PE20001565A1 - Inhibidores de metaloproteasa conteniendo alquenil y alquinil - Google Patents
Inhibidores de metaloproteasa conteniendo alquenil y alquinilInfo
- Publication number
- PE20001565A1 PE20001565A1 PE2000000232A PE0002322000A PE20001565A1 PE 20001565 A1 PE20001565 A1 PE 20001565A1 PE 2000000232 A PE2000000232 A PE 2000000232A PE 0002322000 A PE0002322000 A PE 0002322000A PE 20001565 A1 PE20001565 A1 PE 20001565A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alkenyl
- alkinyl
- compound
- containing alkenyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 208000030533 eye disease Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
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- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE X ES OH, NHOH; W ES S,O,N(R33), (R33)C=C(R33`), N=C(R33),N=N; R33 Y R33' SON H, ALQUILO, ALQUENILO, ALQUINILO, ENTRE OTROS; R1 ES CR6R6 R34 DONDE ES 0-4; R6 Y R6' SON H, ALQUILO, ALQUENILO, ENTRE OTROS; R34 ES H, OH, ALCOXI, ALQUILO, ENTRE OTROS; R2 ES -(CR7R7')m-R35 DONDE m ES 0-4; R7 Y R7' SON H, ALQUILO, ALQUENILO, ALQUINILO, ENTRE OTROS; R35 ES H, ALQUILO, ALQUENILO, ENTRE OTROS; R3 ES (CR8R8')n-R9; n ES 0-4; R8 Y R8' SON H, ALQUILO, ALQUENILO, ALQUINILO, ARILO, ENTRE OTROS; R4 ES (CR10R10')z-A'-(CR10''R10''')o-R11, A' ES O, S, SO2; z Y o SON 0-4; R10, R10', R10'', R10''' SON H, ALQUILO, ALQUENILO, ENTRE OTROS; R11 ES H, ALQUILO, ALQUENILO, ENTRE OTROS; R5 Y R5' SON H, ALQUILO, ALQUENILO, ALQUINILO, ENTRE OTROS; k ES 0-4; A ES (R12)C=C(R12'), CC; R12 Y R12' SON H, ALQUILO, ALQUENILO, ENTRE OTROS; G ES H, (CR14R14')p-R15, ENTRE OTROS; p ES 0-4; R14 Y R14' SON H, ALQUILO, ALQUENILO, ENTRE OTROS; Z ES CICLOALQUILO, HETEROCICLOALQUILO, ENTRE OTROS. UN COMPUESTO PREFERIDO ES ACIDO 2-{[4'-FLUORO-(1,1'-BIFENIL)-4-IL]-SULFONIL}-AMINO-5-FENILPEN-4-TINOICO, ENTRE OTROS. EL COMPUESTO I ES UN INHIBIDOR DE METALOPROTEASAS POR LO QUE PUEDEN SER UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDEA, CANCER, DESORDENES CARDIOVASCULARES, CUTANEOS, OCULARES
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US12264499P | 1999-03-03 | 1999-03-03 |
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PE2000000232A PE20001565A1 (es) | 1999-03-03 | 2000-03-16 | Inhibidores de metaloproteasa conteniendo alquenil y alquinil |
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US (1) | US6197770B1 (es) |
EP (1) | EP1165501A1 (es) |
JP (1) | JP2002538136A (es) |
KR (1) | KR20010102486A (es) |
CN (1) | CN1349498A (es) |
AU (1) | AU764051B2 (es) |
BR (1) | BR0008716A (es) |
CA (1) | CA2364878A1 (es) |
CO (1) | CO5150219A1 (es) |
CZ (1) | CZ20013176A3 (es) |
HK (1) | HK1044754A1 (es) |
HU (1) | HUP0202199A2 (es) |
IL (1) | IL145089A0 (es) |
MA (1) | MA25391A1 (es) |
MX (1) | MXPA01008855A (es) |
NO (1) | NO20014242L (es) |
NZ (1) | NZ513831A (es) |
PE (1) | PE20001565A1 (es) |
PL (1) | PL350340A1 (es) |
RU (1) | RU2001126721A (es) |
SK (1) | SK12452001A3 (es) |
TR (1) | TR200102523T2 (es) |
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SK12452001A3 (sk) | 2002-04-04 |
PL350340A1 (en) | 2002-12-02 |
TR200102523T2 (tr) | 2002-02-21 |
BR0008716A (pt) | 2002-09-24 |
MA25391A1 (fr) | 2002-04-01 |
CN1349498A (zh) | 2002-05-15 |
EP1165501A1 (en) | 2002-01-02 |
IL145089A0 (en) | 2002-06-30 |
HK1044754A1 (zh) | 2002-11-01 |
HUP0202199A2 (en) | 2002-10-28 |
AU3386000A (en) | 2000-09-21 |
CZ20013176A3 (cs) | 2002-04-17 |
US6197770B1 (en) | 2001-03-06 |
CA2364878A1 (en) | 2000-09-08 |
ZA200106967B (en) | 2002-03-13 |
AU764051B2 (en) | 2003-08-07 |
KR20010102486A (ko) | 2001-11-15 |
NO20014242D0 (no) | 2001-08-31 |
JP2002538136A (ja) | 2002-11-12 |
NO20014242L (no) | 2001-09-27 |
WO2000051975A1 (en) | 2000-09-08 |
MXPA01008855A (es) | 2002-07-02 |
RU2001126721A (ru) | 2004-02-20 |
NZ513831A (en) | 2001-09-28 |
CO5150219A1 (es) | 2002-04-29 |
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