PE20050358A1 - Composiciones referidas a inhibidores de canales ionicos regulados por voltaje - Google Patents
Composiciones referidas a inhibidores de canales ionicos regulados por voltajeInfo
- Publication number
- PE20050358A1 PE20050358A1 PE2004000774A PE2004000774A PE20050358A1 PE 20050358 A1 PE20050358 A1 PE 20050358A1 PE 2004000774 A PE2004000774 A PE 2004000774A PE 2004000774 A PE2004000774 A PE 2004000774A PE 20050358 A1 PE20050358 A1 PE 20050358A1
- Authority
- PE
- Peru
- Prior art keywords
- inhibitors
- ion channels
- referred
- voltage regulated
- compositions referred
- Prior art date
Links
- 102000004310 Ion Channels Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 abstract 2
- PXXNTAGJWPJAGM-VCOUNFBDSA-N Decaline Chemical compound C=1([C@@H]2C3)C=C(OC)C(OC)=CC=1OC(C=C1)=CC=C1CCC(=O)O[C@H]3C[C@H]1N2CCCC1 PXXNTAGJWPJAGM-VCOUNFBDSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- BJGKRICBCYVRDX-UHFFFAOYSA-N ethyl 4-(2,4-dichlorophenoxy)butanoate Chemical compound CCOC(=O)CCCOC1=CC=C(Cl)C=C1Cl BJGKRICBCYVRDX-UHFFFAOYSA-N 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- PXXNTAGJWPJAGM-UHFFFAOYSA-N vertaline Natural products C1C2C=3C=C(OC)C(OC)=CC=3OC(C=C3)=CC=C3CCC(=O)OC1CC1N2CCCC1 PXXNTAGJWPJAGM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
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Abstract
REFERIDA A UN COMPUESTO DE FORMULA I-A DONDE RN ES H, C1-C4 ALIIFATICO OPCIONALMENTE SUSTITUIDO; X1 ES O, S O NRX; X2 ES C1-C3 ALIFATICO OPCIONALMENTE SUSTITUIDO; p ES 0-1; Z ES i, ii, ENTRE OTROS; T ES ANILLO BICICLICO O TRICICLICO, AROMATICO O NO, DE 8-14 MIEMBROS TAL COMO NAFTILO, TETRALINA, O DECALINA. SON COMPUESTOS PREFERIDOS: 4-(2,4-DICLOROFENOXI)-BUTIRATO DE ETILO; 5,7-DICLORO-INDOL-2-IL-N-[4-(TIADIAZOL-2-ILSULFAMOIL)-FENIL]AMIDA Y N-[4-(TIAZOL-2-ILSULFAMOIL)-FENIL]-2-(4-FLUOROFENOXI)-ACETAMIDA; ENTRE OTROS. TAMBIEN REFERIDO A COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN DICHOS COMPUESTOS QUE SON UTILES PARA EL TRATAMIENTO DE DOLORES NEUROPATICOS E INTRATABLES
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Families Citing this family (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100860581B1 (ko) | 2002-05-18 | 2008-09-26 | 엘지전자 주식회사 | 멀티캐스트 데이터 전송 방법 |
KR20030097559A (ko) | 2002-06-22 | 2003-12-31 | 엘지전자 주식회사 | 무선이동통신 시스템의 멀티미디어 서비스 방법 |
JP2007501804A (ja) * | 2003-08-08 | 2007-02-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | 電位開口型のナトリウムチャネルのインヒビターとして有用な組成物 |
US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
KR100595646B1 (ko) | 2004-01-09 | 2006-07-03 | 엘지전자 주식회사 | Mbms서비스를 제공하는 무선통신 시스템 |
BRPI0509759A (pt) * | 2004-04-13 | 2007-10-16 | Warner Lambert Co | moduladores de androgênio |
EP1740533A1 (en) | 2004-04-22 | 2007-01-10 | Warner-Lambert Company LLC | Androgen modulators |
MXPA06015169A (es) | 2004-07-08 | 2007-08-21 | Warner Lambert Co | Moduladores de androgenos. |
US7671077B2 (en) * | 2004-07-19 | 2010-03-02 | Leu-Fen Hou Lin | Neuroprotective small organic molecules, compositions and uses related thereto |
AU2005290436A1 (en) * | 2004-10-01 | 2006-04-13 | Banyu Pharmaceutical Co.,Ltd | 2-arylcarboxamide-nitrogeneous heterocycle compound |
ATE544748T1 (de) | 2004-12-28 | 2012-02-15 | Kinex Pharmaceuticals Llc | Zusammensetzungen und verfahren für die behandlung von zellproliferationserkrankungen |
US7968574B2 (en) | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
US20100022582A1 (en) * | 2005-03-10 | 2010-01-28 | Kenji Takahashi | Tetrahydroisoquinoline Compound and Medicinal Use Thereof |
WO2006095822A1 (ja) * | 2005-03-11 | 2006-09-14 | Ono Pharmaceutical Co., Ltd. | スルホンアミド化合物およびその医薬 |
WO2006104751A2 (en) * | 2005-03-30 | 2006-10-05 | The Regents Of The University Of Michigan | Methods and compositions for modulating rho-mediated gene transcription |
EP1871372A4 (en) * | 2005-04-08 | 2010-06-02 | Neuromed Pharmaceuticals Ltd | COMBINATION THERAPY WHICH INCLUDES AN AGENT BLOCKING CALCIUM CHANNELS OF TYPE N FOR THE RELIEF OF PAIN |
RU2007145434A (ru) * | 2005-05-10 | 2009-06-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Бициклические производные в качестве модуляторов ионных каналов |
EP1888558B1 (en) * | 2005-05-16 | 2011-10-05 | Vertex Pharmaceuticals, Inc. | Bicyclic derivatives as modulators of ion channels |
RU2007148504A (ru) | 2005-06-09 | 2009-06-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Индановые производные в качестве модуляторов ионных каналов |
JP5261176B2 (ja) * | 2005-08-16 | 2013-08-14 | アイカジェン, インコーポレイテッド | 電位作動型ナトリウムチャンネル阻害剤 |
KR20080044910A (ko) * | 2005-09-09 | 2008-05-21 | 버텍스 파마슈티칼스 인코포레이티드 | 전압 개폐 이온 채널 조절인자로서의 바이사이클릭 유도체 |
ATE551333T1 (de) * | 2005-10-12 | 2012-04-15 | Vertex Pharma | Biphenylderivate als modulatoren von spannungsabhängigen ionenkanälen |
CN101331115A (zh) * | 2005-10-21 | 2008-12-24 | 沃泰克斯药物股份有限公司 | 调控离子通道的衍生物 |
CA2628312A1 (en) * | 2005-11-02 | 2007-05-18 | Icagen, Inc. | Inhibitors of ion channels |
EP1963281A2 (en) * | 2005-12-21 | 2008-09-03 | Vertex Pharmaceuticals, Inc. | Heterocyclic derivatives as modulators of ion channels |
US8841483B2 (en) * | 2006-04-11 | 2014-09-23 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of voltage-gated sodium channels |
CN101595084B (zh) | 2006-06-29 | 2013-01-02 | 金克斯医药品有限公司 | 用于调整激酶级联的二芳基组合物和方法 |
EP2420494B1 (en) * | 2006-08-16 | 2014-10-08 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Use of thiadiazole compounds as inhibitors of kynurenine-3-monooxygenase |
EP2054397B1 (en) | 2006-08-16 | 2015-10-07 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Small molecule inhibitors of kynurenine-3-monooxygenase |
AU2007318922C1 (en) * | 2006-11-07 | 2013-09-12 | Proteologics Ltd. | Pyrimidine derivatives as POSH and POSH-AP inhibitors |
TWI457336B (zh) | 2006-12-28 | 2014-10-21 | Kinex Pharmaceuticals Llc | 調節激酶級聯之組成物及方法 |
US7935697B2 (en) | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
US7939529B2 (en) | 2007-05-17 | 2011-05-10 | Kinex Pharmaceuticals, Llc | Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof |
WO2008098239A2 (en) * | 2007-02-09 | 2008-08-14 | Emory University | Paramyxovirus family inhibitors and methods of use thereof |
ES2340640T3 (es) * | 2007-03-23 | 2010-06-07 | Icagen, Inc. | Inhibidores de canales de iones. |
WO2008130322A1 (en) * | 2007-04-23 | 2008-10-30 | Astrazeneca Ab | Novel 5-heterocyclyl-chromane derivatives for the treatment of pain |
WO2008130323A1 (en) * | 2007-04-23 | 2008-10-30 | Astrazeneca Ab | Novel 8-piperazine-tetrahydronaphtalene derivatives for the treatment of pain |
WO2008130321A2 (en) * | 2007-04-23 | 2008-10-30 | Astrazeneca Ab | Novel n-tetrahydronaphtalene or 5-heterocyclyl-chromane or 8-heterocyclyl-tetrahydronaphtalene derivatives for the treatment of pain |
WO2008130319A2 (en) * | 2007-04-23 | 2008-10-30 | Astrazeneca Ab | Novel n-tetrahydronaphtalene or n-chromane carboxamide derivatives for the treatment of pain |
SA08290245B1 (ar) * | 2007-04-23 | 2012-02-12 | استرازينيكا ايه بي | مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم |
JP2010528035A (ja) * | 2007-05-25 | 2010-08-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネル調節物質およびその使用 |
WO2009009041A2 (en) | 2007-07-06 | 2009-01-15 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
ES2523196T3 (es) * | 2007-07-13 | 2014-11-21 | Icagen, Inc. | Inhibidores de los canales de sodio |
CA2693588C (en) | 2007-07-13 | 2015-11-17 | Icagen, Inc. | Sodium channel inhibitors |
WO2009016081A2 (en) * | 2007-08-02 | 2009-02-05 | Actar Ab | Benzoind0l-2-one derivatives for use in therapy |
US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
WO2009049181A1 (en) * | 2007-10-11 | 2009-04-16 | Vertex Pharmaceuticals Incorporated | Amides useful as inhibitors of voltage-gated sodium channels |
CA2701946A1 (en) | 2007-10-11 | 2009-04-16 | Vertex Pharmaceuticals Incorporated | Heteroaryl amides useful as inhibitors of voltage-gated sodium channels |
EP2212290B1 (en) * | 2007-10-11 | 2014-12-03 | Vertex Pharmaceuticals Incorporated | Aryl amides useful as inhibitors of voltage-gated sodium channels |
RU2010123781A (ru) * | 2007-11-13 | 2011-12-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Производные 4-(2-фенил)-морфолино)-2-оксопирролидин-1-ил)-n-(тиазол-2-ил)бензолсульфонамида и родственные соединения в качестве модуляторов ионных каналов для лечения боли |
US8097636B2 (en) * | 2007-11-13 | 2012-01-17 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
CN101565418B (zh) * | 2008-04-23 | 2011-09-28 | 华东理工大学 | 酰胺衍生物及其用途 |
US20110031892A1 (en) * | 2008-04-30 | 2011-02-10 | Sharp Kabushiki Kaisha | Lighting device and display device |
EP2307412A2 (en) * | 2008-07-01 | 2011-04-13 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
WO2010033824A1 (en) * | 2008-09-19 | 2010-03-25 | Icagen, Inc. | Sulfonamide derivatives as inhibitors of ion channels |
WO2010035166A1 (en) * | 2008-09-23 | 2010-04-01 | Pfizer Limited | Benzamide derivatives |
MY157017A (en) * | 2009-01-12 | 2016-04-15 | Pfizer Ltd | Sulfonamide derivatives |
CN107441097A (zh) | 2010-04-16 | 2017-12-08 | 阿西纳斯公司 | 用于预防和治疗癌症的组合物以及方法 |
EP2576532B1 (en) | 2010-06-07 | 2018-07-18 | Novomedix, LLC | Furanyl compounds and the use thereof |
US9145407B2 (en) | 2010-07-09 | 2015-09-29 | Pfizer Limited | Sulfonamide compounds |
EP2590957B1 (en) * | 2010-07-09 | 2014-11-12 | Pfizer Limited | N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels |
JP5830534B2 (ja) | 2010-07-09 | 2015-12-09 | ファイザー・リミテッドPfizer Limited | 化合物 |
US9096500B2 (en) | 2010-07-12 | 2015-08-04 | Pfizer Limited | Acyl sulfonamide compounds |
CA2804351A1 (en) | 2010-07-12 | 2012-01-19 | Pfizer Limited | Chemical compounds |
EP2593431B1 (en) | 2010-07-12 | 2014-11-19 | Pfizer Limited | N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels |
ES2532357T3 (es) | 2010-07-12 | 2015-03-26 | Pfizer Limited | Derivados de sulfonamida como inhibidores de Nav1.7 para el tratamiento del dolor |
ES2525581T3 (es) | 2010-07-12 | 2014-12-26 | Pfizer Limited | Derivados de N-sulfonilbenzamida útiles como inhibidores del canal de sodio dependiente de voltaje |
WO2012095781A1 (en) | 2011-01-13 | 2012-07-19 | Pfizer Limited | Indazole derivatives as sodium channel inhibitors |
CN103930437A (zh) | 2011-03-16 | 2014-07-16 | 安姆根有限公司 | Nav1.3和Nav1.7的强效及选择性抑制剂 |
US9499488B2 (en) | 2011-07-11 | 2016-11-22 | Beth Israel Deaconess Medical Center, Inc. | Vitamin D receptor agonists and uses thereof |
US9499489B2 (en) | 2011-10-24 | 2016-11-22 | Emory University | Myxovirus therapeutics, compounds, and uses related thereto |
KR20140105445A (ko) | 2011-10-31 | 2014-09-01 | 제논 파마슈티칼스 인크. | 비아릴 에테르 술폰아미드 및 치료제로서의 그의 용도 |
JP6014154B2 (ja) | 2011-10-31 | 2016-10-25 | ゼノン・ファーマシューティカルズ・インコーポレイテッドXenon Pharmaceuticals Inc. | ベンゼンスルホンアミド化合物および治療剤としてのそれらの使用 |
EP2791108B1 (en) * | 2011-12-15 | 2016-07-27 | Pfizer Limited | Sulfonamide derivatives |
WO2013093688A1 (en) | 2011-12-19 | 2013-06-27 | Pfizer Limited | Sulfonamide derivatives and use thereof as vgsc inhibitors |
US20150291514A1 (en) | 2012-01-04 | 2015-10-15 | Pfizer Limted | N-Aminosulfonyl Benzamides |
CN104718188B (zh) | 2012-05-22 | 2018-08-21 | 基因泰克公司 | N-取代的苯甲酰胺类及其在治疗疼痛中的用途 |
CA2878478A1 (en) | 2012-07-06 | 2014-01-09 | Genentech, Inc. | N-substituted benzamides and methods of use thereof |
CA2883144C (en) | 2012-08-30 | 2023-01-17 | Kinex Pharmaceuticals, Llc | N-(3-fluorobenzyl)-2-(5-(4-morpholinophenyl)pyridin-2-yl) acetamide as protein|tyrosine kinase modulators |
TW201427947A (zh) | 2012-10-12 | 2014-07-16 | Lundbeck & Co As H | 環狀胺 |
TWI598325B (zh) | 2012-10-12 | 2017-09-11 | H 朗德貝克公司 | 苯甲醯胺類 |
ES2828503T3 (es) | 2012-10-15 | 2021-05-26 | Dae Woong Pharma | Bloqueadores de los canales de sodio, método de preparación de los mismos y uso de los mismos |
AR095192A1 (es) * | 2013-01-31 | 2015-09-30 | Vertex Pharma | Quinolina y quinazolinamidas como modulares de canales de sodio |
CN105026373B (zh) * | 2013-01-31 | 2018-03-30 | 沃泰克斯药物股份有限公司 | 作为钠通道调节剂的吡啶酮酰胺 |
US9636418B2 (en) | 2013-03-12 | 2017-05-02 | Amgen Inc. | Potent and selective inhibitors of NAV1.7 |
US10344060B2 (en) | 2013-03-12 | 2019-07-09 | Amgen Inc. | Potent and selective inhibitors of Nav1.7 |
RU2015143906A (ru) | 2013-03-14 | 2017-04-18 | Дженентек, Инк. | Замещенные триазолопиридины и способы их применения |
MX2015010775A (es) | 2013-03-15 | 2016-04-25 | Genentech Inc | Benzoxazoles sustituidos y metodos para usarlos. |
HUE037876T2 (hu) | 2013-07-19 | 2018-09-28 | Vertex Pharma | Szulfonamidok mint nátriumcsatorna-modulátorok |
US9630896B2 (en) | 2013-11-22 | 2017-04-25 | Tansna Therapeutics, Inc. | 2,5-dialkyl-4-H/halo/ether-phenol compounds |
PE20161247A1 (es) | 2013-11-27 | 2016-11-30 | Genentech Inc | Benzamidas sustituidas y metodos para usarlas |
WO2015077905A1 (en) | 2013-11-29 | 2015-06-04 | Merck Sharp & Dohme Corp. | Bicycloamine-substituted-n-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels |
AP2016009287A0 (en) * | 2013-12-13 | 2016-06-30 | Vertex Pharma | Prodrugs of pyridone amides useful as modulators of sodium channels |
CN105130970B (zh) * | 2014-05-30 | 2019-06-25 | 中国人民解放军军事医学科学院毒物药物研究所 | N-磺酰基高丝氨酸内酯类衍生物、其制备方法和用途 |
EP3166939B1 (en) | 2014-07-07 | 2019-06-05 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
MX2017014715A (es) | 2015-05-22 | 2018-03-16 | Genentech Inc | Benzamidas sustituidas y metodos para utilizarlas. |
CN108137477A (zh) | 2015-08-27 | 2018-06-08 | 基因泰克公司 | 治疗化合物及其使用方法 |
SG10202007787RA (en) | 2015-09-28 | 2020-09-29 | Genentech Inc | Therapeutic compounds and methods of use thereof |
EP3368509A4 (en) * | 2015-10-30 | 2019-05-01 | Trillium Therapeutics Inc. | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS |
CN108495851A (zh) | 2015-11-25 | 2018-09-04 | 基因泰克公司 | 取代的苯甲酰胺及其使用方法 |
US10519147B2 (en) | 2015-12-18 | 2019-12-31 | Merck Sharp & Dohme Corp. | Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
JP6572392B2 (ja) * | 2015-12-18 | 2019-09-11 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 電位作動型ナトリウムチャネルにおいて選択的活性を有する、ヒドロキシアルキルアミンおよびヒドロキシシクロアルキルアミンで置換されたジアミン−アリールスルホンアミド化合物 |
US10766858B2 (en) | 2016-03-30 | 2020-09-08 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
MX2018013985A (es) | 2016-05-20 | 2019-08-22 | Xenon Pharmaceuticals Inc | Compuestos de bencenosulfonamida y sus usos como agentes terapéuticos. |
PE20190980A1 (es) * | 2016-10-17 | 2019-07-09 | Genentech Inc | Compuestos terapeuticos y metodos para utilizarlos |
CA3042004A1 (en) | 2016-12-09 | 2018-06-14 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
CN110546148A (zh) | 2017-03-24 | 2019-12-06 | 基因泰克公司 | 作为钠通道抑制剂的4-哌啶-n-(嘧啶-4-基)色满-7-磺酰胺衍生物 |
EP3625214B1 (en) | 2017-05-16 | 2022-07-06 | Vertex Pharmaceuticals Incorporated | Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels |
EP3412652A1 (en) | 2017-06-06 | 2018-12-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Inhibitors of rac1 and uses thereof for treating cancers |
EP3412651A1 (en) | 2017-06-06 | 2018-12-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Inhibitors of rac1 and uses thereof for inducing bronchodilatation |
JP2019099550A (ja) * | 2017-12-07 | 2019-06-24 | 学校法人兵庫医科大学 | スクロース吸収阻害剤、ChREBP阻害剤およびその利用 |
CA3091012A1 (en) | 2018-02-12 | 2019-08-15 | Vertex Pharmaceuticals Incorporated | A method of treating pain |
TW202000651A (zh) | 2018-02-26 | 2020-01-01 | 美商建南德克公司 | 治療性組成物及其使用方法 |
US10947251B2 (en) | 2018-03-30 | 2021-03-16 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
WO2019241533A1 (en) | 2018-06-13 | 2019-12-19 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
GB201810581D0 (en) | 2018-06-28 | 2018-08-15 | Ctxt Pty Ltd | Compounds |
AU2019302534A1 (en) | 2018-07-09 | 2021-01-28 | Lieber Institute, Inc. | Pyridazine compounds for inhibiting NaV1.8 |
WO2020047312A1 (en) | 2018-08-31 | 2020-03-05 | Xenon Pharmaceuticals Inc. | Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors |
EA202190395A1 (ru) | 2018-08-31 | 2021-06-15 | Ксенон Фармасьютикалз Инк. | Замещенные гетероарилом сульфонамидные соединения и их применение в качестве терапевтических средств |
CN113677334B (zh) * | 2019-02-01 | 2024-04-09 | 马歇尔大学科研协会 | 瞬时受体电位melastatin 8(trpm8)拮抗剂和相关方法 |
EP3946301A4 (en) * | 2019-04-02 | 2023-08-09 | The University of Chicago | REMODILINS FOR RESPIRATORY TRACT REMODELING AND ORGAN FIBROSIS |
ES2969616T3 (es) | 2019-06-18 | 2024-05-21 | Pfizer | Derivados de benzisoxazol sulfonamida |
CA3164134A1 (en) | 2019-12-06 | 2021-06-10 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofurans as modulators of sodium channels |
CN113527281B (zh) * | 2020-04-20 | 2023-12-22 | 昆山彭济凯丰生物科技有限公司 | 杂环化合物及其制备方法和应用 |
UY39800A (es) | 2021-06-04 | 2023-01-31 | Vertex Pharma | N–(hidroxialquil (hetero)aril) tetrahidrofuran carboxamidas como moduladores de canales de sodio |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2430051A (en) | 1944-08-16 | 1947-11-04 | Hoffmann La Roche | Soluble sulfanilamide derivatives and process of preparing them |
FR1537695A (fr) | 1967-02-23 | 1968-08-30 | Ferlux | Nouvelles chromones carbonamides n-phénylsulfonamidées et procédé pour leur fabrication |
US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
US5360802A (en) * | 1992-05-11 | 1994-11-01 | Merck Sharpe & Dohme Ltd. | Benzodiazepine derivatives, compositions containing them and their use in therapy |
US5994341A (en) | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
AU1924099A (en) * | 1997-12-18 | 1999-07-05 | Lyonnaise Industrielle Pharmaceutique (Lipha) | Piperazine derivatives useful as hypoglycemic agents |
AU3053199A (en) | 1998-04-01 | 1999-10-25 | Ono Pharmaceutical Co. Ltd. | Fused thiophene derivatives and drugs containing the same as the active ingredient |
EP1218358B1 (en) * | 1999-09-23 | 2006-09-13 | AstraZeneca AB | Therapeutic quinazoline compounds |
FI116940B (fi) | 2001-07-20 | 2006-04-13 | Juvantia Pharma Ltd Oy | Alfa-2B-adrenoseptorivälitteisen sairauden hoitoon tai ehkäisyyn käyttökelpoiset yhdisteet |
EP1414788A1 (en) | 2001-07-31 | 2004-05-06 | Bayer HealthCare AG | Naphthylurea and naphthylacetamide derivatives as vanilloid receptor 1 (vr1) antagonists |
SE0103644D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic isoquinoline compounds |
GB0218625D0 (en) * | 2002-08-10 | 2002-09-18 | Astex Technology Ltd | Pharmaceutical compounds |
US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
JP2007501804A (ja) * | 2003-08-08 | 2007-02-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | 電位開口型のナトリウムチャネルのインヒビターとして有用な組成物 |
US7671077B2 (en) | 2004-07-19 | 2010-03-02 | Leu-Fen Hou Lin | Neuroprotective small organic molecules, compositions and uses related thereto |
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AU2004263179A8 (en) | 2011-07-14 |
CA2539227A1 (en) | 2005-02-17 |
EP1673357A2 (en) | 2006-06-28 |
AU2004263179B2 (en) | 2011-06-30 |
KR20060073930A (ko) | 2006-06-29 |
NZ579370A (en) | 2011-06-30 |
EP2332912A1 (en) | 2011-06-15 |
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