PE20010486A1 - Compuestos de acido hidroxamico utiles como inhibidores de metaloproteinasa de matriz - Google Patents

Compuestos de acido hidroxamico utiles como inhibidores de metaloproteinasa de matriz

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Publication number
PE20010486A1
PE20010486A1 PE2000000833A PE0008332000A PE20010486A1 PE 20010486 A1 PE20010486 A1 PE 20010486A1 PE 2000000833 A PE2000000833 A PE 2000000833A PE 0008332000 A PE0008332000 A PE 0008332000A PE 20010486 A1 PE20010486 A1 PE 20010486A1
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PE
Peru
Prior art keywords
alkyl
hydroxamic acid
inhibitors
acid compounds
sulfonylamine
Prior art date
Application number
PE2000000833A
Other languages
English (en)
Inventor
Christopher Alan Conrad
Patrick Michael O'brien
Drago Robert Sliskovic
Joseph Armand Picard
Daniel Fred Ortwine
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PE20010486A1 publication Critical patent/PE20010486A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
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    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
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    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DE ACIDO HIDROXAMICO DE FORMULA I, DONDE: X ES OH, NHOH; R1 ES EL GRUPO a, b, ENTRE OTROS; Y ES O, S, S(O)d, CH2, ENTRE OTROS; d ES 1-2; R2 ES H, ALQUILO C1-C4, BENCILO OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C4, ALCOXI C1-C4, F, Cl, Br, I, NH2, NO2, CN, CARBOXI, CO2R7; R7 ES H, ALQUILO C1-C4; R3 Y R4 SON ALQUILO C1-C20, CICLOALQUILO C3-C10, FENIL OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C4, ALCOXI C1-C4, HALO, NH2, NO2, CN, COOH, CO2R7, CF3, HETEROCICLICO C3-C19, ENTRE OTROS. SON COMPUESTOS PREFERIDOS ACIDO 1-(4`-BROMO-BIFENIL-4-SULFONILAMINO)-CICLOPENTAN0-CARBOXILICO; HIDROXAMIDA DE ACIDO 1-(4'-BROMO-BIFENIL-4-SULFONILAMINO)-CICLOPENTANO-CARBOXILICO, ACIDO 2-METIL-2-(6,7,8,9-TETRAHIDRO-DIBENZOFURANO-3-SULFONILAMINO)PROPIONICO, ENTRE OTROS. LOS COMPUESTOS DE ACIDO HIDROXAMICO DE FORMULA I SON INHIBIDORES DE LA METALOPROTEINASA DE MATRIZ POR LO QUE PUEDEN SER UTILES EN EL TRATAMIENTO DE ARTRITIS, ESCLEROSIS MULTIPLE, ATEREOESCLEROSIS, RESTENOSIS, OSTEOPOROSIS, INFLAMACION, DOLOR, ANEURISMA AORTICA, CARDIOPATIA, ULCERA DE CORNEA, CANCER
PE2000000833A 1999-08-18 2000-08-17 Compuestos de acido hidroxamico utiles como inhibidores de metaloproteinasa de matriz PE20010486A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14966099P 1999-08-18 1999-08-18

Publications (1)

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PE20010486A1 true PE20010486A1 (es) 2001-04-20

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ID=22531286

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PE2000000833A PE20010486A1 (es) 1999-08-18 2000-08-17 Compuestos de acido hidroxamico utiles como inhibidores de metaloproteinasa de matriz

Country Status (18)

Country Link
US (1) US6677355B1 (es)
EP (1) EP1210326B1 (es)
JP (1) JP2003507362A (es)
AR (1) AR030160A1 (es)
AT (1) ATE260251T1 (es)
AU (1) AU6764400A (es)
BR (1) BR0013390A (es)
CA (1) CA2378332A1 (es)
CO (1) CO5300407A1 (es)
DE (1) DE60008548T2 (es)
DK (1) DK1210326T3 (es)
ES (1) ES2216938T3 (es)
MX (1) MXPA01013324A (es)
PE (1) PE20010486A1 (es)
PT (1) PT1210326E (es)
TR (4) TR200200410T2 (es)
UY (1) UY26302A1 (es)
WO (1) WO2001012592A2 (es)

Families Citing this family (18)

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Publication number Priority date Publication date Assignee Title
WO2004089294A2 (en) 2003-04-04 2004-10-21 Incyte Corporation Compositions, methods and kits relating to her-2 cleavage
GB0326546D0 (en) * 2003-11-14 2003-12-17 Amersham Plc Inhibitor imaging agents
PE20060426A1 (es) * 2004-06-02 2006-06-28 Schering Corp DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa
US7638513B2 (en) 2004-06-02 2009-12-29 Schering Corporation Compounds for the treatment of inflammatory disorders
US7488745B2 (en) * 2004-07-16 2009-02-10 Schering Corporation Compounds for the treatment of inflammatory disorders
US7504424B2 (en) * 2004-07-16 2009-03-17 Schering Corporation Compounds for the treatment of inflammatory disorders
DE602005023172D1 (de) 2004-07-16 2010-10-07 Schering Corp Hydantoinderivate zur behandlung von entzündlichen erkrankungen
AR059036A1 (es) * 2006-01-17 2008-03-12 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
CA2822776A1 (en) 2006-10-28 2008-05-08 Methylgene Inc. Inhibitors of histone deacetylase
CL2008001257A1 (es) * 2007-05-04 2008-07-04 Wyeth Corp Compuestos triciclicos, inhibidores de metaloproteinasas matriciales; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como artritis reumatoide, osteoartritis, aterosclerosis, cancer de pulmon, entre otras.
TW201024304A (en) 2008-09-24 2010-07-01 Schering Corp Compounds for the treatment of inflammatory disorders
TW201024303A (en) 2008-09-24 2010-07-01 Schering Corp Compounds for the treatment of inflammatory disorders
US8541572B2 (en) 2008-11-10 2013-09-24 Merck Sharp & Dohme Corp. Compounds for the treatment of inflammatory disorders
US8569336B2 (en) 2008-11-10 2013-10-29 Ling Tong Compounds for the treatment of inflammatory disorders
CA2744391A1 (en) * 2008-12-05 2010-06-10 Intermed Discovery Gmbh Inhibitors of hif-1 protein accumulation
CA3115038A1 (en) 2018-10-04 2020-04-09 Inserm (Institut National De La Sante Et De La Recherche Medicale) Egfr inhibitors for treating keratodermas
CN113336670B (zh) * 2021-05-28 2023-06-02 河南大学 一种轴手性芴胺-苯酚类衍生物及其制备方法
KR20240069638A (ko) 2022-11-11 2024-05-20 주식회사 메디치바이오 리포-하이드록삼산 유도체 및 이의 약학적 용도

Family Cites Families (4)

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ZA98376B (en) * 1997-01-23 1998-07-23 Hoffmann La Roche Sulfamide-metalloprotease inhibitors
US6376506B1 (en) 1997-01-23 2002-04-23 Syntex (U.S.A.) Llc Sulfamide-metalloprotease inhibitors
YU34599A (sh) * 1997-01-23 2002-03-18 F. Hoffmann-La Roche Ag. Inhibitori sulfamid-metaloproteaze
TR200000368T2 (tr) 1997-08-08 2000-07-21 Pfizer Products Inc. Ariloksiariarilsülfonilamino hidroksamik asit türevleri.

Also Published As

Publication number Publication date
DE60008548D1 (de) 2004-04-01
EP1210326B1 (en) 2004-02-25
TR200202164T2 (tr) 2002-11-21
WO2001012592A2 (en) 2001-02-22
BR0013390A (pt) 2002-04-30
WO2001012592A3 (en) 2001-07-05
ES2216938T3 (es) 2004-11-01
CA2378332A1 (en) 2001-02-22
AR030160A1 (es) 2003-08-13
DE60008548T2 (de) 2004-08-05
TR200200410T2 (tr) 2002-06-21
US6677355B1 (en) 2004-01-13
UY26302A1 (es) 2000-10-31
ATE260251T1 (de) 2004-03-15
MXPA01013324A (es) 2002-07-02
TR200202211T2 (tr) 2002-11-21
PT1210326E (pt) 2004-07-30
EP1210326A2 (en) 2002-06-05
JP2003507362A (ja) 2003-02-25
TR200202163T2 (tr) 2002-11-21
DK1210326T3 (da) 2004-06-21
AU6764400A (en) 2001-03-13
CO5300407A1 (es) 2003-07-31

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