ES2187025T3 - Nuevos agentes quelantes de hierro (iii) activos via oral. - Google Patents
Nuevos agentes quelantes de hierro (iii) activos via oral.Info
- Publication number
- ES2187025T3 ES2187025T3 ES98922968T ES98922968T ES2187025T3 ES 2187025 T3 ES2187025 T3 ES 2187025T3 ES 98922968 T ES98922968 T ES 98922968T ES 98922968 T ES98922968 T ES 98922968T ES 2187025 T3 ES2187025 T3 ES 2187025T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- aryl
- group
- aralkyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se presenta un nuevo compuesto 3-hidroxipiridin-4-ona de la fórmula (I), en la que R es hidrógeno o un grupo que es eliminado metabólicamente in vivo para suministrar un compuesto hidróxido libre, R{sup,1} es un grupo hidrocarburo alifático o un grupo hidrocarburo alifático sustituido por un grupo hidróxido o un éster de ácido carboxílico, un éster de ácido sulfo o un éter alcóxido C{sub,6} o aralcóxido C{sub, 7-10} del mismo, R{sup,3} se selecciona entre hidrógeno y alquilo C{sub,1-6} y R{sup,4} se selecciona entre hidrógeno y alquilo C{sub,1-6ç, alquilo C{sub,1-6} y un grupo como el descrito para R{sup,2}; que se caracteriza en que R{sup,2} se selecciona entre los grupos (i) -CONH-R{sup,5}, (ii) -CH{sub,2}NHCO-R{sup,5}, (iii) -SO{sub,2}NH-R{sup,5}, (iv) -CH{sub,2}NHSO{sub,2}R{sup,5}, (v) -CR{sup,6}R{sup,6}OR{sup,7}, (viii) -CONHCOR{sup,5}, en donde R{sup,5} se selecciona entre hidrógeno y alquilo C{sub,1-13}, arilo y aralquilo C{sub,7-13} opcionalmente sustituidos por hidróxido, alcóxidoo aralcóxido, R{sup,6} se selecciona independiente entre hidrógeno, alquilo C{sub,1-13}, arilo y aralquilo C{sub, 7-13} y R{sup,7} se selecciona entre hidrógeno, alquilo C{sub,1-13}, arilo y aralquilo C{sub,7-13}; también se presenta una sal farmacológicamente aceptable del compuesto con la condición de que cuando R{sup,7} sea hidrógeno, R{sup,6} no se seleccione entre arilo y con la condición de que el compuesto no sea 1-etil-2(1''-hidroxietil)-3-hidroxipiridin-4-ona.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9711093.6A GB9711093D0 (en) | 1997-05-29 | 1997-05-29 | Novel orally active iron (III) chelators |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2187025T3 true ES2187025T3 (es) | 2003-05-16 |
Family
ID=10813233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98922968T Expired - Lifetime ES2187025T3 (es) | 1997-05-29 | 1998-05-26 | Nuevos agentes quelantes de hierro (iii) activos via oral. |
Country Status (12)
Country | Link |
---|---|
US (2) | US6335353B1 (es) |
EP (1) | EP0984934B1 (es) |
JP (1) | JP2002500663A (es) |
AT (1) | ATE230728T1 (es) |
AU (1) | AU751600B2 (es) |
CA (1) | CA2287907C (es) |
DE (1) | DE69810619T2 (es) |
DK (1) | DK0984934T3 (es) |
ES (1) | ES2187025T3 (es) |
GB (1) | GB9711093D0 (es) |
WO (1) | WO1998054138A1 (es) |
ZA (1) | ZA984635B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2385551A1 (en) | 1999-10-01 | 2001-04-12 | Dmi Biosciences, Inc. | Metal-binding compounds and uses therefor |
US6426418B1 (en) | 2001-11-02 | 2002-07-30 | Apotex, Inc. | Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide |
WO2003065991A2 (en) | 2002-02-05 | 2003-08-14 | Bristol-Myers Squibb Company | N-substituted3-hydroxy-4-pyridinones and pharmaceuticals containing thereof |
AU2003282337B2 (en) | 2002-11-07 | 2009-07-16 | Technion Research And Development Foundation Ltd. | Neuroprotective iron chelators and pharmaceutical compositions comprising them |
NZ529657A (en) | 2003-11-20 | 2004-07-30 | Apotex Inc | Iron chelating cycloalkyl derivatives of 3-hydroxy-4-pyridinones |
CA2488034C (en) * | 2004-11-19 | 2009-10-06 | Apotex Inc. | Process for the manufacture of 3-hydroxy-n-alkyl-1-cycloalkyl-6-alkyl-4-oxo-1,4-dihydropyridine-2-carboxamide and its related analogues |
GB0506677D0 (en) * | 2005-04-01 | 2005-05-11 | Btg Int Ltd | Iron modulators |
MX2009010407A (es) | 2007-03-28 | 2009-12-01 | Apotex Technologies Inc | Derivados fluorados de deferiprona. |
GB0803019D0 (en) * | 2008-02-19 | 2008-03-26 | Btg Int Ltd | Fluorinated compounds |
CN102014904B (zh) | 2008-04-25 | 2013-02-06 | 阿普泰克斯科技公司 | 具有适口味道的去铁酮液体配制品 |
KR101772610B1 (ko) | 2008-07-25 | 2017-09-12 | 비이브 헬쓰케어 컴퍼니 | 화합물 |
JP5572168B2 (ja) | 2008-12-11 | 2014-08-13 | ビーブ・ヘルスケア・カンパニー | カルバモイルピリドンhivインテグラーゼ阻害剤の製造方法および中間体 |
WO2010068253A1 (en) | 2008-12-11 | 2010-06-17 | Shionogi & Co., Ltd. | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
WO2011000104A1 (en) | 2009-07-03 | 2011-01-06 | Apotex Technologies Inc. | Fluorinated derivatives of 3-hydroxypyridin-4-ones |
TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Viiv醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
WO2020132820A1 (zh) * | 2018-12-24 | 2020-07-02 | 广东莱佛士制药技术有限公司 | 一种3-(苄氧基)-4-氧代-4h-吡喃-2-羧酸的合成方法 |
CN109438405B (zh) * | 2018-12-24 | 2023-04-07 | 广东莱佛士制药技术有限公司 | 一种3-(苄氧基)-4-氧代-4h-吡喃-2-羧酸的合成方法 |
CN111606879A (zh) * | 2020-05-25 | 2020-09-01 | 安徽金禾实业股份有限公司 | 一锅法制备2-羟甲基-3-烷氧基-4h-吡喃-4-酮的方法 |
CN114736155B (zh) * | 2021-03-10 | 2023-12-05 | 浙江工业大学 | Ala杂合3-羟基吡啶酮衍生物及其制备方法与应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1500765A (fr) * | 1963-09-19 | 1967-11-10 | Pfizer & Co C | Dérivés de l'acide pyroméconique et procédé pour leur préparation |
US3468915A (en) * | 1966-04-18 | 1969-09-23 | Pfizer & Co C | Novel 2-substituted-6-methylpyromeconic acids |
JPS5921954B2 (ja) * | 1980-02-13 | 1984-05-23 | 新日本製鐵株式会社 | 鋼材の防錆処理方法 |
US5112968A (en) * | 1989-07-28 | 1992-05-12 | E. R. Squibb & Sons, Inc. | Monobactam hydrazide derivatives |
GB9006522D0 (en) * | 1990-03-23 | 1990-05-23 | Hider Robert C | Metal complexes |
ES2244967T3 (es) * | 1995-09-29 | 2005-12-16 | Novartis Ag | Nuevas hidroxipiridinonas. |
-
1997
- 1997-05-29 GB GBGB9711093.6A patent/GB9711093D0/en not_active Ceased
-
1998
- 1998-05-26 ES ES98922968T patent/ES2187025T3/es not_active Expired - Lifetime
- 1998-05-26 EP EP98922968A patent/EP0984934B1/en not_active Expired - Lifetime
- 1998-05-26 AU AU75427/98A patent/AU751600B2/en not_active Ceased
- 1998-05-26 CA CA002287907A patent/CA2287907C/en not_active Expired - Fee Related
- 1998-05-26 DK DK98922968T patent/DK0984934T3/da active
- 1998-05-26 WO PCT/GB1998/001517 patent/WO1998054138A1/en active IP Right Grant
- 1998-05-26 AT AT98922968T patent/ATE230728T1/de not_active IP Right Cessation
- 1998-05-26 JP JP50036299A patent/JP2002500663A/ja not_active Ceased
- 1998-05-26 DE DE69810619T patent/DE69810619T2/de not_active Expired - Fee Related
- 1998-05-29 ZA ZA9804635A patent/ZA984635B/xx unknown
-
1999
- 1999-11-10 US US09/437,211 patent/US6335353B1/en not_active Expired - Lifetime
-
2001
- 2001-09-04 US US09/944,113 patent/US6506911B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2287907C (en) | 2009-01-13 |
AU751600B2 (en) | 2002-08-22 |
ATE230728T1 (de) | 2003-01-15 |
ZA984635B (en) | 1999-11-29 |
GB9711093D0 (en) | 1997-07-23 |
DE69810619D1 (de) | 2003-02-13 |
AU7542798A (en) | 1998-12-30 |
WO1998054138A1 (en) | 1998-12-03 |
JP2002500663A (ja) | 2002-01-08 |
EP0984934A1 (en) | 2000-03-15 |
EP0984934B1 (en) | 2003-01-08 |
US6506911B2 (en) | 2003-01-14 |
DK0984934T3 (da) | 2003-05-05 |
US6335353B1 (en) | 2002-01-01 |
CA2287907A1 (en) | 1998-12-03 |
DE69810619T2 (de) | 2003-09-25 |
US20020068758A1 (en) | 2002-06-06 |
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