PE20040728A1 - Inhibidores de caspasa - Google Patents

Inhibidores de caspasa

Info

Publication number
PE20040728A1
PE20040728A1 PE2003000653A PE2003000653A PE20040728A1 PE 20040728 A1 PE20040728 A1 PE 20040728A1 PE 2003000653 A PE2003000653 A PE 2003000653A PE 2003000653 A PE2003000653 A PE 2003000653A PE 20040728 A1 PE20040728 A1 PE 20040728A1
Authority
PE
Peru
Prior art keywords
oxo
halo
ocf3
chloro
refers
Prior art date
Application number
PE2003000653A
Other languages
English (en)
Inventor
Ronald Knegtel
John Studley
Michael Mortimore
David Millan
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PE20040728A1 publication Critical patent/PE20040728A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
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    • A61P31/20—Antivirals for DNA viruses
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE X ES CH, N; Y ES HALO, TRIFLUOROFENOXI, TETRAFLUOROFENOXI; R2 ES ALQUILO C1-C6 DE CADENA RECTA O RAMIFICADA; R3 ES H; HALO, OCF3, CN, CF3; R4 ES H, HALO, OCF3, CN, Ar, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (S)-3-[2-(7-CLORO-1-OXO-1H-ISOQUINOLIN-2-IL)-BUTIRILAMINO]-5-FLUORO-4-OXO-ACIDO PENTANOICO; (S,S)-3-[2-(6-CLORO-4-OXO-4H-QUINAZOLIN-3-IL)-BUTIRILAMINO]-4-OXO-5-(2,3,5,6-TETRAFLUOROFENOXI)-ACIDO PENTANOICO; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE CASPASAS UTILES EN EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR IL-1, ENFERMEDADES INFECCIOSAS, INFLAMATORIAS, ENTRE OTROS
PE2003000653A 2002-06-28 2003-06-27 Inhibidores de caspasa PE20040728A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39259202P 2002-06-28 2002-06-28
US43507302P 2002-12-20 2002-12-20

Publications (1)

Publication Number Publication Date
PE20040728A1 true PE20040728A1 (es) 2004-10-23

Family

ID=30003264

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000653A PE20040728A1 (es) 2002-06-28 2003-06-27 Inhibidores de caspasa

Country Status (19)

Country Link
US (2) US7553852B2 (es)
EP (1) EP1539701A1 (es)
JP (2) JP4616643B2 (es)
KR (1) KR20050013260A (es)
CN (1) CN100503572C (es)
AR (1) AR040350A1 (es)
AU (1) AU2003248758A1 (es)
BR (1) BR0312232A (es)
CA (1) CA2493646A1 (es)
IL (1) IL165986A0 (es)
MX (1) MXPA05000069A (es)
NO (1) NO20050851L (es)
NZ (1) NZ537807A (es)
PE (1) PE20040728A1 (es)
PL (1) PL374598A1 (es)
RU (1) RU2005102094A (es)
TW (1) TW200404783A (es)
UY (1) UY27872A1 (es)
WO (1) WO2004002961A1 (es)

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AR040350A1 (es) 2005-03-30

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