PE20230779A1 - Profarmacos de analogos de nucleotidos de fosfonamida y su uso farmaceutico - Google Patents

Profarmacos de analogos de nucleotidos de fosfonamida y su uso farmaceutico

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Publication number
PE20230779A1
PE20230779A1 PE2023000221A PE2023000221A PE20230779A1 PE 20230779 A1 PE20230779 A1 PE 20230779A1 PE 2023000221 A PE2023000221 A PE 2023000221A PE 2023000221 A PE2023000221 A PE 2023000221A PE 20230779 A1 PE20230779 A1 PE 20230779A1
Authority
PE
Peru
Prior art keywords
bis
phosphonamide
prodrugs
purin
phosphoryl
Prior art date
Application number
PE2023000221A
Other languages
English (en)
Inventor
Daniel H Byun
Byoung-Kwon Chun
Michael O Clarke
Petr Jansa
Devan Naduthambi
Neil H Squires
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of PE20230779A1 publication Critical patent/PE20230779A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/36—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE A COMPUESTOS ANALOGOS DE NUCLEOTIDOS DE FOSFONAMIDA DE FORMULA (I) DONDE R1, R2, R3, R4, R5, R6 Y EL ANILLO B SON TAL COMO SE DESCRIBEN EN EL PRESENTE DOCUMENTO. SON COMPUESTOS PREFERIDOS: BIS(3,3-DIMETILBUTIL) 2,2'-(((((1-(6-AMINO-9H-PURIN-9-IL)PROPAN-2-IL)OXI)METIL)FOSFORIL)BIS(AZANODIIL))(R)-BIS(2-METILPROPANOATO); 2,2'-(((((1-(6-AMINO-9H-PURIN-9-IL)PROPAN-2-IL)OXI)METIL)FOSFORIL)BIS(AZANODIIL))(R)-BIS(2-METILPROPANOATO) DE DI-TERC-BUTILO; 2,2'-((((((R)-1-(6-AMINO-9H-PURIN-9-IL)PROPAN-2-IL)OXI)METIL)FOSFORIL)BIS(AZANODIIL))(2S,2'S)-BIS(2-METILBUTANOATO) DE DIHEXILO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON PROFARMACOS DEL INHIBIDOR DE LA TRANSCRIPTASA INVERSA TENOFOVIR SIENDO UTILES EN EL TRATAMIENTO DE LA INFECCION POR EL VIRUS DE INMUNODEFICIENCIA HUMANA (VIH).
PE2023000221A 2020-08-07 2021-08-05 Profarmacos de analogos de nucleotidos de fosfonamida y su uso farmaceutico PE20230779A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063062899P 2020-08-07 2020-08-07
PCT/US2021/044615 WO2022031894A1 (en) 2020-08-07 2021-08-05 Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use

Publications (1)

Publication Number Publication Date
PE20230779A1 true PE20230779A1 (es) 2023-05-09

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ID=77519827

Family Applications (1)

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PE2023000221A PE20230779A1 (es) 2020-08-07 2021-08-05 Profarmacos de analogos de nucleotidos de fosfonamida y su uso farmaceutico

Country Status (17)

Country Link
US (2) US20220119426A1 (es)
EP (1) EP4192474A1 (es)
JP (1) JP2023536663A (es)
KR (1) KR20230048118A (es)
CN (1) CN116194144A (es)
AU (1) AU2021320236A1 (es)
BR (1) BR112023002164A2 (es)
CA (1) CA3186054A1 (es)
CL (1) CL2023000383A1 (es)
CO (1) CO2023001308A2 (es)
CR (1) CR20230071A (es)
DO (1) DOP2023000026A (es)
IL (1) IL299980A (es)
MX (1) MX2023001507A (es)
PE (1) PE20230779A1 (es)
TW (1) TW202220671A (es)
WO (1) WO2022031894A1 (es)

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WO2024076915A1 (en) 2022-10-04 2024-04-11 Gilead Sciences, Inc. 4'-thionucleoside analogues and their pharmaceutical use

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