HUP0000798A2 - 1-(2,6-Difluor-benzil)-1H-1,2,3-triazol-4-karboxamid új kristálymódosulatai és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

1-(2,6-Difluor-benzil)-1H-1,2,3-triazol-4-karboxamid új kristálymódosulatai és az ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0000798A2
HUP0000798A2 HU0000798A HUP0000798A HUP0000798A2 HU P0000798 A2 HUP0000798 A2 HU P0000798A2 HU 0000798 A HU0000798 A HU 0000798A HU P0000798 A HUP0000798 A HU P0000798A HU P0000798 A2 HUP0000798 A2 HU P0000798A2
Authority
HU
Hungary
Prior art keywords
difluorobenzyl
carboxamide
triazole
pharmaceutical compositions
compositions containing
Prior art date
Application number
HU0000798A
Other languages
English (en)
Inventor
Andreas Burkhard
Urs Christoph Hofmeier
Robert Portmann
Walter Scherrer
Martin Szelagiewicz
Original Assignee
Novartis Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0000798(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag. filed Critical Novartis Ag.
Publication of HUP0000798A2 publication Critical patent/HUP0000798A2/hu
Publication of HUP0000798A3 publication Critical patent/HUP0000798A3/hu
Publication of HU226107B1 publication Critical patent/HU226107B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU0000798A 1997-06-10 1998-06-08 New crystal modifications of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and pharmaceutical compositions containing them HU226107B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10
PCT/EP1998/003427 WO1998056772A1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3--triazole-4-carboxamide and its use as antiepileptic

Publications (3)

Publication Number Publication Date
HUP0000798A2 true HUP0000798A2 (hu) 2000-10-30
HUP0000798A3 HUP0000798A3 (en) 2000-10-30
HU226107B1 HU226107B1 (en) 2008-04-28

Family

ID=4209650

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0002113A HU225153B1 (en) 1997-06-10 1998-06-08 Crystal modifications of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide, their use and pharmaceutical compositions containing them
HU0000798A HU226107B1 (en) 1997-06-10 1998-06-08 New crystal modifications of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and pharmaceutical compositions containing them

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU0002113A HU225153B1 (en) 1997-06-10 1998-06-08 Crystal modifications of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide, their use and pharmaceutical compositions containing them

Country Status (37)

Country Link
US (6) US6740669B1 (hu)
EP (2) EP0994864B1 (hu)
JP (2) JP3672574B2 (hu)
KR (2) KR100409168B1 (hu)
CN (3) CN1132820C (hu)
AR (4) AR012946A1 (hu)
AT (2) ATE237599T1 (hu)
AU (2) AU725528B2 (hu)
BR (2) BR9804947A (hu)
CA (3) CA2256013C (hu)
CO (2) CO4940452A1 (hu)
CY (1) CY2007014I1 (hu)
CZ (2) CZ292481B6 (hu)
DE (3) DE69813560T2 (hu)
DK (2) DK0994864T3 (hu)
ES (2) ES2192779T3 (hu)
FR (1) FR07C0037I2 (hu)
HK (3) HK1028242A1 (hu)
HU (2) HU225153B1 (hu)
ID (2) ID27660A (hu)
IL (2) IL125732A (hu)
LU (1) LU91345I2 (hu)
MY (2) MY125854A (hu)
NL (1) NL300284I2 (hu)
NO (2) NO329314B1 (hu)
NZ (2) NZ331371A (hu)
PE (2) PE79799A1 (hu)
PL (2) PL191943B1 (hu)
PT (1) PT994864E (hu)
RU (2) RU2198167C2 (hu)
SI (2) SI0994863T1 (hu)
SK (2) SK283685B6 (hu)
TR (2) TR199801631T1 (hu)
TW (2) TW403740B (hu)
UY (1) UY25844A1 (hu)
WO (2) WO1998056772A1 (hu)
ZA (2) ZA984967B (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW403740B (en) * 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
AR040233A1 (es) * 2002-05-31 2005-03-23 Schering Corp Polimorfos inhibidores de xantina fosfodiesterasa v
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
US8183269B2 (en) 2008-10-13 2012-05-22 Cipla Limited Process for the preparation of rufinamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) * 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
AU2010290049B2 (en) * 2009-09-04 2013-09-19 Tactical Therapeutics, Inc Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations
EP2465853A1 (en) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
ES2498267T3 (es) * 2010-04-30 2014-09-24 Laboratorios Lesvi, S.L. Procedimiento mejorado para la preparación de un intermedio de rufinamida
ITMI20110718A1 (it) * 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
WO2014013511A2 (en) * 2012-07-20 2014-01-23 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992378A (en) 1973-12-26 1976-11-16 Eli Lilly And Company Fluoralkyl quinoxadinediones
US4156734A (en) * 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
FI834666A (fi) 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
FI93544C (fi) * 1985-04-18 1995-04-25 Ciba Geigy Ag Menetelmä fluorattujen, antikonvulsiivisesti vaikuttavien 1-bentsyyli-1H-1,2,3-triatsoliyhdisteiden valmistamiseksi
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
EP0484437A4 (en) 1989-07-27 1994-06-01 Searle & Co Renal-selective prodrugs for the treatment of hypertension
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
EP0556393B1 (en) 1990-11-06 2000-07-26 Yamanouchi Pharmaceutical Co. Ltd. Fused pyrazine derivative
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) * 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
GB9419318D0 (en) 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
CN1072215C (zh) 1995-02-22 2001-10-03 赫彻斯特药品和化学品公司 无定形吡咯他尼、吡咯他尼多晶型物,其制备方法和用途
SK283990B6 (sk) * 1996-07-11 2004-07-07 Novartis Ag Spôsob prípravy 1-substituovaných 4-kyano-1,2,3-triazolov, 4-kyano-1-(2,6-difluórbenzyl)-1H-1,2,3-triazol
TW403740B (en) 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide

Also Published As

Publication number Publication date
TW526195B (en) 2003-04-01
KR100425656B1 (ko) 2004-05-17
PL330764A1 (en) 1999-05-24
EP0994863B1 (en) 2003-02-19
CA2614926C (en) 2010-02-09
AU725528B2 (en) 2000-10-12
JP2000516259A (ja) 2000-12-05
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
US20010037029A1 (en) 2001-11-01
AU8437198A (en) 1998-12-30
FR07C0037I1 (hu) 2007-08-17
KR19990087835A (ko) 1999-12-27
PE79799A1 (es) 1999-09-03
CY2007014I2 (el) 2009-11-04
EP0994863A1 (en) 2000-04-26
PE80999A1 (es) 1999-09-06
NO983666L (no) 1998-12-17
CA2256013A1 (en) 1998-12-17
LU91345I9 (hu) 2018-12-31
NO329315B1 (no) 2010-09-27
CZ253398A3 (cs) 1999-04-14
NZ331371A (en) 2000-08-25
TW403740B (en) 2000-09-01
US20100310655A1 (en) 2010-12-09
US20040167186A1 (en) 2004-08-26
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
SK283685B6 (sk) 2003-12-02
CN1298708C (zh) 2007-02-07
SI0994863T1 (en) 2003-08-31
US20060116520A1 (en) 2006-06-01
ID21014A (id) 1999-04-08
DE69813560D1 (de) 2003-05-22
CA2614926A1 (en) 1998-12-17
TR199801631T1 (xx) 1999-06-21
LU91345I2 (fr) 2007-09-04
CO4940452A1 (es) 2000-07-24
ES2192779T3 (es) 2003-10-16
CZ292260B6 (cs) 2003-08-13
WO1998056772A1 (en) 1998-12-17
CO4940448A1 (es) 2000-07-24
IL125732A (en) 2002-12-01
PT994864E (pt) 2003-07-31
EP0994864A1 (en) 2000-04-26
HUP0002113A2 (hu) 2001-02-28
CN1259127A (zh) 2000-07-05
ATE232852T1 (de) 2003-03-15
ZA984967B (en) 1999-01-11
ID27660A (id) 2001-04-19
HUP0002113A3 (en) 2002-09-30
CA2256015C (en) 2008-06-03
CA2256013C (en) 2007-10-16
HU226107B1 (en) 2008-04-28
US6455556B2 (en) 2002-09-24
CN1159300C (zh) 2004-07-28
PL192114B1 (pl) 2006-08-31
HK1028241A1 (en) 2001-02-09
JP3672575B2 (ja) 2005-07-20
NO329314B1 (no) 2010-09-27
UY25844A1 (es) 2001-08-27
KR19990087836A (ko) 1999-12-27
IL125733A0 (en) 1999-04-11
DK0994863T3 (da) 2003-05-26
KR100409168B1 (ko) 2004-01-31
NO983666D0 (no) 1998-08-11
CN1572789A (zh) 2005-02-02
US20030125568A1 (en) 2003-07-03
AR061005A2 (es) 2008-07-30
ZA984966B (en) 1999-01-11
CZ292481B6 (cs) 2003-09-17
RU2198167C2 (ru) 2003-02-10
ATE237599T1 (de) 2003-05-15
CA2256015A1 (en) 1998-12-17
RU2194041C2 (ru) 2002-12-10
CY2007014I1 (el) 2009-11-04
AU8437298A (en) 1998-12-30
BR9804947A (pt) 1999-08-24
IL125733A (en) 2002-12-01
EP0994864B1 (en) 2003-04-16
US6740669B1 (en) 2004-05-25
HUP0000798A3 (en) 2000-10-30
DE69811500D1 (de) 2003-03-27
DE69811500T2 (de) 2004-04-01
CZ253498A3 (cs) 1999-04-14
NL300284I2 (nl) 2007-11-01
BR9804946A (pt) 1999-08-24
FR07C0037I2 (hu) 2008-05-16
CN1132820C (zh) 2003-12-31
DE122007000051I2 (de) 2009-02-19
ES2197485T3 (es) 2004-01-01
HK1028242A1 (en) 2001-02-09
AU725517B2 (en) 2000-10-12
PL191943B1 (pl) 2006-07-31
AR061004A2 (es) 2008-07-30
DE69813560T2 (de) 2004-02-05
HK1028031A1 (en) 2001-02-02
JP3672574B2 (ja) 2005-07-20
IL125732A0 (en) 1999-04-11
AR012945A1 (es) 2000-11-22
NO983667L (no) 1998-12-17
SK109498A3 (en) 1998-12-02
MY120156A (en) 2005-09-30
NZ331370A (en) 2000-08-25
DK0994864T3 (da) 2003-07-21
US8076362B2 (en) 2011-12-13
US7750028B2 (en) 2010-07-06
PL330798A1 (en) 1999-06-07
AR012946A1 (es) 2000-11-22
HU225153B1 (en) 2006-07-28
JP2000516258A (ja) 2000-12-05
DE122007000051I1 (de) 2007-11-08
SI0994864T1 (en) 2003-10-31
TR199801630T1 (xx) 1999-06-21
MY125854A (en) 2006-08-30
CN1217716A (zh) 1999-05-26
SK109398A3 (en) 1998-12-02

Similar Documents

Publication Publication Date Title
IL114622A (en) 5-membered heteroaryl-oxazolidinones and pharmaceutical compositions containing them
HUP0101999A3 (en) 4-hydroxyquinoline-3-carboxamides and hydrazides use of them and pharmaceutical compositions containing them
NL300284I1 (nl) Kristalmodificatie van 1-(2,6-difluorbenzyl)1H-1,2,3-triazool-4-carboxamide en de toepassing daarvanals anti-epilepticum.
EP0871444A4 (en) 2.5 SUBSTITUTED ARYL PYRROL, THE COMPOSITIONS THAT CONTAIN AND THE USE THEREOF
HUP9900964A3 (en) Protease inhibitors and pharmaceutical compositions containing these compounds
IL111785A0 (en) Dp-iv inhibitors and pharmaceutical compositions containing them
HUP0002686A3 (en) Guanidine mimics as factor xa inhibitors and pharmaceutical compositions containing the same
HUP9601328A2 (en) 4-(aryl-amino-methylene)-2,4-dihydro-pyrazol-3-one derivatives and pharmaceutical compositions containing them
HUP0001541A3 (en) Phthalazinone derivatives and pharmaceutical compositions containing them
AP9701160A0 (en) Compounds and pharmaceutical compositions containing them
IL115771A (en) Apolipoprotein-B synthesis inhibitors their preparation and pharmaceutical compositions containing them
PL330864A1 (en) Orally administered composition containing antimycotic compounds of triazole
ZA961779B (en) Aromatic heterocyclic compounds pharmaceutical and cosmetic compositions containing them and uses thereof
HUP0001858A3 (en) Bi-aromatic compounds and pharmaceutical and cosmetic compositions containing same and the use of the compounds
HUP0003330A3 (en) Pharmaceutical compositions containing tizoxanide and nitazoxanide
HUP0003710A3 (en) 2-{3-[4-(2-t-butyl-6-trifluoromethylpyridin-4-yl)piperazin-1-yl]propylmercapto}pyrimidin-4-ol-fumarate and pharmaceutical composition containing this compound
IL123424A0 (en) Heterocyclic compounds their preparation and pharmaceutical compositions containing them
HUP9900863A3 (en) 4,4-(disubstituted)cyclohexan-1-ol derivatives pharmaceutical compositions containing these compounds and use thereof
IL110810A0 (en) 1,5-diphenyl-3-(n-hydroxycarbamoyloxyalkyl) pyrazoles and pharmaceutical compositions containing them
TH9801002100B (th) รูปแบบโครงสร้างผลึกดัดแปลงของ 1-(2,6-ไดฟลูออโรเบนซิล)-1h-1,2,3-ไตรอาโซล-4-คาร์บอกซาไมด์
IL115853A (en) Aryloxycycloalkenyl and aryloxyiminocyclo-alkenylhydroxyureas and pharmaceutical compositions containing these compounds
HUP9902989A3 (en) 1-phenylpyrazole compounds and pharmaceutical compositions containing them
IL114619A0 (en) 7-Substituted 1-(4-(1H-1,2,4-triazol-1-yl-methyl)phenyl) substituted quinolonecarboxylic acids their preparation and pharmaceutical compositions containing them
NZ306439A (en) 1-(2-(substituted phenyl)-2-hydroxy-ethyl) substituted imidazolyl or 1,2,4-triazolyl derivatives and antimycotic medicaments
HU0400448D0 (en) Antifungal agents and pharmaceutical compositions containing them