BR112023002164A2 - Profármacos de análogos de nucleotídeos de fosfonamida e seu uso farmacêutico - Google Patents

Profármacos de análogos de nucleotídeos de fosfonamida e seu uso farmacêutico

Info

Publication number
BR112023002164A2
BR112023002164A2 BR112023002164A BR112023002164A BR112023002164A2 BR 112023002164 A2 BR112023002164 A2 BR 112023002164A2 BR 112023002164 A BR112023002164 A BR 112023002164A BR 112023002164 A BR112023002164 A BR 112023002164A BR 112023002164 A2 BR112023002164 A2 BR 112023002164A2
Authority
BR
Brazil
Prior art keywords
phosphonamide
pharmaceutical use
nucleotide analog
prodrugs
analog prodrugs
Prior art date
Application number
BR112023002164A
Other languages
English (en)
Inventor
H Byun Daniel
Chun Byoung-Kwon
O Clarke Michael
Jansa Petr
Naduthambi Devan
H Squires Neil
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of BR112023002164A2 publication Critical patent/BR112023002164A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/36—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROFÁRMACOS DE ANÁLOGOS DE NUCLEOTÍDEOS DE FOSFONAMIDA E SEU USO FARMACÊUTICO. A presente invenção refere-se a compostos, composições e um método úteis para o tratamento de uma infecção viral, como infecção pelo vírus da imunodeficiência humana (HIV) e/ou vírus da hepatite B. Em particular, são revelados profármacos de análogos de nucleotídeos de fosfonamida e métodos para sua preparação e seu uso como agentes terapêuticos ou profiláticos.
BR112023002164A 2020-08-07 2021-08-05 Profármacos de análogos de nucleotídeos de fosfonamida e seu uso farmacêutico BR112023002164A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063062899P 2020-08-07 2020-08-07
PCT/US2021/044615 WO2022031894A1 (en) 2020-08-07 2021-08-05 Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use

Publications (1)

Publication Number Publication Date
BR112023002164A2 true BR112023002164A2 (pt) 2023-03-14

Family

ID=77519827

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023002164A BR112023002164A2 (pt) 2020-08-07 2021-08-05 Profármacos de análogos de nucleotídeos de fosfonamida e seu uso farmacêutico

Country Status (17)

Country Link
US (2) US20220119426A1 (pt)
EP (1) EP4192474A1 (pt)
JP (1) JP2023536663A (pt)
KR (1) KR20230048118A (pt)
CN (1) CN116194144A (pt)
AU (1) AU2021320236A1 (pt)
BR (1) BR112023002164A2 (pt)
CA (1) CA3186054A1 (pt)
CL (1) CL2023000383A1 (pt)
CO (1) CO2023001308A2 (pt)
CR (1) CR20230071A (pt)
DO (1) DOP2023000026A (pt)
IL (1) IL299980A (pt)
MX (1) MX2023001507A (pt)
PE (1) PE20230779A1 (pt)
TW (1) TW202220671A (pt)
WO (1) WO2022031894A1 (pt)

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WO2024076915A1 (en) 2022-10-04 2024-04-11 Gilead Sciences, Inc. 4'-thionucleoside analogues and their pharmaceutical use

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