PE20120015A1 - Metodos y sistemas para predecir la respuesta de las celulas tumorales a un agente terapeutico - Google Patents

Metodos y sistemas para predecir la respuesta de las celulas tumorales a un agente terapeutico

Info

Publication number
PE20120015A1
PE20120015A1 PE2011000159A PE2011000159A PE20120015A1 PE 20120015 A1 PE20120015 A1 PE 20120015A1 PE 2011000159 A PE2011000159 A PE 2011000159A PE 2011000159 A PE2011000159 A PE 2011000159A PE 20120015 A1 PE20120015 A1 PE 20120015A1
Authority
PE
Peru
Prior art keywords
perbb3
therapeutic agent
predicting
response
systems
Prior art date
Application number
PE2011000159A
Other languages
English (en)
Inventor
Birgit Schoeberl
Brian Harms
Francis David Gibbons
Jonathan Basil Fitzgerald
Matthew David Onsum
Ulrik Nielsen
William Kubasek
Original Assignee
Merrimack Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41228727&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120015(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merrimack Pharmaceuticals Inc filed Critical Merrimack Pharmaceuticals Inc
Publication of PE20120015A1 publication Critical patent/PE20120015A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

REFERIDA A UN METODO PARA TRATAR A UN PACIENTE QUE TIENE UN TUMOR NEOPLASICO QUE COMPRENDE: A) OBTENER UNA MUESTRA DEL TUMOR; B) DETERMINAR EL NIVEL DE pErbB3 EN LA MUESTRA Y DEPENDIENDO DE LA CANTIDAD DE pErbB3 EN PORCENTAJE DE UN CULTIVO DE CELULAS ACHN SEGUIDO POR EL CULTIVO DE 20-24 HORAS EN MEDIO LIBRE DE SUERO; C) ADMINISTRAR AL MENOS UN AGENTE TERAPEUTICO ANTINEOPLASICO AL PACIENTE TAL COMO ANTICUERPO ANTI-ErbB3 SI EL NIVEL DE pErbB3 NO ES MENOR QUE 50% O UN ANTICUERPO DIFERENTE CUANDO EL NIVEL DE pErbB3 ES MENOR A 50%. DICHO METODO ES UTIL EN EL TRATAMIENTO DE TUMOR DE COLON, PULMON, RECTO, CEREBRO, MAMAS, RINON, ESTOMAGO, ENTRE OTROS
PE2011000159A 2008-08-15 2009-08-17 Metodos y sistemas para predecir la respuesta de las celulas tumorales a un agente terapeutico PE20120015A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18905308P 2008-08-15 2008-08-15
US19470208P 2008-09-30 2008-09-30
US20820609P 2009-02-20 2009-02-20
US17036709P 2009-04-17 2009-04-17

Publications (1)

Publication Number Publication Date
PE20120015A1 true PE20120015A1 (es) 2012-01-26

Family

ID=41228727

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000159A PE20120015A1 (es) 2008-08-15 2009-08-17 Metodos y sistemas para predecir la respuesta de las celulas tumorales a un agente terapeutico

Country Status (24)

Country Link
US (4) US8623592B2 (es)
EP (1) EP2318548B1 (es)
JP (1) JP2012500008A (es)
KR (1) KR20110044905A (es)
CN (1) CN102224255A (es)
AU (1) AU2009281721A1 (es)
BR (1) BRPI0917871A2 (es)
CA (1) CA2732658A1 (es)
CO (1) CO6341654A2 (es)
CR (1) CR20110128A (es)
DO (1) DOP2011000054A (es)
EA (1) EA022884B1 (es)
EC (1) ECSP11010872A (es)
ES (1) ES2433424T3 (es)
HK (1) HK1155782A1 (es)
IL (1) IL210865A (es)
MA (1) MA32630B1 (es)
MX (1) MX2011001764A (es)
NZ (1) NZ591137A (es)
PE (1) PE20120015A1 (es)
SV (1) SV2011003840A (es)
UA (1) UA104868C2 (es)
WO (1) WO2010019952A2 (es)
ZA (1) ZA201100921B (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2716301T (pt) 2007-02-16 2017-07-04 Merrimack Pharmaceuticals Inc Anticorpos contra erbb3 e suas utilizações
CA2732658A1 (en) 2008-08-15 2010-02-18 Merrimack Pharmaceuticals, Inc. Methods and systems for predicting response of cells to a therapeutic agent
US8927694B2 (en) * 2008-11-18 2015-01-06 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
RU2560583C2 (ru) 2009-12-22 2015-08-20 Рош Гликарт Аг Антитела к her3 и их применения
KR101798679B1 (ko) * 2010-03-11 2017-11-16 메리맥 파마슈티컬즈, 인크. ３중 음성 및 기저형 유방암 치료 시의 ｅｒｂｂ３ 저해제의 용도
US20110318336A1 (en) * 2010-03-29 2011-12-29 George Mason Intellectual Properties, Inc. Identification and Treatment of Aggressive Lung Cancer Tumors
CN105153307A (zh) 2010-05-04 2015-12-16 梅里麦克制药股份有限公司 抗表皮生长因子受体(egfr)的抗体及其用途
WO2011159904A1 (en) * 2010-06-17 2011-12-22 The Trustees Of The University Of Pennsylvania Methods for predicting cellular signaling responses to combinatorial stimuli
TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
DK2635604T3 (en) 2010-11-01 2017-02-27 Symphogen As PAN-HER-ANTIBODY COMPOSITION
EP2680925B1 (en) 2011-03-02 2019-11-20 Berg LLC Interrogatory cell-based assays and uses thereof
AU2012229147B2 (en) 2011-03-11 2015-12-24 Merrimack Pharmaceuticals, Inc. Use of inhibitors of EGFR-family receptors in the treatment of hormone refractory breast cancers
BR112013027021A2 (pt) 2011-04-19 2016-11-29 Merrimack Pharmaceuticals Inc anticorpos anti-igf-1r e anti-erbb3 monoespecíficos e biespecíficos
US8691231B2 (en) 2011-06-03 2014-04-08 Merrimack Pharmaceuticals, Inc. Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies
EP2530462A1 (en) * 2011-06-03 2012-12-05 Merrimack Pharmaceuticals, Inc. Methods and kits for predicting tumor responses to antibodies against epidermal growth factor receptor (EGFR) and uses thereof
AU2012294326A1 (en) * 2011-08-10 2013-03-21 Merrimack Pharmaceuticals, Inc. Treatment of advanced solid tumors using combination of anti-ErbB3 immunotherapy and selected chemotherapy
US9273143B2 (en) 2011-09-30 2016-03-01 Regeneron Pharmaceuticals, Inc. Methods and compositions comprising a combination of an anti-ErbB3 antibody and an anti-EGFR antibody
EP2760893B1 (en) 2011-09-30 2018-09-12 Regeneron Pharmaceuticals, Inc. Anti-erbb3 antibodies and uses thereof
CA2851314A1 (en) * 2011-10-06 2013-04-11 Aveo Pharmaceuticals, Inc. Predicting tumor response to anti-erbb3 antibodies
EP2788377B1 (en) * 2011-11-09 2019-01-23 The UAB Research Foundation Her3 antibodies and uses thereof
CA2859080A1 (en) * 2011-12-16 2013-06-20 Critical Outcome Technologies Inc. Programmable cell model for determining cancer treatments
SG10201608234UA (en) 2012-04-02 2016-11-29 Berg Llc Interrogatory cell-based assays and uses thereof
CN104379563B (zh) * 2012-04-10 2018-12-21 加利福尼亚大学董事会 用于治疗癌症的组合物和方法
WO2013188494A1 (en) * 2012-06-13 2013-12-19 Medimmune, Llc Fixed dosage regimens for anti-type i interferon receptor (ifnar) antibodies
KR101430309B1 (ko) * 2012-11-14 2014-08-13 이선우 바이오 3d 모델링 장치
WO2014081954A1 (en) * 2012-11-21 2014-05-30 Janssen Biotech, Inc. BISPECIFIC EGFR/c-Met ANTIBODIES
US10489717B2 (en) 2013-01-03 2019-11-26 Aetna, Inc. System and method for pharmacovigilance
US11424040B2 (en) * 2013-01-03 2022-08-23 Aetna Inc. System and method for pharmacovigilance
US9180185B2 (en) 2013-01-11 2015-11-10 Hoffman-La Roche Inc. Combination therapy of anti-HER3 antibodies
KR20140093347A (ko) * 2013-01-15 2014-07-28 삼성전자주식회사 항 ｃ-Ｍｅｔ 항체 처리에 의해 부작용을 유발하는 유전자 및 이를 이용한 약물 스크리닝 방법
WO2015048804A2 (en) * 2013-09-30 2015-04-02 Daiichi Sankyo Co., Ltd. Protein biomarker and uses thereof
AU2014324478A1 (en) * 2013-09-30 2016-05-05 Amgen, Inc. Nucleic acid biomarker and use thereof
WO2015100459A2 (en) 2013-12-27 2015-07-02 Merrimack Pharmaceuticals, Inc. Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
KR102359214B1 (ko) 2014-04-04 2022-02-07 델 마 파마슈티컬스 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체
WO2015157109A1 (en) * 2014-04-08 2015-10-15 Biodesix, Inc. Egfr and hgf inhibitor therapy for lung cancer
MA39599A (fr) 2014-05-14 2016-10-05 Merrimack Pharmaceuticals Inc Dosage et administration d'agents thérapeutiques anti-egfr
CN114203296A (zh) 2014-09-11 2022-03-18 博格有限责任公司 基于患者数据的用于健康护理诊断和治疗的贝叶斯因果关系网络模型
WO2016146833A1 (en) 2015-03-19 2016-09-22 F. Hoffmann-La Roche Ag Biomarkers for nad(+)-diphthamide adp ribosyltransferase resistance
EP3283068A1 (en) 2015-04-17 2018-02-21 Merrimack Pharmaceuticals, Inc. Combination treatments with seribantumab
GB201508841D0 (en) * 2015-05-22 2015-07-01 Isis Innovation Treatment
US10184006B2 (en) 2015-06-04 2019-01-22 Merrimack Pharmaceuticals, Inc. Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors
WO2016205377A1 (en) * 2015-06-15 2016-12-22 Nantomics, Llc Systems and methods for patient-specific prediction of drug responses from cell line genomics
JP6836586B2 (ja) 2015-09-29 2021-03-03 エイチティージー モレキュラー ダイアグノスティクス， インコーポレイテッド びまん性大細胞型ｂ細胞性リンパ腫（ｄｌｂｃｌ）を亜型決定するための方法
SG11201806251WA (en) 2016-03-15 2018-08-30 Merrimack Pharmaceuticals Inc Methods for treating er+, her2-, hrg+ breast cancer using combination therapies comprising an anti-erbb3 antibody
US20190371427A1 (en) * 2016-11-17 2019-12-05 Nantbio, Inc. Validation of inferred anticancer pathways
JP7404648B2 (ja) 2019-04-25 2023-12-26 富士通株式会社 治療薬提示方法、治療薬提示装置、及び治療薬提示プログラム
US20230088271A1 (en) * 2020-02-28 2023-03-23 The Board Of Trustees Of The Leland Stanford Junior University Systems and Methods for Determining Spatial Accumulation of Signaling Molecules Within Tissue Samples
WO2021240263A1 (en) 2020-05-26 2021-12-02 Insilico Medicine Ip Limited Biological data signatures of aging and methods of determining a biological aging clock
WO2022058980A1 (en) 2020-09-21 2022-03-24 Insilico Medicine Ip Limited Methylation data signatures of aging and methods of determining a methylation aging clock
CN113049249A (zh) * 2020-12-31 2021-06-29 山东科技大学 一种电机轴承故障诊断方法及***

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5183884A (en) 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
US6657103B1 (en) 1990-01-12 2003-12-02 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5344760A (en) 1991-06-03 1994-09-06 Ciba Corning Diagnostics Corp. Method of cancer detection
US6983227B1 (en) 1995-01-17 2006-01-03 Intertech Ventures, Ltd. Virtual models of complex systems
US5968511A (en) 1996-03-27 1999-10-19 Genentech, Inc. ErbB3 antibodies
ATE342283T1 (de) 1996-03-27 2006-11-15 Genentech Inc Erbb3 antikörper
BR9710357A (pt) 1996-07-12 1999-08-17 Genentech Inc Adesina heteromultimera quimerica recomvinante isolada sequencia de acido nucleiro isolada acido nucleico isolado vetor celula hospedeira anticorpo metodo para formar um complexo adesina-ligante heteromultimera quimerica metodo para inibir a ativa-ao metodo para ativar um receptor hetermultimerico natural composicao farmaceutica artigo manufaturado e metodo para produzir anticorpo
US6255455B1 (en) 1996-10-11 2001-07-03 The Trustees Of The University Of Pennsylvania Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof
US20020002276A1 (en) 1997-02-10 2002-01-03 Genentech, Inc. Chimeric heteromultimer adhesins
US6417168B1 (en) 1998-03-04 2002-07-09 The Trustees Of The University Of Pennsylvania Compositions and methods of treating tumors
GB2336695A (en) 1998-04-20 1999-10-27 Teamware Group Oy Modelling a work process
JP2002515511A (ja) 1998-05-15 2002-05-28 イムクローン システムズ インコーポレイティド 放射線及び成長因子レセプター・チロシン・キナーゼのインヒビターを使用するヒト腫瘍の治療
AUPQ105799A0 (en) 1999-06-18 1999-07-08 Victor Chang Cardiac Research Institute, The Cell growth inhibition
NZ517150A (en) 1999-08-27 2005-01-28 Genentech Inc Dosages for treatment with anti-ErbB2 antibodies
US7097840B2 (en) 2000-03-16 2006-08-29 Genentech, Inc. Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
JP2003534292A (ja) 2000-05-19 2003-11-18 ジェネンテック・インコーポレーテッド Ｅｒｂｂアンタゴニスト癌治療に対する有効な応答の可能性を向上させるための遺伝子検出アッセイ
US20020119148A1 (en) 2000-09-01 2002-08-29 Gerritsen Mary E. ErbB4 antagonists
US6871171B1 (en) 2000-10-19 2005-03-22 Optimata Ltd. System and methods for optimized drug delivery and progression of diseased and normal cells
EP1228766A1 (en) 2001-01-31 2002-08-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. PYK2 phosphorylation by HER3 induces tumor invasion
WO2003011897A1 (en) 2001-07-27 2003-02-13 The Regents Of The University Of California Modulation of heregulin and her3 interaction
AU2002326531A1 (en) 2001-08-03 2003-02-17 The Trustees Of The University Of Pennsylvania Monoclonal antibodies to activated erbb family members and methods of use thereof
JP2005508887A (ja) 2001-08-03 2005-04-07 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼイション Ｅｇｆ受容体の結晶構造に基づいたスクリーニング方法
EP1283053A1 (en) 2001-08-09 2003-02-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibitors of HER3 activity
MXPA04003674A (es) 2001-10-19 2004-07-23 Pharma Mar Sa Uso mejorado de compuesto antitumoral en terapia de cancer.
US7415359B2 (en) 2001-11-02 2008-08-19 Gene Network Sciences, Inc. Methods and systems for the identification of components of mammalian biochemical networks as targets for therapeutic agents
EP1495123B1 (en) 2002-03-26 2013-10-30 Zensun (Shanghai) Science and Technology Limited Erbb3 based methods and compositions for treating neoplasms
US20040248151A1 (en) 2002-04-05 2004-12-09 Ventana Medical Systems, Inc. Method for predicting the response to HER2-directed therapy
US7332580B2 (en) 2002-04-05 2008-02-19 The Regents Of The University Of California Bispecific single chain Fv antibody molecules and methods of use thereof
US20040229380A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
WO2004000102A2 (en) 2002-06-19 2003-12-31 Abgenix, Inc. Method for predicting response to epidermal growth factor receptor-directed therapy
PT1517921E (pt) 2002-06-28 2006-09-29 Domantis Ltd Ligandos duplamente especificos com semi-vida no soro aumentada
AU2004225439A1 (en) * 2003-04-01 2004-10-14 Monogram Biosciences, Inc. Intracellular complexes as biomarkers
US20050079184A1 (en) 2003-08-08 2005-04-14 Immunomedics, Inc. Bispecific antibodies for inducing apoptosis of tumor and diseased cells
EP1664716A4 (en) 2003-08-15 2008-08-13 Smithkline Beecham Corp CANCER BIOMARKERS
US7519496B2 (en) * 2003-09-19 2009-04-14 Nxp B.V. Electronic circuit comprising a secret sub-module
US8554486B2 (en) 2004-02-20 2013-10-08 The Mathworks, Inc. Method, computer program product, and apparatus for selective memory restoration of a simulation
KR101347613B1 (ko) 2004-03-31 2014-01-06 다나-파버 캔서 인스티튜트 인크. 암에 걸린 인간 환자의 표피성장인자 수용체 표적 치료의 유효 가능성 결정 방법, 키트, 핵산 프로브 및 프라이머쌍
CN1997382A (zh) 2004-05-05 2007-07-11 梅里麦克制药股份有限公司 调节生物活性的双特异性结合剂
ES2677562T3 (es) 2004-05-27 2018-08-03 The Regents Of The University Of Colorado Métodos para la predicción del resultado clínico para inhibidores del receptor del factor de crecimiento epidérmico para pacientes de cáncer
WO2005121380A1 (en) 2004-06-04 2005-12-22 Smithkline Beecham Corporation Predictive biomarkers in cancer therapy
US7329737B2 (en) 2004-08-03 2008-02-12 Dyax Corp. Antibodies that bind hK-1
CA2575755C (en) 2004-08-06 2014-04-08 Genentech, Inc. Assays and methods using biomarkers
AU2005272848A1 (en) 2004-08-12 2006-02-23 Dyax Corp. Tie complex binding proteins
WO2006044378A2 (en) 2004-10-12 2006-04-27 University Of Iowa Research Foundation Rapid computational identification of targets
WO2006044748A2 (en) 2004-10-15 2006-04-27 Monogram Biosciences, Inc. RESPONSE PREDICTORS FOR ErbB PATHWAY-SPECIFIC DRUGS
GB0427131D0 (en) * 2004-12-10 2005-01-12 Glaxosmithkline Biolog Sa Novel combination
CN101163501A (zh) 2005-02-23 2008-04-16 梅里麦克制药股份有限公司 调节生物活性的双特异性结合剂
TW200642695A (en) 2005-03-08 2006-12-16 Genentech Inc Methods for identifying tumors responsive to treatment with her dimerization inhibitors (HDIs)
WO2007015935A2 (en) 2005-07-29 2007-02-08 Bayer Healthcare Llc Diagnostic methods for the prediction of therapeutic success, recurrence free and overall survival in cancer therapy
WO2007041502A2 (en) 2005-09-30 2007-04-12 Monogram Biosciences Methods for determining responsiveness to cancer therapy
WO2007039705A1 (en) 2005-10-05 2007-04-12 Astrazeneca Uk Limited Method to predict or monitor the response of a patient to an erbb receptor drug
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
WO2007109571A2 (en) 2006-03-17 2007-09-27 Prometheus Laboratories, Inc. Methods of predicting and monitoring tyrosine kinase inhibitor therapy
EP2049568A2 (en) 2006-04-07 2009-04-22 Københavns Universitet Erbb receptor-derived peptide fragments
EP2032982B1 (en) 2006-05-05 2012-08-29 Yale University Use of subcellular localization profiles as prognostic or predictive indicators
EP2047262A4 (en) 2006-07-13 2011-03-16 Univ Yale PROGNOSTIC METHODS OF CANCER FROM THE SUBCELLULAR LOCATION OF BIOMARKERS
AU2007324868B2 (en) 2006-11-28 2014-03-20 Daiichi Sankyo Europe Gmbh Activated HER3 as a marker for predicting therapeutic efficacy
US7825127B2 (en) 2006-12-28 2010-11-02 Takeda Pharmaceutical Company, Limited Method for treating cancer
PT2716301T (pt) * 2007-02-16 2017-07-04 Merrimack Pharmaceuticals Inc Anticorpos contra erbb3 e suas utilizações
EP2132573B1 (en) 2007-03-02 2014-04-23 Genentech, Inc. Predicting response to a her dimerisation inhbitor based on low her3 expression
EP2851091B1 (en) * 2007-04-13 2017-12-27 Dana-Farber Cancer Institute, Inc. Methods for treating cancer resistant to ERBB therapeutics
CA2732658A1 (en) 2008-08-15 2010-02-18 Merrimack Pharmaceuticals, Inc. Methods and systems for predicting response of cells to a therapeutic agent

Also Published As

Publication number Publication date
ES2433424T3 (es) 2013-12-11
AU2009281721A1 (en) 2010-02-18
CA2732658A1 (en) 2010-02-18
US8623592B2 (en) 2014-01-07
CO6341654A2 (es) 2011-11-21
EP2318548A2 (en) 2011-05-11
US20140127238A1 (en) 2014-05-08
WO2010019952A2 (en) 2010-02-18
MX2011001764A (es) 2011-05-19
NZ591137A (en) 2012-10-26
HK1155782A1 (en) 2012-05-25
US20170307631A1 (en) 2017-10-26
US20110027291A1 (en) 2011-02-03
IL210865A0 (en) 2011-04-28
US20110159513A1 (en) 2011-06-30
CN102224255A (zh) 2011-10-19
DOP2011000054A (es) 2011-04-30
ECSP11010872A (es) 2011-09-30
BRPI0917871A2 (pt) 2017-06-20
CR20110128A (es) 2011-09-27
EA201100373A1 (ru) 2011-08-30
WO2010019952A3 (en) 2010-06-24
SV2011003840A (es) 2011-07-06
IL210865A (en) 2014-04-30
KR20110044905A (ko) 2011-05-02
EP2318548B1 (en) 2013-10-16
JP2012500008A (ja) 2012-01-05
EA022884B1 (ru) 2016-03-31
ZA201100921B (en) 2014-06-25
MA32630B1 (fr) 2011-09-01
UA104868C2 (uk) 2014-03-25

Similar Documents

Publication Publication Date Title
PE20120015A1 (es) Metodos y sistemas para predecir la respuesta de las celulas tumorales a un agente terapeutico
MX2009005849A (es) Composiciones y metodos para tratar cancer con adn rico en cpg y cupredoxinas.
MX2009012722A (es) Variantes geneticas sobre chr 5p12 y 10q26 como marcadores para el uso en la evaluacion del riesgo, diagnostico, pronostico y tratamiento del cancer de mama.
EA201591131A1 (ru) Днк-конструкции антитела и способ их применения
SG10201901076WA (en) Methods of treating alzheimer's disease
UY31114A1 (es) Anticuerpos humanizados contra el globulómero ab(20-42) y sus usos
EP2308885A3 (en) Novel compounds and methods for therapy
EA201001695A1 (ru) Применение эпотилона d для лечения заболеваний, связанных с тау-белком
EA200900177A1 (ru) Замещенные ациланилиды и способы их применения
BR112012018132A2 (pt) "marcadores de células - tronco tumorais e uso dos mesmos".
ATE455463T1 (de) Verfahren zur herstellung gefriergetrockneter blutplättchen, gefriergetrocknete blutplättchen enthaltende zusammensetzungen und verwendungsverfahren
MX2008006076A (es) Metodos, composiciones y kits para el tratamiento de condiciones medicas.
EA201000644A1 (ru) Антитела для лечения и профилактики болезни альцгеймера и их применение
GB2459228A (en) Exosome-associated microrna as a diagnostic marker
AR061136A1 (es) Procedimiento
MY153198A (en) Inhibitors of protein aggregation
ES2422739T3 (es) Composición para el diagnóstico, prevención o tratamiento de enfermedades relacionadas con células que expresan IL-8 o GRO-, que comprende MSC de UCB
ATE461294T1 (de) Brustkrebsdiagnoseverfahren
MX2009010439A (es) Variantes geneticas de chr2 y chr16 como marcadores para el uso en valoracion, diagnosis, prognosis y tratamiento de riesgo de cancer de mama.
EP2209495A4 (en) TAZ / WWTR1 FOR THE DIAGNOSIS AND TREATMENT OF CANCER
MX2009013649A (es) Variantes geneticas en el cromosoma 15q24 como marcadores para usarse en diagnostico, prognosis y tratamiento de sindrome de exfoliacion y glaucoma.
AR081209A1 (es) Tratamiento de enfermedades relacionadas con la proteina 11 del tipo linfoma 2 de celulas b, (bcl2, bcl2l11) mediante la inhibicion del transcripto antisentido natural a bcl2l11
ATE555814T1 (de) Radioaktive mittel für die in vivo pet-bildgebung von ccr5
EP2957642A3 (en) Microrna patterns for the diagnosis, prognosis and treatment of melanoma
EA201290107A1 (ru) Способ определения пациента как восприимчивого или не восприимчивого к иммунотерапии

Legal Events

Date Code Title Description
FX Voluntary withdrawal