PE20232044A1 - Compuestos heterociclicos de heteroarilo y usos de los mismos - Google Patents
Compuestos heterociclicos de heteroarilo y usos de los mismosInfo
- Publication number
- PE20232044A1 PE20232044A1 PE2023001166A PE2023001166A PE20232044A1 PE 20232044 A1 PE20232044 A1 PE 20232044A1 PE 2023001166 A PE2023001166 A PE 2023001166A PE 2023001166 A PE2023001166 A PE 2023001166A PE 20232044 A1 PE20232044 A1 PE 20232044A1
- Authority
- PE
- Peru
- Prior art keywords
- independently
- halogen
- alkyl
- deuterium
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 4
- 229910052805 deuterium Inorganic materials 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Abstract
Referido a compuestos heterociclicos de heteroarilo de formula I, o una sal farmaceuticamente aceptable del mismo, solvato, mezcla racemica, enantiomero, diastereomero o tautomero del mismo, en donde X1, X2 y X3 son cada uno independientemente CH o N; U y V son cada uno independientemente N o CR9; Y1 e Y2 son cada uno independientemente CR10 o N; R1 y R2 son cada uno independientemente elegidos de H, deuterio, halogeno, -CN, entre otros; R3 es H, deuterio, halogeno, -CN o haloalquilo C1-6; R4 es H, halogeno, -CN, alquilo C1-6, entre otros; R5 es H, alquilo C1-6 y cicloalquilo C3-6, entre otros; Z1, Z2, Z3 y Z4 son cada uno independientemente CH o N; R6 y R7 son cada uno independientemente elegidos de alquilo C1-6; R8 es H, alquilo C1-6, cicloalquilo C3-6 o heterociclilo de 4-8 miembros, entre otros; R9 es H, deuterio o halogeno; R10 es H, deuterio, halogeno, CN, alquilo C1-6 o haloalquilo C1-6; n es 0, 1 o 2; con la condicion de que cuando n es 1, R3 no es H. Tambien se refiere a un metodo para inhibir la actividad de BTK, sintesis de dichos compuestos, compuestos intermediarios, una composicion farmaceutica que lo comprende, y su uso para tratar o prevenir una enfermedad autoinmune, una enfermedad inflamatoria o cancer..
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010993583 | 2020-09-21 | ||
| CN202110175357 | 2021-02-07 | ||
| CN202111077860 | 2021-09-15 | ||
| PCT/CN2021/119056 WO2022057894A1 (en) | 2020-09-21 | 2021-09-17 | Heteroaryl heterocyclic compounds and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20232044A1 true PE20232044A1 (es) | 2023-12-27 |
Family
ID=80775929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2023001166A PE20232044A1 (es) | 2020-09-21 | 2021-09-17 | Compuestos heterociclicos de heteroarilo y usos de los mismos |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11655254B2 (es) |
| EP (1) | EP4214206A1 (es) |
| JP (1) | JP2023542040A (es) |
| KR (1) | KR20230104125A (es) |
| CN (1) | CN116568687A (es) |
| AU (1) | AU2021343591A1 (es) |
| CA (1) | CA3195525A1 (es) |
| CL (1) | CL2023000772A1 (es) |
| IL (1) | IL301275A (es) |
| MX (1) | MX2023003183A (es) |
| PE (1) | PE20232044A1 (es) |
| TW (1) | TW202220998A (es) |
| WO (1) | WO2022057894A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022057894A1 (en) * | 2020-09-21 | 2022-03-24 | Hutchison Medipharma Limited | Heteroaryl heterocyclic compounds and uses thereof |
| WO2023143491A1 (zh) * | 2022-01-28 | 2023-08-03 | 和记黄埔医药（上海）有限公司 | 7,8-二氢-2h-环戊二烯并吡咯并吡嗪酮化合物的合成方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2552681T3 (es) | 2008-07-15 | 2015-12-01 | F. Hoffmann-La Roche Ag | Nuevas fenil-imidazopiridinas y piridazinas |
| CN110818724B (zh) | 2010-05-07 | 2020-11-13 | 吉利德康涅狄格有限公司 | 吡啶酮和氮杂吡啶酮化合物及使用方法 |
| UA111756C2 (uk) * | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
| BR112014010391A2 (pt) * | 2011-11-03 | 2017-04-18 | Hoffmann La Roche | composto, composição farmacêutica, processo de produção de uma composição farmacêutica, método de tratamento, kit e uso de uma composição farmacêutica |
| US8669251B2 (en) | 2011-11-03 | 2014-03-11 | Genentech, Inc. | 8-fluorophthalazin-1(2H)-one compounds |
| MX2014005289A (es) | 2011-11-03 | 2014-05-30 | Hoffmann La Roche | Compuestos de piperazina alquilados. |
| BR112014013582A2 (pt) | 2011-12-09 | 2017-06-13 | Hoffmann La Roche | inibidores de quinase de tirosina de bruton |
| CA2912359A1 (en) * | 2013-07-03 | 2015-01-08 | F. Hoffmann-La Roche Ag | Heteroaryl pyridone and aza-pyridone amide compounds |
| CA2929918C (en) | 2013-12-05 | 2018-01-23 | F. Hoffmann-La Roche Ag | Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality |
| WO2016050921A1 (en) | 2014-10-02 | 2016-04-07 | F. Hoffmann-La Roche Ag | Pyrazole carboxamide compounds for use in the treament of disorders mediated by bruton's tyrosine kinase (btk) |
| AR102177A1 (es) * | 2014-10-06 | 2017-02-08 | Merck Patent Gmbh | Compuestos de heteroarilo como inhibidores de btk y usos de los mismos |
| US10266528B2 (en) | 2016-08-16 | 2019-04-23 | Merck Patent Gmbh | 2-oxo-imidazopyridines as reversible BTK inhibitors and uses thereof |
| EP3555099B1 (en) | 2016-12-15 | 2021-08-18 | F. Hoffmann-La Roche AG | Process for preparing btk inhibitors |
| UY37559A (es) | 2017-01-06 | 2018-05-31 | Pharmacyclics Llc | Pirazolo[3,4-b]piridina y pirrolo[2,3-b]piridina como inhibidores de la tirosina quinasa de bruton |
| US11100492B2 (en) | 2018-02-19 | 2021-08-24 | Peter Garrett | General purpose re-loadable card aggregation implementation |
| CN110256446B (zh) * | 2018-08-01 | 2021-12-14 | 上海海雁医药科技有限公司 | 苯并杂环取代的环戊二烯并[4,5]吡咯并吡嗪-1-酮衍生物及其应用 |
| KR20220158712A (ko) * | 2020-02-20 | 2022-12-01 | 허치슨 메디파르마 리미티드 | 헤테로아릴 헤테로사이클릭 화합물 및 그의 용도 |
| WO2022057894A1 (en) * | 2020-09-21 | 2022-03-24 | Hutchison Medipharma Limited | Heteroaryl heterocyclic compounds and uses thereof |
-
2021
- 2021-09-17 WO PCT/CN2021/119056 patent/WO2022057894A1/en active Application Filing
- 2021-09-17 CA CA3195525A patent/CA3195525A1/en active Pending
- 2021-09-17 KR KR1020237011979A patent/KR20230104125A/ko unknown
- 2021-09-17 JP JP2023518212A patent/JP2023542040A/ja active Pending
- 2021-09-17 AU AU2021343591A patent/AU2021343591A1/en active Pending
- 2021-09-17 TW TW110134912A patent/TW202220998A/zh unknown
- 2021-09-17 IL IL301275A patent/IL301275A/en unknown
- 2021-09-17 CN CN202180063816.7A patent/CN116568687A/zh active Pending
- 2021-09-17 EP EP21868716.8A patent/EP4214206A1/en active Pending
- 2021-09-17 PE PE2023001166A patent/PE20232044A1/es unknown
- 2021-09-17 MX MX2023003183A patent/MX2023003183A/es unknown
-
2022
- 2022-04-25 US US17/728,097 patent/US11655254B2/en active Active
-
2023
- 2023-03-16 CL CL2023000772A patent/CL2023000772A1/es unknown
- 2023-04-17 US US18/301,762 patent/US20230382916A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2023003183A (es) | 2023-04-12 |
| JP2023542040A (ja) | 2023-10-04 |
| US20230382916A1 (en) | 2023-11-30 |
| IL301275A (en) | 2023-05-01 |
| WO2022057894A1 (en) | 2022-03-24 |
| EP4214206A1 (en) | 2023-07-26 |
| KR20230104125A (ko) | 2023-07-07 |
| CA3195525A1 (en) | 2022-03-24 |
| CN116568687A (zh) | 2023-08-08 |
| US20220332719A1 (en) | 2022-10-20 |
| CL2023000772A1 (es) | 2023-09-01 |
| TW202220998A (zh) | 2022-06-01 |
| US11655254B2 (en) | 2023-05-23 |
| AU2021343591A1 (en) | 2023-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20230249A1 (es) | Compuestos de heteroarilo biciclicos y usos de estos | |
| AR046297A1 (es) | Inhibidores de la dpp - iv metodos para prepararlos y composiciones farmaceuticas que los contienen como agente activo | |
| PE20220143A1 (es) | Agonistas de glp-1r y usos de los mismos | |
| PE20220931A1 (es) | Inhibidores de shp2 fosfatasa de tipo pirazolo[3,4-b]pirazina | |
| PE20230238A1 (es) | Inhibidores de kras g12c | |
| PE20200700A1 (es) | Compuestos macrociclicos y usos de los mismos | |
| PE20221910A1 (es) | Derivados de pirazolilo utiles como agentes anticancerigenos | |
| CO5680412A2 (es) | Agonistas del receptor adrenergico etilamino beta 2 sustituido con amino | |
| PE20232044A1 (es) | Compuestos heterociclicos de heteroarilo y usos de los mismos | |
| ECSP034475A (es) | Derivados de 4-fenil-piridin como antagonistas del receptor de neuroquinina-1 | |
| PE20220567A1 (es) | Nuevos derivados piperidinilo, un proceso para su preparacion y composiciones farmaceuticas que los contienen | |
| UY28578A1 (es) | Derivados de amida | |
| AR054560A1 (es) | Espiropiperidina como inhibidores de beta-secretasa para el tratamiento de la enfermedad de alzheimer | |
| AR052902A1 (es) | Derivados de piridazina, composicion farmaceutica que los contiene y su uso como agentes terapeuticos para enfermedades mediadas por la estearoil-coa desaturasa | |
| CO5590915A2 (es) | Derivados de piperidina como antagonistas nk1 ( receptor del neuropeptido neuroquinina-1) con actividad antagonista superior en tratamientos de trastornos fisiologicos y disminucion de efectos colaterales | |
| AR034390A1 (es) | Derivados de 1-sulfonil-tetrahidro quinolinas sustituidas, composiciones farmaceuticas y el uso de las mismas para la elaboracion de medicamentos como inhibidores de la gama secretasa | |
| AR083849A1 (es) | Antagonistas de mdm2 de espiro-oxindol | |
| AR052943A1 (es) | Derivados de 2-(4-oxo-4h-quinazolin-3-il)acetamida | |
| AR055878A1 (es) | Derivados de ciclopropanocarboxamida | |
| AR048523A1 (es) | Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos | |
| AR055592A1 (es) | Derivados de 2-amino-5-cicloalquil-hidantoina como moduladores y/o inhibidores de la beta-secretasa(bace) | |
| AR053195A1 (es) | Compuestos inhibidores de dipeptidil peptidasa-iv metodos para preparar los mismos y composiciones farmaceuticas que los contienen como un agente activo | |
| AR053186A1 (es) | Derivados del 1- bencil indol carboxamida | |
| AR037907A1 (es) | Derivados de azaindolilalquilamina como ligandos de 5-hidroxitriptamina-6 | |
| PE20191784A1 (es) | Compuestos inhibidores de vmat2, composiciones y metodos relativos a los mismos |