AR114136A1 - Compuestos heterocíclicos - Google Patents

Compuestos heterocíclicos

Info

Publication number
AR114136A1
AR114136A1 ARP180102900A ARP180102900A AR114136A1 AR 114136 A1 AR114136 A1 AR 114136A1 AR P180102900 A ARP180102900 A AR P180102900A AR P180102900 A ARP180102900 A AR P180102900A AR 114136 A1 AR114136 A1 AR 114136A1
Authority
AR
Argentina
Prior art keywords
substituted
aryl
alkyl
heterocyclyl
group
Prior art date
Application number
ARP180102900A
Other languages
English (en)
Inventor
Ludovic Collin
Martin Ritter
Blent Kocer
Bernd Kuhn
Uwe Grether
Charles Bell
Simon E Johnson
Satoshi Tsuchiya
Fionn Ohara
Hans Richter
Benoit Hornsperger
Jrg Benz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR114136A1 publication Critical patent/AR114136A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Abstract

Reivindicación 1: Compuesto de fórmula (1), en la que: X es C-H o N; Y¹ se selecciona del grupo que consiste en C-H, C-F, C-alquilo, C-haloalquilo y N; Y² se selecciona del grupo que consiste en C-H, C-halógeno, C-alquilo y C-haloalquilo; R¹ se selecciona del grupo que consiste en: i) arilo, ii) arilo sustituido, iii) heteroarilo, iv) heteroarilo sustituido, v) heterociclilo, vi) heterociclilo sustituido, vii) cicloalquilo y viii) cicloalquilo sustituido, en el que: cada uno de dichos arilo sustituido, heteroarilo sustituido, heterociclilo sustituido y cicloalquilo sustituido se sustituye independientemente con uno o más sustituyentes seleccionados del grupo que consiste en aminoalquilo, amino, haloalquilarilo, cicloalquilo, cicloalquilarilo, arilo-alquenilo, haloarilo-alquenilo, ciano(haloarilo), haloarilsulfonilo, alquilo(hidroxiheterociclilo), alquil(haloheterociclilo), arilalcoxialquilheteroarilo, hidroxialquinilo, halolalquilarilo-alcoxialquilo, haloalquiloheteroarilo, haloalquilheterociclilo, alquilheteroarilo, arilocicloalquilo, hidroxialquilheterociclilo, alquilsulfanilo, alcoxiheterociclilo, cicloalquilheteroarilo, alquilcicloalquilheteroarilo, haloalquilcicloalquilheteroarilo, alcoxialquilheteroarilo, alcoxialquilheterociclilo, alcoxialquilarilo, cicloalquilalcoxi, arilalcoxi, ariloxialquilo, haloariloxialquilo, ariloxiarilo, ariloxiheteroarilo, ariloxi, haloalquilariloxi, halógeno, heterociclilo, hidroxiheterociclilo, heterocicliloalquilo, heteroarilo, arilo, arilo-C(O)-, haloarilo, haloheteroarilo, halocicloalquilo, haloalcoxi, hidroxialcoxi, alcoxialcoxi, hidroxialcoxiarilo, hidroxialcoxiheteroarilo, alcoxi, alquilo, haloalquilo, ciano, cianoarilo, cianoheteroarilo, cianocicloalquilo, cianoalquilarilo, ariloheterociclilo, alcoxi-(haloalquilo)arilo, alquilarilo, arilalcoxi-(alquil)arilo, haloariloxi, hidroxialquilarilo, hidroxialquilheteroarilo, alqueniloxi, pentafluoro-l⁶-sulfanilo, heteroarilalquilo, heteroarilalcoxi, haloheteroarilalcoxi, alcoxiarilo, alcoxiheteroarilo, (arilalcoxi)arilo, (arilalcoxi)heteroarilo, carbamoiloarilo, alquilo-(alcoxi)arilo, haloalcoxiarilo, haloalcoxiheteroarilo, alquiloheterociclilo, haloheterociclilo, alquilhaloarilo, haloalquilhaloarilo y haloarilalcoxi, en los que: dicho aminoalquilo se sustituye en el átomo de nitrógeno con uno o dos sustituyentes seleccionados independientemente del grupo que consiste en H, alquilo, cicloalquilo, alcanoilo, arilalquilo y haloalquilarilalquilo, y dicho amino se sustituye en el átomo de nitrógeno con uno o dos sustituyentes seleccionados independientemente del grupo que consiste en H, alquilo, haloalquilo, cicloalquilo, hidroxialquilo, alcoxialquilo, haloarilalquilo, haloalcoxiarilalquilo, bencilo y bencilo sustituido con un sustituyente seleccionado del grupo que consiste en halógeno, alquilo y haloalquilo; y R² se selecciona del grupo que consiste en hidrógeno y alquilo; o una sal farmacéuticamente aceptable del mismo.
ARP180102900A 2017-10-10 2018-10-08 Compuestos heterocíclicos AR114136A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17195653 2017-10-10

Publications (1)

Publication Number Publication Date
AR114136A1 true AR114136A1 (es) 2020-07-29

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Family Applications (1)

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ARP180102900A AR114136A1 (es) 2017-10-10 2018-10-08 Compuestos heterocíclicos

Country Status (7)

Country Link
US (1) US11390610B2 (es)
EP (1) EP3694840B1 (es)
JP (1) JP7244500B2 (es)
CN (1) CN111247129A (es)
AR (1) AR114136A1 (es)
TW (1) TW201922728A (es)
WO (1) WO2019072785A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR114136A1 (es) 2017-10-10 2020-07-29 Hoffmann La Roche Compuestos heterocíclicos
EP3717477B1 (en) 2017-11-28 2022-07-20 F. Hoffmann-La Roche AG New heterocyclic compounds
EP3737680A1 (en) 2018-01-08 2020-11-18 F. Hoffmann-La Roche AG Octahydropyrido[1,2-alpha]pyrazines as magl inhibitors
AU2019322538B2 (en) 2018-08-13 2021-09-30 F. Hoffmann-La Roche Ag New heterocyclic compounds as monoacylglycerol lipase inhibitors
CN110105300B (zh) * 2019-06-28 2023-04-14 福州大学 一种合成2-三氟乙基取代苯并噁唑化合物的方法
BR112022002375A2 (pt) 2019-09-12 2022-07-19 Hoffmann La Roche Compostos de 4,4a,5,7,8,8a-hexapirido[4,3-b][1,4]oxazin-3-ona como inibidores de magl
KR102351054B1 (ko) * 2019-11-11 2022-01-14 엠비디 주식회사 신규한 퀴놀린 화합물 및 이의 용도
EP3875452A1 (en) * 2020-03-04 2021-09-08 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Monoacylglycerol lipase inhibitors
WO2023076219A2 (en) * 2021-10-26 2023-05-04 Vasocardea, Inc. Antagonists of gpr39 protein

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US11390610B2 (en) 2022-07-19
TW201922728A (zh) 2019-06-16
EP3694840A1 (en) 2020-08-19
US20200299277A1 (en) 2020-09-24
WO2019072785A1 (en) 2019-04-18
EP3694840B1 (en) 2021-08-04
JP2021500322A (ja) 2021-01-07
CN111247129A (zh) 2020-06-05
JP7244500B2 (ja) 2023-03-22

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