PE20120355A1 - DERIVADOS DE PIRAZOL COMO INHIBIDORES DE LA ENZIMA 11ßHSD1 - Google Patents

DERIVADOS DE PIRAZOL COMO INHIBIDORES DE LA ENZIMA 11ßHSD1

Info

Publication number
PE20120355A1
PE20120355A1 PE2012000020A PE2012000020A PE20120355A1 PE 20120355 A1 PE20120355 A1 PE 20120355A1 PE 2012000020 A PE2012000020 A PE 2012000020A PE 2012000020 A PE2012000020 A PE 2012000020A PE 20120355 A1 PE20120355 A1 PE 20120355A1
Authority
PE
Peru
Prior art keywords
alkyl
11ßhsd1
propylsulfanil
cycloalkanylidene
pirazol
Prior art date
Application number
PE2012000020A
Other languages
English (en)
Inventor
Paul Robert Owen Whittamore
James Stewart Scott
Martin John Packer
Andrew Stocker
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39438215&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120355(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20120355A1 publication Critical patent/PE20120355A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE PIRAZOL DE FORMULA (1), DONDE Q ES O, S O UN ENLACE SIMPLE; R1 ES ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS; R2 ES CICLOALQUIL C3-C7(CH2)m, POLICICLOALQUILC6-C12(CH2)m, ENTRE OTROS; R3 ES H, ALQUILO C1-C4-CICLALQUILO C3-C5, CICLOALQUILMETILO C3-C5, ENTRE OTROS; A ES UN ANILLO FENILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS CON R10 O R11; R10 ES ALQUILO C1-C4, OH, CIANO, TRIFLUOROMETILO, HALO, ENTRE OTROS; R11 ES ALQUILO C1-C3 OPCIONALMENTE SUSTITUIDO CON FLUOR; X ES UN ENLACE DIRECTO, CICLOALCANDIILO C3-C4, CICLOALCANILIDENO C3-C4, CH2O, ENTRE OTROS; Y ES UN ENLACE DIRECTO, CICLOALCANDIILO C3-C4, CICLOALCANILIDENO C3-C4, ENTRE OTROS; m ES 0 A 2. SON COMPUESTOS PREFERIDOS: ACIDO 4-[4-[[(1S,3R)-5-HIDROXI-2-ADAMANTIL]CARBAMOIL]-5-PROPILSULFANIL-PIRAZOL-1-IL]BENZOICO, ACIDO 4-[4-(2-ADAMANTILCARBAMOIL)-5-PROPILSULFANIL-PIRAZOL-1-IL]BENZOICO, ACIDO 4-[4-(OXAN-4-ILCARBAMOIL)-5-PROPILSULFANIL-PIRAZOL-1-IL]BENZOICO, ENTRE OTROS. REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCESO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA ENZIMA 11-BETA-HIDROXIESTEROIDE DESHIDROGENASA DE TIPO 1 HUMANA (11ßHSD1) Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES RELACIONADAS CON EL SINDROME METABOLICO
PE2012000020A 2007-02-12 2008-02-11 DERIVADOS DE PIRAZOL COMO INHIBIDORES DE LA ENZIMA 11ßHSD1 PE20120355A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88933607P 2007-02-12 2007-02-12
US98573507P 2007-11-06 2007-11-06

Publications (1)

Publication Number Publication Date
PE20120355A1 true PE20120355A1 (es) 2012-05-17

Family

ID=39438215

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2008000295A PE20090649A1 (es) 2007-02-12 2008-02-11 DERIVADOS DE PIRAZOL COMO INHIBIDORES DE LA ENZIMA 11ßHSD1
PE2012000020A PE20120355A1 (es) 2007-02-12 2008-02-11 DERIVADOS DE PIRAZOL COMO INHIBIDORES DE LA ENZIMA 11ßHSD1

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2008000295A PE20090649A1 (es) 2007-02-12 2008-02-11 DERIVADOS DE PIRAZOL COMO INHIBIDORES DE LA ENZIMA 11ßHSD1

Country Status (23)

Country Link
US (2) US7816391B2 (es)
EP (2) EP2292228A1 (es)
JP (1) JP2010518063A (es)
KR (1) KR20090108726A (es)
CN (1) CN102503891A (es)
AR (1) AR065300A1 (es)
AU (1) AU2008215976B2 (es)
BR (1) BRPI0808450A2 (es)
CA (1) CA2676154A1 (es)
CL (1) CL2008000422A1 (es)
CO (1) CO6220949A2 (es)
EC (1) ECSP099571A (es)
IL (1) IL200047A0 (es)
MX (1) MX2009008506A (es)
NZ (1) NZ578568A (es)
PE (2) PE20090649A1 (es)
RU (2) RU2462456C2 (es)
SA (1) SA08290055B1 (es)
SG (1) SG177892A1 (es)
TW (1) TW200836719A (es)
UY (1) UY30912A1 (es)
WO (1) WO2008099145A1 (es)
ZA (1) ZA201000838B (es)

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Also Published As

Publication number Publication date
ZA201000838B (en) 2010-10-27
JP2010518063A (ja) 2010-05-27
IL200047A0 (en) 2010-04-15
RU2012125372A (ru) 2013-12-27
AU2008215976B2 (en) 2011-11-24
WO2008099145A1 (en) 2008-08-21
UY30912A1 (es) 2008-09-30
CN102503891A (zh) 2012-06-20
EP2292228A1 (en) 2011-03-09
SG177892A1 (en) 2012-02-28
CO6220949A2 (es) 2010-11-19
AR065300A1 (es) 2009-05-27
RU2462456C2 (ru) 2012-09-27
EP2124937A1 (en) 2009-12-02
US8344016B2 (en) 2013-01-01
PE20090649A1 (es) 2009-06-26
MX2009008506A (es) 2009-10-12
NZ578568A (en) 2012-01-12
US7816391B2 (en) 2010-10-19
BRPI0808450A2 (pt) 2014-08-12
CL2008000422A1 (es) 2009-01-02
US20110224273A1 (en) 2011-09-15
TW200836719A (en) 2008-09-16
RU2009133259A (ru) 2011-03-20
AU2008215976A1 (en) 2008-08-21
CA2676154A1 (en) 2008-08-21
SA08290055B1 (ar) 2012-09-26
ECSP099571A (es) 2009-09-29
US20090221663A1 (en) 2009-09-03
KR20090108726A (ko) 2009-10-16

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