PT89482A - Processo para a preparacao de derivados de nucleosidos disesoxi-didesidro-carboxilico - Google Patents

Processo para a preparacao de derivados de nucleosidos disesoxi-didesidro-carboxilico

Info

Publication number
PT89482A
PT89482A PT89482A PT8948289A PT89482A PT 89482 A PT89482 A PT 89482A PT 89482 A PT89482 A PT 89482A PT 8948289 A PT8948289 A PT 8948289A PT 89482 A PT89482 A PT 89482A
Authority
PT
Portugal
Prior art keywords
disesoxydesidro
carboxylic
preparation
nucleoside derivatives
nucleoside
Prior art date
Application number
PT89482A
Other languages
English (en)
Other versions
PT89482B (pt
Inventor
Richard Storer
Peter Leslie Myers
Robert Vince
Mei Hua
Original Assignee
Univ Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/146,252 external-priority patent/US4916224A/en
Priority claimed from GB888821011A external-priority patent/GB8821011D0/en
Priority claimed from US07/278,652 external-priority patent/US4931559A/en
Application filed by Univ Minnesota filed Critical Univ Minnesota
Publication of PT89482A publication Critical patent/PT89482A/pt
Publication of PT89482B publication Critical patent/PT89482B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PT89482A 1988-01-20 1989-01-19 Processo para a preparacao de derivados de nucleosidos disesoxi-didesidro-carboxilico PT89482B (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/146,252 US4916224A (en) 1988-01-20 1988-01-20 Dideoxycarbocyclic nucleosides
GB888821011A GB8821011D0 (en) 1988-09-07 1988-09-07 Chemical compounds
US07/278,652 US4931559A (en) 1988-01-20 1988-12-05 Optically-active isomers of dideoxycarbocyclic nucleosides

Publications (2)

Publication Number Publication Date
PT89482A true PT89482A (pt) 1989-10-04
PT89482B PT89482B (pt) 1994-02-28

Family

ID=27264063

Family Applications (1)

Application Number Title Priority Date Filing Date
PT89482A PT89482B (pt) 1988-01-20 1989-01-19 Processo para a preparacao de derivados de nucleosidos disesoxi-didesidro-carboxilico

Country Status (29)

Country Link
JP (1) JP2793825B2 (pt)
KR (1) KR0127137B1 (pt)
AT (1) AT397801B (pt)
AU (2) AU626278B2 (pt)
BE (1) BE1003815A4 (pt)
CA (1) CA1339896C (pt)
CH (1) CH679152A5 (pt)
DE (1) DE3901502C2 (pt)
DK (1) DK175131B1 (pt)
ES (1) ES2010091A6 (pt)
FI (1) FI93546C (pt)
FR (1) FR2626002B1 (pt)
GB (1) GB2217320B (pt)
GR (1) GR890100033A (pt)
HU (1) HU203755B (pt)
IE (1) IE62275B1 (pt)
IL (1) IL88999A (pt)
IT (1) IT1229531B (pt)
LU (1) LU87437A1 (pt)
MY (1) MY103801A (pt)
NL (1) NL8900122A (pt)
NO (1) NO169123C (pt)
NZ (1) NZ227663A (pt)
OA (1) OA09031A (pt)
PL (1) PL163814B1 (pt)
PT (1) PT89482B (pt)
RU (1) RU2114846C1 (pt)
SE (1) SE505213C2 (pt)
YU (1) YU47791B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1215339B (it) * 1987-01-14 1990-02-08 Co Pharma Corp Srl Procedimento per la preparazione di 9-(idrossialchil)-ipoxantine
US5631370A (en) 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
US4939252A (en) * 1989-04-20 1990-07-03 Hoffmann-La Roche Inc. Novel intermediates for the preparation of Carbovir
ES2136061T3 (es) * 1989-06-27 1999-11-16 Wellcome Found Nucleosidos terapeuticos.
GB8916479D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916480D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916477D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916478D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
US5126452A (en) * 1990-04-06 1992-06-30 Glaxo Inc. Synthesis of purine substituted cyclopentene derivatives
US5144034A (en) * 1990-04-06 1992-09-01 Glaxo Inc. Process for the synthesis of cyclopentene derivatives of purines
US5057630A (en) * 1990-04-06 1991-10-15 Glaxo Inc. Synthesis of cyclopentene derivatives
US5241069A (en) * 1990-04-06 1993-08-31 Glaxo Inc. Carbonate intermediates for the synthesis of purine substituted cyclopentene derivatives
GB9108376D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Cyclopentenes
HUT74989A (en) * 1993-11-12 1997-03-28 Merrell Pharma Inc 6-oxo-nucleosides useful as immunosuppressants
GB9721780D0 (en) * 1997-10-14 1997-12-10 Glaxo Group Ltd Process for the synthesis of chloropurine intermediates
DE59905679D1 (de) 1998-10-30 2003-06-26 Lonza Ag Verfahren zur herstellung von 4-[(2',5'-diamino-6'-halogenpyrimidin-4'-yl)amino]-cyclopent-2-enylmethanolen
DK1124805T3 (da) * 1998-10-30 2003-09-15 Lonza Ag Fremgangsmåde til fremstilling af 4-[(2',5'-diamino-6'-halogenpyrimidin-4'-yl)amino]cyclopent-2-enylmethanoler
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB9903091D0 (en) * 1999-02-12 1999-03-31 Glaxo Group Ltd Therapeutic nucleoside compound
AR039540A1 (es) * 2002-05-13 2005-02-23 Tibotec Pharm Ltd Compuestos microbicidas con contenido de pirimidina o triazina
EP3831388B1 (en) 2018-07-27 2024-02-28 FUJIFILM Corporation Cyclopentenyl purine derivative or salt thereof for use in suppressing adenovirus
EP4125840A1 (en) 2020-03-27 2023-02-08 Som Innovation Biotech, S.A. Compounds for use in the treatment of synucleinopathies

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268672A (en) * 1977-02-09 1981-05-19 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
US4742064A (en) * 1985-09-10 1988-05-03 Regents Of The University Of Minnesota Antiviral carbocyclic analogs of xylofuranosylpurines
JPS62177234A (ja) * 1986-01-30 1987-08-04 Mitsubishi Heavy Ind Ltd 遠心紡糸によるカ−ボン繊維の製造装置
IN164556B (pt) * 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
NZ229453A (en) * 1988-06-10 1991-08-27 Univ Minnesota & Southern Rese A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.

Also Published As

Publication number Publication date
IE62275B1 (en) 1995-01-25
IE890153L (en) 1989-07-20
NO890253D0 (no) 1989-01-19
NO169123C (no) 1992-05-13
FI890286A0 (fi) 1989-01-19
DE3901502A1 (de) 1989-07-27
SE505213C2 (sv) 1997-07-14
FI93546C (fi) 1995-04-25
NO169123B (no) 1992-02-03
ATA10689A (de) 1993-11-15
GB8901187D0 (en) 1989-03-15
CA1339896C (en) 1998-06-02
SE8900192L (sv) 1989-07-21
IL88999A0 (en) 1989-08-15
PL277261A1 (en) 1989-09-18
YU47791B (sr) 1996-01-09
PT89482B (pt) 1994-02-28
RU2114846C1 (ru) 1998-07-10
KR0127137B1 (ko) 1997-12-29
IT8947546A0 (it) 1989-01-19
CH679152A5 (pt) 1991-12-31
IL88999A (en) 1994-12-29
GB2217320B (en) 1992-04-08
YU12389A (en) 1991-10-31
AU626278B2 (en) 1992-07-30
DK23489D0 (da) 1989-01-19
NL8900122A (nl) 1989-08-16
MY103801A (en) 1993-09-30
JPH02196788A (ja) 1990-08-03
FI890286A (fi) 1989-07-21
DE3901502C2 (de) 2002-06-13
IT1229531B (it) 1991-09-04
FI93546B (fi) 1995-01-13
HU203755B (en) 1991-09-30
GR890100033A (el) 1994-03-31
NZ227663A (en) 1990-09-26
SE8900192D0 (sv) 1989-01-19
KR890011902A (ko) 1989-08-23
AU1018092A (en) 1992-03-12
FR2626002A1 (fr) 1989-07-21
NO890253L (no) 1989-07-21
PL163814B1 (en) 1994-05-31
ES2010091A6 (es) 1989-10-16
AT397801B (de) 1994-07-25
AU2867189A (en) 1989-07-20
OA09031A (en) 1991-03-31
AU637015B2 (en) 1993-05-13
FR2626002B1 (fr) 1994-01-28
DK23489A (da) 1989-07-21
JP2793825B2 (ja) 1998-09-03
LU87437A1 (fr) 1989-08-30
DK175131B1 (da) 2004-06-14
BE1003815A4 (fr) 1992-06-23
HUT48887A (en) 1989-07-28
GB2217320A (en) 1989-10-25

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19930813

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20090119