JP2000516259A - 薬剤の結晶変形 - Google Patents
薬剤の結晶変形Info
- Publication number
- JP2000516259A JP2000516259A JP10536289A JP53628998A JP2000516259A JP 2000516259 A JP2000516259 A JP 2000516259A JP 10536289 A JP10536289 A JP 10536289A JP 53628998 A JP53628998 A JP 53628998A JP 2000516259 A JP2000516259 A JP 2000516259A
- Authority
- JP
- Japan
- Prior art keywords
- weak
- variant
- strong
- difluorobenzyl
- triazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.X線粉末パターンの手段で測定して、11.0Å、8.3Å、5.18Å、4. 88Å、4.80Å、4.42Å、4.33Å、4.19Å、4.12Å、3.81Å 、3.50Å、3.41Å、3.36Å、3.32Å、3.28Å、3.24Å、3. 05Åおよび2.83Åの平面間間隙(d値)の特徴的なラインを有する式 の化合物1−(2,6−ジフルオロベンジル)−1H−1,2,3−トリアゾール− 4−カルボキサミドの変形B。 2.11.0Å(中間)、8.3Å(中間)、8.1Å(非常に弱い)、5.68Å(非 常に弱い)、5.18Å(非常に強い)、5.11Å(弱い)、4.88Å(中間)、4. 80Å(強い)、4.71Å(非常に弱い)、4.61Å(弱い)、4.45Å(弱い)、 4.42Å(強い)、4.33Å(非常に強い)、4.19Å(中間)、4.12Å(強い) 、4.09Å(弱い)、3.99Å(非常に弱い)、3.95Å(非常に弱い)、3.84 Å(弱い)、3.81Å(中間)、3.65Å(弱い)、3.61Å(非常に弱い)、3.5 8Å(非常に弱い)、3.54Å(弱い)、3.50Å(中間)、3.47Å(非常に弱い )、3.41Å(中間)、3.36Å(非常に強い)、3.32Å(強い)、3.28Å(中 間)、3.24Å(中間)、3.10Å(弱い)、3.07Å(弱い)、3.05Å(中間) 、2.93Å(弱い)、2.88Å(弱い)、2.87Å(非常に弱い)、2.83Å(中 間)、2.66Å(弱い)、2.63Å(非常に弱い)、2.55Å(弱い)、2.50Å( 弱い)、2.46Å(弱い)、2.44Å(弱い)、2.37Å(弱い)、2.35Å(弱い )の平面間間隙(d値)の特徴的ラインのX線粉末パターンを有する、請求項1記 載の変形。 3.FT−IRスペクトル(KBrペレット−透過法)で1678cm-1の吸収を 有する、請求項1または2記載の変形。 4.FT−IRスペクトル(KBrペレット−透過法)で3404、3199、 3125、1678、1635、1560、1475、1393、1357、1 322、1286、1237、1051、1036、1028、889、837 、800、719、667および645cm-1の吸収を有する、請求項3記載の変 形。 5.FTラマンスペクトル(粉末−反射法180°)3166、3089、29 70、1678、1628、1614、1559、1464、1441、139 1、1275、1244、1147、1086、1062、1036、1014 、839、773、724、690、668、595、549、500、493 、430および365cm-1の吸収を有する、請求項1から4のいずれかに記載の 変形。 6.示差走査熱量測定の温度記録図において、230℃から260℃の範囲の 吸熱シグナルに加えて(ピーク温度239−245℃)、205℃(180−22 0℃)に弱い熱シグナルを有する、請求項1から5のいずれかに記載の変形B。 7.X線粉末パターンの手段で測定して、9.0Å、4.73Å、4.65Å、 3.75Å、3.54Å、3.42Å、3.25Åの平面間間隙(d値)の特徴的なラ インを有する式 の化合物1−(2,6−ジフルオロベンジル)−1H−1,2,3−トリアゾール− 4−カルボキサミドの変形C。 8.9.0Å(中間)、7.0Å(弱い)、5.49Å(弱い)、5.11Å(非常に弱 い)、4.80Å(弱い)、4.73Å(強い)、4.65Å(非常に強い)、4.47Å( 非常に弱い)、4.19Å(非常に弱い)、4.11Å(非常に弱い)、3.98Å(非 常に弱い)、3.83Å(非常に弱い)、3.75Å(強い)、3.73Å(弱い)、3. 54Å(中間)、3.50Å(弱い)、3.42Å(強い)、3.25Å(中間)、2.88 Å(非常に弱い)、2.80Å(非常に弱い)、2.74Å(非常に弱い)、2.67Å (非常に弱い)、2.64Å(弱い)の平面間間隙(d値)の特徴的なラインのX線粉 末パターンを有する、請求項7記載の変形。 9.赤外線スペクトル(KBrペレット−透過法)で3137cm-1の吸収を有す る、請求項7または8記載の変形。 10.赤外線スペクトル(KBrペレット−透過法)で3396、3287、3 137、1657、1631、1602、1559、1475、1392、13 23、1287、1237、1122、1104、1047、1035、101 2、876、839、797、773、729および653cm-1吸収を有する、 請求項9記載の変形。 11.FTラマンスペクトル(粉末−反射法180°)で3137、3080、 3012、2971、1673、1629、1602、1561、1436、1 271、1248、1105、1065、1035、1013、839、800 、767、726、690、672、593、549、500、492、435 および370cm-1の吸収を有する、請求項7から10のいずれかに記載の変形。 12.230℃から260℃の範囲の吸熱シグナルに加えて(ピーク温度23 9−245℃)、180℃に非常に広く、弱い発熱シグナルを有する、請求項7 から11のいずれかに記載の変形C。 13.実質的に純粋な形である、請求項1から12のいずれかに記載の変形B またはC。 14.請求項1から13のいずれかに記載の1−(2,6−ジフルオロベンジル )−1H−1,2,3−トリアゾール−4−カルボキサミドの変形BまたはCおよ び製薬学的に使用可能な賦形剤および添加剤を含む医薬製剤。 15.医薬製剤としての請求項1から13のいずれかに記載の1−(2,6−ジ フルオロベンジル)−1H−1,2,3−トリアゾール−4−カルボキサミドの変 形BまたはCの使用。 16.癲癇およびこれに類する適応症の処置のための医薬製剤の製造における 、 請求項1から13のいずれかに記載の1−(2,6−ジフルオロベンジル)−1H −1,2,3−トリアゾール−4−カルボキサミドの変形BまたはCの使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH140497 | 1997-06-10 | ||
CH1404/97 | 1997-06-10 | ||
PCT/EP1998/003428 WO1998056773A1 (en) | 1997-06-10 | 1998-06-08 | Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000516259A true JP2000516259A (ja) | 2000-12-05 |
JP3672575B2 JP3672575B2 (ja) | 2005-07-20 |
Family
ID=4209650
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53628898A Expired - Lifetime JP3672574B2 (ja) | 1997-06-10 | 1998-06-08 | 薬剤の結晶変形 |
JP53628998A Expired - Lifetime JP3672575B2 (ja) | 1997-06-10 | 1998-06-08 | 薬剤の結晶変形 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53628898A Expired - Lifetime JP3672574B2 (ja) | 1997-06-10 | 1998-06-08 | 薬剤の結晶変形 |
Country Status (37)
Country | Link |
---|---|
US (6) | US6740669B1 (ja) |
EP (2) | EP0994864B1 (ja) |
JP (2) | JP3672574B2 (ja) |
KR (2) | KR100409168B1 (ja) |
CN (3) | CN1132820C (ja) |
AR (4) | AR012946A1 (ja) |
AT (2) | ATE237599T1 (ja) |
AU (2) | AU725528B2 (ja) |
BR (2) | BR9804947A (ja) |
CA (3) | CA2256013C (ja) |
CO (2) | CO4940452A1 (ja) |
CY (1) | CY2007014I1 (ja) |
CZ (2) | CZ292481B6 (ja) |
DE (3) | DE69813560T2 (ja) |
DK (2) | DK0994864T3 (ja) |
ES (2) | ES2192779T3 (ja) |
FR (1) | FR07C0037I2 (ja) |
HK (3) | HK1028242A1 (ja) |
HU (2) | HU225153B1 (ja) |
ID (2) | ID27660A (ja) |
IL (2) | IL125732A (ja) |
LU (1) | LU91345I2 (ja) |
MY (2) | MY125854A (ja) |
NL (1) | NL300284I2 (ja) |
NO (2) | NO329314B1 (ja) |
NZ (2) | NZ331371A (ja) |
PE (2) | PE79799A1 (ja) |
PL (2) | PL191943B1 (ja) |
PT (1) | PT994864E (ja) |
RU (2) | RU2198167C2 (ja) |
SI (2) | SI0994863T1 (ja) |
SK (2) | SK283685B6 (ja) |
TR (2) | TR199801631T1 (ja) |
TW (2) | TW403740B (ja) |
UY (1) | UY25844A1 (ja) |
WO (2) | WO1998056772A1 (ja) |
ZA (2) | ZA984967B (ja) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW403740B (en) * | 1997-06-10 | 2000-09-01 | Novartis Ag | Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide |
AR040233A1 (es) * | 2002-05-31 | 2005-03-23 | Schering Corp | Polimorfos inhibidores de xantina fosfodiesterasa v |
GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
US7875284B2 (en) * | 2006-03-10 | 2011-01-25 | Cook Incorporated | Methods of manufacturing and modifying taxane coatings for implantable medical devices |
US20090069390A1 (en) * | 2007-09-12 | 2009-03-12 | Protia, Llc | Deuterium-enriched rufinamide |
US8183269B2 (en) | 2008-10-13 | 2012-05-22 | Cipla Limited | Process for the preparation of rufinamide |
CN101768124B (zh) * | 2008-12-30 | 2012-01-04 | 北京本草天源药物研究院 | 一种药物晶体及其制备方法和用途 |
IT1395736B1 (it) * | 2009-08-04 | 2012-10-19 | Dipharma Francis Srl | Forme cristalline di rufinamide |
AU2010290049B2 (en) * | 2009-09-04 | 2013-09-19 | Tactical Therapeutics, Inc | Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations |
EP2465853A1 (en) * | 2010-12-14 | 2012-06-20 | Laboratorios Lesvi, S.L. | Polymorph of rufinamide and process for obtaining it |
ES2498267T3 (es) * | 2010-04-30 | 2014-09-24 | Laboratorios Lesvi, S.L. | Procedimiento mejorado para la preparación de un intermedio de rufinamida |
ITMI20110718A1 (it) * | 2011-04-29 | 2012-10-30 | Dipharma Francis Srl | Procedimento per la purificazione di rufinamide |
WO2014013511A2 (en) * | 2012-07-20 | 2014-01-23 | Hetero Research Foundation | Rufinamide solid dispersion |
WO2021099481A1 (en) | 2019-11-20 | 2021-05-27 | Medichem, S.A. | Solid composition containing rufinamide |
Family Cites Families (23)
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US3992378A (en) | 1973-12-26 | 1976-11-16 | Eli Lilly And Company | Fluoralkyl quinoxadinediones |
US4156734A (en) * | 1976-02-13 | 1979-05-29 | Merck & Co., Inc. | Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid |
GB1511195A (en) | 1976-10-18 | 1978-05-17 | Ici America Inc | Triazole derivatives |
US4536518A (en) * | 1979-11-01 | 1985-08-20 | Pfizer Inc. | Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine |
US4346097A (en) * | 1980-09-30 | 1982-08-24 | Warner-Lambert Company | Method for treating convulsions with pyrazole-4-carboxamide derivatives |
FI834666A (fi) | 1982-12-23 | 1984-06-24 | Ciba Geigy Ag | Foerfarande foer framstaellning av nya aralkyltriazolfoereningar. |
US4789680A (en) * | 1982-12-23 | 1988-12-06 | Ciba-Geigy Corporation | Aralkyltriazole compounds |
US4511572A (en) * | 1983-03-18 | 1985-04-16 | The University Of Kentucky Research Foundation | Triazoline anticonvulsant drugs |
FI93544C (fi) * | 1985-04-18 | 1995-04-25 | Ciba Geigy Ag | Menetelmä fluorattujen, antikonvulsiivisesti vaikuttavien 1-bentsyyli-1H-1,2,3-triatsoliyhdisteiden valmistamiseksi |
CA2002864C (en) | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
JPH02214504A (ja) | 1989-02-15 | 1990-08-27 | Nissan Chem Ind Ltd | 光学活性キノキサリン化合物の晶析法 |
EP0484437A4 (en) | 1989-07-27 | 1994-06-01 | Searle & Co | Renal-selective prodrugs for the treatment of hypertension |
IL96507A0 (en) | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
EP0556393B1 (en) | 1990-11-06 | 2000-07-26 | Yamanouchi Pharmaceutical Co. Ltd. | Fused pyrazine derivative |
JP2753911B2 (ja) | 1991-12-06 | 1998-05-20 | キッセイ薬品工業株式会社 | N−tert−ブチル−1−メチル−3,3−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法 |
DE4217952A1 (de) | 1992-05-30 | 1993-12-02 | Basf Ag | Chinoxalin-2,3(1H,4H)-dione |
US5248699A (en) * | 1992-08-13 | 1993-09-28 | Pfizer Inc. | Sertraline polymorph |
US5631373A (en) | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
GB9418443D0 (en) | 1994-09-13 | 1994-11-02 | Pfizer Ltd | Therapeutic agents |
GB9419318D0 (en) | 1994-09-24 | 1994-11-09 | Pfizer Ltd | Therapeutic agents |
CN1072215C (zh) | 1995-02-22 | 2001-10-03 | 赫彻斯特药品和化学品公司 | 无定形吡咯他尼、吡咯他尼多晶型物,其制备方法和用途 |
SK283990B6 (sk) * | 1996-07-11 | 2004-07-07 | Novartis Ag | Spôsob prípravy 1-substituovaných 4-kyano-1,2,3-triazolov, 4-kyano-1-(2,6-difluórbenzyl)-1H-1,2,3-triazol |
TW403740B (en) | 1997-06-10 | 2000-09-01 | Novartis Ag | Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide |
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1998
- 1998-06-04 TW TW087108859A patent/TW403740B/zh not_active IP Right Cessation
- 1998-06-04 TW TW087108858A patent/TW526195B/zh not_active IP Right Cessation
- 1998-06-08 ES ES98934929T patent/ES2192779T3/es not_active Expired - Lifetime
- 1998-06-08 CZ CZ19982533A patent/CZ292481B6/cs not_active IP Right Cessation
- 1998-06-08 IL IL12573298A patent/IL125732A/en not_active IP Right Cessation
- 1998-06-08 HU HU0002113A patent/HU225153B1/hu unknown
- 1998-06-08 JP JP53628898A patent/JP3672574B2/ja not_active Expired - Lifetime
- 1998-06-08 DE DE69813560T patent/DE69813560T2/de not_active Expired - Lifetime
- 1998-06-08 PL PL330764A patent/PL191943B1/pl unknown
- 1998-06-08 PL PL330798A patent/PL192114B1/pl unknown
- 1998-06-08 IL IL12573398A patent/IL125733A/en active Protection Beyond IP Right Term
- 1998-06-08 DE DE122007000051C patent/DE122007000051I2/de active Active
- 1998-06-08 KR KR10-1998-0708149A patent/KR100409168B1/ko not_active IP Right Cessation
- 1998-06-08 CA CA002256013A patent/CA2256013C/en not_active Expired - Lifetime
- 1998-06-08 JP JP53628998A patent/JP3672575B2/ja not_active Expired - Lifetime
- 1998-06-08 ES ES98934930T patent/ES2197485T3/es not_active Expired - Lifetime
- 1998-06-08 AT AT98934930T patent/ATE237599T1/de active
- 1998-06-08 SK SK1093-98A patent/SK283685B6/sk not_active IP Right Cessation
- 1998-06-08 ID IDW980065D patent/ID27660A/id unknown
- 1998-06-08 NZ NZ331371A patent/NZ331371A/xx not_active IP Right Cessation
- 1998-06-08 DK DK98934930T patent/DK0994864T3/da active
- 1998-06-08 SI SI9830405T patent/SI0994863T1/xx unknown
- 1998-06-08 AU AU84371/98A patent/AU725528B2/en not_active Expired
- 1998-06-08 DK DK98934929T patent/DK0994863T3/da active
- 1998-06-08 BR BR9804947A patent/BR9804947A/pt not_active Application Discontinuation
- 1998-06-08 PE PE1998000478A patent/PE79799A1/es not_active IP Right Cessation
- 1998-06-08 ID IDW980066D patent/ID21014A/id unknown
- 1998-06-08 US US09/125,329 patent/US6740669B1/en not_active Expired - Lifetime
- 1998-06-08 RU RU99104300/04A patent/RU2198167C2/ru active
- 1998-06-08 KR KR10-1998-0708150A patent/KR100425656B1/ko not_active IP Right Cessation
- 1998-06-08 CN CN988000113A patent/CN1132820C/zh not_active Expired - Lifetime
- 1998-06-08 AT AT98934929T patent/ATE232852T1/de active
- 1998-06-08 PT PT98934930T patent/PT994864E/pt unknown
- 1998-06-08 CZ CZ19982534A patent/CZ292260B6/cs not_active IP Right Cessation
- 1998-06-08 TR TR1998/01631T patent/TR199801631T1/xx unknown
- 1998-06-08 WO PCT/EP1998/003427 patent/WO1998056772A1/en active IP Right Grant
- 1998-06-08 HU HU0000798A patent/HU226107B1/hu unknown
- 1998-06-08 EP EP98934930A patent/EP0994864B1/en not_active Expired - Lifetime
- 1998-06-08 CA CA002256015A patent/CA2256015C/en not_active Expired - Lifetime
- 1998-06-08 CA CA2614926A patent/CA2614926C/en not_active Expired - Lifetime
- 1998-06-08 TR TR1998/01630T patent/TR199801630T1/xx unknown
- 1998-06-08 RU RU99104299/04A patent/RU2194041C2/ru active
- 1998-06-08 SK SK1094-98A patent/SK283734B6/sk not_active IP Right Cessation
- 1998-06-08 CN CNB988056755A patent/CN1159300C/zh not_active Expired - Lifetime
- 1998-06-08 SI SI9830450T patent/SI0994864T1/xx unknown
- 1998-06-08 WO PCT/EP1998/003428 patent/WO1998056773A1/en active IP Right Grant
- 1998-06-08 CN CNB2004100473675A patent/CN1298708C/zh not_active Expired - Lifetime
- 1998-06-08 AU AU84372/98A patent/AU725517B2/en not_active Expired
- 1998-06-08 BR BR9804946A patent/BR9804946A/pt not_active Application Discontinuation
- 1998-06-08 NZ NZ331370A patent/NZ331370A/xx not_active IP Right Cessation
- 1998-06-08 EP EP98934929A patent/EP0994863B1/en not_active Expired - Lifetime
- 1998-06-08 PE PE1998000479A patent/PE80999A1/es not_active IP Right Cessation
- 1998-06-08 DE DE69811500T patent/DE69811500T2/de not_active Expired - Lifetime
- 1998-06-09 ZA ZA984967A patent/ZA984967B/xx unknown
- 1998-06-09 MY MYPI98002572A patent/MY125854A/en unknown
- 1998-06-09 AR ARP980102708A patent/AR012946A1/es not_active Application Discontinuation
- 1998-06-09 ZA ZA984966A patent/ZA984966B/xx unknown
- 1998-06-09 CO CO98032879A patent/CO4940452A1/es unknown
- 1998-06-09 CO CO98032885A patent/CO4940448A1/es unknown
- 1998-06-09 MY MYPI98002570A patent/MY120156A/en unknown
- 1998-06-09 AR ARP980102707A patent/AR012945A1/es not_active Application Discontinuation
- 1998-08-11 NO NO19983666A patent/NO329314B1/no not_active IP Right Cessation
- 1998-08-11 NO NO19983667A patent/NO329315B1/no not_active IP Right Cessation
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1999
- 1999-12-10 UY UY25844A patent/UY25844A1/es not_active Application Discontinuation
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2000
- 2000-10-25 HK HK00106807A patent/HK1028242A1/xx not_active IP Right Cessation
- 2000-10-25 HK HK00106804A patent/HK1028241A1/xx not_active IP Right Cessation
- 2000-11-17 HK HK00107340A patent/HK1028031A1/xx not_active IP Right Cessation
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2001
- 2001-05-31 US US09/871,366 patent/US6455556B2/en not_active Expired - Lifetime
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2002
- 2002-11-14 US US10/294,408 patent/US20030125568A1/en not_active Abandoned
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2004
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2006
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2007
- 2007-05-17 AR ARP070102132A patent/AR061005A2/es not_active Application Discontinuation
- 2007-05-17 AR ARP070102131A patent/AR061004A2/es unknown
- 2007-07-03 NL NL300284C patent/NL300284I2/nl unknown
- 2007-07-04 LU LU91345C patent/LU91345I2/fr unknown
- 2007-07-06 FR FR07C0037C patent/FR07C0037I2/fr active Active
- 2007-07-13 CY CY200700014C patent/CY2007014I1/el unknown
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2010
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