
Leslie Richard Hughes
Original Assignee
Nat Res Dev
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Res Dev, Ici Plc filed Critical Nat Res Dev
Publication of PT84571A publication Critical patent/PT84571A/pt
Publication of PT84571B publication Critical patent/PT84571B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT84571A 1986-03-27 1987-03-26 Processo para a preparacao de derivados de quinazolina com efeito anti-tumoral PT84571B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868607683A GB8607683D0 (en) 1986-03-27 1986-03-27 Anti-tumor agents

Publications (2)

Publication Number Publication Date
PT84571A PT84571A (en) 1987-04-01
PT84571B true PT84571B (pt) 1989-11-30

Family

ID=10595358

Family Applications (1)

Application Number Title Priority Date Filing Date
PT84571A PT84571B (pt) 1986-03-27 1987-03-26 Processo para a preparacao de derivados de quinazolina com efeito anti-tumoral

Country Status (22)

Country Link
US (2) US4992550A (pt)
EP (1) EP0239362B1 (pt)
JP (1) JPH0657699B2 (pt)
AR (1) AR244213A1 (pt)
AT (1) ATE70057T1 (pt)
AU (1) AU592628B2 (pt)
CA (1) CA1285943C (pt)
DE (1) DE3774909D1 (pt)
DK (1) DK166621B1 (pt)
ES (1) ES2038170T3 (pt)
FI (1) FI89912C (pt)
GB (2) GB8607683D0 (pt)
GR (1) GR3003282T3 (pt)
HK (1) HK8594A (pt)
HU (1) HU197317B (pt)
IE (1) IE60302B1 (pt)
IL (1) IL81924A (pt)
LU (1) LU88797I2 (pt)
NL (1) NL970024I2 (pt)
NO (2) NO173545C (pt)
PT (1) PT84571B (pt)
ZA (1) ZA871998B (pt)

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US5286726A (en) * 1990-04-12 1994-02-15 The Regents Of The University Of Michigan Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
IL98167A0 (en) * 1990-05-30 1992-06-21 Ici Plc Anti-tumour quinazoline derivatives,processes for their preparation and pharmaceutical compositions comprising them
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GB9205320D0 (en) * 1992-03-11 1992-04-22 Ici Plc Anti-tumour compounds
GB9205907D0 (en) * 1992-03-18 1992-04-29 Cancer Res Inst Royal Anti-cancer compounds
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Also Published As

Publication number Publication date
AU592628B2 (en) 1990-01-18
NO1998020I1 (no) 1998-09-28
AU7047287A (en) 1987-10-01
PT84571A (en) 1987-04-01
NL970024I2 (nl) 1997-10-01
NO173545B (no) 1993-09-20
NO173545C (no) 1993-12-29
US4992550A (en) 1991-02-12
GB8607683D0 (en) 1986-04-30
ATE70057T1 (de) 1991-12-15
FI871139A (fi) 1987-09-28
IL81924A (en) 1991-07-18
NL970024I1 (nl) 1997-09-01
NO871266D0 (no) 1987-03-26
DK166621B1 (da) 1993-06-21
GB2188319A (en) 1987-09-30
IE870699L (en) 1987-09-27
FI89912B (fi) 1993-08-31
GB8706948D0 (en) 1987-04-29
HK8594A (en) 1994-02-04
JPH0657699B2 (ja) 1994-08-03
IE60302B1 (en) 1994-06-29
LU88797I2 (fr) 1996-11-05
GR3003282T3 (en) 1993-02-17
HUT43835A (en) 1987-12-28
ZA871998B (en) 1987-11-25
ES2038170T3 (es) 1993-07-16
EP0239362A3 (en) 1989-07-05
FI89912C (fi) 1993-12-10
CA1285943C (en) 1991-07-09
HU197317B (en) 1989-03-28
FI871139A0 (fi) 1987-03-16
JPH01125373A (ja) 1989-05-17
DK155087A (da) 1987-09-28
US5081124A (en) 1992-01-14
DE3774909D1 (de) 1992-01-16
DK155087D0 (da) 1987-03-26
AR244213A1 (es) 1993-10-29
NO871266L (no) 1987-09-28
EP0239362B1 (en) 1991-12-04
EP0239362A2 (en) 1987-09-30
GB2188319B (en) 1989-12-13

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