NI201400024A - Agentes de ligación al factor de crecimiento endotelial vascular/ligando 4 similar a delta ( vegf/dll4) y usos de los mismos. - Google Patents

Agentes de ligación al factor de crecimiento endotelial vascular/ligando 4 similar a delta ( vegf/dll4) y usos de los mismos.

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Publication number
NI201400024A
NI201400024A NI201400024A NI201400024A NI201400024A NI 201400024 A NI201400024 A NI 201400024A NI 201400024 A NI201400024 A NI 201400024A NI 201400024 A NI201400024 A NI 201400024A NI 201400024 A NI201400024 A NI 201400024A
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NI
Nicaragua
Prior art keywords
dll4
vegf
binding agents
ligando
present
Prior art date
Application number
NI201400024A
Other languages
English (en)
Inventor
L Gurney Austin
Ken Sato Aaron
John Bond Christopher
Original Assignee
Oncomed Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncomed Pharm Inc filed Critical Oncomed Pharm Inc
Publication of NI201400024A publication Critical patent/NI201400024A/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

La presente invención se refiere a agentes de ligación a VEGF, agentes de ligación a DLL4, agentes de ligación biespecíficos a VEGF/DLL4, y métodos para usar los agentes para tratar las enfermedades tales como cáncer. La presente invención proporciona anticuerpos que se ligan específicamente a VEGF humano, anticuerpos que se ligan específicamente a DLL4 humano, y anticuerpos biespecíficos que se ligan específicamente a VEGF humano y/o DLL4 humano. La presente invención proporciona además métodos para usar los agentes para inhibir el crecimiento tumoral. También se describen métodos para tratar cáncer que comprenden administrar una cantidad terapéuticamente efectiva de un agente o anticuerpo de la presente invención a un paciente que tiene un tumor o cáncer.
NI201400024A 2011-09-23 2014-03-21 Agentes de ligación al factor de crecimiento endotelial vascular/ligando 4 similar a delta ( vegf/dll4) y usos de los mismos. NI201400024A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161538454P 2011-09-23 2011-09-23
US201261597409P 2012-02-10 2012-02-10
US201261692978P 2012-08-24 2012-08-24

Publications (1)

Publication Number Publication Date
NI201400024A true NI201400024A (es) 2014-06-26

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NI201400024A NI201400024A (es) 2011-09-23 2014-03-21 Agentes de ligación al factor de crecimiento endotelial vascular/ligando 4 similar a delta ( vegf/dll4) y usos de los mismos.

Country Status (33)

Country Link
US (8) US8858941B2 (es)
EP (2) EP3485903B1 (es)
JP (1) JP6170496B2 (es)
KR (1) KR102091293B1 (es)
CN (2) CN104168914B (es)
AU (1) AU2013201095C1 (es)
BR (1) BR112014007035B1 (es)
CA (1) CA2849562C (es)
CL (1) CL2014000725A1 (es)
CO (1) CO6940382A2 (es)
CR (1) CR20140172A (es)
CY (1) CY1121148T1 (es)
DK (2) DK2758073T3 (es)
EA (1) EA029958B1 (es)
ES (2) ES2707580T3 (es)
FI (1) FI3485903T3 (es)
HK (1) HK1199209A1 (es)
HR (2) HRP20230078T1 (es)
HU (2) HUE042192T2 (es)
IL (1) IL231628B (es)
IN (1) IN2014KN00871A (es)
LT (2) LT2758073T (es)
MX (2) MX361712B (es)
MY (1) MY188192A (es)
NI (1) NI201400024A (es)
PE (1) PE20141537A1 (es)
PL (2) PL3485903T3 (es)
PT (2) PT2758073T (es)
RS (2) RS63965B1 (es)
SG (1) SG11201400870WA (es)
SI (2) SI3485903T1 (es)
TW (1) TWI583699B (es)
WO (1) WO2013044215A1 (es)

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