SV2011003840A - Metodos, sistemas y productos para predecir la respuesta de las celulas tumorales a un agente terapeutico y tratar un paciente de acuerdo con la respuesta predicha - Google Patents

Metodos, sistemas y productos para predecir la respuesta de las celulas tumorales a un agente terapeutico y tratar un paciente de acuerdo con la respuesta predicha

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Publication number
SV2011003840A
SV2011003840A SV2011003840A SV2011003840A SV2011003840A SV 2011003840 A SV2011003840 A SV 2011003840A SV 2011003840 A SV2011003840 A SV 2011003840A SV 2011003840 A SV2011003840 A SV 2011003840A SV 2011003840 A SV2011003840 A SV 2011003840A
Authority
SV
El Salvador
Prior art keywords
methods
response
cells
preach
tumor cells
Prior art date
Application number
SV2011003840A
Other languages
English (en)
Inventor
Birgit Schoeberl
Brian Harms
Francis David Gibbons
Jonathan Basil Fitzgerald
William Kubasek
Ulrik Nielsen
Matthew David Onsum
Original Assignee
Merrimack Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41228727&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SV2011003840(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merrimack Pharmaceuticals Inc filed Critical Merrimack Pharmaceuticals Inc
Publication of SV2011003840A publication Critical patent/SV2011003840A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Abstract

MÉTODOS PARA TRATAR PACIENTES, DICHOS MÉTODOS COMPRENDEN MÉTODOS PARA PREDECIR LAS RESPUESTAS DE LAS CÉLULAS, TALES COMO LAS CÉLULAS TUMORALES, AL TRATAMIENTO CON AGENTES TERAPÉUTICOS. ESTOS MÉTODOS INCLUYEN MEDIR, EN UNA MUESTRA DE LAS CÉLULAS, LOS NIVELES DE UNO O MÁS COMPONENTES DE UNA RED CELULAR Y DESPUÉS CALCULAR UN ESTADO DE ACTIVACIÓN DE LA RED (ÑAS) O UN ESTADO DE INHIBICIÓN DE LA RED (NIS) PARA LAS CÉLULAS USANDO UN MODELO COMPUTACIONAL DE LA RED CELULAR. LA RESPUESTA DE LAS CÉLULAS AL TRATAMIENTO ES ENTONCES PREDICHA EN BASE AL VALOR DE ÑAS O NIS QUE HA SIDO CALCULADO. LA INVENCIÓN TAMBIÉN COMPRENDE MÉTODOS PREDICTIVOS PARA LA RESPUESTA £ 15 CELULAR EN LOS CUALES EL CÁLCULO DE UN VALOR DE ÑAS O NIS PARA LAS CÉLULAS (POR EJEMPLO, LAS CÉLULAS TUMORALES) SE COMBINA CON EL USO DE UN ALGORITMO DE CLASIFICACIÓN ESTADÍSTICA. TAMBIÉN SE PROPORCIONAN BIOMARCADORES PARA PREDECIR LA RESPUESTA AL TRATAMIENTO CON UN AGENTE TERAPÉUTICO QUE DIRIGE UN COMPONENTE DENTRO DE LA VÍA DE SEÑALIZACIÓN ERBB
SV2011003840A 2008-08-15 2011-02-15 Metodos, sistemas y productos para predecir la respuesta de las celulas tumorales a un agente terapeutico y tratar un paciente de acuerdo con la respuesta predicha SV2011003840A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18905308P 2008-08-15 2008-08-15
US19470208P 2008-09-30 2008-09-30
US20820609P 2009-02-20 2009-02-20
US17036709P 2009-04-17 2009-04-17

Publications (1)

Publication Number Publication Date
SV2011003840A true SV2011003840A (es) 2011-07-06

Family

ID=41228727

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2011003840A SV2011003840A (es) 2008-08-15 2011-02-15 Metodos, sistemas y productos para predecir la respuesta de las celulas tumorales a un agente terapeutico y tratar un paciente de acuerdo con la respuesta predicha

Country Status (24)

Country Link
US (4) US8623592B2 (es)
EP (1) EP2318548B1 (es)
JP (1) JP2012500008A (es)
KR (1) KR20110044905A (es)
CN (1) CN102224255A (es)
AU (1) AU2009281721A1 (es)
BR (1) BRPI0917871A2 (es)
CA (1) CA2732658A1 (es)
CO (1) CO6341654A2 (es)
CR (1) CR20110128A (es)
DO (1) DOP2011000054A (es)
EA (1) EA022884B1 (es)
EC (1) ECSP11010872A (es)
ES (1) ES2433424T3 (es)
HK (1) HK1155782A1 (es)
IL (1) IL210865A (es)
MA (1) MA32630B1 (es)
MX (1) MX2011001764A (es)
NZ (1) NZ591137A (es)
PE (1) PE20120015A1 (es)
SV (1) SV2011003840A (es)
UA (1) UA104868C2 (es)
WO (1) WO2010019952A2 (es)
ZA (1) ZA201100921B (es)

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IL210865A (en) 2014-04-30
PE20120015A1 (es) 2012-01-26
NZ591137A (en) 2012-10-26
MX2011001764A (es) 2011-05-19
WO2010019952A2 (en) 2010-02-18
EP2318548A2 (en) 2011-05-11
CA2732658A1 (en) 2010-02-18
CO6341654A2 (es) 2011-11-21
US20110027291A1 (en) 2011-02-03
WO2010019952A3 (en) 2010-06-24
IL210865A0 (en) 2011-04-28
EP2318548B1 (en) 2013-10-16
US8623592B2 (en) 2014-01-07
CN102224255A (zh) 2011-10-19
AU2009281721A1 (en) 2010-02-18
MA32630B1 (fr) 2011-09-01
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US20140127238A1 (en) 2014-05-08
ECSP11010872A (es) 2011-09-30
EA022884B1 (ru) 2016-03-31
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US20110159513A1 (en) 2011-06-30
CR20110128A (es) 2011-09-27
HK1155782A1 (en) 2012-05-25
DOP2011000054A (es) 2011-04-30
BRPI0917871A2 (pt) 2017-06-20
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US20170307631A1 (en) 2017-10-26

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