US994637A
(en)
|
1910-09-14 |
1911-06-06 |
Dexter Folder Co |
Paper-cutting machine.
|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
CA1176659A
(en)
|
1981-09-14 |
1984-10-23 |
Gerhard Degischer |
Process for producing n-substituted-n-acetyl-2,6- dialkylanilines
|
US4588585A
(en)
|
1982-10-19 |
1986-05-13 |
Cetus Corporation |
Human recombinant cysteine depleted interferon-β muteins
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
US5681718A
(en)
|
1986-03-14 |
1997-10-28 |
Celltech Limited |
Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
US5567610A
(en)
|
1986-09-04 |
1996-10-22 |
Bioinvent International Ab |
Method of producing human monoclonal antibodies and kit therefor
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
US5229275A
(en)
|
1990-04-26 |
1993-07-20 |
Akzo N.V. |
In-vitro method for producing antigen-specific human monoclonal antibodies
|
US5219837A
(en)
|
1990-06-21 |
1993-06-15 |
Trustees Of The University Of Pennsylvania |
Method of stimulating myelination of cells
|
US6172197B1
(en)
|
1991-07-10 |
2001-01-09 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
EP0814159B1
(en)
|
1990-08-29 |
2005-07-27 |
GenPharm International, Inc. |
Transgenic mice capable of producing heterologous antibodies
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
WO1992009690A2
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with altered binding properties
|
US6582959B2
(en)
|
1991-03-29 |
2003-06-24 |
Genentech, Inc. |
Antibodies to vascular endothelial cell growth factor
|
IL101728A
(en)
|
1991-05-03 |
2007-08-19 |
Univ Yale |
Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
|
ATE463573T1
(de)
|
1991-12-02 |
2010-04-15 |
Medimmune Ltd |
Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
|
US5786158A
(en)
|
1992-04-30 |
1998-07-28 |
Yale University |
Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
|
US20050112121A1
(en)
|
1992-04-30 |
2005-05-26 |
Yale University |
Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
|
US5840299A
(en)
|
1994-01-25 |
1998-11-24 |
Athena Neurosciences, Inc. |
Humanized antibodies against leukocyte adhesion molecule VLA-4
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
DK0861261T3
(da)
|
1995-06-28 |
2009-12-14 |
Imp Cancer Res Tech |
Nukleotid- og proteinsekvenser af hvirveldyrs-Delta-gener og fremgangsmåder baseret derpå
|
US7264963B1
(en)
|
1995-08-18 |
2007-09-04 |
Morphosys Ag |
Protein(poly)peptide libraries
|
WO1997008320A1
(en)
|
1995-08-18 |
1997-03-06 |
Morphosys Gesellschaft Für Proteinoptimierung Mbh |
Protein/(poly)peptide libraries
|
US5730977A
(en)
|
1995-08-21 |
1998-03-24 |
Mitsui Toatsu Chemicals, Inc. |
Anti-VEGF human monoclonal antibody
|
JPH09124697A
(ja)
|
1995-11-01 |
1997-05-13 |
Toagosei Co Ltd |
ペプチド及びモノクローナル抗体
|
EP0861894B1
(en)
|
1995-11-17 |
2006-03-08 |
Asahi Kasei Kabushiki Kaisha |
Differentiation-suppressive polypeptide
|
US20020137890A1
(en)
|
1997-03-31 |
2002-09-26 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
US20060122373A1
(en)
|
1997-04-04 |
2006-06-08 |
Millennium Pharmaceuticals, Inc. |
Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
|
CA2285020A1
(en)
|
1997-04-04 |
1998-10-15 |
Millennium Biotherapeutics, Inc. |
Novel human delta3 compositions and therapeutic and diagnostic uses therefor
|
US20030180784A1
(en)
|
1997-04-04 |
2003-09-25 |
Millennium Pharmaceuticals, Inc. |
Novel human Delta3 compositions and therapeutic and diagnostic uses therefor
|
US6121045A
(en)
|
1997-04-04 |
2000-09-19 |
Millennium Biotherapeutics, Inc. |
Human Delta3 nucleic acid molecules
|
JP3957765B2
(ja)
|
1997-04-07 |
2007-08-15 |
ジェネンテク・インコーポレイテッド |
抗vegf抗体
|
US20020032315A1
(en)
|
1997-08-06 |
2002-03-14 |
Manuel Baca |
Anti-vegf antibodies
|
US20070059302A1
(en)
|
1997-04-07 |
2007-03-15 |
Genentech, Inc. |
Anti-vegf antibodies
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
US7951917B1
(en)
|
1997-05-02 |
2011-05-31 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
DE69830901T2
(de)
|
1997-05-02 |
2006-05-24 |
Genentech Inc., San Francisco |
ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen
|
ES2284205T3
(es)
|
1997-05-14 |
2007-11-01 |
Asahi Kasei Kabushiki Kaisha |
Nuevo inhibidor de diferenciacion.
|
WO1998057621A1
(en)
|
1997-06-18 |
1998-12-23 |
The Trustees Of Columbia University In The City Ofnew York |
Angiogenic modulation by notch signal transduction
|
US6004528A
(en)
|
1997-09-18 |
1999-12-21 |
Bergstein; Ivan |
Methods of cancer diagnosis and therapy targeted against the cancer stemline
|
EP1096946A2
(en)
|
1998-07-13 |
2001-05-09 |
Yale University |
Delta cleavage products and methods based thereon
|
JP2002523018A
(ja)
|
1998-07-27 |
2002-07-30 |
アムジエン・インコーポレーテツド |
デルタ関連ポリペプチド
|
WO2004009618A2
(en)
|
2002-07-18 |
2004-01-29 |
Crucell Holland B.V. |
Recombinant production of mixtures of antibodies
|
NZ514918A
(en)
|
1999-04-28 |
2003-11-28 |
Univ Texas |
Compositions and methods for cancer treatment by selectively inhibiting VEGF
|
EP1133565B1
(en)
|
1999-07-02 |
2010-09-22 |
MorphoSys AG |
Generation of specific binding partners binding to (poly)peptides encoded by genomic dna fragments or ests
|
US6703221B1
(en)
|
1999-08-19 |
2004-03-09 |
Chiron Corporation |
Notch receptor ligands and uses thereof
|
CA2492049A1
(en)
|
1999-12-01 |
2001-06-07 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
US20110131679A2
(en)
*
|
2000-04-19 |
2011-06-02 |
Thomas La Rosa |
Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
|
US20020028488A1
(en)
|
2000-06-19 |
2002-03-07 |
Sujay Singh |
Transgenic avian species for making human and chimeric antibodies
|
US8044259B2
(en)
|
2000-08-03 |
2011-10-25 |
The Regents Of The University Of Michigan |
Determining the capability of a test compound to affect solid tumor stem cells
|
US6984522B2
(en)
|
2000-08-03 |
2006-01-10 |
Regents Of The University Of Michigan |
Isolation and use of solid tumor stem cells
|
US6689744B2
(en)
|
2000-09-22 |
2004-02-10 |
Genentech, Inc. |
Notch receptor agonists and uses
|
JP4336498B2
(ja)
|
2000-12-12 |
2009-09-30 |
メディミューン,エルエルシー |
延長した半減期を有する分子ならびにその組成物および用途
|
US7667004B2
(en)
|
2001-04-17 |
2010-02-23 |
Abmaxis, Inc. |
Humanized antibodies against vascular endothelial growth factor
|
JP2004537314A
(ja)
|
2001-07-25 |
2004-12-16 |
ロランティス リミテッド |
ノッチシグナル伝達モジュレーターを検出する方法
|
US6833441B2
(en)
|
2001-08-01 |
2004-12-21 |
Abmaxis, Inc. |
Compositions and methods for generating chimeric heteromultimers
|
EP1414964B1
(en)
|
2001-08-01 |
2010-03-24 |
University Of Bristol |
Vegf isoform
|
AU2002339157A1
(en)
|
2001-11-14 |
2003-05-26 |
Lorantis Limited |
Inhibitors of the notch signalling pathway for use in the treatment of cancer
|
US20050137130A1
(en)
|
2001-11-14 |
2005-06-23 |
Bodmer Mark W. |
Medical treatment
|
EP1446424A2
(en)
|
2001-11-14 |
2004-08-18 |
Lorantis Limited |
Composition comprising inhibitors of the notch signalling pathway for the modulation of the immune system
|
CA2469204A1
(en)
|
2001-12-07 |
2003-06-19 |
Regents Of The University Of Michigan |
Prospective identification and characterization of breast cancer stem cells
|
US8034904B2
(en)
*
|
2002-06-14 |
2011-10-11 |
Immunogen Inc. |
Anti-IGF-I receptor antibody
|
GB0216648D0
(en)
|
2002-07-18 |
2002-08-28 |
Lonza Biologics Plc |
Method of expressing recombinant protein in CHO cells
|
GB0218879D0
(en)
|
2002-08-14 |
2002-09-25 |
Lorantis Ltd |
Medical treatment
|
WO2004024764A1
(en)
|
2002-09-10 |
2004-03-25 |
Lorantis Limited |
Pharmaceutical composition and medical treatments comprising notch ligand proteins
|
EP1539228B1
(en)
|
2002-09-11 |
2010-12-29 |
Genentech, Inc. |
Novel composition and methods for the treatment of immune related diseases
|
US7365168B2
(en)
|
2002-10-15 |
2008-04-29 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
CN1511850A
(zh)
|
2002-12-31 |
2004-07-14 |
王小宁 |
Mhc-肽抗体多聚体的制备方法
|
EP1631317A2
(en)
|
2003-06-06 |
2006-03-08 |
Regeneron Pharmaceuticals, Inc. |
Use of vegf inhibitors for tumor regression
|
US7758859B2
(en)
|
2003-08-01 |
2010-07-20 |
Genentech, Inc. |
Anti-VEGF antibodies
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
AU2004263538B2
(en)
|
2003-08-08 |
2009-09-17 |
Immunomedics, Inc. |
Bispecific antibodies for inducing apoptosis of tumor and diseased cells
|
FR2859725B1
(fr)
|
2003-09-16 |
2006-03-10 |
Neovacs |
Procede a haut rendement pour l'obtention d'anticorps humains neutralisant l'activite biologique d'une cytokine humaine
|
EP2385069A3
(en)
|
2003-11-12 |
2012-05-30 |
Biogen Idec MA Inc. |
Neonatal Fc rReceptor (FcRn)- binding polypeptide variants, dimeric Fc binding proteins and methods related thereto
|
CA2548208A1
(en)
|
2003-12-05 |
2005-06-16 |
Angiogenetics Sweden Ab |
Angiogenesis affecting polypeptides, proteins, and compositions, and methods of use thereof
|
US20050232927A1
(en)
|
2004-02-03 |
2005-10-20 |
The Regents Of The University Of Michigan |
Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
|
EP1725585A2
(en)
|
2004-03-10 |
2006-11-29 |
Lonza Ltd |
Method for producing antibodies
|
WO2005123104A2
(en)
|
2004-06-10 |
2005-12-29 |
Regeneron Pharmaceuticals, Inc. |
Use of vegf inhibitors for the treatment of human cancer
|
WO2005124364A1
(en)
|
2004-06-15 |
2005-12-29 |
F. Hoffmann-La Roche Ag |
The use of cardiac hormones for diagnosing the risk of suffering from a cardiovascular complication as a consequence of cardiotoxic medication
|
WO2006009809A2
(en)
|
2004-06-18 |
2006-01-26 |
Regeneron Pharmaceuticals, Inc. |
Vegf inhibitors for the treatment of malignant pleural effusion
|
EP1615036B1
(en)
|
2004-07-07 |
2007-09-19 |
F.Hoffmann-La Roche Ag |
Multimarker panel for diabetes type 1 and 2
|
WO2006024497A1
(en)
|
2004-08-30 |
2006-03-09 |
Lonza Biologics Plc. |
Affinity- plus ion exchange- chromatography for purifying antibodies
|
AU2005282700A1
(en)
|
2004-09-02 |
2006-03-16 |
Genentech, Inc. |
Heteromultimeric molecules
|
EP1786906A2
(en)
|
2004-09-09 |
2007-05-23 |
Exonhit Therapeutics SA |
Tumor specific genes and variant rnas and uses thereof as targets for cancer therapy and diagnosis
|
CA2580981C
(en)
|
2004-09-22 |
2013-10-22 |
Kirin Beer Kabushiki Kaisha |
Stabilized human igg4 antibodies
|
US20080107648A1
(en)
|
2005-12-16 |
2008-05-08 |
Regeneron Pharmaceuticals, Inc. |
Therapeutic methods for inhibiting tumor growth with DII4 antagonists
|
US20060134121A1
(en)
|
2004-10-29 |
2006-06-22 |
Gavin Thurston |
DII4 antagonists, assays, and therapeutic methods thereof
|
US8048418B2
(en)
|
2004-10-29 |
2011-11-01 |
Regeneron Pharmaceuticals, Inc. |
Therapeutic methods for inhibiting tumor growth with combination of Dll4 antagonists and VEGF antagonists
|
RU2392961C2
(ru)
|
2004-11-10 |
2010-06-27 |
Хубрехт Лабораториум |
Лечение аденомы и/или аденокарциномы кишечника с помощью ингибирования активации пути notch
|
EP1812064A4
(en)
|
2004-11-19 |
2009-07-08 |
Cornell Res Foundation Inc |
USE OF ENDOTHELIAL VASCULAR GROWTH FACTOR RECEPTOR CELLS IN THE TREATMENT AND MONITORING OF CANCER AND IN THE SCREENING OF CHEMOTHERAPEUTIC AGENTS
|
US7432107B2
(en)
|
2005-01-24 |
2008-10-07 |
Roche Diagnostics Operations, Inc. |
Cardiac hormones for assessing cardiovascular risk
|
PT1849009E
(pt)
|
2005-01-24 |
2009-01-14 |
Hoffann La Roche Ag F |
Utilização de hormonas cardíacas para avaliar um risco cardiovascular em relação à administração de fármacos anti-inflamatórios
|
CA2597247A1
(en)
|
2005-02-11 |
2006-08-17 |
Regeneron Pharmaceuticals, Inc. |
Therapeutic combination of a vegf antagonist (vegf trap) and an anti-hypertensive agent
|
ES2592271T3
(es)
|
2005-03-31 |
2016-11-29 |
Chugai Seiyaku Kabushiki Kaisha |
Métodos de producción de polipéptidos mediante la regulación de la asociación de los polipéptidos
|
EP1868650B1
(en)
|
2005-04-15 |
2018-10-03 |
MacroGenics, Inc. |
Covalent diabodies and uses thereof
|
PT2439273T
(pt)
|
2005-05-09 |
2019-05-13 |
Ono Pharmaceutical Co |
Anticorpos monoclonais humanos para morte programada 1 (pd- 1) e métodos para o tratamento de cancro utilizando anticorpos anti-pd-1 isoladamente ou em combinação com outros imunoterapêuticos
|
WO2006124667A2
(en)
|
2005-05-12 |
2006-11-23 |
Zymogenetics, Inc. |
Compositions and methods for modulating immune responses
|
BRPI0611009A2
(pt)
|
2005-06-02 |
2010-08-10 |
Galaxy Biotech Llc |
usos de um anticorpo monoclonal (mab), e, de um anticorpo anti-hgf de neutralização
|
JP2009504679A
(ja)
|
2005-08-12 |
2009-02-05 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Vegfアンタゴニストを用いて疾患を処置する方法
|
US7774903B2
(en)
|
2005-08-16 |
2010-08-17 |
Lummus Corporation |
Roller gin apparatus, method and system
|
CA2621226A1
(en)
|
2005-09-01 |
2007-03-08 |
Vasgene Therapeutics, Inc. |
Methods for using and identifying modulators of delta-like 4
|
US7906116B2
(en)
|
2005-09-01 |
2011-03-15 |
Parkash Gill |
Methods for using and identifying modulators of Delta-like 4
|
AR056142A1
(es)
|
2005-10-21 |
2007-09-19 |
Amgen Inc |
Metodos para generar el anticuerpo igg monovalente
|
AU2006308847C1
(en)
|
2005-10-31 |
2012-05-10 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for treating and diagnosing cancer
|
EP1993541A2
(en)
|
2006-02-17 |
2008-11-26 |
Gilead Colorado, Inc. |
Antihypertensive therapy
|
WO2011053822A2
(en)
|
2009-11-01 |
2011-05-05 |
The Brigham And Women's Hospital, Inc. |
Notch inhibition in the treatment and prevention of obesity and metabolic syndrome
|
WO2007103114A2
(en)
|
2006-03-07 |
2007-09-13 |
The Brigham & Women's Hospital, Inc. |
Notch inhibition in the treatment or prevention of atherosclerosis
|
US7354582B2
(en)
|
2006-03-10 |
2008-04-08 |
Regeneron Pharmaceuticals, Inc. |
Use of VEGF antagonists for the treatment of malignant gliomas
|
EP1999154B1
(en)
|
2006-03-24 |
2012-10-24 |
Merck Patent GmbH |
Engineered heterodimeric protein domains
|
KR20090016762A
(ko)
|
2006-06-06 |
2009-02-17 |
제넨테크, 인크. |
혈관 발달을 조정하기 위한 조성물 및 방법
|
EP2032604A2
(en)
|
2006-06-06 |
2009-03-11 |
Genentech, Inc. |
Anti-dll4 antibodies and methods using same
|
US7919092B2
(en)
|
2006-06-13 |
2011-04-05 |
Oncomed Pharmaceuticals, Inc. |
Antibodies to notch receptors
|
EP2035456A1
(en)
|
2006-06-22 |
2009-03-18 |
Novo Nordisk A/S |
Production of bispecific antibodies
|
MX2009000674A
(es)
|
2006-08-07 |
2009-02-04 |
Regeneron Pharma |
Metodos terapeuticos para el tratamiento de trastornos oculares vasculares con antagonistas de dll4.
|
WO2008027236A2
(en)
|
2006-08-30 |
2008-03-06 |
Genentech, Inc. |
Multispecific antibodies
|
UA110315C2
(uk)
*
|
2006-09-29 |
2015-12-25 |
Oncomed Pharm Inc |
Композиція та спосіб лікування раку
|
PT2066694E
(pt)
*
|
2006-09-29 |
2016-01-27 |
Oncomed Pharm Inc |
Composições e métodos de diagnóstico e tratamento do cancro
|
JP2010507594A
(ja)
|
2006-10-20 |
2010-03-11 |
シェーリング コーポレイション |
完全ヒト抗vegf抗体および使用方法
|
WO2008070350A2
(en)
|
2006-10-27 |
2008-06-12 |
The Board Of Regents Of The University Of Texas System |
Methods and compositions related to wrapping of dehydrons
|
WO2008070042A2
(en)
|
2006-12-04 |
2008-06-12 |
Medimmune, Inc. |
High potency recombinant antibodies, methods for producing them and use in cancer therapy
|
US20100086544A1
(en)
|
2006-12-11 |
2010-04-08 |
Mass Robert D |
Compositions and methods for treating a neoplasm
|
RU2448979C2
(ru)
|
2006-12-14 |
2012-04-27 |
Ридженерон Фармасьютикалз, Инк. |
Антитела человека к дельта-подобному лиганду-4 человека
|
KR20140148491A
(ko)
|
2006-12-19 |
2014-12-31 |
제넨테크, 인크. |
조기 종양의 치료 및 아주반트 및 네오아주반트 요법을 위한 vegf-특이적 길항제
|
EP2120996A2
(en)
|
2006-12-20 |
2009-11-25 |
Vasgene Therapeutics, Inc. |
Methods for using and identifying modulators of delta-like 4
|
US7691980B2
(en)
|
2007-01-09 |
2010-04-06 |
Bio-Rad Laboratories, Inc. |
Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
|
WO2008091222A1
(en)
|
2007-01-26 |
2008-07-31 |
Bioinvent International Ab |
Dll4 signaling inhibitors and uses thereof
|
MX2009011898A
(es)
|
2007-05-04 |
2009-11-18 |
Ironwood Pharmaceuticals Inc |
Composiciones y metodos para tratar trastornos asociados con retencion de sal o fluido.
|
GB0709333D0
(en)
|
2007-05-15 |
2007-06-20 |
Smart Targeting Ltd |
Binding protein
|
CA2702637A1
(en)
|
2007-10-22 |
2009-04-30 |
Schering Corporation |
Fully human anti-vegf antibodies and methods of using
|
AU2008315414A1
(en)
|
2007-10-25 |
2009-04-30 |
Philogene, Inc. |
Antibodies specific to pro-angiogenic isoforms of vascular endothelial growth factor (VEGF)
|
AR069501A1
(es)
*
|
2007-11-30 |
2010-01-27 |
Genentech Inc |
Anticuerpos anti- vegf (factor de crecimiento endotelial vascular)
|
WO2009075565A1
(en)
|
2007-12-12 |
2009-06-18 |
Erasmus University Medical Center Rotterdam |
Methods for controlling vasculogenesis
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
JP6157046B2
(ja)
|
2008-01-07 |
2017-07-05 |
アムジェン インコーポレイテッド |
静電的ステアリング(electrostaticsteering)効果を用いた抗体Fcヘテロ二量体分子を作製するための方法
|
EP2287174B8
(en)
|
2008-01-18 |
2016-12-07 |
Bio-Rad Laboratories, Inc. |
Enhanced purification of antibody fragments by apatite chromatography
|
EP2947097A1
(en)
|
2008-04-07 |
2015-11-25 |
Ablynx N.V. |
Amino acid sequences directed against the Notch pathways and uses thereof
|
KR101924831B1
(ko)
|
2008-04-09 |
2018-12-05 |
제넨테크, 인크. |
면역 관련 질병의 치료를 위한 신규한 조성물 및 방법
|
BRPI0910482A2
(pt)
|
2008-04-29 |
2019-09-24 |
Abbott Lab |
imunoglobinas de domínio variável duplo e usos das mesmas
|
US20100260668A1
(en)
|
2008-04-29 |
2010-10-14 |
Abbott Laboratories |
Dual Variable Domain Immunoglobulins and Uses Thereof
|
US8226943B2
(en)
|
2008-07-08 |
2012-07-24 |
Oncomed Pharmaceuticals, Inc. |
Antibodies to notch receptors
|
EP2324358A1
(en)
|
2008-07-23 |
2011-05-25 |
F. Hoffmann-La Roche AG |
Monitoring anti-angiogenesis therapy
|
EP2321651B1
(en)
|
2008-07-23 |
2017-08-23 |
F. Hoffmann-La Roche AG |
Identification of subjects being susceptible to anti-angiogenesis therapy
|
WO2010032060A1
(en)
|
2008-09-19 |
2010-03-25 |
Medimmune Llc |
Antibodies directed to dll4 and uses thereof
|
JP2012508017A
(ja)
|
2008-11-07 |
2012-04-05 |
ファブラス エルエルシー |
抗dll4抗体及びその使用
|
TWI471139B
(zh)
*
|
2008-12-12 |
2015-02-01 |
Boehringer Ingelheim Int |
抗-igf抗體
|
CA2759030A1
(en)
|
2009-04-20 |
2010-10-28 |
Genentech, Inc. |
Adjuvant cancer therapy
|
WO2010124009A2
(en)
|
2009-04-21 |
2010-10-28 |
Schering Corporation |
Fully human anti-vegf antibodies and methods of using
|
EP3505636A1
(en)
|
2009-04-27 |
2019-07-03 |
OncoMed Pharmaceuticals, Inc. |
Method for making heteromultimeric molecules
|
TWI513465B
(zh)
|
2009-06-25 |
2015-12-21 |
Regeneron Pharma |
以dll4拮抗劑與化學治療劑治療癌症之方法
|
WO2011005621A1
(en)
|
2009-07-08 |
2011-01-13 |
Amgen Inc. |
Design of stable and aggregation free antibody fc molecules through ch3 domain interface engineering
|
CA2771575A1
(en)
|
2009-08-29 |
2011-03-03 |
Abbott Laboratories |
Therapeutic dll4 binding proteins
|
UY32870A
(es)
|
2009-09-01 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
UY32917A
(es)
|
2009-10-02 |
2011-04-29 |
Boehringer Ingelheim Int |
Moléculas de unión a dll-4
|
UY32920A
(es)
|
2009-10-02 |
2011-04-29 |
Boehringer Ingelheim Int |
Moleculas de unión biespecíficas para la terapia anti-angiogénesis
|
DK2488204T3
(en)
|
2009-10-16 |
2016-06-06 |
Oncomed Pharm Inc |
Therapeutic combination and use of DLL4 antagonist antibodies and blood pressure lowering agents
|
CN102686609A
(zh)
|
2009-10-23 |
2012-09-19 |
加文医学研究所 |
修饰的可变域分子及其生产和使用方法
|
CA2782299A1
(en)
*
|
2009-12-01 |
2011-06-09 |
Oncomed Pharmaceuticals, Inc. |
Methods for treating cancers comprising k-ras mutations
|
JO3183B1
(ar)
|
2010-01-29 |
2018-03-08 |
Regeneron Pharma |
طرق لمعالجة أمراض المناعة الذاتية مضادات dll4
|
WO2011100566A2
(en)
|
2010-02-12 |
2011-08-18 |
Oncomed Pharmaceuticals, Inc. |
Methods for identifying and isolating cells expressing a polypeptide
|
KR101839161B1
(ko)
|
2010-02-23 |
2018-03-16 |
제넨테크, 인크. |
난소암의 치료를 위한 항혈관신생 요법
|
SG183872A1
(en)
*
|
2010-03-02 |
2012-11-29 |
Abbvie Inc |
Therapeutic dll4 binding proteins
|
AU2011323521A1
(en)
|
2010-11-02 |
2013-06-20 |
Abbott Laboratories |
Dual variable domain immunoglobulins and uses thereof
|
US20130323265A1
(en)
|
2010-11-15 |
2013-12-05 |
Oncomed Pharmaceuticals, Inc. |
Methods for treating cancer with dll4 antagonists
|
WO2012092539A2
(en)
|
2010-12-31 |
2012-07-05 |
Takeda Pharmaceutical Company Limited |
Antibodies to dll4 and uses thereof
|
TWI530489B
(zh)
|
2011-03-22 |
2016-04-21 |
必治妥美雅史谷比公司 |
雙(氟烷基)-1,4-苯二氮呯酮化合物
|
CA2838973A1
(en)
|
2011-06-17 |
2012-12-20 |
Adrian L. Harris |
Methods of enhancing the response to radiation in tumor therapy using anti-dll4 antibodies
|
SI2758073T1
(sl)
|
2011-09-23 |
2019-02-28 |
Oncomed Pharmaceuticals, Inc. |
Sredstva, ki vežejo VEGF/DLL4, in njihove uporabe
|
US20150005475A1
(en)
|
2012-02-03 |
2015-01-01 |
Medimmune Limited |
Process for reducing antibody aggregate levels and antibodies produced thereby
|
EP2825558B1
(en)
|
2012-03-13 |
2019-05-15 |
F.Hoffmann-La Roche Ag |
Combination therapy for the treatment of ovarian cancer
|
EA037351B8
(ru)
|
2012-05-15 |
2021-04-29 |
Бристол-Майерс Сквибб Компани |
Способ лечения злокачественных опухолей с использованием комбинации антител против pd-1 и ctla-4
|
AR092325A1
(es)
|
2012-05-31 |
2015-04-15 |
Regeneron Pharma |
Formulaciones estabilizadas que contienen anticuerpos anti-dll4 y kit
|
CA2874979A1
(en)
|
2012-05-31 |
2014-04-24 |
Edwige Gros |
Antigen binding proteins that bind dll-4
|
KR101535341B1
(ko)
|
2012-07-02 |
2015-07-13 |
한화케미칼 주식회사 |
Dll4에 특이적으로 결합하는 신규한 단일클론항체 및 이의 용도
|
IN2014DN11157A
(pl)
|
2012-07-13 |
2015-10-02 |
Roche Glycart Ag |
|
WO2014049100A1
(en)
|
2012-09-28 |
2014-04-03 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf agents
|
US20150368329A1
(en)
|
2012-10-15 |
2015-12-24 |
Oncomed Pharmaceuticals, Inc. |
Methods of Treating Ocular Diseases
|
EP2914961A4
(en)
|
2012-10-31 |
2016-04-20 |
Oncomed Pharm Inc |
METHODS AND MONITORING A TREATMENT BY AN ANTAGONIST OF DLL4
|
MY171664A
(en)
|
2012-11-01 |
2019-10-22 |
Abbvie Inc |
Anti-dll4/vegf dual variable domain immunoglobulins and uses thereof
|
TW201438736A
(zh)
|
2012-11-14 |
2014-10-16 |
Regeneron Pharma |
以dll4拮抗劑治療卵巢癌之方法
|
US20140154255A1
(en)
|
2012-11-30 |
2014-06-05 |
Abbvie Biotherapeutics Inc. |
Anti-vegf antibodies and their uses
|
PL3020731T3
(pl)
|
2013-07-09 |
2019-11-29 |
Ablbio |
Nowe podwójnie nakierowane białko specyficznie wiążące się z dll4 i vegf oraz zastosowanie tego białka
|
KR20160030936A
(ko)
|
2013-07-16 |
2016-03-21 |
제넨테크, 인크. |
Pd-1 축 결합 길항제 및 tigit 억제제를 사용한 암을 치료하는 방법
|
WO2015130751A1
(en)
|
2014-02-26 |
2015-09-03 |
Medimmune, Llc |
Methods of treatment with dll4 antagonists
|
BR112016023011A2
(pt)
|
2014-04-04 |
2017-10-17 |
Oncomed Pharm Inc |
tratamento de câncer gástrico
|
US9914774B2
(en)
|
2014-07-11 |
2018-03-13 |
Genentech, Inc. |
Notch pathway inhibition
|
SG10201811841UA
(en)
|
2014-07-16 |
2019-02-27 |
Genentech Inc |
Methods of treating cancer using tigit inhibitors and anti-cancer agents
|
TWI724997B
(zh)
|
2014-08-19 |
2021-04-21 |
美商默沙東藥廠 |
抗tigit抗體
|
CA2966042A1
(en)
|
2014-10-31 |
2016-05-06 |
Oncomed Pharmaceuticals, Inc. |
Combination therapy for treatment of disease
|
EA039219B1
(ru)
|
2014-12-23 |
2021-12-20 |
Бристол-Майерс Сквибб Компани |
Антитела к tigit
|
EP3353204B1
(en)
|
2015-09-23 |
2023-10-18 |
Mereo BioPharma 5, Inc. |
Bi-specific anti-vegf/dll4 antibody for use in treating platinum-resistant ovarian cancer
|
KR20230125094A
(ko)
|
2015-09-25 |
2023-08-28 |
제넨테크, 인크. |
항-tigit 항체 및 이의 이용 방법
|
CA3119458A1
(en)
|
2018-11-15 |
2020-05-22 |
Oncomed Pharmaceuticals, Inc. |
Methods and monitoring of treatment with vegf/dll4 binding agent
|