CL2021002883A1 - Moduladores de thr-ß y métodos de uso de estos - Google Patents
Moduladores de thr-ß y métodos de uso de estosInfo
- Publication number
- CL2021002883A1 CL2021002883A1 CL2021002883A CL2021002883A CL2021002883A1 CL 2021002883 A1 CL2021002883 A1 CL 2021002883A1 CL 2021002883 A CL2021002883 A CL 2021002883A CL 2021002883 A CL2021002883 A CL 2021002883A CL 2021002883 A1 CL2021002883 A1 CL 2021002883A1
- Authority
- CL
- Chile
- Prior art keywords
- formula
- methods
- thr
- modulators
- disclosed
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
En la presente se divulgan compuestos de la Fórmula I: (I) TL-La-CE-HD o una sal, profármaco, amida o éster aceptable desde el punto de vista farmacéutico de estos, donde i) TL es una porción de la Fórmula IIa, IIb, IIIa, IIIb, IIIc o IIId; ii) CE es una porción de la Fórmula IV; iii) HD es una porción de la Fórmula V o VI; donde los sustituyentes son como se definen en la presente. También se divulgan composiciones farmacéuticas que comprenden los compuestos anteriores y métodos para tratar enfermedades mediante la administración o el contacto de un paciente con uno o más de los compuestos anteriores.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962845252P | 2019-05-08 | 2019-05-08 | |
US201962944052P | 2019-12-05 | 2019-12-05 | |
US202063005661P | 2020-04-06 | 2020-04-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021002883A1 true CL2021002883A1 (es) | 2022-10-28 |
Family
ID=70919081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021002883A CL2021002883A1 (es) | 2019-05-08 | 2021-11-03 | Moduladores de thr-ß y métodos de uso de estos |
Country Status (17)
Country | Link |
---|---|
US (2) | US11091467B2 (es) |
EP (1) | EP3965884A1 (es) |
JP (1) | JP2022532706A (es) |
KR (1) | KR20220017917A (es) |
CN (1) | CN114096531A (es) |
AU (1) | AU2020267576A1 (es) |
BR (1) | BR112021021718A2 (es) |
CA (1) | CA3139101A1 (es) |
CL (1) | CL2021002883A1 (es) |
CO (1) | CO2021015698A2 (es) |
IL (1) | IL287720A (es) |
MA (1) | MA55890A (es) |
MX (1) | MX2021013472A (es) |
PE (1) | PE20220255A1 (es) |
SG (1) | SG11202111552YA (es) |
TW (1) | TW202108569A (es) |
WO (1) | WO2020227549A1 (es) |
Families Citing this family (18)
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MA55890A (fr) * | 2019-05-08 | 2022-03-16 | Aligos Therapeutics Inc | Modulateurs de thr-beta et leurs procédés d'utilisation |
CN113454069A (zh) * | 2019-11-26 | 2021-09-28 | 昆药集团股份有限公司 | 1,2,4-三嗪-3,5-二酮类化合物及其制备方法和应用 |
CN114787153A (zh) * | 2019-12-26 | 2022-07-22 | 苏州科睿思制药有限公司 | 一种Resmetirom晶型及其制备方法和用途 |
CN113278013B (zh) * | 2020-02-20 | 2022-09-23 | 昆药集团股份有限公司 | 2,6-二取代的1,2,4-三嗪-3,5-二酮化合物及其制备方法和应用 |
WO2022053028A1 (zh) * | 2020-09-10 | 2022-03-17 | 南京明德新药研发有限公司 | 1,2,4-三嗪-3,5(2h,4h)-二酮类化合物及其应用 |
AU2021341182A1 (en) * | 2020-09-10 | 2023-04-27 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Crystal form of resmetirom, preparation method therefor, and use thereof |
CA3197234A1 (en) * | 2020-11-06 | 2022-05-12 | David Craig Mcgowan | Pyridazinone derivatives as thyroid receptor agonists and uses thereof |
EP4240722A1 (en) | 2020-11-06 | 2023-09-13 | Aligos Therapeutics, Inc. | Oxindoles and methods of use thereof |
CN112645936B (zh) * | 2020-12-17 | 2022-03-01 | 山东第一医科大学(山东省医学科学院) | 取代的哒嗪酮类化合物及其用途 |
CN114907327A (zh) * | 2021-02-10 | 2022-08-16 | 杭州领业医药科技有限公司 | Resmetirom的晶型及其制备方法和用途 |
IL305495A (en) * | 2021-03-03 | 2023-10-01 | Terns Pharmaceuticals Inc | Thyroid hormone receptor beta agonist compounds |
CN115073429A (zh) * | 2021-03-15 | 2022-09-20 | 昆药集团股份有限公司 | 一种1,2,4-三嗪-3,5-二酮类化合物的盐型、晶型及其制备方法 |
TW202313615A (zh) * | 2021-05-21 | 2023-04-01 | 大陸商深圳微芯生物科技股份有限公司 | 一種雜環化合物及其應用 |
WO2023023474A1 (en) * | 2021-08-16 | 2023-02-23 | Senya Pharmaceuticals, Inc. | Tr-beta modulators, pharmaceutical compositions, and therapeutic applications |
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KR20240053635A (ko) | 2021-09-08 | 2024-04-24 | 알리고스 테라퓨틱스 인코포레이티드 | 변형된 짧은 간섭 핵산 (sina) 분자 및 그의 용도 |
CN116354934A (zh) * | 2021-12-28 | 2023-06-30 | 中国科学院上海药物研究所 | 一类喹啉类化合物及其制备方法、药物组合物和用途 |
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2020
- 2020-05-07 MA MA055890A patent/MA55890A/fr unknown
- 2020-05-07 CN CN202080047744.2A patent/CN114096531A/zh active Pending
- 2020-05-07 US US16/869,211 patent/US11091467B2/en active Active
- 2020-05-07 PE PE2021001847A patent/PE20220255A1/es unknown
- 2020-05-07 WO PCT/US2020/031904 patent/WO2020227549A1/en unknown
- 2020-05-07 KR KR1020217039735A patent/KR20220017917A/ko unknown
- 2020-05-07 JP JP2021566558A patent/JP2022532706A/ja active Pending
- 2020-05-07 CA CA3139101A patent/CA3139101A1/en active Pending
- 2020-05-07 EP EP20729390.3A patent/EP3965884A1/en active Pending
- 2020-05-07 MX MX2021013472A patent/MX2021013472A/es unknown
- 2020-05-07 SG SG11202111552YA patent/SG11202111552YA/en unknown
- 2020-05-07 BR BR112021021718A patent/BR112021021718A2/pt unknown
- 2020-05-07 AU AU2020267576A patent/AU2020267576A1/en active Pending
- 2020-05-08 TW TW109115446A patent/TW202108569A/zh unknown
-
2021
- 2021-05-25 US US17/330,232 patent/US20210355112A1/en active Pending
- 2021-10-31 IL IL287720A patent/IL287720A/en unknown
- 2021-11-03 CL CL2021002883A patent/CL2021002883A1/es unknown
- 2021-11-23 CO CONC2021/0015698A patent/CO2021015698A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
BR112021021718A2 (pt) | 2022-01-18 |
US20200354345A1 (en) | 2020-11-12 |
CA3139101A1 (en) | 2020-11-12 |
CN114096531A (zh) | 2022-02-25 |
JP2022532706A (ja) | 2022-07-19 |
IL287720A (en) | 2021-12-01 |
TW202108569A (zh) | 2021-03-01 |
CO2021015698A2 (es) | 2022-01-17 |
PE20220255A1 (es) | 2022-02-16 |
WO2020227549A1 (en) | 2020-11-12 |
AU2020267576A1 (en) | 2021-12-09 |
US20210355112A1 (en) | 2021-11-18 |
EP3965884A1 (en) | 2022-03-16 |
SG11202111552YA (en) | 2021-11-29 |
WO2020227549A8 (en) | 2021-05-27 |
KR20220017917A (ko) | 2022-02-14 |
MX2021013472A (es) | 2022-01-06 |
US11091467B2 (en) | 2021-08-17 |
MA55890A (fr) | 2022-03-16 |
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