PE20221910A1 - Derivados de pirazolilo utiles como agentes anticancerigenos - Google Patents
Derivados de pirazolilo utiles como agentes anticancerigenosInfo
- Publication number
- PE20221910A1 PE20221910A1 PE2022001123A PE2022001123A PE20221910A1 PE 20221910 A1 PE20221910 A1 PE 20221910A1 PE 2022001123 A PE2022001123 A PE 2022001123A PE 2022001123 A PE2022001123 A PE 2022001123A PE 20221910 A1 PE20221910 A1 PE 20221910A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- anticancer agents
- derivatives useful
- atropisomer
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
Refiere a un compuesto de formula (I), o un estereoisomero, o un atropisomero, o una sal farmaceuticamente aceptable del mismo o de un atropisomero, en donde, A se selecciona de un anillo heteroarilo de 8-10 miembros que comprende N, O, S o un anillo heterobiciclico parcialmente saturado de 8-10 miembros seleccionados de N, O, S y S(=O)2., entre otros; B se selecciona de B1, que es arilo C6-10 opcionalmente sustituido con 1, 2, 3 o 4 RBa, y de B2, que es un heteroarilo de 6-13 miembros con 1 - 3 atomos de nitrogeno y opcionalmente sustituido con 1, 2, 3 o 4 RBb; C se selecciona de -CH(CN)-CH3, -CH(OH)-CH3, entre otros; L se selecciona de un grupo que comprende RL, seleccionado de -CH2-CN, -CH2-OH, entre otros, y G , que representa el punto de union a G, en donde R2,R3,R4,R5,R6 Y R7 son hidrogeno, metilo, entre otros. Asimismo, se refiere a metodos para fabricar dicho compuesto y su uso para el tratamiento de un cancer o de un tumor solido, mediante una combinacion de agentes farmacologicamente activos y una composicion farmaceutica que comprende dicho compuesto.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962951400P | 2019-12-20 | 2019-12-20 | |
PCT/CN2020/125425 WO2021120890A1 (en) | 2019-12-20 | 2020-10-30 | Pyrazolyl derivatives useful as anti-cancer agents |
PCT/IB2020/062144 WO2021124222A1 (en) | 2019-12-20 | 2020-12-17 | Pyrazolyl derivatives useful as anti-cancer agents |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20221910A1 true PE20221910A1 (es) | 2022-12-23 |
Family
ID=76477081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2022001123A PE20221910A1 (es) | 2019-12-20 | 2020-12-17 | Derivados de pirazolilo utiles como agentes anticancerigenos |
Country Status (22)
Country | Link |
---|---|
US (1) | US11702409B2 (es) |
EP (2) | EP4076662B1 (es) |
JP (1) | JP2023506841A (es) |
KR (1) | KR20220114064A (es) |
CN (1) | CN114929342A (es) |
AR (1) | AR120855A1 (es) |
AU (1) | AU2020410531B2 (es) |
CA (1) | CA3165148A1 (es) |
CL (1) | CL2022001625A1 (es) |
CO (1) | CO2022008344A2 (es) |
CR (1) | CR20220281A (es) |
DK (1) | DK4076662T3 (es) |
DO (1) | DOP2022000124A (es) |
EC (1) | ECSP22047876A (es) |
FI (1) | FI4076662T3 (es) |
IL (1) | IL293893A (es) |
JO (1) | JOP20220155A1 (es) |
MX (1) | MX2022007350A (es) |
PE (1) | PE20221910A1 (es) |
TW (1) | TW202136241A (es) |
UY (1) | UY38990A (es) |
WO (2) | WO2021120890A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL292438A (en) | 2019-10-28 | 2022-06-01 | Merck Sharp & Dohme | Small molecules that inhibit the g12c mutant of kras |
CN116034106A (zh) | 2020-06-02 | 2023-04-28 | 勃林格殷格翰国际有限公司 | 用于治疗癌症的环状2-氨基-3-氰基噻吩及衍生物 |
AU2021344830A1 (en) | 2020-09-03 | 2023-04-06 | Revolution Medicines, Inc. | Use of SOS1 inhibitors to treat malignancies with SHP2 mutations |
KR20230067635A (ko) | 2020-09-15 | 2023-05-16 | 레볼루션 메디슨즈, 인크. | 암의 치료에서 ras 억제제로서 인돌 유도체 |
BR112023007912A2 (pt) * | 2020-10-30 | 2024-01-02 | Novartis Ag | Formas cristalinas de um composto inibidor de kras g12c |
US20230107642A1 (en) | 2020-12-18 | 2023-04-06 | Erasca, Inc. | Tricyclic pyridones and pyrimidones |
KR20230127256A (ko) * | 2020-12-22 | 2023-08-31 | 노파르티스 아게 | Kras g12c 억제제를 포함하는 약제학적 조합물 및 암의치료를 위한 kras g12c 억제제의 용도 |
WO2022133731A1 (en) * | 2020-12-22 | 2022-06-30 | Novartis Ag | Pharmaceutical combinations comprising a kras g12c inhibitor and uses of a kras g12c inhibitor and for the treatment of cancers |
WO2022235870A1 (en) | 2021-05-05 | 2022-11-10 | Revolution Medicines, Inc. | Ras inhibitors for the treatment of cancer |
CR20230570A (es) | 2021-05-05 | 2024-01-22 | Revolution Medicines Inc | Inhibidores de ras |
CN117337193A (zh) * | 2021-05-19 | 2024-01-02 | 基因泰克公司 | 组合疗法 |
TW202317100A (zh) | 2021-06-23 | 2023-05-01 | 瑞士商諾華公司 | 包含kras g12c抑制劑的藥物組合及其用於治療癌症之用途 |
WO2022269508A1 (en) * | 2021-06-23 | 2022-12-29 | Novartis Ag | Pyrazolyl derivatives as inhibitors of the kras mutant protein |
CN117677398A (zh) | 2021-07-27 | 2024-03-08 | 东丽株式会社 | 用于癌的治疗和/或预防的药品 |
CA3224341A1 (en) | 2021-09-01 | 2023-03-09 | Novartis Ag | Pharmaceutical combinations comprising a tead inhibitor and uses thereof for the treatment of cancers |
AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
US20230203062A1 (en) | 2021-11-24 | 2023-06-29 | Genentech, Inc. | Therapeutic compounds and methods of use |
WO2023097195A1 (en) | 2021-11-24 | 2023-06-01 | Genentech, Inc. | Therapeutic indazole compounds and methods of use in the treatment of cancer |
WO2023099592A1 (en) * | 2021-12-01 | 2023-06-08 | Boehringer Ingelheim International Gmbh | Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer |
TW202340214A (zh) | 2021-12-17 | 2023-10-16 | 美商健臻公司 | 做為shp2抑制劑之吡唑并吡𠯤化合物 |
WO2023122662A1 (en) | 2021-12-22 | 2023-06-29 | The Regents Of The University Of California | Covalently binding inhibitors of g12s, g12d and/or g12e mutants of k-ras gtpase |
TW202332434A (zh) * | 2022-01-31 | 2023-08-16 | 瑞士商諾華公司 | 可用作抗癌劑的吡唑基衍生物之合成方法 |
EP4227307A1 (en) | 2022-02-11 | 2023-08-16 | Genzyme Corporation | Pyrazolopyrazine compounds as shp2 inhibitors |
WO2023172940A1 (en) | 2022-03-08 | 2023-09-14 | Revolution Medicines, Inc. | Methods for treating immune refractory lung cancer |
WO2023199180A1 (en) | 2022-04-11 | 2023-10-19 | Novartis Ag | Therapeutic uses of a krasg12c inhibitor |
US11878958B2 (en) | 2022-05-25 | 2024-01-23 | Ikena Oncology, Inc. | MEK inhibitors and uses thereof |
WO2023240263A1 (en) | 2022-06-10 | 2023-12-14 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
WO2024040131A1 (en) | 2022-08-17 | 2024-02-22 | Treeline Biosciences, Inc. | Pyridopyrimidine kras inhibitors |
WO2024081674A1 (en) | 2022-10-11 | 2024-04-18 | Aadi Bioscience, Inc. | Combination therapies for the treatment of cancer |
CN116478141B (zh) * | 2023-06-20 | 2023-10-24 | 药康众拓(江苏)医药科技有限公司 | 氘代kras抑制剂药物及用途 |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1199600A (en) * | 1998-10-02 | 2000-04-26 | Board Of Trustees Of The University Of Illinois, The | Estrogen receptor ligands |
CL2004000234A1 (es) | 2003-02-12 | 2005-04-15 | Biogen Idec Inc | Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid |
US20080171755A1 (en) | 2004-08-31 | 2008-07-17 | Wen-Cherng Lee | Pyrimidinylpyrazoles as Tgf-Beta Inhibitors |
TW200639163A (en) * | 2005-02-04 | 2006-11-16 | Genentech Inc | RAF inhibitor compounds and methods |
ES2525217T3 (es) * | 2005-06-27 | 2014-12-19 | Exelixis Patent Company Llc | Moduladores de LXR basados en imidazol |
WO2007105058A2 (en) | 2006-03-16 | 2007-09-20 | Pfizer Products Inc. | Pyrazole compounds |
US8188083B2 (en) | 2007-06-28 | 2012-05-29 | Abbott Laboratories | Triazolopyridazines |
AU2008276521B2 (en) * | 2007-07-17 | 2011-11-03 | Amgen Inc. | Heterocyclic modulators of PKB |
AP2010005167A0 (en) * | 2007-08-01 | 2010-02-28 | Pfizer | Pyrazole compounds and their use as RAF inhibitors |
MX2011000738A (es) * | 2008-07-24 | 2011-02-23 | Nerviano Medical Sciences Srl | 3,4-diarilpirazoles como inhibidoers de proteina cinasa. |
US20120010186A1 (en) * | 2009-03-23 | 2012-01-12 | Merck Frosst Canada Ltd. | Heterocyclic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
US9114137B2 (en) | 2010-08-03 | 2015-08-25 | Nerviano Medical Sciences S.R.L. | Derivatives of pyrazolophenyl-benzenesulfonamide compounds and use thereof as antitumor agents |
EP2836482B1 (en) | 2012-04-10 | 2019-12-25 | The Regents of The University of California | Compositions and methods for treating cancer |
EP2970121B1 (en) | 2013-03-15 | 2017-12-13 | Araxes Pharma LLC | Covalent inhibitors of kras g12c |
KR20160076519A (ko) * | 2013-10-10 | 2016-06-30 | 아락세스 파마 엘엘씨 | Kras g12c 억제제 |
TW201702232A (zh) | 2015-04-10 | 2017-01-16 | 亞瑞克西斯製藥公司 | 經取代之喹唑啉化合物及其使用方法 |
EP3356339A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
US10730867B2 (en) | 2015-09-28 | 2020-08-04 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
ES2863873T3 (es) | 2016-05-18 | 2021-10-11 | Mirati Therapeutics Inc | Inhibidores de KRAS G12C |
CN110312711A (zh) | 2016-10-07 | 2019-10-08 | 亚瑞克西斯制药公司 | 作为ras抑制剂的杂环化合物及其使用方法 |
CN108069955B (zh) * | 2016-11-14 | 2021-04-06 | 江苏恒瑞医药股份有限公司 | 3-吡啶基-4-苯并噻唑基吡唑类衍生物、其制备方法及其在医药上的应用 |
BR112019008516A2 (pt) * | 2016-11-14 | 2019-07-09 | Jiangsu Hengrui Medicine Co | derivado de 3,4-bipiridil pirazol, e método de preparação para o mesmo e aplicação médica do mesmo |
RS62456B1 (sr) | 2016-12-22 | 2021-11-30 | Amgen Inc | Derivati benzizotiazola, izotiazolo[3,4-b]piridina, hinazolina, ftalazina, pirido[2,3-d]piridazina i pirido[2,3-d]pirimidina kao kras g12c inhibitori za tretman raka pluća, pankreasa ili debelog creva |
CN110382483A (zh) | 2017-01-26 | 2019-10-25 | 亚瑞克西斯制药公司 | 稠合的n-杂环化合物及其使用方法 |
EP3573964A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Benzothiophene and benzothiazole compounds and methods of use thereof |
US11059819B2 (en) | 2017-01-26 | 2021-07-13 | Janssen Biotech, Inc. | Fused hetero-hetero bicyclic compounds and methods of use thereof |
WO2018140513A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
WO2018140514A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer |
JOP20190186A1 (ar) | 2017-02-02 | 2019-08-01 | Astellas Pharma Inc | مركب كينازولين |
JOP20190272A1 (ar) | 2017-05-22 | 2019-11-21 | Amgen Inc | مثبطات kras g12c وطرق لاستخدامها |
CA3063440A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Covalent inhibitors of kras |
EP3710439B1 (en) * | 2017-11-15 | 2023-02-15 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
WO2019136147A1 (en) * | 2018-01-03 | 2019-07-11 | The Board Of Trustees Of The University Of Illinois | Toll-like receptor signaling inhibitors |
KR20200126393A (ko) * | 2018-02-23 | 2020-11-06 | 사뮤메드, 엘엘씨 | 5-헤테로아릴 치환된 인다졸-3-카복사미드 및 그의 제조 및 용도 |
EP3788038B1 (en) * | 2018-05-04 | 2023-10-11 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
WO2019217691A1 (en) * | 2018-05-10 | 2019-11-14 | Amgen Inc. | Kras g12c inhibitors for the treatment of cancer |
US11096939B2 (en) | 2018-06-01 | 2021-08-24 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
-
2020
- 2020-10-30 WO PCT/CN2020/125425 patent/WO2021120890A1/en not_active Application Discontinuation
- 2020-12-17 JP JP2022536692A patent/JP2023506841A/ja active Pending
- 2020-12-17 KR KR1020227024285A patent/KR20220114064A/ko unknown
- 2020-12-17 CA CA3165148A patent/CA3165148A1/en active Pending
- 2020-12-17 WO PCT/IB2020/062144 patent/WO2021124222A1/en active Application Filing
- 2020-12-17 EP EP20829365.4A patent/EP4076662B1/en active Active
- 2020-12-17 PE PE2022001123A patent/PE20221910A1/es unknown
- 2020-12-17 JO JOP/2022/0155A patent/JOP20220155A1/ar unknown
- 2020-12-17 EP EP24151713.5A patent/EP4344702A3/en active Pending
- 2020-12-17 CR CR20220281A patent/CR20220281A/es unknown
- 2020-12-17 CN CN202080089867.2A patent/CN114929342A/zh active Pending
- 2020-12-17 IL IL293893A patent/IL293893A/en unknown
- 2020-12-17 US US17/125,335 patent/US11702409B2/en active Active
- 2020-12-17 MX MX2022007350A patent/MX2022007350A/es unknown
- 2020-12-17 DK DK20829365.4T patent/DK4076662T3/da active
- 2020-12-17 FI FIEP20829365.4T patent/FI4076662T3/fi active
- 2020-12-17 UY UY0001038990A patent/UY38990A/es unknown
- 2020-12-17 AU AU2020410531A patent/AU2020410531B2/en active Active
- 2020-12-18 TW TW109145169A patent/TW202136241A/zh unknown
- 2020-12-21 AR ARP200103593A patent/AR120855A1/es unknown
-
2022
- 2022-06-15 CL CL2022001625A patent/CL2022001625A1/es unknown
- 2022-06-15 CO CONC2022/0008344A patent/CO2022008344A2/es unknown
- 2022-06-15 DO DO2022000124A patent/DOP2022000124A/es unknown
- 2022-06-15 EC ECSENADI202247876A patent/ECSP22047876A/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL293893A (en) | 2022-08-01 |
US20220363670A1 (en) | 2022-11-17 |
JOP20220155A1 (ar) | 2023-01-30 |
US11702409B2 (en) | 2023-07-18 |
JP2023506841A (ja) | 2023-02-20 |
UY38990A (es) | 2021-07-30 |
DOP2022000124A (es) | 2022-07-31 |
WO2021124222A1 (en) | 2021-06-24 |
ECSP22047876A (es) | 2022-07-29 |
EP4076662A1 (en) | 2022-10-26 |
FI4076662T3 (fi) | 2024-04-24 |
CO2022008344A2 (es) | 2022-06-30 |
AU2020410531B2 (en) | 2024-03-07 |
AR120855A1 (es) | 2022-03-23 |
TW202136241A (zh) | 2021-10-01 |
MX2022007350A (es) | 2022-07-19 |
CN114929342A (zh) | 2022-08-19 |
WO2021120890A1 (en) | 2021-06-24 |
CA3165148A1 (en) | 2021-06-24 |
CR20220281A (es) | 2022-07-01 |
AU2020410531A1 (en) | 2022-07-28 |
EP4344702A2 (en) | 2024-04-03 |
KR20220114064A (ko) | 2022-08-17 |
EP4076662B1 (en) | 2024-01-31 |
EP4344702A3 (en) | 2024-04-10 |
CL2022001625A1 (es) | 2023-03-24 |
DK4076662T3 (da) | 2024-04-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20221910A1 (es) | Derivados de pirazolilo utiles como agentes anticancerigenos | |
CL2022001392A1 (es) | Compuestos tricíclicos sustituidos | |
MX2022008066A (es) | Compuestos triciclicos sustituidos. | |
CL2021002883A1 (es) | Moduladores de thr-ß y métodos de uso de estos | |
PE20230249A1 (es) | Compuestos de heteroarilo biciclicos y usos de estos | |
AR074876A1 (es) | Derivados de indol-pirimidina para tratar cancer | |
DOP2018000187A (es) | Derivados de pirazolo[1,5-a]pirazin-4-ilo | |
AR046297A1 (es) | Inhibidores de la dpp - iv metodos para prepararlos y composiciones farmaceuticas que los contienen como agente activo | |
RU2012140961A (ru) | ПРОИЗВОДНОЕ 1,3,4,8-ТЕТРАГИДРО-2Н-ПИРИДО[1,2-a]ПИРАЗИНА И ЕГО ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНИБИТОРА ИНТЕГРАЗЫ ВИЧ | |
CU20110216A7 (es) | Derivados aminobutíricos sustituidos como inhibidores de neprilisina | |
CO2022002729A2 (es) | Métodos de tratamiento del cáncer de mama con derivados de tetrahidronaftaleno como degradadores del receptor de estrógenos | |
UY27503A1 (es) | Nuevos derivados de piperazina | |
PE20212303A1 (es) | Inhibidores aza-heterobiciclicos de mat2a y metodos de uso en el tratamiento de cancer | |
AR053364A1 (es) | Compuesto de 1h-imidazo 84,5-c) piridin -2- ilo, composicion farmaceutica que lo comprende, proceso para prepararla y su uso para preparar un medicamento para tratamiento de cancer o artritis | |
AR126701A1 (es) | Derivados de n-ciclopropilpirido[4,3-d]pirimidin-4-amina y usos de los mismos | |
PE20212329A1 (es) | Derivados de pladeniolida como agentes dirigidos a empalmosoma para tratar el cancer | |
PE20211769A1 (es) | Compuestos heteroaromaticos como inhibidores de vanina | |
AR039190A1 (es) | Derivados de benzofurano, composicion farmaceutica y medicamento que comprende el compuesto | |
AR126854A1 (es) | Compuestos macrocíclicos para el tratamiento de cáncer | |
CL2020002139A1 (es) | Compuestos de sulfonimidoilpurinona 7-sustituidos y sus derivados para el tratamiento y prevención del cáncer de hígado. | |
DOP2019000100A (es) | Derivados de naftiridinona y su uso en el tratamiento de la arritmia | |
CL2022000893A1 (es) | Derivados de 2-azaspiro[3,4]octano como agonistas de m4 | |
PE20200727A1 (es) | Compuestos heteroaromaticos sustituidos con cicloolefinas y su uso | |
CL2022000892A1 (es) | Derivados de 2–azaespiro[3.4]octano como agonistas de m4 | |
PE20232044A1 (es) | Compuestos heterociclicos de heteroarilo y usos de los mismos |