PE20081512A1 - Compuestos y composiciones como inhibidores de la actividad del receptor de canabinoide 1 - Google Patents

Compuestos y composiciones como inhibidores de la actividad del receptor de canabinoide 1

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Publication number
PE20081512A1
PE20081512A1 PE2007001785A PE2007001785A PE20081512A1 PE 20081512 A1 PE20081512 A1 PE 20081512A1 PE 2007001785 A PE2007001785 A PE 2007001785A PE 2007001785 A PE2007001785 A PE 2007001785A PE 20081512 A1 PE20081512 A1 PE 20081512A1
Authority
PE
Peru
Prior art keywords
phenyl
alkyl
halo
compounds
inhibitors
Prior art date
Application number
PE2007001785A
Other languages
English (en)
Inventor
Hong Liu
Xiaohui He
Dean Phillips
Xuefeng Zhu
Thomas Lau
Baogen Wu
Yongping Xie
Truc Ngoc Nguyen
Xing Wang
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of PE20081512A1 publication Critical patent/PE20081512A1/es

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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
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    • C07F7/1804—Compounds having Si-O-C linkages

Abstract

REFERIDA A UN COMPUESTO DE FORMULA (I), EN DONDE Y1 ES N y CR11; Y2 ES N Y CR8; Z1 ES S, O, NH, ENTRE OTROS; Z2 ES O, -CH2CHR1a, -NR1a, ENTRE OTROS; R1a ES H, CIANO, ALQUILO C1-C6, ENTRE OTROS; R2a ES H, ALQUILO C1-C6; HALOALQUILO C1-C6, ENTRE OTROS; R2b ES H, ALQUILO C1-C6, ENTRE OTROS; R3, R5, R6 Y R7 SON H, HALO Y AMINO; R4 ES H, HALO, HIDROXI, ALQUILO C1-C6, ENTRE OTROS; R8, R9, R11 y R12a SON H, HALO, ALQUILO C1-C6, ENTRE OTROS; R10 ES HALO, CIANO, ALCOXI C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-[4-(4-CLORO-FENOXI)-FENIL]-5-FENIL-PIRROLIDI-2-NONA, 5-(4-AMINO-3-TRIFLUOROMETIL-FENIL)-1-[4-(4-CLORO-FENOXI)-FENIL]-PIRROLIDI-2-ONA, 1-[4-(4-CLORO-FENOXI)-FENIL]-5-(3-TRIFLUOROMETIL-FENIL)-PIRROLIDI-2-NONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DEL RECEPTOR DE CANABINOIDE 1 (CB1) Y SON UTILES EN EL TRATAMIENTO DE LA PSICOSIS, DEFICIENCIA DE LA MEMORIA, MIGRANA, NEUROPATIA, ACCIDENTES CEREBROVASCULARES, ENTRE OTROS
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Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2537898T3 (es) 2005-10-25 2015-06-15 Shionogi & Co., Ltd. Derivados de aminotiazolidina y aminotetrahidrotiazepina como inhibidores de BACE 1
US20100197564A1 (en) * 2007-04-19 2010-08-05 Schering Corporation Diaryl morpholines as cb1 modulators
JP5383483B2 (ja) * 2007-04-24 2014-01-08 塩野義製薬株式会社 アルツハイマー症治療用医薬組成物
JP5383484B2 (ja) 2007-04-24 2014-01-08 塩野義製薬株式会社 環式基で置換されたアミノジヒドロチアジン誘導体
CA2725680A1 (en) 2008-05-30 2009-12-03 Takeda Pharmaceutical Company Limited Heterocyclic compound
US8637504B2 (en) 2008-06-13 2014-01-28 Shionogi & Co., Ltd. Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
US8962860B2 (en) 2008-09-04 2015-02-24 Probiodrug Ag Inhibitors of glutaminyl cyclase
JPWO2010047372A1 (ja) * 2008-10-22 2012-03-22 塩野義製薬株式会社 Ｂａｃｅ１阻害活性を有する２−アミノピリミジン−４−オンおよび２−アミノピリジン誘導体
FR2938538B1 (fr) * 2008-11-17 2011-08-05 Univ Nice Sophia Antipolis Procede de preparation d'acides et d'esters boroniques en presence de magnesium metallique
WO2010068564A1 (en) * 2008-12-11 2010-06-17 Merck Sharp & Dohme Corp. Method for treating alzheimer's disease and related conditions
FR2941696B1 (fr) * 2009-02-05 2011-04-15 Sanofi Aventis Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
BR112012013854A2 (pt) 2009-12-11 2019-09-24 Shionogi & Co derivados de oxazina.
JO2998B1 (ar) 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
JP5816630B2 (ja) 2010-10-29 2015-11-18 塩野義製薬株式会社 ナフチリジン誘導体
WO2012057247A1 (ja) 2010-10-29 2012-05-03 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
WO2012147763A1 (ja) 2011-04-26 2012-11-01 塩野義製薬株式会社 オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤
CA2850166C (en) 2011-09-27 2019-12-03 Amgen Inc. Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer
WO2013134079A1 (en) * 2012-03-05 2013-09-12 Amgen Inc. Oxazolidinone compounds and derivatives thereof
WO2014065434A1 (en) 2012-10-24 2014-05-01 Shionogi & Co., Ltd. Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
MX368703B (es) 2013-02-28 2019-10-11 Amgen Inc Un inhibidor de mdm2 derivado de acido benzoico para el tratamiento del cancer.
WO2014151863A1 (en) 2013-03-14 2014-09-25 Amgen Inc. Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer
JOP20200296A1 (ar) 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
AP2016009080A0 (en) * 2013-09-17 2016-03-31 Vectus Biosystems Pty Ltd Compositions for the treatment of hypertension and/or fibrosis
TW201609710A (zh) * 2013-12-10 2016-03-16 杜邦股份有限公司 除草用經取代嘧啶氧基苯化合物
ES2719410T3 (es) 2014-01-16 2019-07-10 Fmc Corp Derivados del pirimidiniloxi benceno como herbicidas
CN106572994B (zh) * 2014-06-09 2020-09-18 中外制药株式会社 含有乙内酰脲衍生物的药物组合物
TWI828952B (zh) 2015-06-05 2024-01-11 美商艾佛艾姆希公司 作為除草劑之嘧啶氧基苯衍生物
AU2018262478B2 (en) 2017-05-02 2022-03-03 Fmc Corporation Pyrimidinyloxy benzo-fused compounds as herbicides
WO2019173182A1 (en) 2018-03-05 2019-09-12 Bristol-Myers Squibb Company Phenylpyrrolidinone formyl peptide 2 receptor agonists
US10897925B2 (en) 2018-07-27 2021-01-26 Joseph Pandolfino Articles and formulations for smoking products and vaporizers
US20200035118A1 (en) 2018-07-27 2020-01-30 Joseph Pandolfino Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes
US11292782B2 (en) 2018-11-30 2022-04-05 Nuvation Bio Inc. Diarylhydantoin compounds and methods of use thereof
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
CN111434655A (zh) * 2019-01-15 2020-07-21 武汉朗来科技发展有限公司 溶血磷脂酸受体拮抗剂及其制备方法
CN113173916A (zh) * 2021-03-31 2021-07-27 翟洪 一种托匹司他的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3129228A (en) * 1964-04-14 -chj-n h
FR1516714A (fr) * 1962-11-07 1968-02-05 Bayer Ag Procédé de préparation de dérivés de l'imidazolidine
FR2097038A1 (en) 1970-07-29 1972-03-03 Bellon Labor Sa Roger 1-(substd phenyl)-2-oxo-4-piperazinocarbonyl pyrrolidines - analgesic
NL7312944A (nl) * 1973-09-20 1975-03-24 Akzo Nv Werkwijze ter bereiding van nieuwe imidazolidino-deri- vaten en de toepassing hiervan.
FI875101A (fi) * 1986-12-03 1988-06-04 Tanabe Seiyaku Co Laktamderivat och preparat innehaollande dessa.
JPS63264458A (ja) 1986-12-03 1988-11-01 Tanabe Seiyaku Co Ltd ラクタム誘導体
DE4107857A1 (de) * 1991-03-12 1992-09-17 Thomae Gmbh Dr K Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4426757A1 (de) * 1994-07-28 1996-02-01 Bayer Ag 2-Imidazolidinon-Derivate
BR0008755A (pt) * 1999-01-13 2007-05-29 Genentech Inc compostos inibidores de protease de serina, composição, método de inibição da atividade de tf/fator viia, fator xa, trombina ou calicreìna, método de tratamento de uma disfunção mediada por tf/fator viia, fator xa, trombina ou calicreìna e método de prevenção de trombose ou tratamento de trombose anormal
UA74781C2 (en) * 1999-04-02 2006-02-15 Abbott Lab Antiinflammatory and immumosuppressive compounds inhibiting cell adhesion
US20060025589A1 (en) * 2002-10-01 2006-02-02 Jean Binet 2-Thiohydantoine derivative compounds and use thereof for the treatment of diabetes
US7223870B2 (en) * 2002-11-01 2007-05-29 Pfizer Inc. Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
GB0230088D0 (en) * 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents
US20040209928A1 (en) * 2002-12-30 2004-10-21 Ravi Kurukulasuriya Glucagon receptor antagonists/inverse agonists
NZ555320A (en) 2004-12-03 2010-11-26 Schering Corp Substituted piperazines as CB1 antagonists
CA2591940A1 (en) * 2004-12-23 2006-06-29 Chiesi Farmaceutici S.P.A. Azole derivatives with antimuscarinic activity
SI1891038T1 (sl) * 2005-05-13 2009-04-30 Lilly Co Eli Substituirani n-arilpirolodini kot selektivni modulatorji androgenskega receptorja
WO2007020502A2 (en) * 2005-08-16 2007-02-22 Pharmacia & Upjohn Company Llc Cannabinoid receptor ligands and uses thereof
JP2009525954A (ja) * 2006-01-13 2009-07-16 シェーリング コーポレイション Ｃｂ１モジュレーターとしてのジアリールピペリジン

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