ES8502969A1 - Procedimiento para preparar azetidinas. - Google Patents
Procedimiento para preparar azetidinas.Info
- Publication number
- ES8502969A1 ES8502969A1 ES523064A ES523064A ES8502969A1 ES 8502969 A1 ES8502969 A1 ES 8502969A1 ES 523064 A ES523064 A ES 523064A ES 523064 A ES523064 A ES 523064A ES 8502969 A1 ES8502969 A1 ES 8502969A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- phenylmethylene
- analgesic
- antidepressant
- cycloalkylamines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
- C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
- C07C49/683—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR AZETIDINAS DE FORMULA GENERAL (I).CONSISTE EN HACER REACCIONAR UN 3-N-2-(R1-FENIL)METILEN-R-CICLOALQUILAMINO-R4-1-PROPANOL CON UN AGENTE SULFONANTE, PARA FORMAR UN DERIVADO DE ACIDO SULFONICO DE FORMULA GENERAL (II). EL DERIVADO DE ACIDO SULFONICO OBTENIDO SE CALIENTA SUFICIENTEMENTE CON UNA BASE PARA CICLIZAR EL COMPUESTO EN EL PRODUCTO AZETIDINA.DE APLICACION COMO MEDICAMENTOS ANALGESICOS Y COMO ANTIDEPRESORES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34712382A | 1982-02-09 | 1982-02-09 | |
US06/408,333 US4540690A (en) | 1982-02-09 | 1982-08-16 | 2-(Phenylmethylene)cycloalkylamines and -azetidines |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8502969A1 true ES8502969A1 (es) | 1984-10-01 |
ES523064A0 ES523064A0 (es) | 1984-10-01 |
Family
ID=26995138
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES519331A Granted ES519331A0 (es) | 1982-02-09 | 1983-01-28 | Procedimiento para preparar un compuesto de 2-(fenilmetilen) cicloalquilaminas y -azetidinas. |
ES523066A Expired ES8501745A1 (es) | 1982-02-09 | 1983-06-07 | Procedimiento para preparar compuestos de azetidinas. desglose de la patente n 519.331. |
ES523065A Granted ES523065A0 (es) | 1982-02-09 | 1983-06-07 | Procedimiento para preparar compuestos de n-(2-(fenilmetilen)cicloalquil) aminas libres. desglose de la patente n 519.331. |
ES523064A Granted ES523064A0 (es) | 1982-02-09 | 1983-06-07 | Procedimiento para preparar azetidinas. |
ES523067A Granted ES523067A0 (es) | 1982-02-09 | 1983-06-07 | Procedimiento para preparar 1-(2-(fenilmetilen)ciclohexil) azetidinas. |
ES532058A Expired ES8507483A1 (es) | 1982-02-09 | 1984-04-30 | Procedimiento para preparar un compuesto de 2-(fenilmetilen) cicloalquilaminas y azetidinas |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES519331A Granted ES519331A0 (es) | 1982-02-09 | 1983-01-28 | Procedimiento para preparar un compuesto de 2-(fenilmetilen) cicloalquilaminas y -azetidinas. |
ES523066A Expired ES8501745A1 (es) | 1982-02-09 | 1983-06-07 | Procedimiento para preparar compuestos de azetidinas. desglose de la patente n 519.331. |
ES523065A Granted ES523065A0 (es) | 1982-02-09 | 1983-06-07 | Procedimiento para preparar compuestos de n-(2-(fenilmetilen)cicloalquil) aminas libres. desglose de la patente n 519.331. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES523067A Granted ES523067A0 (es) | 1982-02-09 | 1983-06-07 | Procedimiento para preparar 1-(2-(fenilmetilen)ciclohexil) azetidinas. |
ES532058A Expired ES8507483A1 (es) | 1982-02-09 | 1984-04-30 | Procedimiento para preparar un compuesto de 2-(fenilmetilen) cicloalquilaminas y azetidinas |
Country Status (11)
Country | Link |
---|---|
US (1) | US4540690A (es) |
EP (1) | EP0085811B1 (es) |
AU (2) | AU562051B2 (es) |
DE (1) | DE3271073D1 (es) |
DK (1) | DK53083A (es) |
ES (6) | ES519331A0 (es) |
GR (1) | GR78061B (es) |
HU (1) | HU190887B (es) |
IL (1) | IL67442A (es) |
NZ (1) | NZ202728A (es) |
PH (1) | PH17709A (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2634483B2 (fr) * | 1987-12-29 | 1994-03-04 | Esteve Labor Dr | Derives des acides 7-(1-azetidinyl)-1,4-dihydro-4-oxoquinoleine-3-carboxyliques, leur preparation et leur application en tant que medicaments |
JP3739377B2 (ja) * | 2003-12-10 | 2006-01-25 | シャープ株式会社 | 洗濯乾燥機 |
US7488747B2 (en) * | 2003-12-29 | 2009-02-10 | Sepracor Inc. | Pyrrole and pyrazole DAAO inhibitors |
MX2008000250A (es) | 2005-07-06 | 2008-03-19 | Sepracor Inc | Combinaciones de eszopiclona y trans-4-(3,4-diclorofenil)-1,2,3,4- tetrahidro-n-metil-1-naftalenamina o trans 4-(3,4-diclorofenil)-1, 2,3,4-tetrahidro-1-naftalenamina y metodos de tratamiento de menopausia y trastornos del estado de animo, ansiedad y |
CN101426372A (zh) * | 2006-01-06 | 2009-05-06 | 塞普拉柯公司 | 基于四氢萘酮的单胺再摄取抑制剂 |
CN101394847B (zh) | 2006-01-06 | 2017-05-24 | 塞普拉柯公司 | 作为单胺重摄取抑制剂的环烷基胺类 |
CA2648121C (en) | 2006-03-31 | 2013-08-06 | Sepracor Inc. | Preparation of chiral amides and amines |
US7579370B2 (en) * | 2006-06-30 | 2009-08-25 | Sepracor Inc. | Fused heterocycles |
US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
US20080082066A1 (en) * | 2006-10-02 | 2008-04-03 | Weyerhaeuser Co. | Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks |
MX2009007410A (es) * | 2007-01-18 | 2009-09-09 | Sepracor Inc | Inhibidores de d-aminoacido oxidasa. |
US7902252B2 (en) * | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
CN101686672A (zh) * | 2007-05-31 | 2010-03-31 | 塞普拉柯公司 | 苯基取代的环烷胺作为一元胺再摄取抑制剂 |
US20100120740A1 (en) * | 2008-08-07 | 2010-05-13 | Sepracor Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
US20110034434A1 (en) * | 2009-08-07 | 2011-02-10 | Sepracor Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
JP2014527981A (ja) * | 2011-09-23 | 2014-10-23 | アドヴィナス・セラピューティックス・リミテッド | アミド化合物、組成物およびその用途 |
DK3152188T3 (en) * | 2014-06-06 | 2019-04-29 | Allergan Inc | UNKNOWN EP4 AGONISTS AS THERAPEUTIC RELATIONS |
KR102270026B1 (ko) * | 2020-01-31 | 2021-06-28 | 현대약품 주식회사 | (3s)-3-(4-(3-(1,4-다이옥사스파이로[4,5]데스-7-엔-8-일)벤질옥시)페닐)헥스-4-이노익산의 품질 평가 방법 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3558599A (en) * | 1966-06-13 | 1971-01-26 | Upjohn Co | 1-(2-(alpha-alkoxybenzyl and substituted benzyl)cycloalkyl)heterocyclic amines |
US3632813A (en) * | 1966-06-13 | 1972-01-04 | Upjohn Co | Substituted phenyl 2-piperidinocycloalkyl ketones |
US3595867A (en) * | 1966-06-13 | 1971-07-27 | Upjohn Co | 2 - piperidino- and methyl-substituted piperidino-substituted-phentl cycloalkane-methanols and derivatives |
US3705176A (en) * | 1966-06-13 | 1972-12-05 | Upjohn Co | 1,3-aminoalcohols |
US3668199A (en) * | 1966-06-13 | 1972-06-06 | Upjohn Co | 1,3-aminoalcohols |
US3458523A (en) * | 1966-08-15 | 1969-07-29 | Upjohn Co | 2-(2 - furoyl)cycloalkanones,2 - furyl-2-(heterocyclicamino) cycloalkyl ketones,and d-(2 - furyl)-2-heterocyclicamino-cyclohexanemethanols |
US3468881A (en) * | 1966-08-15 | 1969-09-23 | Upjohn Co | Allylic amines |
US3506670A (en) * | 1966-09-26 | 1970-04-14 | Upjohn Co | 2-hetero-amino-alpha,alpha-diaryl-cycloalkone-methanols and esters thereof |
US3499033A (en) * | 1967-01-06 | 1970-03-03 | Upjohn Co | Ethers of alpha-phenyl-2-aminocycloalkanemethanols |
US3651232A (en) * | 1968-09-10 | 1972-03-21 | Upjohn Co | Compositions and methods for lowering blood sugar levels |
US4098904A (en) * | 1976-11-12 | 1978-07-04 | The Upjohn Company | Analgesic n-(2-aminocycloaliphatic)benzamides |
US4145435A (en) * | 1976-11-12 | 1979-03-20 | The Upjohn Company | 2-aminocycloaliphatic amide compounds |
US4242261A (en) * | 1979-07-19 | 1980-12-30 | A. H. Robins Company, Inc. | Production of methylene-cycloamines |
US4260606A (en) * | 1979-07-19 | 1981-04-07 | A. H. Robins Company, Inc. | 3-Methyleneazetidine derivatives |
-
1982
- 1982-08-16 US US06/408,333 patent/US4540690A/en not_active Expired - Fee Related
- 1982-12-07 NZ NZ202728A patent/NZ202728A/en unknown
- 1982-12-08 AU AU91343/82A patent/AU562051B2/en not_active Expired - Fee Related
- 1982-12-09 IL IL67442A patent/IL67442A/xx unknown
- 1982-12-20 DE DE8282306779T patent/DE3271073D1/de not_active Expired
- 1982-12-20 EP EP82306779A patent/EP0085811B1/en not_active Expired
-
1983
- 1983-01-03 PH PH28337A patent/PH17709A/en unknown
- 1983-01-28 ES ES519331A patent/ES519331A0/es active Granted
- 1983-02-04 GR GR70420A patent/GR78061B/el unknown
- 1983-02-08 HU HU83432A patent/HU190887B/hu unknown
- 1983-02-08 DK DK53083A patent/DK53083A/da not_active Application Discontinuation
- 1983-06-07 ES ES523066A patent/ES8501745A1/es not_active Expired
- 1983-06-07 ES ES523065A patent/ES523065A0/es active Granted
- 1983-06-07 ES ES523064A patent/ES523064A0/es active Granted
- 1983-06-07 ES ES523067A patent/ES523067A0/es active Granted
-
1984
- 1984-04-30 ES ES532058A patent/ES8507483A1/es not_active Expired
-
1986
- 1986-10-03 AU AU63504/86A patent/AU6350486A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US4540690A (en) | 1985-09-10 |
DE3271073D1 (de) | 1986-06-12 |
EP0085811B1 (en) | 1986-05-07 |
DK53083D0 (da) | 1983-02-08 |
ES8502673A1 (es) | 1985-02-01 |
AU6350486A (en) | 1987-01-15 |
IL67442A (en) | 1986-01-31 |
ES8501746A1 (es) | 1984-12-16 |
ES8501744A1 (es) | 1984-12-16 |
AU9134382A (en) | 1983-08-18 |
DK53083A (da) | 1983-08-10 |
ES532058A0 (es) | 1985-09-16 |
ES523066A0 (es) | 1984-12-16 |
IL67442A0 (en) | 1983-05-15 |
ES523067A0 (es) | 1984-12-16 |
ES8507483A1 (es) | 1985-09-16 |
ES523064A0 (es) | 1984-10-01 |
PH17709A (en) | 1984-11-19 |
ES519331A0 (es) | 1984-12-16 |
NZ202728A (en) | 1985-12-13 |
EP0085811A1 (en) | 1983-08-17 |
GR78061B (es) | 1984-09-26 |
HU190887B (en) | 1986-12-28 |
AU562051B2 (en) | 1987-05-28 |
ES523065A0 (es) | 1985-02-01 |
ES8501745A1 (es) | 1984-12-16 |
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