NO20050851L - Kaspase-inhibitorer og anvendelser derav - Google Patents

Kaspase-inhibitorer og anvendelser derav

Info

Publication number
NO20050851L
NO20050851L NO20050851A NO20050851A NO20050851L NO 20050851 L NO20050851 L NO 20050851L NO 20050851 A NO20050851 A NO 20050851A NO 20050851 A NO20050851 A NO 20050851A NO 20050851 L NO20050851 L NO 20050851L
Authority
NO
Norway
Prior art keywords
compounds
caspase inhibitors
methods
present
compositions
Prior art date
Application number
NO20050851A
Other languages
English (en)
Norwegian (no)
Inventor
John Studley
Ronald Knegtel
Michael Mortimore
David Millan
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of NO20050851L publication Critical patent/NO20050851L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
NO20050851A 2002-06-28 2005-02-17 Kaspase-inhibitorer og anvendelser derav NO20050851L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39259202P 2002-06-28 2002-06-28
US43507302P 2002-12-20 2002-12-20
PCT/US2003/020557 WO2004002961A1 (en) 2002-06-28 2003-06-27 Caspase inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
NO20050851L true NO20050851L (no) 2005-03-29

Family

ID=30003264

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050851A NO20050851L (no) 2002-06-28 2005-02-17 Kaspase-inhibitorer og anvendelser derav

Country Status (19)

Country Link
US (2) US7553852B2 (es)
EP (1) EP1539701A1 (es)
JP (2) JP4616643B2 (es)
KR (1) KR20050013260A (es)
CN (1) CN100503572C (es)
AR (1) AR040350A1 (es)
AU (1) AU2003248758A1 (es)
BR (1) BR0312232A (es)
CA (1) CA2493646A1 (es)
IL (1) IL165986A0 (es)
MX (1) MXPA05000069A (es)
NO (1) NO20050851L (es)
NZ (1) NZ537807A (es)
PE (1) PE20040728A1 (es)
PL (1) PL374598A1 (es)
RU (1) RU2005102094A (es)
TW (1) TW200404783A (es)
UY (1) UY27872A1 (es)
WO (1) WO2004002961A1 (es)

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MXPA05000069A (es) 2002-06-28 2005-04-11 Vertex Pharma Inhibidores de caspasa y uso de los mismos.
JP4675628B2 (ja) * 2002-12-20 2011-04-27 バーテックス ファーマシューティカルズ インコーポレイテッド ４−オキソ−３−（１−オキソ−１ｈ−イソキノリン−２−イルアセチルアミノ）−ペンタン酸のエステル誘導体およびアミド誘導体、ならびにカスパーゼインヒビターとしてのそれらの使用
PE20050159A1 (es) 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
PT1725548E (pt) * 2004-03-12 2015-04-16 Vertex Pharma Processo e intermediários para a preparação de inibidores de caspase de acetal de ácido aspártico
WO2005115362A1 (en) 2004-05-15 2005-12-08 Vertex Pharmaceuticals Incorporated Treating seizures using ice inhibitors
EP2295054A1 (en) 2004-05-27 2011-03-16 Vertex Pharmaceuticals Incorporated Ice inhibitors for the treatment of autoinflammatory diseases
CA2569763C (en) * 2004-06-08 2013-03-12 Decode Chemistry, Inc. 2,4-diaminoquinazolines for spinal muscular atrophy
EP1784390A2 (en) 2004-08-13 2007-05-16 Amgen Inc. Substituted benzofused heterocycles
EP1802292A4 (en) 2004-09-17 2008-02-13 Biomas Ltd COMPOSITIONS AND METHODS FOR TRIGGERING HAIR GROWTH
ES2380632T3 (es) * 2004-11-24 2012-05-17 Vertex Pharmceuticals Incorporated Derivados de ácido3-(2-(3-ACILAMINO-2-OXO-2H-PIRIDIN)-ACETILAMINO)-4-OXO-PENTANOICO y su uso como inhibidores de caspasas
WO2006074223A2 (en) * 2005-01-03 2006-07-13 Myriad Genetics, Inc. Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof
WO2006133338A1 (en) * 2005-06-07 2006-12-14 The Trustees Of The University Of Pennesylvania INHIBITORS OF THE α2β1/GPIa-IIa INTEGRIN
US8987306B2 (en) * 2005-06-07 2015-03-24 The Trustees Of The University Of Pennsylvania Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold
ATE529430T1 (de) * 2005-07-28 2011-11-15 Vertex Pharma Caspase-hemmer-propharmaka
WO2007027742A2 (en) * 2005-08-31 2007-03-08 The Trustees Of The University Of Pennsylvania SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS
WO2008016973A1 (en) 2006-08-01 2008-02-07 Families Of Spinal Muscular Atrophy 2,4-diaminoquinazolines for spinal muscular atrophy
CA2663193A1 (en) * 2006-09-11 2008-03-20 N.V. Organon 2-(1-oxo-1h-isoquinolin-2-yl)acetamide derivatives
WO2008073388A2 (en) * 2006-12-11 2008-06-19 Mutual Pharmaceutical Company, Inc. Alfuzosin formulations, methods of making and methods of use
US20100092556A1 (en) * 2006-12-11 2010-04-15 Kristin Arnold Alfuzosin formulations, methods of making, and methods of use
FR2923160B1 (fr) * 2007-11-02 2013-07-26 Pasteur Institut Composes destines a prevenir ou traiter une infection virale.
WO2012061786A1 (en) 2010-11-05 2012-05-10 Brandeis University Ice cleaved alpha-synuclein a biomarker
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
CN104203239B (zh) 2012-01-26 2017-09-08 Ptc医疗公司 用于治疗脊髓性肌萎缩的化合物
EP3142649B1 (en) 2014-05-12 2019-07-24 Conatus Pharmaceuticals, Inc. Treatment of the complications of chronic liver disease with caspase inhibitor emricasan
WO2017079566A1 (en) 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Caspase inhibitors for use in the treatment of liver cancer
KR20180101418A (ko) 2015-12-31 2018-09-12 코나터스 파마슈티칼스, 인크. 간 질환의 치료에서의 카스파제 억제제의 사용 방법
BR112019005985A2 (pt) 2016-10-05 2019-06-25 Novartis Ag composições de combinação compreendendo agonistas de fxr para tratar ou prevenir uma doença ou distúrbio fibrótico, cirrótico
WO2022123062A1 (en) 2020-12-11 2022-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients

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AR040350A1 (es) 2005-03-30
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TW200404783A (en) 2004-04-01
MXPA05000069A (es) 2005-04-11
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US8129381B2 (en) 2012-03-06
BR0312232A (pt) 2005-05-10
US7553852B2 (en) 2009-06-30
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US20040072850A1 (en) 2004-04-15
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JP4616643B2 (ja) 2011-01-19
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