LU91345I2 - Rufinamide et ses sels pharmaceutiquement acceptables (inovelon) - Google Patents

Rufinamide et ses sels pharmaceutiquement acceptables (inovelon)

Info

Publication number: LU91345I2
Authority: LU; Luxembourg
Prior art keywords: inovelon; rufinamide; pharmaceutically acceptable; acceptable salts; salts
Prior art date: 1997-06-10

Application number

LU91345C

Other languages

English (en)

Other versions

LU91345I9 (fr

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-10

Filing date

2007-07-04

Publication date

2007-09-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU91345(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-07-04 Application filed by Novartis Ag filed Critical Novartis Ag

2007-09-04 Publication of LU91345I2 publication Critical patent/LU91345I2/fr

2018-12-31 Publication of LU91345I9 publication Critical patent/LU91345I9/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

LU91345C 1997-06-10 2007-07-04 Rufinamide et ses sels pharmaceutiquement acceptables (inovelon) LU91345I2 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH140497		1997-06-10
PCT/EP1998/003427 WO1998056772A1 (fr)	1997-06-10	1998-06-08	Modification cristalline de 1-(2,6-difluorobenzyle)-1h-1,2,3-triazole-4-carboxamide et son utilisation en tant qu'anti-epileptique

Publications (2)

Publication Number	Publication Date
LU91345I2 true LU91345I2 (fr)	2007-09-04
LU91345I9 LU91345I9 (fr)	2018-12-31

Family

ID=4209650

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU91345C LU91345I2 (fr)	1997-06-10	2007-07-04	Rufinamide et ses sels pharmaceutiquement acceptables (inovelon)

Country Status (37)

Country	Link
US (6)	US6740669B1 (fr)
EP (2)	EP0994864B1 (fr)
JP (2)	JP3672574B2 (fr)
KR (2)	KR100409168B1 (fr)
CN (3)	CN1132820C (fr)
AR (4)	AR012946A1 (fr)
AT (2)	ATE237599T1 (fr)
AU (2)	AU725528B2 (fr)
BR (2)	BR9804947A (fr)
CA (3)	CA2256013C (fr)
CO (2)	CO4940452A1 (fr)
CY (1)	CY2007014I1 (fr)
CZ (2)	CZ292481B6 (fr)
DE (3)	DE69813560T2 (fr)
DK (2)	DK0994864T3 (fr)
ES (2)	ES2192779T3 (fr)
FR (1)	FR07C0037I2 (fr)
HK (3)	HK1028242A1 (fr)
HU (2)	HU225153B1 (fr)
ID (2)	ID27660A (fr)
IL (2)	IL125732A (fr)
LU (1)	LU91345I2 (fr)
MY (2)	MY125854A (fr)
NL (1)	NL300284I2 (fr)
NO (2)	NO329314B1 (fr)
NZ (2)	NZ331371A (fr)
PE (2)	PE79799A1 (fr)
PL (2)	PL191943B1 (fr)
PT (1)	PT994864E (fr)
RU (2)	RU2198167C2 (fr)
SI (2)	SI0994863T1 (fr)
SK (2)	SK283685B6 (fr)
TR (2)	TR199801631T1 (fr)
TW (2)	TW403740B (fr)
UY (1)	UY25844A1 (fr)
WO (2)	WO1998056772A1 (fr)
ZA (2)	ZA984967B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW403740B (en) *	1997-06-10	2000-09-01	Novartis Ag	Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
AR040233A1 (es) *	2002-05-31	2005-03-23	Schering Corp	Polimorfos inhibidores de xantina fosfodiesterasa v
GB0507298D0 (en)	2005-04-11	2005-05-18	Novartis Ag	Organic compounds
US7875284B2 (en) *	2006-03-10	2011-01-25	Cook Incorporated	Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) *	2007-09-12	2009-03-12	Protia, Llc	Deuterium-enriched rufinamide
US8183269B2 (en)	2008-10-13	2012-05-22	Cipla Limited	Process for the preparation of rufinamide
CN101768124B (zh) *	2008-12-30	2012-01-04	北京本草天源药物研究院	一种药物晶体及其制备方法和用途
IT1395736B1 (it) *	2009-08-04	2012-10-19	Dipharma Francis Srl	Forme cristalline di rufinamide
AU2010290049B2 (en) *	2009-09-04	2013-09-19	Tactical Therapeutics, Inc	Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations
EP2465853A1 (fr) *	2010-12-14	2012-06-20	Laboratorios Lesvi, S.L.	Polymorphe de rufinamide et son procédé d'obtention
ES2498267T3 (es) *	2010-04-30	2014-09-24	Laboratorios Lesvi, S.L.	Procedimiento mejorado para la preparación de un intermedio de rufinamida
ITMI20110718A1 (it) *	2011-04-29	2012-10-30	Dipharma Francis Srl	Procedimento per la purificazione di rufinamide
WO2014013511A2 (fr) *	2012-07-20	2014-01-23	Hetero Research Foundation	Dispersion solide de rufinamide
WO2021099481A1 (fr)	2019-11-20	2021-05-27	Medichem, S.A.	Composition solide contenant du rufinamide

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3992378A (en)	1973-12-26	1976-11-16	Eli Lilly And Company	Fluoralkyl quinoxadinediones
US4156734A (en) *	1976-02-13	1979-05-29	Merck & Co., Inc.	Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en)	1976-10-18	1978-05-17	Ici America Inc	Triazole derivatives
US4536518A (en) *	1979-11-01	1985-08-20	Pfizer Inc.	Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) *	1980-09-30	1982-08-24	Warner-Lambert Company	Method for treating convulsions with pyrazole-4-carboxamide derivatives
FI834666A (fi)	1982-12-23	1984-06-24	Ciba Geigy Ag	Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
US4789680A (en) *	1982-12-23	1988-12-06	Ciba-Geigy Corporation	Aralkyltriazole compounds
US4511572A (en) *	1983-03-18	1985-04-16	The University Of Kentucky Research Foundation	Triazoline anticonvulsant drugs
FI93544C (fi) *	1985-04-18	1995-04-25	Ciba Geigy Ag	Menetelmä fluorattujen, antikonvulsiivisesti vaikuttavien 1-bentsyyli-1H-1,2,3-triatsoliyhdisteiden valmistamiseksi
CA2002864C (fr)	1988-11-29	1999-11-16	Eddy J. E. Freyne	Derives de quinoline, quinazoline ou quinoxaline (1h-azol-1-ylmethyl) substitues
JPH02214504A (ja)	1989-02-15	1990-08-27	Nissan Chem Ind Ltd	光学活性キノキサリン化合物の晶析法
EP0484437A4 (en)	1989-07-27	1994-06-01	Searle & Co	Renal-selective prodrugs for the treatment of hypertension
IL96507A0 (en)	1989-12-08	1991-08-16	Merck & Co Inc	Nitrogen-containing spirocycles and pharmaceutical compositions containing them
EP0556393B1 (fr)	1990-11-06	2000-07-26	Yamanouchi Pharmaceutical Co. Ltd.	Derive de pyrazine fusionnee
JP2753911B2 (ja)	1991-12-06	1998-05-20	キッセイ薬品工業株式会社	Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de)	1992-05-30	1993-12-02	Basf Ag	Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) *	1992-08-13	1993-09-28	Pfizer Inc.	Sertraline polymorph
US5631373A (en)	1993-11-05	1997-05-20	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon	Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en)	1994-09-13	1994-11-02	Pfizer Ltd	Therapeutic agents
GB9419318D0 (en)	1994-09-24	1994-11-09	Pfizer Ltd	Therapeutic agents
CN1072215C (zh)	1995-02-22	2001-10-03	赫彻斯特药品和化学品公司	无定形吡咯他尼、吡咯他尼多晶型物,其制备方法和用途
SK283990B6 (sk) *	1996-07-11	2004-07-07	Novartis Ag	Spôsob prípravy 1-substituovaných 4-kyano-1,2,3-triazolov, 4-kyano-1-(2,6-difluórbenzyl)-1H-1,2,3-triazol
TW403740B (en)	1997-06-10	2000-09-01	Novartis Ag	Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide

1998
- 1998-06-04 TW TW087108859A patent/TW403740B/zh not_active IP Right Cessation
- 1998-06-04 TW TW087108858A patent/TW526195B/zh not_active IP Right Cessation
- 1998-06-08 ES ES98934929T patent/ES2192779T3/es not_active Expired - Lifetime
- 1998-06-08 CZ CZ19982533A patent/CZ292481B6/cs not_active IP Right Cessation
- 1998-06-08 IL IL12573298A patent/IL125732A/en not_active IP Right Cessation
- 1998-06-08 HU HU0002113A patent/HU225153B1/hu unknown
- 1998-06-08 JP JP53628898A patent/JP3672574B2/ja not_active Expired - Lifetime
- 1998-06-08 DE DE69813560T patent/DE69813560T2/de not_active Expired - Lifetime
- 1998-06-08 PL PL330764A patent/PL191943B1/pl unknown
- 1998-06-08 PL PL330798A patent/PL192114B1/pl unknown
- 1998-06-08 IL IL12573398A patent/IL125733A/en active Protection Beyond IP Right Term
- 1998-06-08 DE DE122007000051C patent/DE122007000051I2/de active Active
- 1998-06-08 KR KR10-1998-0708149A patent/KR100409168B1/ko not_active IP Right Cessation
- 1998-06-08 CA CA002256013A patent/CA2256013C/fr not_active Expired - Lifetime
- 1998-06-08 JP JP53628998A patent/JP3672575B2/ja not_active Expired - Lifetime
- 1998-06-08 ES ES98934930T patent/ES2197485T3/es not_active Expired - Lifetime
- 1998-06-08 AT AT98934930T patent/ATE237599T1/de active
- 1998-06-08 SK SK1093-98A patent/SK283685B6/sk not_active IP Right Cessation
- 1998-06-08 ID IDW980065D patent/ID27660A/id unknown
- 1998-06-08 NZ NZ331371A patent/NZ331371A/xx not_active IP Right Cessation
- 1998-06-08 DK DK98934930T patent/DK0994864T3/da active
- 1998-06-08 SI SI9830405T patent/SI0994863T1/xx unknown
- 1998-06-08 AU AU84371/98A patent/AU725528B2/en not_active Expired
- 1998-06-08 DK DK98934929T patent/DK0994863T3/da active
- 1998-06-08 BR BR9804947A patent/BR9804947A/pt not_active Application Discontinuation
- 1998-06-08 PE PE1998000478A patent/PE79799A1/es not_active IP Right Cessation
- 1998-06-08 ID IDW980066D patent/ID21014A/id unknown
- 1998-06-08 US US09/125,329 patent/US6740669B1/en not_active Expired - Lifetime
- 1998-06-08 RU RU99104300/04A patent/RU2198167C2/ru active
- 1998-06-08 KR KR10-1998-0708150A patent/KR100425656B1/ko not_active IP Right Cessation
- 1998-06-08 CN CN988000113A patent/CN1132820C/zh not_active Expired - Lifetime
- 1998-06-08 AT AT98934929T patent/ATE232852T1/de active
- 1998-06-08 PT PT98934930T patent/PT994864E/pt unknown
- 1998-06-08 CZ CZ19982534A patent/CZ292260B6/cs not_active IP Right Cessation
- 1998-06-08 TR TR1998/01631T patent/TR199801631T1/xx unknown
- 1998-06-08 WO PCT/EP1998/003427 patent/WO1998056772A1/fr active IP Right Grant
- 1998-06-08 HU HU0000798A patent/HU226107B1/hu unknown
- 1998-06-08 EP EP98934930A patent/EP0994864B1/fr not_active Expired - Lifetime
- 1998-06-08 CA CA002256015A patent/CA2256015C/fr not_active Expired - Lifetime
- 1998-06-08 CA CA2614926A patent/CA2614926C/fr not_active Expired - Lifetime
- 1998-06-08 TR TR1998/01630T patent/TR199801630T1/xx unknown
- 1998-06-08 RU RU99104299/04A patent/RU2194041C2/ru active
- 1998-06-08 SK SK1094-98A patent/SK283734B6/sk not_active IP Right Cessation
- 1998-06-08 CN CNB988056755A patent/CN1159300C/zh not_active Expired - Lifetime
- 1998-06-08 SI SI9830450T patent/SI0994864T1/xx unknown
- 1998-06-08 WO PCT/EP1998/003428 patent/WO1998056773A1/fr active IP Right Grant
- 1998-06-08 CN CNB2004100473675A patent/CN1298708C/zh not_active Expired - Lifetime
- 1998-06-08 AU AU84372/98A patent/AU725517B2/en not_active Expired
- 1998-06-08 BR BR9804946A patent/BR9804946A/pt not_active Application Discontinuation
- 1998-06-08 NZ NZ331370A patent/NZ331370A/xx not_active IP Right Cessation
- 1998-06-08 EP EP98934929A patent/EP0994863B1/fr not_active Expired - Lifetime
- 1998-06-08 PE PE1998000479A patent/PE80999A1/es not_active IP Right Cessation
- 1998-06-08 DE DE69811500T patent/DE69811500T2/de not_active Expired - Lifetime
- 1998-06-09 ZA ZA984967A patent/ZA984967B/xx unknown
- 1998-06-09 MY MYPI98002572A patent/MY125854A/en unknown
- 1998-06-09 AR ARP980102708A patent/AR012946A1/es not_active Application Discontinuation
- 1998-06-09 ZA ZA984966A patent/ZA984966B/xx unknown
- 1998-06-09 CO CO98032879A patent/CO4940452A1/es unknown
- 1998-06-09 CO CO98032885A patent/CO4940448A1/es unknown
- 1998-06-09 MY MYPI98002570A patent/MY120156A/en unknown
- 1998-06-09 AR ARP980102707A patent/AR012945A1/es not_active Application Discontinuation
- 1998-08-11 NO NO19983666A patent/NO329314B1/no not_active IP Right Cessation
- 1998-08-11 NO NO19983667A patent/NO329315B1/no not_active IP Right Cessation
1999
- 1999-12-10 UY UY25844A patent/UY25844A1/es not_active Application Discontinuation
2000
- 2000-10-25 HK HK00106807A patent/HK1028242A1/xx not_active IP Right Cessation
- 2000-10-25 HK HK00106804A patent/HK1028241A1/xx not_active IP Right Cessation
- 2000-11-17 HK HK00107340A patent/HK1028031A1/xx not_active IP Right Cessation
2001
- 2001-05-31 US US09/871,366 patent/US6455556B2/en not_active Expired - Lifetime
2002
- 2002-11-14 US US10/294,408 patent/US20030125568A1/en not_active Abandoned
2004
- 2004-02-26 US US10/787,528 patent/US20040167186A1/en not_active Abandoned
2006
- 2006-01-11 US US11/329,945 patent/US7750028B2/en not_active Expired - Fee Related
2007
- 2007-05-17 AR ARP070102132A patent/AR061005A2/es not_active Application Discontinuation
- 2007-05-17 AR ARP070102131A patent/AR061004A2/es unknown
- 2007-07-03 NL NL300284C patent/NL300284I2/nl unknown
- 2007-07-04 LU LU91345C patent/LU91345I2/fr unknown
- 2007-07-06 FR FR07C0037C patent/FR07C0037I2/fr active Active
- 2007-07-13 CY CY200700014C patent/CY2007014I1/el unknown
2010
- 2010-04-26 US US12/767,003 patent/US8076362B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
TW526195B (en)	2003-04-01
KR100425656B1 (ko)	2004-05-17
PL330764A1 (en)	1999-05-24
EP0994863B1 (fr)	2003-02-19
CA2614926C (fr)	2010-02-09
AU725528B2 (en)	2000-10-12
JP2000516259A (ja)	2000-12-05
SK283734B6 (sk)	2003-12-02
WO1998056773A1 (fr)	1998-12-17
US20010037029A1 (en)	2001-11-01
AU8437198A (en)	1998-12-30
FR07C0037I1 (fr)	2007-08-17
KR19990087835A (ko)	1999-12-27
PE79799A1 (es)	1999-09-03
CY2007014I2 (el)	2009-11-04
EP0994863A1 (fr)	2000-04-26
PE80999A1 (es)	1999-09-06
NO983666L (no)	1998-12-17
CA2256013A1 (fr)	1998-12-17
LU91345I9 (fr)	2018-12-31
NO329315B1 (no)	2010-09-27
CZ253398A3 (cs)	1999-04-14
NZ331371A (en)	2000-08-25
TW403740B (en)	2000-09-01
US20100310655A1 (en)	2010-12-09
US20040167186A1 (en)	2004-08-26
NL300284I1 (nl)	2007-10-01
NO983667D0 (no)	1998-08-11
SK283685B6 (sk)	2003-12-02
CN1298708C (zh)	2007-02-07
SI0994863T1 (en)	2003-08-31
HUP0000798A2 (hu)	2000-10-30
US20060116520A1 (en)	2006-06-01
ID21014A (id)	1999-04-08
DE69813560D1 (de)	2003-05-22
CA2614926A1 (fr)	1998-12-17
TR199801631T1 (xx)	1999-06-21
CO4940452A1 (es)	2000-07-24
ES2192779T3 (es)	2003-10-16
CZ292260B6 (cs)	2003-08-13
WO1998056772A1 (fr)	1998-12-17
CO4940448A1 (es)	2000-07-24
IL125732A (en)	2002-12-01
PT994864E (pt)	2003-07-31
EP0994864A1 (fr)	2000-04-26
HUP0002113A2 (hu)	2001-02-28
CN1259127A (zh)	2000-07-05
ATE232852T1 (de)	2003-03-15
ZA984967B (en)	1999-01-11
ID27660A (id)	2001-04-19
HUP0002113A3 (en)	2002-09-30
CA2256015C (fr)	2008-06-03
CA2256013C (fr)	2007-10-16
HU226107B1 (en)	2008-04-28
US6455556B2 (en)	2002-09-24
CN1159300C (zh)	2004-07-28
PL192114B1 (pl)	2006-08-31
HK1028241A1 (en)	2001-02-09
JP3672575B2 (ja)	2005-07-20
NO329314B1 (no)	2010-09-27
UY25844A1 (es)	2001-08-27
KR19990087836A (ko)	1999-12-27
IL125733A0 (en)	1999-04-11
DK0994863T3 (da)	2003-05-26
KR100409168B1 (ko)	2004-01-31
NO983666D0 (no)	1998-08-11
CN1572789A (zh)	2005-02-02
US20030125568A1 (en)	2003-07-03
AR061005A2 (es)	2008-07-30
ZA984966B (en)	1999-01-11
CZ292481B6 (cs)	2003-09-17
RU2198167C2 (ru)	2003-02-10
ATE237599T1 (de)	2003-05-15
CA2256015A1 (fr)	1998-12-17
RU2194041C2 (ru)	2002-12-10
CY2007014I1 (el)	2009-11-04
AU8437298A (en)	1998-12-30
BR9804947A (pt)	1999-08-24
IL125733A (en)	2002-12-01
EP0994864B1 (fr)	2003-04-16
US6740669B1 (en)	2004-05-25
HUP0000798A3 (en)	2000-10-30
DE69811500D1 (de)	2003-03-27
DE69811500T2 (de)	2004-04-01
CZ253498A3 (cs)	1999-04-14
NL300284I2 (nl)	2007-11-01
BR9804946A (pt)	1999-08-24
FR07C0037I2 (fr)	2008-05-16
CN1132820C (zh)	2003-12-31
DE122007000051I2 (de)	2009-02-19
ES2197485T3 (es)	2004-01-01
HK1028242A1 (en)	2001-02-09
AU725517B2 (en)	2000-10-12
PL191943B1 (pl)	2006-07-31
AR061004A2 (es)	2008-07-30
DE69813560T2 (de)	2004-02-05
HK1028031A1 (en)	2001-02-02
JP3672574B2 (ja)	2005-07-20
IL125732A0 (en)	1999-04-11
AR012945A1 (es)	2000-11-22
NO983667L (no)	1998-12-17
SK109498A3 (en)	1998-12-02
MY120156A (en)	2005-09-30
NZ331370A (en)	2000-08-25
DK0994864T3 (da)	2003-07-21
US8076362B2 (en)	2011-12-13
US7750028B2 (en)	2010-07-06
PL330798A1 (en)	1999-06-07
AR012946A1 (es)	2000-11-22
HU225153B1 (en)	2006-07-28
JP2000516258A (ja)	2000-12-05
DE122007000051I1 (de)	2007-11-08
SI0994864T1 (en)	2003-10-31
TR199801630T1 (xx)	1999-06-21
MY125854A (en)	2006-08-30
CN1217716A (zh)	1999-05-26
SK109398A3 (en)	1998-12-02

Publication	Publication Date	Title
LU91345I2 (fr)	2007-09-04	Rufinamide et ses sels pharmaceutiquement acceptables (inovelon)
LU91291I2 (fr)	2007-01-29	Deferasirox et ses sels pharmaceutiquement acceptables (EXJADEr)
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