CR20230071A - Profármacos de análogos de nucleótidos de fosfonamida y su uso farmacéutico - Google Patents

Profármacos de análogos de nucleótidos de fosfonamida y su uso farmacéutico

Info

Publication number
CR20230071A
CR20230071A CR20230071A CR20230071A CR20230071A CR 20230071 A CR20230071 A CR 20230071A CR 20230071 A CR20230071 A CR 20230071A CR 20230071 A CR20230071 A CR 20230071A CR 20230071 A CR20230071 A CR 20230071A
Authority
CR
Costa Rica
Prior art keywords
phosphonamide
prodrugs
nucleotide analogues
pharmaceutical use
disclosed
Prior art date
Application number
CR20230071A
Other languages
English (en)
Inventor
Neil H Squires
Michael O Clarke
Byoung-Kwon Chun
Devan Naduthambi
Petr Jansa
Daniel H Byun
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of CR20230071A publication Critical patent/CR20230071A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
    • C07F9/36—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Abstract

Se describen compuestos, composiciones, y métodos útiles para tratar una infección viral, tal como la infección por el virus de inmunodeficiencia humana (VIH) y/o el virus de la hepatitis B (VHB). En particular, se describen profármacos de análogos de nucleótidos de fosfonamida y métodos para su preparación y uso como agentes terapéuticos o profilácticos.
CR20230071A 2020-08-07 2021-08-05 Profármacos de análogos de nucleótidos de fosfonamida y su uso farmacéutico CR20230071A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063062899P 2020-08-07 2020-08-07
PCT/US2021/044615 WO2022031894A1 (en) 2020-08-07 2021-08-05 Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use

Publications (1)

Publication Number Publication Date
CR20230071A true CR20230071A (es) 2023-04-11

Family

ID=77519827

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20230071A CR20230071A (es) 2020-08-07 2021-08-05 Profármacos de análogos de nucleótidos de fosfonamida y su uso farmacéutico

Country Status (17)

Country Link
US (2) US20220119426A1 (es)
EP (1) EP4192474A1 (es)
JP (1) JP2023536663A (es)
KR (1) KR20230048118A (es)
CN (1) CN116194144A (es)
AU (1) AU2021320236A1 (es)
BR (1) BR112023002164A2 (es)
CA (1) CA3186054A1 (es)
CL (1) CL2023000383A1 (es)
CO (1) CO2023001308A2 (es)
CR (1) CR20230071A (es)
DO (1) DOP2023000026A (es)
IL (1) IL299980A (es)
MX (1) MX2023001507A (es)
PE (1) PE20230779A1 (es)
TW (1) TW202220671A (es)
WO (1) WO2022031894A1 (es)

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WO2024076915A1 (en) 2022-10-04 2024-04-11 Gilead Sciences, Inc. 4'-thionucleoside analogues and their pharmaceutical use

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