ATE63553T1 - Chinazolindione und pyridopyrimidindione. - Google Patents

Chinazolindione und pyridopyrimidindione.

Info

Publication number: ATE63553T1
Authority: AT; Austria
Prior art keywords: carbon atoms; benzyl; alkyl; carboxy; pharmaceutically acceptable
Prior art date: 1986-08-21

Application number

AT87307311T

Other languages

English (en)

Inventor

John Adams Lowe Iii

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-21

Filing date

1987-08-19

Publication date

1991-06-15

1986-08-21 Priority claimed from PCT/US1986/001718 external-priority patent/WO1988001270A1/en

1987-08-19 Application filed by Pfizer filed Critical Pfizer

1991-06-15 Application granted granted Critical

1991-06-15 Publication of ATE63553T1 publication Critical patent/ATE63553T1/de

Links

125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical group O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
BJLUORNGPCXNHM-UHFFFAOYSA-N 1h-pyrido[3,2-d]pyrimidine-2,4-dione Chemical class C1=CN=C2C(=O)NC(=O)NC2=C1 BJLUORNGPCXNHM-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
230000001088 anti-asthma Effects 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
239000000924 antiasthmatic agent Substances 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
125000005518 carboxamido group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
-1 nitro, carboxy Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000008515 quinazolinediones Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003831 tetrazolyl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Plural Heterocyclic Compounds (AREA)

AT87307311T 1986-08-21 1987-08-19 Chinazolindione und pyridopyrimidindione. ATE63553T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/US1986/001718 WO1988001270A1 (en)	1986-08-21	1986-08-21	Pyridopyrimidinediones
US07/076,976 US4797403A (en)	1986-08-21	1987-07-23	Quinazolinediones and pyridopyrimidinediones

Publications (1)

Publication Number	Publication Date
ATE63553T1 true ATE63553T1 (de)	1991-06-15

Family

ID=26758725

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87307311T ATE63553T1 (de)	1986-08-21	1987-08-19	Chinazolindione und pyridopyrimidindione.

Country Status (6)

Country	Link
US (1)	US4880810A (de)
EP (1)	EP0260817B1 (de)
AT (1)	ATE63553T1 (de)
DE (1)	DE3770095D1 (de)
ES (1)	ES2031513T3 (de)
GR (1)	GR3002065T3 (de)

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US6037345A (en) *	1998-01-13	2000-03-14	Cell Pathways, Inc.	Method for inhibiting neoplastic cells and related conditions by exposure to quinazolinedione and pyridopyrimidinedione derivatives
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US5942520A (en) *	1998-01-27	1999-08-24	Cell Pathways, Inc.	Method for inhibiting neoplastic cells by exposure to substituted N-cycloalkylmethyl-1-H-pyrazolo (3,4-B) quinolone-4 amines
US5990117A (en) *	1998-04-15	1999-11-23	Cell Pathways, Inc.	Method for inhibiting neoplastic cells and related conditions by exposure to quinazoline derivatives
US6180629B1 (en)	1998-08-14	2001-01-30	Cell Pathways, Inc.	[4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia
US6268372B1 (en)	1998-09-11	2001-07-31	Cell Pathways, Inc.	Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones
US6124303A (en) *	1998-09-11	2000-09-26	Cell Pathways, Inc.	Method for inhibiting neoplastic cells and related conditions by exposure to 9-substituted 2-(2-N-aloxyphenyl) purin-6-ones
US6200771B1 (en)	1998-10-15	2001-03-13	Cell Pathways, Inc.	Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia
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JP2000119272A (ja) *	1998-10-15	2000-04-25	Nippon Zoki Pharmaceut Co Ltd	新規７−アミノピリド〔２，３−ｄ〕ピリミジン誘導体
US6133271A (en) *	1998-11-19	2000-10-17	Cell Pathways, Inc.	Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives
US6187779B1 (en)	1998-11-20	2001-02-13	Cell Pathways, Inc.	Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives
US6369092B1 (en)	1998-11-23	2002-04-09	Cell Pathways, Inc.	Method for treating neoplasia by exposure to substituted benzimidazole derivatives
US6034099A (en) *	1998-11-24	2000-03-07	Cell Pathways, Inc.	Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones
US6077842A (en) *	1998-11-24	2000-06-20	Cell Pathways, Inc.	Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives
US6486155B1 (en)	1998-11-24	2002-11-26	Cell Pathways Inc	Method of inhibiting neoplastic cells with isoquinoline derivatives
US6025394A (en)	1999-01-29	2000-02-15	Cell Pathways, Inc.	Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols
US6020379A (en) *	1999-02-19	2000-02-01	Cell Pathways, Inc.	Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia
US6555547B1 (en)	2000-02-28	2003-04-29	Cell Pathways, Inc.	Method for treating a patient with neoplasia by treatment with a vinca alkaloid derivative
US6569638B1 (en)	2000-03-03	2003-05-27	Cell Pathways, Inc	Method for screening compounds for the treatment of neoplasia
TWI243055B (en)	2000-04-13	2005-11-11	Nippon Zoki Pharmaceutical Co	Pharmaceutical composition for use in treatment of dermatitis
US6825180B2 (en) *	2001-05-18	2004-11-30	Cell Therapeutics, Inc.	Pyridopyrimidine compounds and their uses
ES2427930T3 (es)	2001-05-23	2013-11-04	Mitsubishi Tanabe Pharma Corporation	Composición terapéutica para el tratamiento regenerativo de enfermedades de los cartílagos
WO2002094321A1 (fr)	2001-05-23	2002-11-28	Tanabe Seiyaku Co., Ltd.	Compositions favorisant la guérison d'une fracture osseuse
US6479493B1 (en)	2001-08-23	2002-11-12	Cell Pathways, Inc.	Methods for treatment of type I diabetes
US7208516B2 (en) *	2002-03-20	2007-04-24	Celgene Corporation	Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US7893101B2 (en)	2002-03-20	2011-02-22	Celgene Corporation	Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US6962940B2 (en)	2002-03-20	2005-11-08	Celgene Corporation	(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
US7276529B2 (en) *	2002-03-20	2007-10-02	Celgene Corporation	Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US20050148034A1 (en) *	2002-04-12	2005-07-07	Hariri Robert J.	Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compounds
AU2003262187A1 (en) *	2002-04-12	2003-10-27	Celgene Corporation	Modulation of stem and progenitor cell differentiation, assays, and uses thereof
WO2006019965A2 (en) *	2004-07-16	2006-02-23	Takeda San Diego, Inc.	Dipeptidyl peptidase inhibitors
TW200726767A (en) *	2005-07-04	2007-07-16	Astrazeneca Ab	Chemical compounds 2
US20070155791A1 (en) *	2005-12-29	2007-07-05	Zeldis Jerome B	Methods for treating cutaneous lupus using aminoisoindoline compounds
MX2010010334A (es) *	2008-03-24	2010-10-08	Celgene Corp	Tratamiento de psoriasis o artritis psoriatica utilizando ciclopropil-n-{2-{(1s)-1-(3-etoxi-4-metoxifenil)-2-(metilsulfonil )etil]-3-oxoisoindolina-4-il}carboxamida.
EP2297106B1 (de)	2008-05-27	2014-07-16	AstraZeneca AB	Phenoxypyridinylamidderivate und ihre verwendung zur behandlung von pde4-vermittelten krankheitszuständen
LT3083564T (lt)	2013-12-20	2018-09-25	Novartis Ag	Heteroarilo butano rūgšties dariniai, kaip lta4h inhibitoriai
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GB1064259A (en) *	1963-12-19	1967-04-05	Union Pharma Scient Appl	New derivatives of 2-anilino-nicotinic acid and process for their preparation
US3794643A (en) *	1971-04-20	1974-02-26	Hisamitsu Pharmaceutical Co	Quinazolinedione derivatives
DE2334266A1 (de) *	1972-07-07	1974-01-31	Hisamitsu Pharmaceutical Co	Pyrido eckige klammer auf 2,3-d eckige klammer zu pyrimidin-2,4 (1h, 3h)-dione
US3922275A (en) *	1972-11-09	1975-11-25	Hisamitsu Pharmaceutical Co	Pyrido{8 2,3-D{9 {0 pyrimidine-2,4(1H,3H)-diones
JPS5069096A (de) *	1973-10-25	1975-06-09
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DE3347526A1 (de) *	1983-12-30	1985-07-11	Troponwerke GmbH & Co KG, 5000 Köln	Verfahren zur herstellung substituierter chinazolin-2.4(1h.3h)-dione
US4808587A (en) *	1986-04-16	1989-02-28	Nippon Zoki Pharmaceutical Co., Ltd.	5-substituted pyrido[2,3-d]pyrimidine-2,4-diones
WO1988001270A1 (en) *	1986-08-21	1988-02-25	Pfizer Inc.	Pyridopyrimidinediones

1987
- 1987-08-19 DE DE8787307311T patent/DE3770095D1/de not_active Expired - Fee Related
- 1987-08-19 ES ES198787307311T patent/ES2031513T3/es not_active Expired - Lifetime
- 1987-08-19 AT AT87307311T patent/ATE63553T1/de not_active IP Right Cessation
- 1987-08-19 EP EP87307311A patent/EP0260817B1/de not_active Expired - Lifetime
1989
- 1989-01-03 US US07/273,305 patent/US4880810A/en not_active Expired - Lifetime
1991
- 1991-06-06 GR GR91400735T patent/GR3002065T3/el unknown

Also Published As

Publication number	Publication date
EP0260817B1 (de)	1991-05-15
US4880810A (en)	1989-11-14
EP0260817A1 (de)	1988-03-23
DE3770095D1 (de)	1991-06-20
ES2031513T3 (es)	1992-12-16
GR3002065T3 (en)	1992-12-30

Legal Events

Date	Code	Title	Description
1992-03-15	UEP	Publication of translation of european patent specification
2006-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3770095D1 (de)	1991-06-20	Chinazolindione und pyridopyrimidindione.
AU1433588A (en)	1988-10-13	1-phenyl-3-naphthalenyloxypropanamines
DK160877C (da)	1991-10-14	Fremgangsmaade til fremstilling af 2-penemforbindelser
GB9711650D0 (en)	1997-07-30	Compounds useful in therapy
AU636351B2 (en)	1993-04-29	N-heteroaryl-purin-6-amines, a process for their preparation and their use as medicaments
IE781473L (en)	1979-01-25	Pyrrolo-pyrrole-1-carboxylic acid derivatives
AU567117B2 (en)	1987-11-12	Indene derivatives
DK0894787T3 (da)	2002-09-30	3,4-disubstituerede phenylethanolaminolaminotetralincarboxylsyre-derivater
IE790996L (en)	1979-11-24	Phenylaminothiophene derivatives
BR8900317A (pt)	1989-09-19	Processo para a preparacao de compostos herbicidas e compostos herbicidas
DE3665708D1 (en)	1989-10-26	Compounds and compositions having anti-inflammatory and analgesic activity
ES8707530A1 (es)	1987-08-01	Un procedimiento para la preparacion de una octahidroindolizina
AU640590B2 (en)	1993-08-26	3-(1h-indazol-3-yl)-4-pyridinamines
ATE52776T1 (de)	1990-06-15	1-phenyl-3-benzazepine.
ES8608488A1 (es)	1986-06-16	Un metodo para preparar nuevas 1-aminoalquil-amino-4-arilo- xipiperidinas sustituidas
ES2080891T3 (es)	1996-02-16	Preparacion de derivados de amina norbornil opticamente activos.
DE69834388D1 (de)	2006-06-08	Hexahydroindenopyridinverbindungen mit antispermatogener aktivität
EP0201775A3 (de)	1987-08-05	Propionsäurederivat und dieses enthaltende selektive Herbizide
JPS56131576A (en)	1981-10-15	Novel phenylacetamide derivative
ES8307812A1 (es)	1983-08-01	Un procedimiento para la preparacion de nuevos amidin derivados del acido clavulawilo.