PE80999A1 - Forma cristalina de 1-(2,6-difluorbencil)-1h-1,2,3-triazol-4-carboxamida - Google Patents

Forma cristalina de 1-(2,6-difluorbencil)-1h-1,2,3-triazol-4-carboxamida

Info

Publication number
PE80999A1
PE80999A1 PE1998000479A PE00047998A PE80999A1 PE 80999 A1 PE80999 A1 PE 80999A1 PE 1998000479 A PE1998000479 A PE 1998000479A PE 00047998 A PE00047998 A PE 00047998A PE 80999 A1 PE80999 A1 PE 80999A1
Authority
PE
Peru
Prior art keywords
crystalline form
difluorbencil
carboxamide
triazole
endothermal
Prior art date
Application number
PE1998000479A
Other languages
English (en)
Inventor
Andreas Burkhard
Robert Portmann
Walter Scherrer
Martin Szelagiewicz
Urs Christoph Hofmeier
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE80999(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE80999A1 publication Critical patent/PE80999A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A LA FORMA CRISTALINA A Y A` DEL COMPUESTO 1-(2,6-DIFLUORBENCIL)-1H-1,2,3-TRIAZOL-4-CARBOXAMIDA DE FORMULA (I) CARACTERIZADA POR SUS PARAMETROS FISICOS COMO: a)LAS LINEAS CARACTERISTICAS EN EL DIAGRAMA DE POLVO DE RAYOS X; b)POR LOS PATRONES DE ABSORCION EN EL ESPECTRO INFRAROJO; c)POR LOS PATRONES DE ABSORCION EN EL ESPECTRO RAMAN FT; d)POR UN PICO ENDOTERMICO Y UNA SENAL ENDOTERMICA. LA FORMA CRITALINA A' PRESENTA PUNTOS DEFECTUOSOS EN LA REJILLA DE CRISTAL. LA FORMA CRISTALINA A Y A' SE DISUELVEN LENTAMENTE EN AGUA POR LO QUE PUEDEN UTILIZARSE EN PREPARADOS DE LIBERACION A LARGO PLAZO
PE1998000479A 1997-06-10 1998-06-08 Forma cristalina de 1-(2,6-difluorbencil)-1h-1,2,3-triazol-4-carboxamida PE80999A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10

Publications (1)

Publication Number Publication Date
PE80999A1 true PE80999A1 (es) 1999-09-06

Family

ID=4209650

Family Applications (2)

Application Number Title Priority Date Filing Date
PE1998000478A PE79799A1 (es) 1997-06-10 1998-06-08 Forma cristalina de 1-(2,6-difluorbencil)-1h-1,2,3-triazol-4-carboxamida
PE1998000479A PE80999A1 (es) 1997-06-10 1998-06-08 Forma cristalina de 1-(2,6-difluorbencil)-1h-1,2,3-triazol-4-carboxamida

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE1998000478A PE79799A1 (es) 1997-06-10 1998-06-08 Forma cristalina de 1-(2,6-difluorbencil)-1h-1,2,3-triazol-4-carboxamida

Country Status (37)

Country Link
US (6) US6740669B1 (es)
EP (2) EP0994864B1 (es)
JP (2) JP3672574B2 (es)
KR (2) KR100409168B1 (es)
CN (3) CN1132820C (es)
AR (4) AR012946A1 (es)
AT (2) ATE237599T1 (es)
AU (2) AU725528B2 (es)
BR (2) BR9804947A (es)
CA (3) CA2256013C (es)
CO (2) CO4940452A1 (es)
CY (1) CY2007014I1 (es)
CZ (2) CZ292481B6 (es)
DE (3) DE69813560T2 (es)
DK (2) DK0994864T3 (es)
ES (2) ES2192779T3 (es)
FR (1) FR07C0037I2 (es)
HK (3) HK1028242A1 (es)
HU (2) HU225153B1 (es)
ID (2) ID27660A (es)
IL (2) IL125732A (es)
LU (1) LU91345I2 (es)
MY (2) MY125854A (es)
NL (1) NL300284I2 (es)
NO (2) NO329314B1 (es)
NZ (2) NZ331371A (es)
PE (2) PE79799A1 (es)
PL (2) PL191943B1 (es)
PT (1) PT994864E (es)
RU (2) RU2198167C2 (es)
SI (2) SI0994863T1 (es)
SK (2) SK283685B6 (es)
TR (2) TR199801631T1 (es)
TW (2) TW403740B (es)
UY (1) UY25844A1 (es)
WO (2) WO1998056772A1 (es)
ZA (2) ZA984967B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW403740B (en) * 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
AR040233A1 (es) * 2002-05-31 2005-03-23 Schering Corp Polimorfos inhibidores de xantina fosfodiesterasa v
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
US8183269B2 (en) 2008-10-13 2012-05-22 Cipla Limited Process for the preparation of rufinamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) * 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
AU2010290049B2 (en) * 2009-09-04 2013-09-19 Tactical Therapeutics, Inc Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations
EP2465853A1 (en) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
ES2498267T3 (es) * 2010-04-30 2014-09-24 Laboratorios Lesvi, S.L. Procedimiento mejorado para la preparación de un intermedio de rufinamida
ITMI20110718A1 (it) * 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
WO2014013511A2 (en) * 2012-07-20 2014-01-23 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

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US3992378A (en) 1973-12-26 1976-11-16 Eli Lilly And Company Fluoralkyl quinoxadinediones
US4156734A (en) * 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
FI834666A (fi) 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
FI93544C (fi) * 1985-04-18 1995-04-25 Ciba Geigy Ag Menetelmä fluorattujen, antikonvulsiivisesti vaikuttavien 1-bentsyyli-1H-1,2,3-triatsoliyhdisteiden valmistamiseksi
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
EP0484437A4 (en) 1989-07-27 1994-06-01 Searle & Co Renal-selective prodrugs for the treatment of hypertension
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
EP0556393B1 (en) 1990-11-06 2000-07-26 Yamanouchi Pharmaceutical Co. Ltd. Fused pyrazine derivative
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) * 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
GB9419318D0 (en) 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
CN1072215C (zh) 1995-02-22 2001-10-03 赫彻斯特药品和化学品公司 无定形吡咯他尼、吡咯他尼多晶型物,其制备方法和用途
SK283990B6 (sk) * 1996-07-11 2004-07-07 Novartis Ag Spôsob prípravy 1-substituovaných 4-kyano-1,2,3-triazolov, 4-kyano-1-(2,6-difluórbenzyl)-1H-1,2,3-triazol
TW403740B (en) 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide

Also Published As

Publication number Publication date
TW526195B (en) 2003-04-01
KR100425656B1 (ko) 2004-05-17
PL330764A1 (en) 1999-05-24
EP0994863B1 (en) 2003-02-19
CA2614926C (en) 2010-02-09
AU725528B2 (en) 2000-10-12
JP2000516259A (ja) 2000-12-05
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
US20010037029A1 (en) 2001-11-01
AU8437198A (en) 1998-12-30
FR07C0037I1 (es) 2007-08-17
KR19990087835A (ko) 1999-12-27
PE79799A1 (es) 1999-09-03
CY2007014I2 (el) 2009-11-04
EP0994863A1 (en) 2000-04-26
NO983666L (no) 1998-12-17
CA2256013A1 (en) 1998-12-17
LU91345I9 (es) 2018-12-31
NO329315B1 (no) 2010-09-27
CZ253398A3 (cs) 1999-04-14
NZ331371A (en) 2000-08-25
TW403740B (en) 2000-09-01
US20100310655A1 (en) 2010-12-09
US20040167186A1 (en) 2004-08-26
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
SK283685B6 (sk) 2003-12-02
CN1298708C (zh) 2007-02-07
SI0994863T1 (en) 2003-08-31
HUP0000798A2 (hu) 2000-10-30
US20060116520A1 (en) 2006-06-01
ID21014A (id) 1999-04-08
DE69813560D1 (de) 2003-05-22
CA2614926A1 (en) 1998-12-17
TR199801631T1 (xx) 1999-06-21
LU91345I2 (fr) 2007-09-04
CO4940452A1 (es) 2000-07-24
ES2192779T3 (es) 2003-10-16
CZ292260B6 (cs) 2003-08-13
WO1998056772A1 (en) 1998-12-17
CO4940448A1 (es) 2000-07-24
IL125732A (en) 2002-12-01
PT994864E (pt) 2003-07-31
EP0994864A1 (en) 2000-04-26
HUP0002113A2 (hu) 2001-02-28
CN1259127A (zh) 2000-07-05
ATE232852T1 (de) 2003-03-15
ZA984967B (en) 1999-01-11
ID27660A (id) 2001-04-19
HUP0002113A3 (en) 2002-09-30
CA2256015C (en) 2008-06-03
CA2256013C (en) 2007-10-16
HU226107B1 (en) 2008-04-28
US6455556B2 (en) 2002-09-24
CN1159300C (zh) 2004-07-28
PL192114B1 (pl) 2006-08-31
HK1028241A1 (en) 2001-02-09
JP3672575B2 (ja) 2005-07-20
NO329314B1 (no) 2010-09-27
UY25844A1 (es) 2001-08-27
KR19990087836A (ko) 1999-12-27
IL125733A0 (en) 1999-04-11
DK0994863T3 (da) 2003-05-26
KR100409168B1 (ko) 2004-01-31
NO983666D0 (no) 1998-08-11
CN1572789A (zh) 2005-02-02
US20030125568A1 (en) 2003-07-03
AR061005A2 (es) 2008-07-30
ZA984966B (en) 1999-01-11
CZ292481B6 (cs) 2003-09-17
RU2198167C2 (ru) 2003-02-10
ATE237599T1 (de) 2003-05-15
CA2256015A1 (en) 1998-12-17
RU2194041C2 (ru) 2002-12-10
CY2007014I1 (el) 2009-11-04
AU8437298A (en) 1998-12-30
BR9804947A (pt) 1999-08-24
IL125733A (en) 2002-12-01
EP0994864B1 (en) 2003-04-16
US6740669B1 (en) 2004-05-25
HUP0000798A3 (en) 2000-10-30
DE69811500D1 (de) 2003-03-27
DE69811500T2 (de) 2004-04-01
CZ253498A3 (cs) 1999-04-14
NL300284I2 (nl) 2007-11-01
BR9804946A (pt) 1999-08-24
FR07C0037I2 (es) 2008-05-16
CN1132820C (zh) 2003-12-31
DE122007000051I2 (de) 2009-02-19
ES2197485T3 (es) 2004-01-01
HK1028242A1 (en) 2001-02-09
AU725517B2 (en) 2000-10-12
PL191943B1 (pl) 2006-07-31
AR061004A2 (es) 2008-07-30
DE69813560T2 (de) 2004-02-05
HK1028031A1 (en) 2001-02-02
JP3672574B2 (ja) 2005-07-20
IL125732A0 (en) 1999-04-11
AR012945A1 (es) 2000-11-22
NO983667L (no) 1998-12-17
SK109498A3 (en) 1998-12-02
MY120156A (en) 2005-09-30
NZ331370A (en) 2000-08-25
DK0994864T3 (da) 2003-07-21
US8076362B2 (en) 2011-12-13
US7750028B2 (en) 2010-07-06
PL330798A1 (en) 1999-06-07
AR012946A1 (es) 2000-11-22
HU225153B1 (en) 2006-07-28
JP2000516258A (ja) 2000-12-05
DE122007000051I1 (de) 2007-11-08
SI0994864T1 (en) 2003-10-31
TR199801630T1 (xx) 1999-06-21
MY125854A (en) 2006-08-30
CN1217716A (zh) 1999-05-26
SK109398A3 (en) 1998-12-02

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