IL81924A - Quinazolinone derivatives,their preparation and antitumor pharmaceutical compositions containing them - Google Patents
Quinazolinone derivatives,their preparation and antitumor pharmaceutical compositions containing themInfo
- Publication number
- IL81924A IL81924A IL81924A IL8192487A IL81924A IL 81924 A IL81924 A IL 81924A IL 81924 A IL81924 A IL 81924A IL 8192487 A IL8192487 A IL 8192487A IL 81924 A IL81924 A IL 81924A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- quinazolinone derivatives
- antitumor pharmaceutical
- Prior art date
Links
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB868607683A GB8607683D0 (en) | 1986-03-27 | 1986-03-27 | Anti-tumor agents |
Publications (1)
Publication Number | Publication Date |
---|---|
IL81924A true IL81924A (en) | 1991-07-18 |
Family
ID=10595358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL81924A IL81924A (en) | 1986-03-27 | 1987-03-18 | Quinazolinone derivatives,their preparation and antitumor pharmaceutical compositions containing them |
Country Status (22)
Country | Link |
---|---|
US (2) | US4992550A (xx) |
EP (1) | EP0239362B1 (xx) |
JP (1) | JPH0657699B2 (xx) |
AR (1) | AR244213A1 (xx) |
AT (1) | ATE70057T1 (xx) |
AU (1) | AU592628B2 (xx) |
CA (1) | CA1285943C (xx) |
DE (1) | DE3774909D1 (xx) |
DK (1) | DK166621B1 (xx) |
ES (1) | ES2038170T3 (xx) |
FI (1) | FI89912C (xx) |
GB (2) | GB8607683D0 (xx) |
GR (1) | GR3003282T3 (xx) |
HK (1) | HK8594A (xx) |
HU (1) | HU197317B (xx) |
IE (1) | IE60302B1 (xx) |
IL (1) | IL81924A (xx) |
LU (1) | LU88797I2 (xx) |
NL (1) | NL970024I2 (xx) |
NO (2) | NO173545C (xx) |
PT (1) | PT84571B (xx) |
ZA (1) | ZA871998B (xx) |
Families Citing this family (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8513754D0 (en) * | 1985-05-31 | 1985-07-03 | Jones T R | Anti-cancer quinazoline derivatives |
GB8625019D0 (en) * | 1986-10-18 | 1986-11-19 | Wellcome Found | Compounds |
GB8707053D0 (en) * | 1987-03-25 | 1987-04-29 | Ici Plc | Anti-tumour agents |
US4857530A (en) * | 1987-11-03 | 1989-08-15 | Warner-Lambert Company | Substituted quinazolinones as anticancer agents |
GB8727737D0 (en) * | 1987-11-26 | 1987-12-31 | Ici Plc | Antitumour agents |
US5019577A (en) * | 1988-04-15 | 1991-05-28 | Burroughs Welcome Co. | Novel compounds and use |
US4940713A (en) * | 1988-04-15 | 1990-07-10 | Burroughs Wellcome Co. | Substituted glutamic acids |
GB8809978D0 (en) * | 1988-04-27 | 1988-06-02 | Ici Plc | Anti-tumour agents |
EP0365763A1 (en) * | 1988-09-30 | 1990-05-02 | Agouron Pharmaceuticals, Inc. | Antiproliferative cyclic compounds |
GB8829296D0 (en) * | 1988-12-15 | 1989-01-25 | Ici Plc | Anti-tumour compounds |
US5252573A (en) * | 1988-12-15 | 1993-10-12 | Imperial Chemical Industries Plc | Anti-tumor agents |
US5286726A (en) * | 1990-04-12 | 1994-02-15 | The Regents Of The University Of Michigan | Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases |
IL98167A0 (en) * | 1990-05-30 | 1992-06-21 | Ici Plc | Anti-tumour quinazoline derivatives,processes for their preparation and pharmaceutical compositions comprising them |
GB9013615D0 (en) | 1990-06-19 | 1990-08-08 | Wellcome Found | Pharmaceutical compounds |
US5290780A (en) * | 1991-01-30 | 1994-03-01 | American Cyanamid Co. | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones |
GB9105771D0 (en) * | 1991-03-19 | 1991-05-01 | Cancer Res Inst Royal | Anti-cancer compounds |
NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
US5403843A (en) * | 1991-08-12 | 1995-04-04 | Takeda Chemical Industries, Ltd. | Pyrrolopyrimidinyalglutaminate derivatives and their use |
US5145854A (en) * | 1991-11-27 | 1992-09-08 | Nair Madhavan G | 1-formyl-5,8,10-trideazafolates |
GB9205320D0 (en) * | 1992-03-11 | 1992-04-22 | Ici Plc | Anti-tumour compounds |
GB9205907D0 (en) * | 1992-03-18 | 1992-04-29 | Cancer Res Inst Royal | Anti-cancer compounds |
ES2049659B1 (es) * | 1992-10-08 | 1994-10-16 | Ici Plc | Una composicion farmaceutica a base de derivados de quinazolina con actividad anti-cancerigena. |
GB9223352D0 (en) * | 1992-11-06 | 1992-12-23 | Ici Plc | Tricyclic compounds |
GB9323290D0 (en) | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
US7910624B1 (en) | 1995-03-03 | 2011-03-22 | The Trustees Of Boston University | Compositions for the treatment of blood disorders |
EP0731712A4 (en) * | 1993-10-29 | 2005-11-09 | Univ Boston | PHYSIOLOGICAL STABILIZED BUTTERIC ACID PREPARATIONS, AND BUTTERIC ACIDS AND DERIVATIVES AS ANTINEOPLASTIC ACTIVE SUBSTANCE |
US6011000A (en) * | 1995-03-03 | 2000-01-04 | Perrine; Susan P. | Compositions for the treatment of blood disorders |
GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
US5593999A (en) * | 1995-06-07 | 1997-01-14 | Nair; Madhavan G. | Non-classical folate analogue inhibitors of glycinamide ribonucleotide formyltransferase (GARFT) |
US6420427B1 (en) * | 1997-10-09 | 2002-07-16 | Ono Pharmaceutical Co., Ltd. | Aminobutyric acid derivatives |
US5912251A (en) * | 1998-01-17 | 1999-06-15 | Nair; Madhavan G. | Metabolically inert anti-inflammatory and anti-tumor antifolates |
CA2324426A1 (en) * | 1998-02-11 | 1999-08-19 | Douglas V. Faller | Compositions and methods for the treatment of cystic fibrosis |
GB9904275D0 (en) | 1999-02-24 | 1999-04-21 | Cancer Res Campaign Tech | Anti-cancer compounds |
US7671200B2 (en) * | 1999-10-27 | 2010-03-02 | Cytokinetics, Inc. | Quinazolinone KSP inhibitors |
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JP6379296B2 (ja) * | 2014-12-02 | 2018-08-22 | イーライ リリー アンド カンパニー | 1−オキソ−1,2−ジヒドロイソキノリン−7−イル−(5−置換−チオフェン−2−イル)−スルホンアミド化合物、それらの化合物を含む製剤、がん治療におけるaicarft阻害剤としてのそれらの使用 |
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Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1021196A (en) * | 1964-02-20 | 1966-03-02 | Parke Davis & Co | Novel amino acids and means for producing the same |
EP0031237B1 (en) * | 1979-12-19 | 1984-10-17 | National Research Development Corporation | Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents |
GB8513754D0 (en) * | 1985-05-31 | 1985-07-03 | Jones T R | Anti-cancer quinazoline derivatives |
-
1986
- 1986-03-27 GB GB868607683A patent/GB8607683D0/en active Pending
-
1987
- 1987-03-16 FI FI871139A patent/FI89912C/fi not_active IP Right Cessation
- 1987-03-16 IE IE69987A patent/IE60302B1/en not_active IP Right Cessation
- 1987-03-18 IL IL81924A patent/IL81924A/xx not_active IP Right Cessation
- 1987-03-18 ZA ZA871998A patent/ZA871998B/xx unknown
- 1987-03-20 AU AU70472/87A patent/AU592628B2/en not_active Expired
- 1987-03-24 DE DE8787302525T patent/DE3774909D1/de not_active Expired - Lifetime
- 1987-03-24 LU LU88797C patent/LU88797I2/fr unknown
- 1987-03-24 GB GB8706948A patent/GB2188319B/en not_active Expired
- 1987-03-24 AT AT87302525T patent/ATE70057T1/de active
- 1987-03-24 EP EP87302525A patent/EP0239362B1/en not_active Expired - Lifetime
- 1987-03-24 ES ES198787302525T patent/ES2038170T3/es not_active Expired - Lifetime
- 1987-03-26 NO NO871266A patent/NO173545C/no unknown
- 1987-03-26 PT PT84571A patent/PT84571B/pt unknown
- 1987-03-26 CA CA000533035A patent/CA1285943C/en not_active Expired - Lifetime
- 1987-03-26 DK DK155087A patent/DK166621B1/da not_active IP Right Cessation
- 1987-03-27 JP JP62071960A patent/JPH0657699B2/ja not_active Expired - Lifetime
- 1987-03-27 AR AR87307137A patent/AR244213A1/es active
- 1987-03-27 HU HU871343A patent/HU197317B/hu unknown
-
1989
- 1989-04-06 US US07/334,748 patent/US4992550A/en not_active Expired - Lifetime
-
1990
- 1990-09-05 US US07/577,579 patent/US5081124A/en not_active Expired - Lifetime
-
1991
- 1991-12-05 GR GR91401138T patent/GR3003282T3/el unknown
-
1994
- 1994-01-21 HK HK85/94A patent/HK8594A/xx not_active IP Right Cessation
-
1997
- 1997-07-07 NL NL970024C patent/NL970024I2/nl unknown
-
1998
- 1998-09-08 NO NO1998020C patent/NO1998020I1/no unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
KB | Patent renewed | ||
PEL | Intention of commissioner to extend period of protection | ||
EXTG | Extension of patent term granted | ||
KB | Patent renewed | ||
EXTN | Extension order renewed | ||
EXTN | Extension order renewed | ||
EXP | Patent expired |