PA8806801A1 - Compuestos de amida como refuerzos de antivirales - Google Patents

Compuestos de amida como refuerzos de antivirales

Info

Publication number
PA8806801A1
PA8806801A1 PA20088806801A PA8806801A PA8806801A1 PA 8806801 A1 PA8806801 A1 PA 8806801A1 PA 20088806801 A PA20088806801 A PA 20088806801A PA 8806801 A PA8806801 A PA 8806801A PA 8806801 A1 PA8806801 A1 PA 8806801A1
Authority
PA
Panama
Prior art keywords
compounds
reinforcements
antiviral
amida
amida compounds
Prior art date
Application number
PA20088806801A
Other languages
English (en)
Inventor
Tim Hugo Maria Jonckers
Wim Bert Griet Schepens
Geerwin Yvonne Paul Hache
Sabine Hallenberger
Jennifer Chiyomi Sasaki
Judith Eva Baumeister
Original Assignee
Tibotecpharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39386111&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PA8806801(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotecpharmaceuticals Ltd filed Critical Tibotecpharmaceuticals Ltd
Publication of PA8806801A1 publication Critical patent/PA8806801A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS QUE TIENEN PROPIEDADES INHIBIDORAS DE CYP450 Y POR LO TANTO SON ÚTILES COMO REFUERZOS DE DETERMINADAS DROGAS, ES DECIR, SON CAPACES DE AUMENTAR POR LO MENOS UNA DE LA VARIABLES FARMACOCINÉTICAS DE DETERMINADAS DROGAS CUANDO SE CO-ADMINISTRAN. LA INVENCIÓN PROPORCIONA ADEMÁS EL USO DE DICHOS COMPUESTOS COMO MEJORADORES DE LA BIODISPONIBILIDAD DE DETERMINADAS DROGAS. ADEMÁS SE PROPORCIOAN MÉTODOS PARA LA PREPARACIÓN DE LOS COMPUESTOS DE LA INVENCIÓN Y COMPOSICIONES FARMACÉUTICAS.
PA20088806801A 2007-12-06 2008-12-05 Compuestos de amida como refuerzos de antivirales PA8806801A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07122468 2007-12-06

Publications (1)

Publication Number Publication Date
PA8806801A1 true PA8806801A1 (es) 2009-07-23

Family

ID=39386111

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20088806801A PA8806801A1 (es) 2007-12-06 2008-12-05 Compuestos de amida como refuerzos de antivirales

Country Status (24)

Country Link
US (1) US8350048B2 (es)
EP (1) EP2235008B1 (es)
JP (1) JP5509092B2 (es)
KR (1) KR101624675B1 (es)
CN (1) CN101878210B (es)
AP (1) AP2804A (es)
AR (1) AR069595A1 (es)
AU (1) AU2008333165B2 (es)
BR (1) BRPI0821021A2 (es)
CA (1) CA2706155C (es)
CL (1) CL2008003639A1 (es)
EA (1) EA019616B1 (es)
HK (1) HK1149553A1 (es)
IL (1) IL205489A (es)
MX (1) MX2010006166A (es)
MY (1) MY151005A (es)
NZ (1) NZ585652A (es)
PA (1) PA8806801A1 (es)
PE (1) PE20091263A1 (es)
TW (1) TWI438202B (es)
UA (1) UA103013C2 (es)
UY (1) UY31513A1 (es)
WO (1) WO2009071650A2 (es)
ZA (1) ZA201004025B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009301131B2 (en) * 2008-10-07 2014-03-27 Janssen Sciences Ireland Uc New amide compounds as boosters of antivirals
US20120172368A1 (en) * 2009-09-03 2012-07-05 Koen Vandyck Bis-Benzimidazole Derivatives
US8759535B2 (en) 2010-02-18 2014-06-24 High Point Pharmaceuticals, Llc Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
CA2833006A1 (en) * 2011-04-22 2012-10-26 Merck Sharp & Dohme Corp. Taste-masked formulations of raltegravir
WO2014194519A1 (en) 2013-06-07 2014-12-11 Merck Sharp & Dohme Corp. Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug
CN104000824B (zh) * 2014-05-28 2016-07-06 中山大学 苯并五元杂环类化合物在制备抗hiv-1病毒药物中的应用
WO2016089648A1 (en) 2014-12-01 2016-06-09 Vtv Therapeutics Llc Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof
CN105985356B (zh) * 2015-02-05 2018-06-22 四川大学 咪唑[2,1-b]噻唑衍生物及其制备方法和用途
AU2016375634B2 (en) 2015-12-22 2021-03-25 Kancera Ab Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity
AR114136A1 (es) 2017-10-10 2020-07-29 Hoffmann La Roche Compuestos heterocíclicos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037157A (en) * 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
AR037797A1 (es) 2001-12-12 2004-12-01 Tibotec Pharm Ltd Combinacion de inhibidores de proteasa dependientes del citocromo p450
MY142238A (en) 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
CN101445493A (zh) * 2002-08-02 2009-06-03 泰博特克药品有限公司 广谱2-氨基-苯并噻唑磺酰胺类hiv蛋白酶抑制剂
AR053845A1 (es) * 2005-04-15 2007-05-23 Tibotec Pharm Ltd 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450
WO2008022345A2 (en) * 2006-08-18 2008-02-21 Sequoia Pharmaceuticals, Inc. Compositions and methods for inhibiting cytochrome p450

Also Published As

Publication number Publication date
EA201070691A1 (ru) 2010-10-29
AU2008333165B2 (en) 2013-04-11
BRPI0821021A2 (pt) 2015-06-16
MY151005A (en) 2014-03-31
KR101624675B1 (ko) 2016-05-27
HK1149553A1 (en) 2011-10-07
NZ585652A (en) 2011-10-28
CL2008003639A1 (es) 2010-01-15
IL205489A (en) 2016-09-29
AR069595A1 (es) 2010-02-03
AP2804A (en) 2013-11-30
EP2235008B1 (en) 2016-03-16
TWI438202B (zh) 2014-05-21
KR20100092489A (ko) 2010-08-20
MX2010006166A (es) 2010-10-05
WO2009071650A2 (en) 2009-06-11
EA019616B1 (ru) 2014-05-30
CN101878210A (zh) 2010-11-03
WO2009071650A3 (en) 2009-09-11
AP2010005285A0 (en) 2010-06-30
TW200938540A (en) 2009-09-16
CA2706155C (en) 2016-07-19
ZA201004025B (en) 2011-12-28
UA103013C2 (uk) 2013-09-10
JP2011506291A (ja) 2011-03-03
EP2235008A2 (en) 2010-10-06
PE20091263A1 (es) 2009-08-14
US8350048B2 (en) 2013-01-08
IL205489A0 (en) 2010-12-30
US20100305073A1 (en) 2010-12-02
UY31513A1 (es) 2009-07-17
CA2706155A1 (en) 2009-06-11
CN101878210B (zh) 2013-07-17
JP5509092B2 (ja) 2014-06-04
AU2008333165A1 (en) 2009-06-11

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