BR0312232A - Inibidores de caspases e seus usos - Google Patents

Inibidores de caspases e seus usos

Info

Publication number
BR0312232A
BR0312232A BR0312232-8A BR0312232A BR0312232A BR 0312232 A BR0312232 A BR 0312232A BR 0312232 A BR0312232 A BR 0312232A BR 0312232 A BR0312232 A BR 0312232A
Authority
BR
Brazil
Prior art keywords
compounds
caspase inhibitors
present
compositions
disorders
Prior art date
Application number
BR0312232-8A
Other languages
English (en)
Inventor
Ronald Knegtel
Michael Mortimore
John Studley
David Millan
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of BR0312232A publication Critical patent/BR0312232A/pt

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
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    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Abstract

"INIBIDORES DE CASPASES E SEUS USOS". A presente invenção refere-se a compostos da fórmula (I), úteis como inibidores de caspases. A presente invenção fornece também composições farmaceuticamente aceitáveis que compreendem os ditos compostos, processos para preparar os compostos, e métodos para usar os compostos e composições no tratamento de várias doenças, condições ou distúrbios.
BR0312232-8A 2002-06-28 2003-06-27 Inibidores de caspases e seus usos BR0312232A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39259202P 2002-06-28 2002-06-28
US43507302P 2002-12-20 2002-12-20
PCT/US2003/020557 WO2004002961A1 (en) 2002-06-28 2003-06-27 Caspase inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
BR0312232A true BR0312232A (pt) 2005-05-10

Family

ID=30003264

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312232-8A BR0312232A (pt) 2002-06-28 2003-06-27 Inibidores de caspases e seus usos

Country Status (19)

Country Link
US (2) US7553852B2 (pt)
EP (1) EP1539701A1 (pt)
JP (2) JP4616643B2 (pt)
KR (1) KR20050013260A (pt)
CN (1) CN100503572C (pt)
AR (1) AR040350A1 (pt)
AU (1) AU2003248758A1 (pt)
BR (1) BR0312232A (pt)
CA (1) CA2493646A1 (pt)
IL (1) IL165986A0 (pt)
MX (1) MXPA05000069A (pt)
NO (1) NO20050851L (pt)
NZ (1) NZ537807A (pt)
PE (1) PE20040728A1 (pt)
PL (1) PL374598A1 (pt)
RU (1) RU2005102094A (pt)
TW (1) TW200404783A (pt)
UY (1) UY27872A1 (pt)
WO (1) WO2004002961A1 (pt)

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RU2019113150A (ru) 2016-10-05 2020-11-06 Новартис Аг Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения
WO2022123062A1 (en) 2020-12-11 2022-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients

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CN1675184A (zh) 2005-09-28
NZ537807A (en) 2007-05-31
IL165986A0 (en) 2006-01-15
PE20040728A1 (es) 2004-10-23
WO2004002961A1 (en) 2004-01-08
MXPA05000069A (es) 2005-04-11
US20090281128A1 (en) 2009-11-12
US8129381B2 (en) 2012-03-06
UY27872A1 (es) 2003-12-31
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JP2010143942A (ja) 2010-07-01
AR040350A1 (es) 2005-03-30
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RU2005102094A (ru) 2006-02-27
US7553852B2 (en) 2009-06-30
AU2003248758A1 (en) 2004-01-19
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US20040072850A1 (en) 2004-04-15

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