EA201791485A1 - Анти-cd47-антитела и их применения - Google Patents

Анти-cd47-антитела и их применения

Info

Publication number
EA201791485A1
EA201791485A1 EA201791485A EA201791485A EA201791485A1 EA 201791485 A1 EA201791485 A1 EA 201791485A1 EA 201791485 A EA201791485 A EA 201791485A EA 201791485 A EA201791485 A EA 201791485A EA 201791485 A1 EA201791485 A1 EA 201791485A1
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EA
Eurasian Patent Office
Prior art keywords
antibodies
methods
applications
suggested
involved
Prior art date
Application number
EA201791485A
Other languages
English (en)
Other versions
EA037654B1 (ru
Inventor
Аарон Сато
Райан Стаффорд
Цзюньхао Янг
Original Assignee
Селджин Корпорейшн
Аарон Сато
Райан Стаффорд
Цзюньхао Янг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Селджин Корпорейшн, Аарон Сато, Райан Стаффорд, Цзюньхао Янг filed Critical Селджин Корпорейшн
Publication of EA201791485A1 publication Critical patent/EA201791485A1/ru
Publication of EA037654B1 publication Critical patent/EA037654B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

В изобретении предлагаются композиции, способы и применения, в которые вовлечены антитела, которые специфично связываются с CD47 человека. Также предлагаются применения и способы, такие как терапевтические способы, диагностические способы и способы получения таких антител.
EA201791485A 2014-12-30 2015-12-28 Анти-cd47-антитела и их применения EA037654B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462098291P 2014-12-30 2014-12-30
PCT/US2015/067642 WO2016109415A1 (en) 2014-12-30 2015-12-28 Anti-cd47 antibodies and uses thereof

Publications (2)

Publication Number Publication Date
EA201791485A1 true EA201791485A1 (ru) 2018-02-28
EA037654B1 EA037654B1 (ru) 2021-04-27

Family

ID=56284963

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791485A EA037654B1 (ru) 2014-12-30 2015-12-28 Анти-cd47-антитела и их применения

Country Status (17)

Country Link
US (2) US10870699B2 (ru)
EP (1) EP3240569A4 (ru)
JP (2) JP6850255B2 (ru)
KR (1) KR102489471B1 (ru)
CN (1) CN107530421B (ru)
AU (1) AU2015374301B2 (ru)
BR (1) BR112017014258A2 (ru)
CA (1) CA2972604C (ru)
CL (1) CL2017001736A1 (ru)
CO (1) CO2017007673A2 (ru)
EA (1) EA037654B1 (ru)
EC (1) ECSP17041865A (ru)
HK (1) HK1245154A1 (ru)
MX (1) MX2017008819A (ru)
SG (2) SG10202007176TA (ru)
WO (1) WO2016109415A1 (ru)
ZA (1) ZA201704467B (ru)

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ECSP17041865A (es) 2017-08-31
KR20170100652A (ko) 2017-09-04
CA2972604C (en) 2023-07-04
HK1245154A1 (zh) 2018-08-24
CO2017007673A2 (es) 2018-01-05
US20170369572A1 (en) 2017-12-28
BR112017014258A2 (pt) 2018-03-06
EP3240569A4 (en) 2018-05-30
CL2017001736A1 (es) 2018-03-16
JP2018506964A (ja) 2018-03-15
CA2972604A1 (en) 2016-07-07
EA037654B1 (ru) 2021-04-27
US10870699B2 (en) 2020-12-22
SG10202007176TA (en) 2020-08-28
WO2016109415A1 (en) 2016-07-07
US11787860B2 (en) 2023-10-17
AU2015374301A1 (en) 2017-07-20
ZA201704467B (en) 2019-09-25
JP6850255B2 (ja) 2021-03-31
CN107530421B (zh) 2021-07-20
SG11201705310TA (en) 2017-07-28
AU2015374301B2 (en) 2021-02-11
JP2021048858A (ja) 2021-04-01
CN107530421A (zh) 2018-01-02
KR102489471B1 (ko) 2023-01-18
US20210054070A1 (en) 2021-02-25
MX2017008819A (es) 2018-03-14
EP3240569A1 (en) 2017-11-08

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