PT3609898T - Compostos úteis como inibidores de ret - Google Patents
Compostos úteis como inibidores de retInfo
- Publication number
- PT3609898T PT3609898T PT187192760T PT18719276T PT3609898T PT 3609898 T PT3609898 T PT 3609898T PT 187192760 T PT187192760 T PT 187192760T PT 18719276 T PT18719276 T PT 18719276T PT 3609898 T PT3609898 T PT 3609898T
- Authority
- PT
- Portugal
- Prior art keywords
- compounds useful
- ret inhibitors
- ret
- inhibitors
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1705971.8A GB201705971D0 (en) | 2017-04-13 | 2017-04-13 | Inhibitor compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3609898T true PT3609898T (pt) | 2022-08-25 |
Family
ID=58744532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT187192760T PT3609898T (pt) | 2017-04-13 | 2018-04-13 | Compostos úteis como inibidores de ret |
Country Status (19)
Country | Link |
---|---|
US (2) | US11352361B2 (pt) |
EP (2) | EP3609898B1 (pt) |
JP (2) | JP7277376B2 (pt) |
CN (2) | CN115785100A (pt) |
AU (2) | AU2018252251B2 (pt) |
BR (1) | BR112019021231A2 (pt) |
CA (1) | CA3059134A1 (pt) |
DK (1) | DK3609898T3 (pt) |
ES (1) | ES2925077T3 (pt) |
GB (1) | GB201705971D0 (pt) |
HR (1) | HRP20221040T1 (pt) |
HU (1) | HUE059716T2 (pt) |
LT (1) | LT3609898T (pt) |
PL (1) | PL3609898T3 (pt) |
PT (1) | PT3609898T (pt) |
RS (1) | RS63514B1 (pt) |
RU (1) | RU2760669C2 (pt) |
SI (1) | SI3609898T1 (pt) |
WO (1) | WO2018189553A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HRP20231681T1 (hr) | 2015-11-02 | 2024-04-12 | Blueprint Medicines Corporation | Inhibitori za ret |
GB201705971D0 (en) * | 2017-04-13 | 2017-05-31 | Cancer Res Tech Ltd | Inhibitor compounds |
CN111971286B (zh) | 2018-01-18 | 2023-04-14 | 阿雷生物药品公司 | 作为RET激酶抑制剂的取代的吡咯并[2,3-d]嘧啶化合物 |
JP7061195B2 (ja) * | 2018-01-18 | 2022-04-27 | アレイ バイオファーマ インコーポレイテッド | RETキナーゼ阻害剤としての置換ピラゾロ[3,4-d]ピリミジン化合物 |
US11472802B2 (en) | 2018-01-18 | 2022-10-18 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors |
MX2020010417A (es) | 2018-04-03 | 2021-01-08 | Blueprint Medicines Corp | Inhibidor de ret para uso en tratar cancer que tiene una alteracion de ret. |
JP2021534129A (ja) | 2018-08-10 | 2021-12-09 | ブループリント メディシンズ コーポレイション | Egfr変異がんの処置 |
WO2020094084A1 (zh) * | 2018-11-07 | 2020-05-14 | 南京明德新药研发有限公司 | 作为ret抑制剂的三并环衍生物 |
CN111454268B (zh) * | 2019-01-18 | 2023-09-08 | 明慧医药(上海)有限公司 | 作为布鲁顿酪氨酸激酶抑制剂的环状分子 |
EP3950685A4 (en) * | 2019-04-03 | 2022-12-14 | Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory | PYRAZOLOPYRIDINE COMPOUND USED AS RET INHIBITOR AND USES THEREOF |
CN113214294A (zh) * | 2020-06-10 | 2021-08-06 | 深圳铂立健医药有限公司 | 三环化合物、药物组合物及其应用 |
US20230365596A1 (en) * | 2020-09-29 | 2023-11-16 | Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory | Crystal forms of pyridopyrazole compounds and preparation method therefor |
US20230039586A1 (en) * | 2021-07-12 | 2023-02-09 | Nido Biosciences, Inc. | Bicyclic compounds as androgen receptor modulators |
WO2023064843A1 (en) * | 2021-10-15 | 2023-04-20 | Stemline Therapeutics, Inc. | Inhibitors of mutant ret kinases for use in treating cancer |
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US7119200B2 (en) | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
US7429596B2 (en) | 2003-06-20 | 2008-09-30 | The Regents Of The University Of California | 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof |
US9512125B2 (en) | 2004-11-19 | 2016-12-06 | The Regents Of The University Of California | Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents |
US9271963B2 (en) | 2005-03-03 | 2016-03-01 | Universitat Des Saarlandes | Selective inhibitors of human corticosteroid synthases |
PT1951724E (pt) | 2005-11-17 | 2011-08-02 | Osi Pharm Inc | Inibidores mtor fundidos bicíclicos |
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US20080299113A1 (en) * | 2005-12-19 | 2008-12-04 | Arnold Lee D | Combined treatment with and composition of 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents |
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KR101315610B1 (ko) | 2006-09-22 | 2013-10-10 | 파마시클릭스, 인코포레이티드 | 브루톤 티로신 키나제 억제제 |
US20090274698A1 (en) | 2007-07-06 | 2009-11-05 | Shripad Bhagwat | Combination anti-cancer therapy |
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US9765037B2 (en) | 2010-01-28 | 2017-09-19 | University Of Washington Through Its Center For Commercialization | Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases |
EP2528919B1 (en) | 2010-01-28 | 2016-11-02 | University of Washington | Compositions and methods for treating toxoplasmosis. cryptosporidiosis and other apicomplexan protozoan related diseases |
WO2011153553A2 (en) | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
US20110304649A1 (en) * | 2010-06-10 | 2011-12-15 | Microsoft Corporation | Character selection |
US20130296316A1 (en) | 2010-07-09 | 2013-11-07 | Michael P. Pollastri | Antiparasitic Agents Based On mTOR Inhibitors |
AR085397A1 (es) | 2011-02-23 | 2013-09-25 | Intellikine Inc | Combinacion de inhibidores de quinasa y sus usos |
CN103703174B (zh) | 2011-05-04 | 2017-05-10 | 因特利凯有限责任公司 | 联合药物组合物及其用途 |
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KR101766194B1 (ko) * | 2015-08-07 | 2017-08-10 | 한국과학기술연구원 | RET 키나아제 저해제인 신규 3-(이속사졸-3-일)-피라졸로[3,4-d]피리미딘-4-아민 화합물 |
US10550124B2 (en) | 2015-08-13 | 2020-02-04 | San Diego State University Foundation | Atropisomerism for increased kinase inhibitor selectivity |
TW201722958A (zh) * | 2015-09-15 | 2017-07-01 | 葛蘭素史克智慧財產(第二)有限公司 | 化學化合物 |
WO2017160717A2 (en) | 2016-03-15 | 2017-09-21 | Memorial Sloan Kettering Cancer Center | Method of treating diseases using kinase modulators |
DK3442535T3 (da) | 2016-04-15 | 2022-09-05 | Cancer Research Tech Ltd | Heterocykliske stoffer som as ret-kinase-hæmmere |
KR102390578B1 (ko) | 2016-04-15 | 2022-04-26 | 캔써 리서치 테크놀로지 리미티드 | Ret 키나아제 억제제로서의 헤테로사이클릭 화합물 |
GB201705971D0 (en) * | 2017-04-13 | 2017-05-31 | Cancer Res Tech Ltd | Inhibitor compounds |
-
2017
- 2017-04-13 GB GBGB1705971.8A patent/GB201705971D0/en not_active Ceased
-
2018
- 2018-04-13 JP JP2019555675A patent/JP7277376B2/ja active Active
- 2018-04-13 AU AU2018252251A patent/AU2018252251B2/en active Active
- 2018-04-13 WO PCT/GB2018/050986 patent/WO2018189553A1/en unknown
- 2018-04-13 SI SI201830743T patent/SI3609898T1/sl unknown
- 2018-04-13 HR HRP20221040TT patent/HRP20221040T1/hr unknown
- 2018-04-13 US US16/604,332 patent/US11352361B2/en active Active
- 2018-04-13 ES ES18719276T patent/ES2925077T3/es active Active
- 2018-04-13 HU HUE18719276A patent/HUE059716T2/hu unknown
- 2018-04-13 CN CN202211253646.1A patent/CN115785100A/zh active Pending
- 2018-04-13 RS RS20220789A patent/RS63514B1/sr unknown
- 2018-04-13 PL PL18719276.0T patent/PL3609898T3/pl unknown
- 2018-04-13 PT PT187192760T patent/PT3609898T/pt unknown
- 2018-04-13 DK DK18719276.0T patent/DK3609898T3/da active
- 2018-04-13 EP EP18719276.0A patent/EP3609898B1/en active Active
- 2018-04-13 RU RU2019132155A patent/RU2760669C2/ru active
- 2018-04-13 BR BR112019021231A patent/BR112019021231A2/pt unknown
- 2018-04-13 LT LTEPPCT/GB2018/050986T patent/LT3609898T/lt unknown
- 2018-04-13 CN CN201880024433.7A patent/CN110506043B/zh active Active
- 2018-04-13 EP EP22175240.5A patent/EP4105219A1/en active Pending
- 2018-04-13 CA CA3059134A patent/CA3059134A1/en active Pending
-
2022
- 2022-04-07 AU AU2022202325A patent/AU2022202325A1/en active Pending
- 2022-05-06 US US17/738,278 patent/US11680068B2/en active Active
-
2023
- 2023-05-08 JP JP2023076767A patent/JP2023103326A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
RS63514B1 (sr) | 2022-09-30 |
ES2925077T3 (es) | 2022-10-13 |
WO2018189553A1 (en) | 2018-10-18 |
RU2019132155A3 (pt) | 2021-05-13 |
EP3609898B1 (en) | 2022-06-01 |
SI3609898T1 (sl) | 2022-11-30 |
AU2018252251A1 (en) | 2019-10-17 |
CN110506043B (zh) | 2022-11-01 |
JP2023103326A (ja) | 2023-07-26 |
US20200157107A1 (en) | 2020-05-21 |
EP3609898A1 (en) | 2020-02-19 |
HRP20221040T1 (hr) | 2022-11-11 |
EP4105219A1 (en) | 2022-12-21 |
RU2760669C2 (ru) | 2021-11-29 |
RU2019132155A (ru) | 2021-05-13 |
PL3609898T3 (pl) | 2022-09-26 |
AU2018252251B2 (en) | 2022-03-31 |
DK3609898T3 (da) | 2022-09-05 |
CN115785100A (zh) | 2023-03-14 |
US20220348585A1 (en) | 2022-11-03 |
JP7277376B2 (ja) | 2023-05-18 |
HUE059716T2 (hu) | 2022-12-28 |
LT3609898T (lt) | 2022-09-12 |
CN110506043A (zh) | 2019-11-26 |
JP2020516636A (ja) | 2020-06-11 |
BR112019021231A2 (pt) | 2020-04-28 |
US11680068B2 (en) | 2023-06-20 |
US11352361B2 (en) | 2022-06-07 |
GB201705971D0 (en) | 2017-05-31 |
CA3059134A1 (en) | 2018-10-18 |
AU2022202325A1 (en) | 2022-04-28 |
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