PE20060426A1 - DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa - Google Patents
DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfaInfo
- Publication number
- PE20060426A1 PE20060426A1 PE2005000615A PE2005000615A PE20060426A1 PE 20060426 A1 PE20060426 A1 PE 20060426A1 PE 2005000615 A PE2005000615 A PE 2005000615A PE 2005000615 A PE2005000615 A PE 2005000615A PE 20060426 A1 PE20060426 A1 PE 20060426A1
- Authority
- PE
- Peru
- Prior art keywords
- tace
- alkyl
- mmps
- adams
- inhibitors
- Prior art date
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- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Abstract
SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE A ES (R1)(R2)NCO-, (R1)(R2)NCS-, ENTRE OTROS; J Y E SON O, S O NR5; T ES O U S; R1 Y R2 SON INDEPENDIENTEMENTE H, ALQUILO, CICLOALQUILO, ENTRE OTROS, O JUNTOS CON EL N AL CUAL ESTAN UNIDOS FORMAN UN HETEROCICLO DE 4 A 8 MIEMBROS CON 1 A 3 HETEROATOMOS DE N OPCIONALMENTE SUSTITUIDOS POR R70 U OPCIONALMENTE FUSIONADO CON ARILO, HETEROARILO, ENTRE OTROS; OPCIONALMENTE SUSTITUIDOS; R10, R20, R30, R40 Y R50 SON INDEPENDIENTEMENTE H, ALQUILO, ENTRE OTROS; W ES -(CR(13)2)n- O UN ENLACE COVALENTE; X ESTA PRESENTE O NO, ES ALQUILO, ARILO TAL COMO, FENILO, AZETIDINO, PIRIDINILO, PIRROLIDINO, PIPERIDINILO, TIENILO, OXAZOLILO, IMIDAZOLILO, ENTRE OTROS; Y ESTA PRESENTE O NO, ES UN ENLACE COVALENTE O -C(R6)2]n-; Z ES H, ARILO O HETEROARILO, TAL COMO FENILO, INDOLILO, BENZOIMIDAZOLILO, PIRAZOLILO, TIENILO, PIRIDINILO, IMIDAZOLILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS POR CIANO, ALCOXI, HALOGENO, ALQUILO, ENTRE OTROS. ESTOS COMPUESTOS SON INHIBIDORES DE LAS MALOPROTEINASAS DE MATRIZ (MMPS), UNA DESINTEGRINA Y METALOPROTEASAS (ADAMs) Y/O A LA ENZIMA CONVERTIDORA DEL FACTOR DE NECROSIS TUMORAL ALFA (TACE) POR LO QUE EVITAN LA LIBERACION DEL FACTOR DE NECROSIS TUMORAL ALFA (TNF-a), POR LO QUE SON UTILES EN EL TRATAMIENTO DE OSTEOARTRITIS Y ARTRITIS REUMATOIDEA Y OTRAS ENFERMEDADES AUTOINMUNES
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US11629136B1 (en) | 2021-07-28 | 2023-04-18 | Nura Bio, Inc. | Substituted pyridine derivatives as SARM1 inhibitors |
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DE1123468B (de) | 1955-01-22 | 1962-02-08 | Hermann Leinfelder | Verfahren zur Herstellung wasserloeslicher, poly-N-quaternaerer, die Diffusion in Geweben erhoehender Substanzen |
US5618842A (en) | 1991-12-31 | 1997-04-08 | Lifegroup S.P.A. | N-acyl derivatives of aminoalcohols with polycarboxylic acids able to modulate mast cells in inflammatory processes having neuroimmunogenic origin |
US6228869B1 (en) * | 1996-10-16 | 2001-05-08 | American Cyanamid Company | Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
FR2762315B1 (fr) * | 1997-04-22 | 1999-05-28 | Logeais Labor Jacques | Derives d'amino-acides inhibiteurs des metalloproteases de la matrice extracellulaire et de la liberation du tnf alpha |
ATE260251T1 (de) * | 1999-08-18 | 2004-03-15 | Warner Lambert Co | Hydroxamsäurederivate als matrix- metalloproteinase-inhibitoren |
AU7270600A (en) | 1999-09-20 | 2001-04-24 | Novo Nordisk A/S | Bivalent inhibitor of fviia/tf/fxa complex |
WO2001044179A1 (en) | 1999-12-17 | 2001-06-21 | Versicor, Inc. | Novel succinate compounds, compositions and methods of use and preparation |
WO2001070734A2 (en) * | 2000-03-17 | 2001-09-27 | Bristol-Myers Squibb Pharma Company | Beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha |
US6534651B2 (en) | 2000-04-06 | 2003-03-18 | Inotek Pharmaceuticals Corp. | 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof |
CA2413702A1 (en) * | 2000-06-28 | 2002-01-03 | Teva Pharmaceuticals Industries Ltd. | Carvedilol |
CN1512991A (zh) | 2001-06-15 | 2004-07-14 | ά����ҩ�﹫˾ | 吡咯烷双环化合物 |
JP2005538936A (ja) | 2002-03-12 | 2005-12-22 | ノボ ノルディスク アクティーゼルスカブ | 二量体のtfアンタゴニスト |
CA2536576C (en) | 2003-08-23 | 2012-12-18 | Vernalis (Oxford) Limited | Derivatives of hydroxamic acid as metalloproteinase inhibitors |
US20070167426A1 (en) * | 2004-06-02 | 2007-07-19 | Schering Corporation | Compounds for the treatment of inflammatory disorders and microbial diseases |
PE20060426A1 (es) * | 2004-06-02 | 2006-06-28 | Schering Corp | DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa |
US7638513B2 (en) * | 2004-06-02 | 2009-12-29 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
AU2006320604A1 (en) * | 2005-12-01 | 2007-06-07 | Schering Corporation | Compounds for the treatment of inflammatory disorders and microbial diseases |
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2005
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- 2005-06-01 AR ARP050102245A patent/AR051172A1/es not_active Application Discontinuation
- 2005-06-01 MX MXPA06014054A patent/MXPA06014054A/es unknown
- 2005-06-01 CA CA002569111A patent/CA2569111A1/en not_active Abandoned
- 2005-06-01 KR KR1020067026812A patent/KR20070103671A/ko not_active Application Discontinuation
- 2005-06-01 JP JP2007515501A patent/JP2008501691A/ja not_active Withdrawn
- 2005-06-01 AU AU2005252201A patent/AU2005252201A1/en not_active Abandoned
- 2005-06-01 TW TW094117942A patent/TW200612911A/zh unknown
- 2005-06-01 CN CNA2005800261890A patent/CN101027295A/zh active Pending
- 2005-06-01 WO PCT/US2005/019131 patent/WO2005121130A2/en active Application Filing
- 2005-06-01 EP EP05759261A patent/EP1773821A2/en not_active Withdrawn
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2009
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KR20070103671A (ko) | 2007-10-24 |
WO2005121130A3 (en) | 2006-07-20 |
CN101027295A (zh) | 2007-08-29 |
US20100145048A1 (en) | 2010-06-10 |
WO2005121130A2 (en) | 2005-12-22 |
JP2008501691A (ja) | 2008-01-24 |
US20060252778A1 (en) | 2006-11-09 |
ZA200610055B (en) | 2009-05-27 |
AU2005252201A1 (en) | 2005-12-22 |
TW200612911A (en) | 2006-05-01 |
US7652020B2 (en) | 2010-01-26 |
US8039467B2 (en) | 2011-10-18 |
EP1773821A2 (en) | 2007-04-18 |
IL179674A0 (en) | 2007-05-15 |
CA2569111A1 (en) | 2005-12-22 |
MXPA06014054A (es) | 2007-01-31 |
AR051172A1 (es) | 2006-12-27 |
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