BR9712792A - Inibidores de metaloprotease bidentada. - Google Patents

Inibidores de metaloprotease bidentada.

Info

Publication number
BR9712792A
BR9712792A BR9712792-2A BR9712792A BR9712792A BR 9712792 A BR9712792 A BR 9712792A BR 9712792 A BR9712792 A BR 9712792A BR 9712792 A BR9712792 A BR 9712792A
Authority
BR
Brazil
Prior art keywords
compounds
bidentate
pharmaceutical compositions
relates
metalloprotease inhibitors
Prior art date
Application number
BR9712792-2A
Other languages
English (en)
Inventor
Neil Gregory Almstead
Biswanath De
Rimma Sandler Bradley
Garry Steven Garrett
John Emory Ii Marlin
John Mcmillan Mciver
Zhe Wang
Yetunde Olabisi Taiwo
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Priority claimed from PCT/US1997/012536 external-priority patent/WO1998009016A1/en
Publication of BR9712792A publication Critical patent/BR9712792A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Patente de Invenção: <B>"INIBIDORE DE METALOPROTEASE BIDENTADA"<D>. A invenção refere-se a compostos que são úteis como inibidores de metaloproteases, e que são eficazes em tratamento de condição caracterizada pelo excesso de atividade desta enzima. Em particular, a presente invenção refere-se a um composto tendo a estrutura de acordo com a Fómula (I) como descrito nas reivindicações, ou um isómero, diastereómero ou enantiómero ótico dele, ou um sal farmaceuticamente aceitável, ou alcoxiamida, ester, aciloxiamida, ou suas imidas biohidrolizáveis. Também descritos são compostos, composições farmacêuticas e métodos de tratamento de doenças caracterizadas pela atividade de metaloprotease, empregando-se estes compostos ou as composições farmacêuticas contendo-os.
BR9712792-2A 1996-08-28 1997-07-09 Inibidores de metaloprotease bidentada. BR9712792A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2474696P 1996-08-28 1996-08-28
PCT/US1997/012536 WO1998009016A1 (en) 1996-08-30 1997-07-09 Permeable, liquid flow control material

Publications (1)

Publication Number Publication Date
BR9712792A true BR9712792A (pt) 1999-12-14

Family

ID=21822181

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9712792-2A BR9712792A (pt) 1996-08-28 1997-07-09 Inibidores de metaloprotease bidentada.

Country Status (20)

Country Link
US (1) US6121272A (pt)
EP (1) EP0923547A1 (pt)
JP (1) JP2000516954A (pt)
KR (1) KR20000035921A (pt)
CN (1) CN1228767A (pt)
AU (1) AU4074097A (pt)
BR (1) BR9712792A (pt)
CA (1) CA2263914A1 (pt)
CO (1) CO5420196A1 (pt)
CZ (1) CZ62499A3 (pt)
HU (1) HUP0000616A2 (pt)
ID (1) ID18417A (pt)
IL (1) IL128665A0 (pt)
NO (1) NO990896L (pt)
PE (1) PE109298A1 (pt)
PL (1) PL331803A1 (pt)
SK (1) SK24899A3 (pt)
TR (1) TR199900401T2 (pt)
WO (1) WO1998008814A1 (pt)
ZA (1) ZA977697B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ503945A (en) 1997-07-31 2002-11-26 Procter & Gamble Metalloprotease-inhibiting amide derivatives
HUP0101176A3 (en) 1998-02-04 2002-06-28 Novartis Ag Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases, process for their preparation and pharmaceutical compositions containing them
US6410580B1 (en) 1998-02-04 2002-06-25 Novartis Ag Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
US6846478B1 (en) 1998-02-27 2005-01-25 The Procter & Gamble Company Promoting whole body health
EA200001247A1 (ru) 1998-06-03 2001-08-27 Джи Пи Ай Нил Холдингс, Инк. N-связанные сульфонамиды n-гетероциклических карбоновых кислот или изостеры карбоновых кислот
CA2344412A1 (en) 1998-09-21 2000-03-30 Takeda Chemical Industries, Ltd. Thiol compound, their production and use
NZ513831A (en) 1999-03-03 2001-09-28 Procter & Gamble Alkenyl- and alkynyl-containing metalloprotease inhibitors
KR20010102485A (ko) 1999-03-03 2001-11-15 데이비드 엠 모이어 디헤테로-치환된 메탈로프로테아제 저해제
AU6388500A (en) * 1999-08-05 2001-03-05 Procter & Gamble Company, The Multivalent sulfonamides
WO2001010838A1 (en) * 1999-08-05 2001-02-15 The Procter & Gamble Company Multivalent compounds
DE60134854D1 (de) 2000-06-30 2008-08-28 Procter & Gamble Orale zubereitungen, die wirtsantwortmodulierenden wirkstoffe enthalten
US8283135B2 (en) 2000-06-30 2012-10-09 The Procter & Gamble Company Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
EP1303485A1 (en) * 2000-07-19 2003-04-23 F. Hoffmann-La Roche Ag Pyrrolidine derivatives as inhibitors of endothelin-converting enzyme
AU2001278479B2 (en) 2000-07-19 2007-06-21 F. Hoffmann-La Roche Ag Pyrrolidine derivatives as metalloprotease inhibitors
CN1443184A (zh) * 2000-07-19 2003-09-17 霍夫曼-拉罗奇有限公司 嘧啶衍生物
FR2819252A1 (fr) * 2001-01-11 2002-07-12 Servier Lab Nouveaux derives d'acide hydroxamique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2005500270A (ja) * 2001-05-29 2005-01-06 ギルフォード ファーマシュウティカルズ インコーポレイテッド 手術の結果として発生した神経損傷を治療するための方法
US7485664B2 (en) * 2002-12-19 2009-02-03 Vertex Pharmaceuticals Incorporated Inhibitors of TACE
US7897776B2 (en) 2007-04-23 2011-03-01 Salutria Pharmaceuticals Llc Sulfonamide containing compounds for treatment of inflammatory disorders
CN106905183B (zh) * 2017-02-24 2018-07-31 三峡大学 一类含氨基的ɑ-酰氧基羰基酰胺类衍生物，制备方法及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
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US3501489A (en) * 1966-01-21 1970-03-17 American Home Prod 1-phenylsulfonyl-2-(2-thiazolin-2-yl-oxy and thiol) pyrrolidines
US4695575A (en) * 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
IL74140A (en) * 1984-04-10 1988-05-31 Robins Co Inc A H Substituted n-((amino)alkyl)-1-pyrrolidine,-1-piperidine and-1-homopiperidine-carboxamides and pharmaceutical compositions containing them
US4595700A (en) * 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
IT1215590B (it) * 1987-06-29 1990-02-14 Roussel Maestretti Spa Derivati della 1-benzene solfonil 2-oco 5-alchiltio pirrolidina, un loro procedimentodi preparazione e il loro impiegocome stostanze medicinali.
GB8814813D0 (en) * 1988-06-22 1988-07-27 Beecham Group Plc Novel compounds
DE4011172A1 (de) * 1990-04-06 1991-10-10 Degussa Verbindungen zur bekaempfung von pflanzenkrankheiten
CA2048110C (en) * 1990-07-30 2002-06-25 Muneo Takatani Imidazopyridine derivatives and their use
JPH05125029A (ja) * 1991-11-06 1993-05-21 Yamanouchi Pharmaceut Co Ltd 新規なアミド化合物又はその塩
US6090785A (en) * 1992-10-15 2000-07-18 Merck & Co., Inc. Substituted N-carboxyalkylpeptidyl derivatives as antidegenerative agents
US5455258A (en) * 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5455262A (en) * 1993-10-06 1995-10-03 Florida State University Mercaptosulfide metalloproteinase inhibitors
US5470834A (en) * 1993-10-06 1995-11-28 Florida State University Sulfoximine and suldodiimine matrix metalloproteinase inhibitors
DE69511089T2 (de) * 1994-06-22 1999-12-16 British Biotech Pharm Metalloproteinase-inhibitoren
ES2196163T3 (es) * 1995-07-31 2003-12-16 Shionogi & Co Derivados de pirrolidina con una actividad de inhibicion de la fosfolipasa a2.
WO1997020824A1 (en) * 1995-12-08 1997-06-12 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation

Also Published As

Publication number Publication date
CZ62499A3 (cs) 1999-07-14
SK24899A3 (en) 2000-04-10
PE109298A1 (es) 1999-01-31
IL128665A0 (en) 2000-01-31
ZA977697B (en) 1998-02-23
CO5420196A1 (es) 2004-07-30
EP0923547A1 (en) 1999-06-23
WO1998008814A1 (en) 1998-03-05
PL331803A1 (en) 1999-08-02
NO990896L (no) 1999-04-20
CN1228767A (zh) 1999-09-15
NO990896D0 (no) 1999-02-25
KR20000035921A (ko) 2000-06-26
HUP0000616A2 (en) 2000-07-28
TR199900401T2 (xx) 1999-05-21
CA2263914A1 (en) 1998-03-05
ID18417A (id) 1998-04-09
JP2000516954A (ja) 2000-12-19
US6121272A (en) 2000-09-19
AU4074097A (en) 1998-03-19

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]